Why is this medication prescribed?

Zelboraf (vemurafenib) is a prescription medication used for the treatment of certain types of skin cancer, specifically metastatic melanoma. It is indicated for patients whose cancer cells have a specific genetic mutation called BRAF V600E. Zelboraf is a targeted therapy that works by inhibiting the activity of the mutated BRAF protein, which is involved in the uncontrolled growth of cancer cells.

How should this medicine be used?

Here are some key points about the use of Zelboraf:

• Indication: Zelboraf is prescribed for the treatment of unresectable or metastatic melanoma with the BRAF V600E mutation.
• Genetic Testing: Before starting Zelboraf treatment, it is important to confirm the presence of the BRAF V600E mutation in the tumor cells. This is typically done through a genetic test.
• Dosage: The dosage of Zelboraf can vary, and it is usually taken orally. The specific dosage and treatment plan will be determined by the healthcare provider based on the patient’s individual characteristics and overall health.
• Administration: Zelboraf is usually taken twice a day, about 12 hours apart. It is commonly taken with food to help with absorption.
• Adverse Effects: Like any medication, Zelboraf can have side effects. Common side effects may include joint pain, fatigue, rash, hair loss, and photosensitivity. It’s important for patients to report any side effects to their healthcare provider.
• Monitoring: Regular monitoring, including blood tests and imaging studies, may be necessary during Zelboraf treatment to assess its effectiveness and monitor for potential side effects.
• Duration of Treatment: The duration of Zelboraf treatment will depend on the response to the medication and the overall condition of the patient. Some patients may continue treatment for an extended period, while others may switch to other therapies.
• Combination Therapy: Zelboraf may be used alone or in combination with other medications, such as MEK inhibitors, depending on the specific situation and the recommendations of the healthcare provider.

It’s crucial for patients to follow their healthcare provider’s instructions carefully and to communicate any concerns or side effects promptly. As with any cancer treatment, the decision to use Zelboraf and the specific treatment plan should be discussed thoroughly between the patient and their oncologist.

Other uses for this medicine

Zelboraf is primarily used for the treatment of metastatic melanoma with the BRAF V600E mutation. However, it is not typically used for other types of cancer or conditions.

What special precautions should I follow?

In terms of special precautions, here are some general guidelines. However, individualized advice from a healthcare provider should always be followed:

• Genetic Testing: Before starting Zelboraf, it’s crucial to confirm the presence of the BRAF V600E mutation in the tumor cells through genetic testing. Zelboraf is specifically designed for patients with this mutation.
• Liver Function: Zelboraf may affect liver function, so regular liver function tests are often recommended during treatment. Patients with pre-existing liver conditions may require special monitoring.
• Photosensitivity: Zelboraf can make the skin more sensitive to sunlight, leading to an increased risk of sunburn. Patients should use sunscreen and protective clothing and avoid excessive sun exposure.
• Potential Skin Reactions: Skin-related side effects, such as rash, may occur. It’s important to report any skin changes to the healthcare provider promptly.
• Eye Issues: Some patients may experience vision problems while on Zelboraf. If any changes in vision occur, they should be reported to the healthcare provider.
• Bleeding Risk: Zelboraf may increase the risk of bleeding. Patients should inform their healthcare provider about any history of bleeding disorders or concurrent use of medications that may affect bleeding.
• Pregnancy and Contraception: Zelboraf may harm an unborn baby, so it’s important for both men and women to use effective contraception during treatment and for a period after discontinuation. Pregnant women should not use Zelboraf unless the potential benefits outweigh the risks.
• Drug Interactions: Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking, as Zelboraf may interact with other drugs.
• Regular Monitoring: Regular monitoring, including blood tests and imaging studies, is often necessary to assess the response to treatment and monitor for potential side effects.

Patients should follow their healthcare provider’s instructions diligently, attend all scheduled appointments, and promptly report any concerns, side effects, or changes in their health during Zelboraf treatment.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions associated with Zelboraf. However, taking the medication with food is often recommended to improve absorption and reduce the risk of certain side effects. Follow your healthcare provider’s advice regarding whether Zelboraf should be taken with or without food.

What should I do if I forget a dose?

If you forget to take a dose of Zelboraf, follow these general guidelines:

• Timing: Take the missed dose as soon as you remember, unless it is close to the time for your next scheduled dose.
• Do Not Double Dose: Do not take a double dose to make up for the missed one. Taking more than the prescribed amount can increase the risk of side effects.
• Inform Your Healthcare Provider: If you miss a dose, it’s a good idea to inform your healthcare provider. They can provide guidance based on your specific situation.

What side effects can this medication cause?

Zelboraf, whose generic name is vemurafenib, is a medication primarily used to treat certain types of skin cancer, particularly melanoma with a specific genetic mutation called BRAF V600E. Like any medication, Zelboraf can cause side effects. It’s important to note that not everyone will experience these side effects, and some people may experience them to varying degrees of severity. Here are some common and serious side effects associated with Zelboraf:

Common Side Effects:

• Joint pain or stiffness
• Rash
• Fatigue
• Nausea
• Hair loss
• Photosensitivity (increased sensitivity to sunlight)
• Skin growths

Serious Side Effects:

• Cutaneous Squamous Cell Carcinoma (cuSCC): Zelboraf may increase the risk of developing cutaneous squamous cell carcinoma, a type of skin cancer.
• Liver problems: Zelboraf can cause changes in liver function, and in some cases, serious liver problems.
• Heart problems: There may be an increased risk of heart problems, including QT prolongation, which can affect the heart’s rhythm.
• Eye problems: Some patients may experience vision changes, including blurred vision, sensitivity to light, and other visual disturbances.
• Hypersensitivity reactions: Severe allergic reactions are rare but possible. Symptoms may include rash, itching, swelling, severe dizziness, and difficulty breathing.

It’s crucial to promptly report any unusual or severe side effects to your healthcare provider. Additionally, patients taking Zelboraf are often monitored closely through regular medical check-ups to detect and manage any potential side effects.

This information is not exhaustive, and it’s important to consult with a healthcare professional for detailed and personalized information about potential side effects based on individual health conditions and medical history.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zelboraf:

• Storage:
  • Store Zelboraf at room temperature, away from excessive heat and moisture.
  • Keep the medication in its original container, and make sure it is tightly closed.
  • Do not store Zelboraf in the bathroom.
• Disposal:
  • Follow local regulations or guidelines for the proper disposal of unused or expired medications.
  • Do not flush Zelboraf down the toilet or throw it into the household trash. Check with your healthcare provider or local pharmacy for guidance on safe disposal.

In case of emergency/overdose

In case of an emergency or suspected overdose, seek medical attention immediately. The symptoms of an overdose may include severe dizziness, vomiting, or loss of consciousness. It’s important to have the container of Zelboraf or information about the medication available when seeking medical help.

What other information should I know?

• Regular Follow-up: Attend all scheduled appointments with your healthcare provider for regular check-ups and monitoring.
• Communication: Keep an open line of communication with your healthcare team. Report any side effects, changes in symptoms, or concerns promptly.
• Medication Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Zelboraf may interact with certain drugs.
• Pregnancy and Contraception: Zelboraf may harm an unborn baby, so it’s important to use effective contraception during treatment and for a specified period after discontinuation. Discuss family planning with your healthcare provider.
• Sun Protection: Due to the increased risk of sunburn, practice sun protection measures, such as using sunscreen, wearing protective clothing, and limiting sun exposure.
• Regular Monitoring: Zelboraf treatment often involves regular monitoring, including blood tests and imaging studies, to assess the response to treatment and monitor for potential side effects.
• Travel Considerations: If you plan to travel, discuss this with your healthcare provider in advance. Ensure you have an adequate supply of medication, and be aware of any specific precautions you need to take.
• Supportive Care: If you experience side effects, your healthcare provider may recommend supportive care measures to manage symptoms. This could include medications or other interventions.

Always follow your healthcare provider’s instructions and guidance. The information provided here is a general guideline, and individual circumstances may vary. If you have specific questions or concerns about Zelboraf, consult with your healthcare team for personalized advice.