WARNING

Taking Zemdri (plazomicin) carries certain risks, as with any medication. It’s important to weigh the potential benefits of the medication against the risks, and your healthcare provider will consider your specific medical history and conditions. Here are some potential risks associated with Zemdri:

• Nephrotoxicity: Zemdri may be associated with kidney problems (nephrotoxicity). Regular monitoring of renal function is typically recommended, and dosage adjustments may be necessary in individuals with impaired renal function.
• Ototoxicity: Aminoglycoside antibiotics, including Zemdri, can cause hearing loss and vestibular dysfunction (ototoxicity). Monitoring of auditory and vestibular function is advised, especially in patients with pre-existing hearing impairment.
• Allergic Reactions: Serious allergic reactions are possible with Zemdri. If you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing, seek immediate medical attention.
• Neuromuscular Blockade: Zemdri may enhance the effects of neuromuscular-blocking agents, and caution is advised when administering the medication in patients receiving such agents.
• Superinfection: Prolonged use of Zemdri may lead to the overgrowth of nonsusceptible organisms, including fungi.
• Pregnancy and Breastfeeding: The use of Zemdri during pregnancy should be based on a risk-benefit assessment. It is generally not recommended during breastfeeding.
• Other Common Side Effects: Common side effects may include nausea, headache, dizziness, vomiting, and elevated liver enzymes.

It’s crucial to take Zemdri exactly as prescribed by your healthcare provider and to promptly report any unusual or severe side effects. If you have concerns about the risks associated with Zemdri, discuss them with your healthcare provider. The decision to use this medication will depend on your individual health status and the specific circumstances of your condition. Always follow the guidance of your healthcare provider for the most accurate and personalized information.

Why is this medication prescribed?

Zemdri (plazomicin) is an antibiotic that belongs to the class of drugs known as aminoglycosides. It is primarily prescribed to treat complicated urinary tract infections (cUTIs) caused by certain bacteria.

Zemdri is often used when other commonly used antibiotics may not be effective due to bacterial resistance. It has been approved for use in adults with cUTIs, including pyelonephritis, which is a severe form of kidney infection.

How should this medicine be used?

Zemdri (plazomicin) is an antibiotic used to treat complicated urinary tract infections (cUTIs), including pyelonephritis, caused by certain bacteria. However, please note that medical guidelines and drug information may change, so it’s crucial to consult the most recent sources or a healthcare professional for the latest information.

As of my last update, the general guidelines for using Zemdri are as follows:

• Dosage: The dosage of Zemdri can vary based on factors such as the patient’s weight, the severity of the infection, and renal function. It is typically administered intravenously.
• Administration: Zemdri is usually given over a specific duration as prescribed by the healthcare provider. The infusion may take some time, and it’s essential to follow the recommended rate of administration.
• Frequency: The frequency of administration and the total duration of treatment will depend on the specific infection being treated and the healthcare provider’s instructions.
• Renal Function Monitoring: Zemdri is excreted primarily through the kidneys. Therefore, it’s important to monitor renal function during treatment. Dose adjustments may be necessary in patients with impaired renal function.
• Follow Healthcare Provider’s Instructions: It’s crucial to follow the healthcare provider’s instructions regarding the use of Zemdri precisely. This includes adhering to the prescribed dosage, duration of treatment, and any other specific recommendations.
• Complete the Course: Even if symptoms improve before the completion of the prescribed course, it’s important to finish the entire treatment to ensure that the infection is completely eradicated.
• Possible Interactions: Inform your healthcare provider about all the medications you are taking, including over-the-counter drugs and supplements, as there may be potential interactions.
• Side Effects: Be aware of potential side effects and contact your healthcare provider if you experience any unusual or severe reactions.

Remember, these are general guidelines, and individual cases may vary. Always consult with your healthcare provider for specific and up-to-date information tailored to your situation. If you have a prescription for Zemdri, your healthcare provider or pharmacist will provide detailed instructions on how to use the medication.

Other uses for this medicine

Plazomicin (Zemdri) is primarily indicated for the treatment of complicated urinary tract infections (cUTIs), including pyelonephritis. It is important to note that using antibiotics for conditions other than the ones they are specifically designed to treat should only be done under the guidance and prescription of a healthcare professional.

What special precautions should I follow?

Regarding special precautions for Zemdri, the following considerations are relevant:

• Renal Function Monitoring: Zemdri is excreted primarily through the kidneys. Therefore, monitoring of renal function is important before and during treatment. Dose adjustments may be necessary in individuals with impaired renal function.
• Ototoxicity (Hearing Loss) and Vestibular Dysfunction: Aminoglycoside antibiotics, including Zemdri, are associated with the risk of ototoxicity (hearing loss) and vestibular dysfunction. Monitoring of auditory and vestibular function is advised, especially in patients with pre-existing hearing impairment.
• Neuromuscular Blockade: Aminoglycosides can enhance the effects of neuromuscular-blocking agents. Caution is advised when administering Zemdri in patients receiving neuromuscular-blocking agents.
• Pregnancy and Breastfeeding:
• Zemdri may be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not recommended during breastfeeding.
• Allergic Reactions:As with any medication, patients should be monitored for signs of allergic reactions, and the medication should be discontinued if an allergic reaction occurs.
• Superinfection: Prolonged use of Zemdri may result in the overgrowth of nonsusceptible organisms, including fungi. Careful observation of the patient is necessary.

It’s essential to follow your healthcare provider’s instructions and inform them of any pre-existing conditions, medications, or concerns you may have. The information provided here is a general overview, and individual patient circumstances may influence the specific precautions and recommendations. Always consult with your healthcare professional for personalized advice and the most up-to-date information on medications. If there have been any updates or changes in guidelines since my last update, your healthcare provider will have the latest information.

What special dietary instructions should I follow?

As of last update, there were no specific dietary restrictions associated with Zemdri. However, it’s crucial to follow any dietary advice or restrictions provided by your healthcare provider or pharmacist. If there are specific dietary considerations related to Zemdri, your healthcare provider will inform you.

What should I do if I forget a dose?

If you forget a dose of Zemdri, follow these general guidelines:

• As Soon as Possible: If you remember shortly after the missed dose, you can take it as soon as possible.
• Close to the Next Dose: If it’s close to the time of the next scheduled dose, it’s usually recommended to skip the missed dose and resume the regular dosing schedule.
• Double Dosing: Avoid taking a double dose to make up for a missed one.

What side effects can this medication cause?

Zemdri (plazomicin) is an antibiotic used to treat complicated urinary tract infections (cUTIs). Like all medications, Zemdri can cause side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary. Below are some potential side effects associated with Zemdri:

• Nausea: Feeling a sensation of discomfort or unease in the stomach, often leading to the urge to vomit.
• Headache: Pain or discomfort in the head or upper neck region.
• Dizziness: A sensation of lightheadedness or unsteadiness.
• Vomiting: The forceful expulsion of stomach contents through the mouth.
• Elevated Liver Enzymes: Changes in liver function may be observed in some individuals.
• Renal Toxicity: Zemdri may affect kidney function, leading to renal toxicity. Regular monitoring of renal function is usually recommended.
• Ototoxicity: Aminoglycoside antibiotics, including Zemdri, are associated with the risk of ototoxicity, which can manifest as hearing loss and vestibular dysfunction.
• Allergic Reactions: Serious allergic reactions, though rare, can occur. Symptoms may include rash, itching, swelling, severe dizziness, or difficulty breathing.
• Neuromuscular Blockade: Zemdri may enhance the effects of neuromuscular-blocking agents, leading to muscular weakness or paralysis.
• Superinfection: Prolonged use of Zemdri may result in the overgrowth of nonsusceptible organisms, including fungi.

It’s important to promptly report any unusual or severe side effects to your healthcare provider. Additionally, some side effects may require immediate medical attention, especially allergic reactions or signs of ototoxicity.

Keep in mind that this list is not exhaustive, and individual responses to medications can vary. If you have specific concerns about potential side effects or are experiencing any symptoms, consult with your healthcare provider for personalized advice and guidance.

What should I know about storage and disposal of this medication?

Storage of Zemdri:

• Follow the storage instructions provided by your healthcare provider or pharmacist.
• Zemdri is typically stored in a healthcare setting, and the storage conditions are managed by healthcare professionals.

Disposal of Zemdri:

• Dispose of Zemdri according to local regulations and guidelines.
• If you have any unused medication, consult with your healthcare provider or pharmacist on the appropriate disposal method.

In case of emergency/overdose

In the case of a potential overdose or emergency situation:

• In case of an emergency or suspected overdose, contact your local poison control center or emergency room immediately.
• Symptoms of overdose may include dizziness, loss of balance, and hearing loss. Seek prompt medical attention.

What other information should I know?

• Follow Prescription Guidelines: Take Zemdri exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking the medication without consulting your healthcare provider.
• Inform Your Healthcare Provider: Inform your healthcare provider of any allergies, medical conditions, or medications you are currently taking, including over-the-counter drugs and supplements.
• Regular Monitoring: Regular monitoring of renal function, hearing, and vestibular function may be part of the treatment plan. Attend all scheduled appointments.
• Avoid Alcohol: It’s advisable to avoid alcohol while taking Zemdri, as alcohol may exacerbate certain side effects.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The use of Zemdri during pregnancy and breastfeeding should be discussed with your healthcare provider.
• Allergic Reactions: Be aware of signs of allergic reactions, and seek immediate medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.

Always consult your healthcare provider or pharmacist for personalized advice and the most up-to-date information. If there have been any changes or updates since my last knowledge update, your healthcare provider will provide you with the latest guidance.