Why is this medication prescribed?

Zirabev is a medication that contains the active ingredient bevacizumab. Bevacizumab is a monoclonal antibody that works by targeting and inhibiting vascular endothelial growth factor (VEGF). VEGF is a protein that plays a key role in the formation of blood vessels (angiogenesis).

Zirabev is primarily prescribed for the treatment of various types of cancer. It is often used in combination with chemotherapy or other cancer treatments. The inhibition of VEGF helps to limit the growth of blood vessels that supply nutrients to tumors, thereby inhibiting tumor growth and metastasis.

As of last update, Zirabev is prescribed for the following types of cancer:

• Colorectal Cancer: Zirabev, in combination with chemotherapy, is used for the treatment of metastatic colorectal cancer.
• Lung Cancer: It may be prescribed in combination with chemotherapy for the treatment of non-small cell lung cancer.
• Breast Cancer: Zirabev may be considered in combination with chemotherapy for the treatment of certain types of metastatic breast cancer.
• Glioblastoma Multiforme: Zirabev is used for the treatment of recurrent glioblastoma multiforme, a type of brain tumor.
• Renal Cell Carcinoma: It may be used in combination with other medications for the treatment of advanced renal cell carcinoma.

How should this medicine be used?

Zirabev (bevacizumab) is typically administered by a healthcare professional in a clinical setting, such as a hospital or infusion center. The medication is given as an intravenous (IV) infusion, which means it is delivered directly into a vein through a needle. The specific dosage and schedule will be determined by your healthcare provider based on your medical condition, the type of cancer being treated, and other individual factors.

Here are some general guidelines for the use of Zirabev:

• Dosage: The dosage of Zirabev can vary depending on the type of cancer being treated and the overall treatment plan. The medication is often given in combination with chemotherapy or other cancer treatments.
• Administration: Zirabev is administered by a healthcare professional through an IV infusion. The infusion process may take a specific amount of time, and you will be monitored during and after the infusion for any potential side effects.
• Frequency: The frequency of Zirabev infusions will depend on your specific treatment plan. Infusions are typically scheduled at regular intervals, and the treatment course may extend over several weeks or months.
• Monitoring: Your healthcare provider will closely monitor your response to treatment and assess for any potential side effects. This may involve regular check-ups, blood tests, and imaging studies.
• Precautions: Due to potential side effects, your healthcare provider may take certain precautions during the administration of Zirabev to minimize the risk of infusion reactions or other adverse events.
• Follow-up: Attend all scheduled appointments and follow-up visits as recommended by your healthcare provider. It’s important to communicate any changes in your health, symptoms, or concerns during the course of treatment.

It’s crucial to note that Zirabev should only be used under the supervision and guidance of a qualified healthcare professional. The specific details of your treatment plan, including dosage and scheduling, will be determined based on your unique medical situation.

If you have any questions or concerns about the use of Zirabev, it’s important to discuss them with your healthcare provider. They can provide personalized information based on your specific health conditions and the type of cancer being treated.

Other uses for this medicine

The primary uses for Zirabev (bevacizumab) were in the treatment of various cancers, particularly colorectal cancer, lung cancer, breast cancer, glioblastoma multiforme, and renal cell carcinoma. However, medical information can change, and new indications may have been approved since then. Always consult with a healthcare professional or refer to the most recent medical literature for the latest information.

What special precautions should I follow?

When using Zirabev or any medication, it’s essential to follow the specific instructions provided by your healthcare provider. Here are some general precautions that may apply:

• Medical History: Before starting Zirabev, inform your healthcare provider about your complete medical history, including any existing medical conditions, allergies, or previous reactions to medications.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. Bevacizumab may have potential risks to a developing fetus, and the decision to use it during pregnancy should be carefully considered.
• Blood Pressure Monitoring: Bevacizumab may affect blood pressure. Your healthcare provider may monitor your blood pressure regularly during treatment. If you have a history of hypertension, it may need to be controlled before starting Zirabev.
• Wound Healing: Bevacizumab may affect wound healing. Inform your healthcare provider if you have upcoming surgery or if you experience any wounds that are slow to heal.
• Bleeding Risk: Bevacizumab may increase the risk of bleeding. Inform your healthcare provider if you have a history of bleeding disorders or if you are taking medications that affect blood clotting.
• Kidney Function: Bevacizumab is eliminated from the body through the kidneys. Your healthcare provider may monitor your kidney function during treatment.
• Infusion Reactions: Like many intravenous medications, Zirabev may cause infusion reactions. These can include fever, chills, nausea, and other symptoms. Your healthcare provider will take steps to minimize the risk of these reactions during administration.
• Regular Monitoring: Regular check-ups and monitoring of blood counts and other relevant parameters are often part of the treatment plan. Attend all scheduled appointments and inform your healthcare provider of any side effects or concerns.

It’s crucial to remember that individual patients may have unique considerations, and the precautions mentioned above are general guidelines. Always follow your healthcare provider’s advice and report any unusual symptoms or side effects promptly.

For the most accurate and up-to-date information, consult with your healthcare provider or refer to the prescribing information provided by the pharmaceutical company that manufactures Zirabev.

What special dietary instructions should I follow?

As of last update, there were no specific dietary restrictions associated with Zirabev. However, individual dietary considerations may vary based on your overall health and any concurrent medical conditions. Always consult with your healthcare provider for personalized advice.

What should I do if I forget a dose?

Zirabev is typically administered by healthcare professionals as an intravenous infusion. Patients do not administer the medication themselves. If you miss an appointment for your infusion, it’s essential to contact your healthcare provider as soon as possible to reschedule. Do not try to administer the medication on your own.

What side effects can this medication cause?

Zirabev (bevacizumab) is associated with a range of potential side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary from person to person. Common side effects may include:

• Hypertension (High Blood Pressure): Bevacizumab can cause an increase in blood pressure. Regular monitoring of blood pressure is often recommended during treatment.
• Infusion Reactions: Infusion-related reactions may occur during or shortly after the administration of bevacizumab. Symptoms can include fever, chills, nausea, vomiting, headache, and others. Healthcare providers take precautions to minimize the risk of these reactions during infusion.
• Bleeding and Blood Clotting Issues: Bevacizumab may increase the risk of bleeding and blood clotting problems. This can manifest as nosebleeds, easy bruising, or prolonged bleeding after injury. Serious conditions such as gastrointestinal bleeding or blood clots may also occur.
• Proteinuria (Increased Protein in the Urine): Bevacizumab may lead to increased protein levels in the urine, which can be an indicator of kidney problems.
• Gastrointestinal Perforations: There is a risk of gastrointestinal perforations (holes in the stomach or intestines), which can be a serious and potentially life-threatening side effect.
• Impaired Wound Healing: Bevacizumab may affect the normal process of wound healing. It’s important to inform healthcare providers if you have upcoming surgery.
• Reduced White Blood Cell Count (Neutropenia): Bevacizumab can lead to a reduction in the number of white blood cells, increasing the risk of infections.
• Fatigue: Feeling tired or fatigued is a common side effect of many cancer treatments, including bevacizumab.
• Problems with the Nervous System: Some individuals may experience neurological side effects, such as headache or changes in taste.
• Kidney Problems: Bevacizumab can impact kidney function, leading to conditions such as proteinuria.

It’s important to report any side effects or concerns to your healthcare provider promptly. The information provided here is not exhaustive, and the specific side effects experienced can depend on the individual, the type of cancer being treated, and other factors.

Patients receiving Zirabev should be closely monitored during treatment, and healthcare providers will weigh the potential benefits of the medication against the risks based on the patient’s overall health and the specific cancer being treated.

Always consult with your healthcare provider or refer to the prescribing information for the most up-to-date and comprehensive list of side effects associated with Zirabev.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zirabev:

• Storage: Zirabev (bevacizumab) is typically administered in a healthcare setting by a qualified professional. However, if you have the medication at home before administration, it should be stored according to the manufacturer’s instructions. Generally, many medications need to be stored in a cool, dry place away from direct sunlight. Follow specific storage instructions provided with the medication or by your healthcare provider.
• Disposal: Proper disposal of unused or expired medications is crucial to prevent accidental ingestion or environmental contamination. Follow local regulations for medication disposal. Many communities have drug take-back programs or specific guidelines for safe disposal. Do not flush medications down the toilet unless instructed to do so. Consult your pharmacist or healthcare provider for guidance on the proper disposal of Zirabev.

In case of emergency/overdose

In case of an emergency or suspected overdose, contact your local emergency services immediately or go to the nearest emergency room. Symptoms of overdose may vary, and it’s essential to seek prompt medical attention. Be prepared to provide information on the medication, the amount taken, and any symptoms you or the affected person may be experiencing.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Always follow the specific instructions provided by your healthcare provider for the administration of Zirabev. This may include the dosage, schedule, and any pre-treatment requirements.
• Regular Monitoring: Your healthcare provider will likely schedule regular check-ups and monitoring to assess the response to treatment and to manage any potential side effects.
• Inform Healthcare Provider: Keep your healthcare provider informed about any other medications, supplements, or herbal products you are taking. Some drugs may interact with Zirabev.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The use of Zirabev during pregnancy and breastfeeding should be discussed with your healthcare provider.
• Communicate Side Effects: Report any side effects or unusual symptoms to your healthcare provider promptly. They can help manage side effects or adjust treatment if needed.
• Medical Alerts: Wear a medical alert bracelet or carry a medical alert card to inform healthcare professionals about your treatment with Zirabev in case of an emergency.

Always consult with your healthcare provider or pharmacist for the most accurate and up-to-date information regarding the storage, disposal, and other important aspects of Zirabev use.