Why is this medication prescribed?

Zileuton is a medication primarily prescribed for the treatment of asthma. It belongs to a class of drugs known as leukotriene synthesis inhibitors. Leukotrienes are substances in the body that can cause inflammation, bronchoconstriction (narrowing of airways), and other symptoms associated with asthma. Zileuton is used for the prophylaxis and chronic treatment of asthma in adults and children over the age of 12. It is not meant for the relief of acute bronchospasm.

How should this medicine be used?

Zileuton is a medication used for the treatment of asthma. It belongs to a class of drugs known as leukotriene synthesis inhibitors. Zileuton works by blocking the production of certain chemicals in the body that contribute to inflammation and constriction of airways.

Here are general guidelines on how Zileuton should be used:

• Dosage: The typical dose of Zileuton is usually prescribed by a healthcare professional. It is important to follow the prescribed dosage and not exceed it without consulting your healthcare provider.
• Timing: Zileuton is usually taken four times a day, with or without food. It’s important to take the medication at evenly spaced intervals to maintain a consistent level of the drug in your system.
• Swallowing: Zileuton tablets should be swallowed whole and not crushed or chewed. If you have difficulty swallowing tablets, talk to your doctor or pharmacist.
• Consistency: It’s crucial to take Zileuton regularly, even if you are feeling well. Consistency is key for managing asthma symptoms.
• Missed Dose: If you miss a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not double up on doses to make up for a missed one.
• Follow-up: Your healthcare provider will likely monitor your response to Zileuton and may adjust your dosage if needed. It’s important to attend follow-up appointments and communicate any concerns or changes in your symptoms.
• Monitoring: Zileuton can affect liver function, so your doctor may order periodic liver function tests. If you notice symptoms of liver problems, such as yellowing of the skin or eyes, dark urine, or persistent nausea, contact your healthcare provider immediately.
• Interaction with Other Medications: Inform your healthcare provider about all the medications you are taking, including prescription, over-the-counter, and herbal supplements. Some drugs may interact with Zileuton, and adjustments may be necessary.

Always follow the specific instructions provided by your healthcare professional and consult with them if you have any questions or concerns about the use of Zileuton. They can provide guidance tailored to your individual health condition.

Other uses for this medicine

Zileuton is primarily indicated for asthma. It is not typically used for other conditions. It’s important to use the medication only as prescribed by a healthcare professional.

What special precautions should I follow?

When using Zileuton, several special precautions need to be considered:

• Liver Function: Zileuton can affect liver function. Patients taking Zileuton should have liver function monitored through blood tests. If liver function abnormalities are detected, the dosage may need to be adjusted or the medication may need to be discontinued.
• Alcohol: Due to its potential impact on liver function, it is advisable to limit or avoid alcohol consumption while taking Zileuton.
• Concomitant Use with Warfarin: Zileuton may increase the effect of warfarin, a blood thinner. Close monitoring of international normalized ratio (INR) is recommended when Zileuton is used concomitantly with warfarin.
• Hypersensitivity: Individuals with known hypersensitivity or allergic reactions to Zileuton or its components should not use this medication.
• Pregnancy and Breastfeeding: The safety of Zileuton during pregnancy and breastfeeding is not well-established. The potential benefits and risks should be discussed with a healthcare provider.
• Other Medications: Zileuton may interact with other medications, including over-the-counter drugs and supplements. Inform your healthcare provider about all the medications you are taking to avoid potential interactions.
• Monitoring: Regular follow-up appointments with a healthcare provider are important to monitor the effectiveness of the medication and to detect any potential side effects or complications.

Always follow the prescribed dosage and instructions provided by your healthcare provider. If you experience any unusual or severe side effects, contact your healthcare provider promptly. This information is not exhaustive, and individual cases may vary, so it’s crucial to consult with a healthcare professional for personalized advice and guidance based on your specific health condition.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Zileuton. However, taking the medication with food is recommended as it may enhance absorption and reduce the risk of stomach upset. Follow your healthcare provider’s instructions regarding the timing of Zileuton with respect to meals.

What should I do if I forget a dose?

If you forget to take a dose of Zileuton:

• Take It as Soon as You Remember: If it is not almost time for your next scheduled dose, take the missed dose as soon as you remember.
• Skip the Missed Dose If It’s Almost Time for the Next Dose: If it is nearly time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
• Do Not Double Up to Make Up for a Missed Dose: Do not take a double dose to make up for a missed one. Taking extra medication can increase the risk of side effects.

What side effects can this medication cause?

Zileuton, like any medication, can cause side effects. Not everyone will experience these side effects, and some individuals may experience side effects that are not listed. It’s important to be aware of potential side effects and promptly report any unusual or severe symptoms to your healthcare provider. Here are some common and less common side effects associated with Zileuton:

Common Side Effects:

• Gastrointestinal Distress:
  • Upset stomach
  • Nausea
  • Diarrhea
• Liver Function Abnormalities:
  • Elevated liver enzymes (detected through blood tests)
  • Liver problems (rare, but can be serious)

Less Common Side Effects:

• Allergic Reactions:
  • Rash
  • Itching
  • Swelling, especially of the face, lips, or tongue
  • Severe dizziness
  • Difficulty breathing
• Muscle Aches or Weakness
• Flu-like Symptoms:
  • Fever
  • Chills

Serious Side Effects (Rare but Important to Report):

• Liver Damage:
  • Symptoms may include persistent nausea, abdominal pain, dark urine, or jaundice (yellowing of the skin or eyes).
• Neuropsychiatric Effects:
  • Depression
  • Suicidal thoughts (rare)
• Allergic Vasculitis:
  • Inflammation of blood vessels
• Hypersensitivity Reactions:
  • Anaphylaxis (a severe, potentially life-threatening allergic reaction)
• Eosinophilic Conditions:
  • Eosinophilic pneumonia (a type of lung inflammation)

Precautions Regarding Side Effects:

• Liver Function Monitoring: Regular monitoring of liver function through blood tests is crucial.
• Immediate Medical Attention: Seek immediate medical attention if you experience symptoms of a severe allergic reaction, such as difficulty breathing or swelling of the face.
• Contact Your Healthcare Provider: Report any unusual or persistent side effects to your healthcare provider promptly.

It’s important to note that the information provided here is not exhaustive, and individuals may react differently to medications. Always follow the prescribed dosage and instructions from your healthcare provider. If you have concerns about potential side effects or experience any unusual symptoms, consult with your healthcare provider for guidance.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zileuton:

• Storage:
  • Store Zileuton at room temperature, away from moisture and heat.
  • Keep it in its original container, tightly closed.
• Disposal:
  • Follow local regulations for the proper disposal of unused or expired medications.
  • Do not flush Zileuton down the toilet or pour it into a drain unless instructed to do so.

In case of emergency/overdose

• Seek Immediate Medical Attention:
  • In case of an overdose or emergency, call your local poison control center at 1-800-222-1222 or seek emergency medical attention.
• Symptoms of Overdose May Include:
  • Severe nausea
  • Vomiting
  • Loss of appetite
  • Extreme tiredness
  • Confusion
  • Trouble breathing

What other information should I know?

• Follow Healthcare Provider’s Instructions: Take Zileuton exactly as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting your doctor.
• Regular Monitoring: Attend regular follow-up appointments with your healthcare provider to monitor your response to the medication and check for any potential side effects.
• Inform Healthcare Provider: Inform your healthcare provider about all other medications, including over-the-counter drugs and supplements, that you are taking to avoid potential interactions.
• Patient Education: Understand the proper use of Zileuton, including when and how to take it. If you have any questions, consult your healthcare provider or pharmacist.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Zileuton with your healthcare provider.
• Allergies: Inform your healthcare provider about any allergies or adverse reactions to medications.
• Do Not Share Medication: Do not share Zileuton with others, even if they have similar symptoms.
• Carry Identification: Carry identification (e.g., a card or bracelet) indicating that you are taking Zileuton, especially if you have a medical emergency.
• Keep a List of Medications: Maintain a list of all medications you are taking, including dosage and frequency, and share it with healthcare providers.
• Stay Informed: Stay informed about any updates or changes in the information provided with your medication.

Always consult your healthcare provider or pharmacist if you have specific questions or concerns about your medication. This information is not a substitute for professional medical advice, diagnosis, or treatment.