WARNING

While Zestril (lisinopril) is generally considered safe and effective for many people, it is important to be aware of potential risks and side effects associated with its use. Here are some key risks:

• Hypotension (Low Blood Pressure): Zestril can cause a drop in blood pressure, especially during the initial days of treatment. This may result in dizziness or lightheadedness, particularly when standing up quickly.
• Cough: A persistent dry cough is a common side effect of ACE inhibitors like Zestril. If the cough is bothersome, it’s important to inform your healthcare provider.
• Hyperkalemia (High Potassium Levels): Zestril can lead to an increase in potassium levels in the blood. Elevated potassium levels can cause weakness, irregular heartbeat, or other symptoms. Regular monitoring of potassium levels is typically advised.
• Kidney Dysfunction: Zestril can affect kidney function, and in some cases, it may lead to changes in blood urea nitrogen (BUN) and serum creatinine levels. Regular monitoring of kidney function is usually recommended.
• Angioedema: Although rare, ACE inhibitors, including Zestril, have been associated with angioedema—a serious condition involving swelling, especially around the face, lips, and throat. This requires immediate medical attention.
• Allergic Reactions: Some individuals may experience allergic reactions to Zestril. Symptoms may include rash, itching, swelling, severe dizziness, or difficulty breathing.
• Pregnancy Risk: Zestril is not recommended during pregnancy as it can harm the unborn baby. If pregnancy is detected, the medication should be discontinued, and alternative treatments may be considered.
• Interactions with Other Medications: Zestril can interact with other medications, potentially affecting their effectiveness or leading to increased side effects. It’s crucial to inform your healthcare provider about all medications, supplements, or herbal products you are taking.
• Impaired Kidney Function in Susceptible Individuals: Individuals with pre-existing kidney problems may be at a higher risk of experiencing impaired kidney function with Zestril use.

It’s important to note that these risks are not exhaustive, and individual responses to medications can vary. The decision to use Zestril should be made in consultation with a healthcare professional, taking into account your overall health, medical history, and any potential contraindications or interactions. Regular monitoring and communication with your healthcare provider are essential for safe and effective use of Zestril. If you experience any concerning symptoms or side effects, seek medical attention promptly.

Why is this medication prescribed?

Zestril is a brand name for the medication lisinopril, which belongs to a class of drugs known as angiotensin-converting enzyme (ACE) inhibitors. It is commonly prescribed for the treatment of various cardiovascular conditions. Here are some of the primary reasons Zestril may be prescribed:

• Hypertension (High Blood Pressure): Zestril is often prescribed to manage high blood pressure. By inhibiting the action of ACE, it helps relax blood vessels, allowing blood to flow more easily, and consequently, it helps lower blood pressure.
• Heart Failure: Zestril is used in the treatment of heart failure, a condition where the heart is unable to pump blood effectively.
• Post-Heart Attack Treatment: After a heart attack, Zestril may be prescribed to improve survival and reduce the risk of complications.
• Diabetic Nephropathy: In people with diabetes, Zestril may be used to treat diabetic nephropathy, a type of kidney disease.
• Prevention of Stroke: Zestril may be recommended to reduce the risk of stroke in individuals who have certain risk factors.

It’s important to note that Zestril should only be taken under the supervision and prescription of a qualified healthcare professional. The dosage and duration of treatment will depend on the specific condition being treated and the individual’s health status.

How should this medicine be used?

It’s essential to follow your healthcare provider’s instructions and the directions on your prescription label. Here are some general guidelines:

• Dosage: The dosage will be determined by your healthcare provider based on your medical condition and response to treatment.
• Administration: Zestril is usually taken once daily, with or without food. It’s important to take it consistently at the same time each day.
• Follow Instructions: Follow your healthcare provider’s instructions carefully. Do not adjust the dosage or stop taking the medication without consulting your doctor.
• Monitoring: Regular blood pressure checks and monitoring of kidney function may be necessary during the course of treatment.
• Missed Dose: If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Precautions: Inform your healthcare provider about any other medications, supplements, or medical conditions you may have before starting Zestril to avoid potential interactions and complications.
• Side Effects: Be aware of potential side effects and report any unusual symptoms to your healthcare provider.

It’s crucial to have open communication with your healthcare provider to ensure the safe and effective use of Zestril, and to address any concerns or questions you may have about the medication.

Other uses for this medicine

While Zestril is primarily used for the conditions mentioned above, it may sometimes be used off-label for other purposes. Off-label use refers to the use of a medication for a purpose other than what it has been officially approved for. However, any such use should be under the guidance of a healthcare professional.

What special precautions should I follow?

Special precautions and considerations for Zestril may include the following:

• Pregnancy and Breastfeeding: Zestril can cause harm to an unborn baby, so it is generally not recommended during pregnancy. If you become pregnant while taking Zestril, inform your doctor immediately. It is also important to discuss the use of Zestril while breastfeeding.
• Allergies: Inform your healthcare provider of any allergies you may have, especially if you have a history of allergic reactions to ACE inhibitors.
• Kidney Function: Zestril can affect kidney function. Regular monitoring of kidney function is typically recommended, especially if you have pre-existing kidney problems.
• Potassium Levels: ACE inhibitors, including Zestril, can increase potassium levels in the blood. This is of particular concern in individuals with kidney problems or those taking potassium supplements.
• Blood Pressure Drops: If you are dehydrated or have low blood pressure, Zestril can cause a significant drop in blood pressure. This can lead to dizziness or fainting. Ensure that you are well-hydrated, especially during hot weather.
• Angioedema: ACE inhibitors, including Zestril, have been associated with angioedema, a serious condition involving swelling of deeper layers of the skin, often around the eyes and lips. Seek medical attention if you experience symptoms of angioedema.
• Diabetes: Zestril can affect blood sugar levels, and adjustments to diabetes medications may be necessary.
• Surgery and Anesthesia: If you are scheduled for surgery, inform your healthcare provider that you are taking Zestril, as it may need to be temporarily stopped.

Always follow your healthcare provider’s instructions and attend regular check-ups to monitor your response to the medication and detect any potential side effects or complications early on. If you have concerns or experience any unusual symptoms, contact your healthcare provider promptly.

What special dietary instructions should I follow?

While taking Zestril, there are no specific dietary restrictions. However, certain lifestyle changes may be recommended, especially if you are taking it for hypertension or heart-related conditions. These may include adopting a heart-healthy diet that is low in salt (sodium), maintaining a healthy weight, and incorporating regular exercise into your routine.

What should I do if I forget a dose?

If you forget to take a dose of Zestril, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Zestril (lisinopril) is generally well-tolerated, but like any medication, it can cause side effects in some individuals. It’s important to note that not everyone will experience these side effects, and some people may experience side effects that are not listed. If you are prescribed Zestril, your healthcare provider will carefully monitor your response to the medication. Common side effects include:

• Cough: A persistent dry cough is a common side effect of ACE inhibitors like Zestril. If the cough is bothersome, inform your healthcare provider.
• Dizziness or Lightheadedness: Zestril can cause a drop in blood pressure, leading to dizziness or lightheadedness, especially when standing up quickly. It’s important to get up slowly from a sitting or lying position.
• Fatigue: Some people may experience fatigue or weakness while taking Zestril.
• Headache: Headaches are a common side effect but are often mild and temporary.
• Nausea or Abdominal Pain: Gastrointestinal symptoms, including nausea and abdominal pain, may occur.
• Rash: Skin rashes are possible, and if you develop a rash, notify your healthcare provider.
• Hyperkalemia (High Potassium): Zestril can lead to an increase in potassium levels in the blood, which may cause symptoms such as weakness, irregular heartbeat, or numbness. Regular monitoring of potassium levels is typically advised.
• Kidney Dysfunction: Zestril can affect kidney function, and your healthcare provider may monitor your kidney function through blood tests.
• Angioedema: Although rare, ACE inhibitors, including Zestril, have been associated with angioedema, a serious condition involving swelling, especially around the face, lips, and throat. Seek medical attention immediately if you experience symptoms of angioedema.
• Changes in Blood Urea Nitrogen (BUN) and Serum Creatinine: These are indicators of kidney function, and increases may occur in some individuals.

It’s crucial to report any unusual or severe side effects to your healthcare provider promptly. Additionally, if you experience symptoms of a severe allergic reaction, such as difficulty breathing or swelling of the face, lips, or tongue, seek emergency medical attention.

This list is not exhaustive, and individual responses to medications can vary. Your healthcare provider will provide you with information specific to your health and potential side effects. Always follow your healthcare provider’s instructions and attend regular check-ups during the course of your treatment.

What should I know about storage and disposal of this medication?

Here are some general guidelines for storing and disposing of Zestril:

• Storage:
  • Store Zestril at room temperature, away from moisture and heat.
  • Keep it in the original container, and ensure the container is tightly closed.
• Disposal:
  • Do not flush medications down the toilet unless specifically instructed to do so.
  • Ask your pharmacist or local waste disposal company about the best way to dispose of unused or expired medications.
  • Follow any specific disposal instructions provided with your medication.

In case of emergency/overdose

In case of an overdose or emergency, contact your local poison control center at 1-800-222-1222 or seek emergency medical attention immediately. Symptoms of an overdose may include extreme dizziness or fainting.

What other information should I know

• Regular Check-ups: Attend regular check-ups with your healthcare provider to monitor your response to Zestril and assess any potential side effects or complications.
• Inform Healthcare Providers: Inform all healthcare providers, including dentists and surgeons, that you are taking Zestril. This is important in case there are interactions with other medications or if adjustments need to be made before surgical procedures.
• Blood Pressure Monitoring: If you are taking Zestril for hypertension, it’s advisable to monitor your blood pressure regularly as recommended by your healthcare provider.
• Lab Tests: Your healthcare provider may order periodic lab tests to monitor kidney function, electrolytes, and other parameters.
• Avoid Alcohol: Limit alcohol intake, as excessive alcohol consumption can interact with Zestril and increase the risk of side effects.
• Inform About Other Medications: Inform your healthcare provider about all other medications, supplements, or herbal products you are taking, as some may interact with Zestril.

Always follow your healthcare provider’s instructions and ask any questions you may have about Zestril or your treatment plan. If you experience any unusual symptoms or have concerns, contact your healthcare provider promptly.