Why is this medication prescribed?

Dasiglucagon injection is prescribed for the treatment of severe hypoglycemia in people with diabetes. Hypoglycemia, or low blood sugar, can occur when there is an excess of insulin relative to the amount of glucose in the blood. This can happen in individuals with diabetes who are using insulin or certain medications to manage their blood sugar levels.

Dasiglucagon is a glucagon analog, and it works by increasing blood sugar levels. Glucagon is a hormone produced by the pancreas that raises blood sugar levels by stimulating the liver to convert stored glycogen into glucose. In cases of severe hypoglycemia, where the blood sugar level drops dangerously low and causes symptoms such as confusion, unconsciousness, or seizures, an injection of dasiglucagon can be administered to quickly raise blood sugar levels and alleviate the symptoms.

How should this medicine be used?

Here are general guidelines on how dasiglucagon injection is typically used:

• Administration: Dasiglucagon is administered by injection. The injection can be given subcutaneously (under the skin) or intramuscularly (into the muscle). Healthcare providers or caregivers are often trained on how to administer the injection.
• Dosage: The dosage of dasiglucagon is based on factors such as the patient’s weight and the severity of the hypoglycemia. Healthcare providers will determine the appropriate dosage for each individual.
• Emergency Use: Dasiglucagon is intended for emergency use when a person with diabetes is experiencing severe hypoglycemia and is unable to consume oral carbohydrates or when oral treatment is not feasible.
• Reconstitution: Before administration, dasiglucagon powder needs to be reconstituted with the accompanying diluent. Detailed instructions for reconstitution and administration are provided in the product’s prescribing information.
• Monitoring: After administration, the individual’s blood sugar levels should be closely monitored. Response time can vary, and additional doses or other treatments may be necessary depending on the patient’s condition.

It’s important to note that administration of dasiglucagon is typically done by a caregiver, family member, or other individuals who are trained on its use. It is crucial to follow the specific instructions provided by healthcare professionals or detailed in the prescribing information for dasiglucagon.

If you or someone you know is prescribed dasiglucagon, make sure to have a clear understanding of how to use the medication and seek immediate medical attention in case of severe hypoglycemia. Additionally, discuss any questions or concerns with your healthcare provider.

Other uses for this medicine

Dasiglucagon injection is primarily used for the emergency treatment of severe hypoglycemia in individuals with diabetes. Severe hypoglycemia occurs when blood sugar levels drop dangerously low and can lead to unconsciousness or seizures. Dasiglucagon is used to rapidly raise blood sugar levels in emergency situations. Dasiglucagon’s use for other conditions may not have been established. Always consult with a healthcare professional or refer to the latest medical literature for the most up-to-date information.

What special precautions should I follow?

Regarding special precautions for Dasiglucagon injection:

• Allergies: Inform your healthcare provider about any known allergies, especially to glucagon or any other components of dasiglucagon.
• Hypersensitivity Reactions: Dasiglucagon may cause hypersensitivity reactions in some individuals. Seek medical attention immediately if you experience symptoms such as rash, itching, or swelling, especially of the face, lips, or tongue.
• Medical History: Provide your healthcare provider with a detailed medical history, including any history of heart disease, adrenal gland tumor (pheochromocytoma), or chronic low blood sugar (hypoglycemia) conditions.
• Pregnancy and Breastfeeding: The safety of dasiglucagon during pregnancy and breastfeeding is not well-established. Discuss the potential risks and benefits with your healthcare provider if you are pregnant or breastfeeding.
• Interactions with Medications: Inform your healthcare provider about all medications you are taking, including prescription, over-the-counter drugs, and herbal supplements. Certain medications may interact with dasiglucagon.
• Adrenal Insufficiency: Individuals with adrenal insufficiency may have a reduced response to glucagon. This should be considered in the management of severe hypoglycemia.
• Potential for Nausea and Vomiting: Nausea and vomiting are potential side effects of dasiglucagon. Individuals with a history of gastrointestinal disorders may be at higher risk.
• Driving and Operating Machinery: Dasiglucagon may cause dizziness or lightheadedness. Caution is advised when driving or operating machinery until the effects are known.

Always follow your healthcare provider’s instructions and guidance. If you have specific concerns or experience any side effects, contact your healthcare provider promptly. In emergency situations, seek immediate medical attention. It’s crucial to have a clear understanding of how to use dasiglucagon in emergency situations, especially if you are prescribed this medication.

What special dietary instructions should I follow?

• Balanced Diet: Maintain a balanced diet that includes a mix of carbohydrates, proteins, and healthy fats.
• Regular Meals: Eat regular meals and snacks to help stabilize blood sugar levels.
• Carbohydrate Management: Depending on your specific diabetes management plan, you may need to manage your carbohydrate intake. Your healthcare provider or dietitian can provide personalized guidance.

What should I do if I forget a dose?

Dasiglucagon is typically administered in emergency situations, such as severe hypoglycemia. The dosing is usually based on the severity of the hypoglycemia and the individual’s weight. If you have questions about the usage or forget a dose of Dasiglucagon, contact your healthcare provider immediately for guidance. It’s crucial to have a clear understanding of the emergency protocol and how to use the medication in critical situations.

What side effects can this medication cause?

Dasiglucagon injection, like any medication, may cause side effects. It’s important to note that not everyone will experience these side effects, and the severity of side effects can vary from person to person. Always consult with your healthcare provider or refer to the latest prescribing information for the most accurate and up-to-date information.

Common side effects associated with Dasiglucagon Injection may include:

• Nausea: Some individuals may experience nausea after using Dasiglucagon.
• Vomiting: Vomiting is another potential side effect of Dasiglucagon.
• Headache: Headache is a common side effect that may occur.
• Injection Site Reactions: Pain, redness, or swelling at the injection site may occur.
• Increased Heart Rate (Tachycardia): Some individuals may experience an increase in heart rate.
• Low Blood Sugar (Hypoglycemia): While Dasiglucagon is used to treat severe hypoglycemia, there is a potential risk of overcorrection leading to hyperglycemia (high blood sugar). Blood sugar levels should be monitored closely.
• Hypersensitivity Reactions: In rare cases, individuals may experience hypersensitivity reactions, such as rash, itching, or swelling, especially of the face, lips, or tongue. Seek immediate medical attention if such reactions occur.

It’s important to report any side effects to your healthcare provider. If you experience severe or persistent side effects, seek medical attention promptly.

Keep in mind that Dasiglucagon is typically administered in emergency situations for severe hypoglycemia, and the benefits of using the medication in these situations generally outweigh the potential risks of side effects. Always follow your healthcare provider’s instructions for the proper use of Dasiglucagon and seek guidance if you have any concerns or questions.

What should I know about storage and disposal of this medication?

Storage:

• Room Temperature: Dasiglucagon injection is typically stored at room temperature. Check the specific product information for recommended storage conditions.
• Protect from Light: Store Dasiglucagon away from direct light.
• Original Container: Keep Dasiglucagon in its original container to protect it from external factors.
• Do Not Freeze: Do not freeze Dasiglucagon.
• Keep Out of Reach of Children: Store medications in a secure location, out of the reach of children.

Disposal:

• Follow Local Regulations: Dispose of unused or expired medication according to local regulations. Some areas may have specific guidelines for the disposal of pharmaceuticals.
• Do Not Flush: Do not flush Dasiglucagon down the toilet unless specific instructions advise doing so.
• Community Take-Back Programs: Check if there are community programs or authorized collection sites for safe disposal of medications.

In case of emergency/overdose

In the case of a potential overdose or emergency situation:

• Seek Immediate Medical Attention: If you suspect an overdose or if someone has received an excessive dose of Dasiglucagon, seek emergency medical attention immediately.
• Symptoms of Overdose: While Dasiglucagon is used to treat severe hypoglycemia, excessive use may lead to hyperglycemia. Monitor for symptoms such as high blood sugar (hyperglycemia), increased thirst, and frequent urination.

What other information should I know?

• Emergency Use: Dasiglucagon is intended for emergency use in the treatment of severe hypoglycemia. It is typically used when a person with diabetes is unconscious or unable to eat or drink.
• Training: Caregivers and family members may be trained on how to administer Dasiglucagon in emergency situations. Understanding the proper administration technique is crucial.
• Follow Healthcare Provider’s Instructions: Always follow your healthcare provider’s instructions for the use of Dasiglucagon, including the appropriate dosage and when to administer it.
• Medical Alert Bracelet: Consider wearing a medical alert bracelet or carrying a card indicating that you have diabetes and may require emergency treatment with Dasiglucagon.
• Regular Follow-Up: Individuals with diabetes should have regular follow-up appointments with their healthcare provider to discuss their overall diabetes management plan.

Always consult with your healthcare provider for personalized advice and follow their instructions closely. If you have specific concerns or encounter issues, don’t hesitate to reach out to your healthcare team.