WARNING

Taking Ziv-aflibercept injection, like any medication, comes with potential risks. It’s crucial to weigh the risks against the benefits, and decisions about treatment should be made in consultation with a qualified healthcare professional. Here is a brief overview of the potential risks associated with Ziv-aflibercept:

• Eye Infections: There is an increased risk of eye infections, which can lead to redness, swelling, and discharge.
• Increased Eye Pressure: Ziv-aflibercept injections may cause an increase in intraocular pressure.
• Retinal Detachment: In rare cases, there have been reports of retinal detachment following intravitreal injections.
• Cardiovascular Events: Serious cardiovascular events, such as strokes and heart attacks, may be more likely, particularly in individuals with a history of cardiovascular disease.
• Hypertension (High Blood Pressure): An increase in blood pressure may occur.
• Gastrointestinal Perforations: Rare cases of gastrointestinal perforations have been reported.
• Temporary Vision Changes: Ziv-aflibercept may cause temporary changes in vision, such as blurred vision or the perception of floaters.

It’s important to note that these are potential risks, and not everyone will experience them. The decision to use Ziv-aflibercept should be based on a thorough assessment of your individual health status, the severity of your eye condition, and discussions with your healthcare provider. The benefits of treatment, such as preventing vision loss or improving visual outcomes, will be considered in the context of the potential risks.

Regular monitoring and follow-up with a healthcare provider are essential to detect and manage any side effects or complications promptly. If you experience any unusual symptoms or side effects, it’s important to contact your healthcare provider immediately. Always adhere to the prescribed dosage and schedule, and inform your healthcare provider about all medications and health conditions to minimize potential risks.

Why is this medication prescribed?

Ziv-aflibercept injection is prescribed for the treatment of certain eye conditions, particularly neovascular (wet) age-related macular degeneration (AMD), macular edema following central retinal vein occlusion (CRVO), diabetic macular edema (DME), and diabetic retinopathy in patients with DME.

Here’s an overview of the conditions for which Ziv-aflibercept is commonly prescribed:

• Neovascular (Wet) Age-Related Macular Degeneration (AMD): AMD is a condition affecting the macula, a part of the retina responsible for central vision. Neovascular AMD involves the growth of abnormal blood vessels that can lead to vision loss.
• Macular Edema following Central Retinal Vein Occlusion (CRVO): CRVO is a blockage of the central retinal vein that can cause swelling (edema) in the macula and lead to vision impairment.
• Diabetic Macular Edema (DME): DME is a complication of diabetic retinopathy, where fluid accumulates in the macula, causing vision problems.

How should this medicine be used?

Here are general guidelines on how Ziv-aflibercept injection is typically used:

• Administration: Ziv-aflibercept is administered by injection into the eye. This is usually done by a healthcare professional in a clinical setting.
• Dosage: The dosage and frequency of injections will be determined by your eye care specialist based on the specific condition being treated and the individual response to the treatment.
• Preparation: The injection is prepared and administered under sterile conditions. Patients should not attempt to self-administer this medication.
• Follow-up: Regular follow-up appointments with your healthcare provider are important to monitor the progress of the treatment and to determine if additional injections are needed.

It’s crucial to follow the instructions provided by your healthcare provider regarding the use of Ziv-aflibercept. If you have any questions or concerns about the medication, its administration, or potential side effects, it’s important to discuss them with your healthcare team.

As with any medication, there can be potential side effects or contraindications, so it’s important to inform your healthcare provider about your medical history, current medications, and any other relevant information before starting Ziv-aflibercept or any other new treatment.

Other uses for this medicine

Ziv-aflibercept is primarily used for the treatment of certain eye conditions, as mentioned earlier. However, it’s important to note that the use of medications can evolve, and new applications may be identified over time. Always consult with a healthcare professional for the most up-to-date and accurate information regarding medication uses.

What special precautions should I follow?

As for special precautions when using Ziv-aflibercept injection, it’s essential to follow your healthcare provider’s guidance closely. Here are some general precautions and considerations:

• Allergies: Inform your healthcare provider about any allergies you may have, especially if you are allergic to aflibercept or any other ingredients in the medication.
• Medical History: Provide a complete medical history, including information about previous eye surgeries, infections, and other eye conditions. Also, inform your healthcare provider about any systemic health conditions you may have.
• Pregnancy and Breastfeeding: If you are pregnant or planning to become pregnant, or if you are breastfeeding, discuss this with your healthcare provider. The potential risks and benefits of using Ziv-aflibercept during pregnancy or breastfeeding should be carefully considered.
• Infections: Ziv-aflibercept may increase the risk of eye infections. Inform your healthcare provider if you have any signs of infection, such as redness, swelling, or discharge in the eye.
• Monitoring: Regular monitoring of your eye condition is necessary during the treatment period. Your healthcare provider will determine the frequency of follow-up appointments to assess the effectiveness of the medication and identify any potential side effects.
• Driving and Vision: Ziv-aflibercept may cause temporary changes in vision. Avoid driving or engaging in activities that require clear vision until you are certain about how the medication affects you.
• Other Medications: Inform your healthcare provider about all medications, including over-the-counter drugs and supplements, that you are currently taking. This is important to avoid potential drug interactions.
• Injection Site Reactions: It’s not uncommon to experience some discomfort or redness at the injection site. Report any persistent or severe side effects to your healthcare provider.

Always consult with your healthcare provider for personalized advice based on your specific medical history and circumstances. Following their instructions and attending regular check-ups is crucial for the safe and effective use of Ziv-aflibercept.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions associated with Ziv-aflibercept. However, maintaining a healthy and balanced diet is important for overall health, including eye health. Consider discussing your diet with your healthcare provider or a nutritionist for personalized advice.

What should I do if I forget a dose?

Ziv-aflibercept injections are typically administered by healthcare professionals, and patients usually do not self-administer them. If you miss a scheduled appointment for an injection, contact your healthcare provider promptly. They will provide guidance on whether the missed dose needs to be rescheduled and how it might impact your treatment plan.

What side effects can this medication cause?

Ziv-aflibercept, like any medication, may cause side effects. Not everyone will experience these side effects, and their severity can vary from person to person. It’s important to be aware of potential side effects and to promptly report any unusual or severe symptoms to your healthcare provider. Common side effects and some less common but more serious side effects associated with Ziv-aflibercept injection include:

Common Side Effects:

• Eye Discomfort: It is common to experience some discomfort or irritation at the injection site.
• Increased Eye Pressure: Ziv-aflibercept injections may lead to an increase in intraocular pressure.
• Floaters: Some people may notice floaters in their vision.
• Conjunctival Hemorrhage: This refers to bleeding in the conjunctiva, the clear layer covering the white part of the eye.
• Blurred Vision: Temporary blurred vision may occur after the injection.

Less Common but Serious Side Effects:

• Eye Infections: There may be an increased risk of eye infections. Signs of infection include redness, swelling, and discharge.
• Retinal Detachment: In rare cases, there have been reports of retinal detachment following intravitreal injections.
• Serious Cardiovascular Events: Ziv-aflibercept may be associated with an increased risk of serious cardiovascular events, particularly in patients with a history of cardiovascular disease.
• Stroke: There may be an increased risk of stroke in certain populations.
• Gastrointestinal Perforations: Rare cases of gastrointestinal perforations have been reported.
• Hypertension (High Blood Pressure): An increase in blood pressure may occur.

These lists are not exhaustive, and other side effects may occur. It’s essential to report any unusual symptoms or concerns to your healthcare provider promptly. Additionally, discuss your medical history and any pre-existing conditions with your healthcare provider before starting treatment with Ziv-aflibercept to assess the potential risks and benefits for your specific situation. Always follow your healthcare provider’s instructions regarding the medication and attend regular check-ups to monitor your eye health and overall well-being.

What should I know about storage and disposal of this medication?

Storage and Disposal of Ziv-aflibercept Injection:

• Storage:
  • Ziv-aflibercept injections are typically stored by healthcare professionals or in a clinical setting.
  • If you are prescribed Ziv-aflibercept for home use, follow the specific storage instructions provided by your healthcare provider. This often involves refrigeration.
• Disposal:
  • Healthcare providers are responsible for the proper disposal of medical waste, including used syringes and vials containing Ziv-aflibercept.
  • If you are given Ziv-aflibercept injections for home use, follow your healthcare provider’s instructions on proper disposal to ensure safe disposal and prevent accidental exposure.

In case of emergency/overdose

In the case of an emergency or suspected overdose, seek immediate medical attention. Overdose situations with Ziv-aflibercept are not common due to the controlled and monitored nature of the injections administered by healthcare professionals. Symptoms of an overdose may include severe eye pain, redness, or other unusual eye symptoms.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Adhere strictly to the dosing schedule and administration instructions provided by your healthcare provider. Attend all scheduled follow-up appointments for monitoring and assessment.
• Inform Healthcare Provider: Keep your healthcare provider informed about any changes in your health, including new symptoms or side effects.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The use of Ziv-aflibercept during pregnancy and breastfeeding should be carefully considered.
• Regular Eye Exams: Regular eye examinations are crucial for monitoring the progress of treatment and identifying any potential issues.
• Driving and Vision: Ziv-aflibercept may cause temporary changes in vision. Avoid driving or engaging in activities that require clear vision until you are certain about how the medication affects you.
• Medication Interactions: Inform your healthcare provider about all medications, including over-the-counter drugs and supplements, that you are taking to prevent potential interactions.
• Storage and Handling: If you have any questions about the storage or handling of Ziv-aflibercept, consult your healthcare provider.

Always consult with your healthcare provider or pharmacist for personalized advice and information specific to your situation. It’s important to be well-informed about your medication, follow instructions diligently, and seek assistance if any issues or concerns arise.