Why is this medication prescribed?

Zarxio is a biosimilar to Neupogen, which is a medication that contains filgrastim, a granulocyte colony-stimulating factor (G-CSF). G-CSF is a naturally occurring substance in the body that stimulates the production of white blood cells, particularly neutrophils. Zarxio is used to treat and prevent neutropenia, a condition characterized by a low number of neutrophils, which are a type of white blood cell important for fighting infections.

Conditions for which Zarxio may be prescribed include:

• Cancer Treatment: Used to reduce the risk of infection in patients undergoing chemotherapy, which can often suppress the bone marrow’s ability to produce white blood cells.
• Bone Marrow Transplantation: Administered to help the recovery of white blood cell counts in patients who have undergone a bone marrow transplant.
• Severe Chronic Neutropenia: Used in individuals with certain conditions, such as severe chronic neutropenia, to increase the production of neutrophils.

How should this medicine be used?

Zarxio (filgrastim-sndz) is used to stimulate the production of white blood cells, specifically neutrophils, in the body. Neutrophils are essential for fighting infections. The following information provides general guidelines on how Zarxio is typically used, but it’s crucial to follow the specific instructions provided by the healthcare provider. Dosage and administration may vary based on the individual’s medical condition.

• Administration Route: Zarxio is commonly administered as a subcutaneous injection (under the skin) or intravenously (directly into a vein). The specific route of administration will depend on the healthcare provider’s instructions and the patient’s condition.
• Injection Site: If administered subcutaneously, the injection is usually given into the fatty tissue just under the skin. Healthcare providers will provide guidance on the proper technique for self-administration if applicable.
• Frequency of Administration: The frequency of Zarxio injections will depend on the medical condition being treated and the healthcare provider’s recommendations. It may be given daily or on a schedule determined by the healthcare professional.
• Dose Adjustment: The dosage of Zarxio may be adjusted based on the patient’s response to treatment and individual health factors. Healthcare providers will monitor blood counts and adjust the dose accordingly.
• Patient Education: Patients and caregivers should receive proper education on the correct administration technique, including injection site rotation to minimize irritation and discomfort.
• Monitoring: Regular monitoring of blood counts and overall health is typically part of the treatment plan. This allows healthcare providers to assess the effectiveness of Zarxio and make any necessary adjustments.
• Follow-up Appointments: Patients should attend scheduled follow-up appointments to discuss progress, any side effects, and to receive further guidance on the use of Zarxio.

It’s crucial for patients to communicate with their healthcare providers and adhere to the prescribed dosage and administration schedule. Additionally, if there are any concerns about side effects or if a dose is missed, it’s important to contact the healthcare provider promptly.

As with any medication, individual responses and needs may vary, so it’s essential to rely on the guidance provided by healthcare professionals. If you have been prescribed Zarxio or are caring for someone who is, always consult with the healthcare team for specific and personalized instructions.

Other uses for this medicine

Zarxio is primarily used to stimulate the production of white blood cells and reduce the risk of infection in certain medical situations. It is commonly used in cancer patients, particularly those undergoing chemotherapy or stem cell transplantation. Zarxio is a biosimilar to Neupogen (filgrastim) and is not used interchangeably with other forms of filgrastim without medical supervision.

What special precautions should I follow?

Regarding special precautions, individuals using Zarxio should be aware of the following considerations:

• Allergies: Inform your healthcare provider if you are allergic to filgrastim or any other components of Zarxio. Allergic reactions can occur, and immediate medical attention is necessary if you experience symptoms such as difficulty breathing, swelling, or severe rash.
• Bone Pain: Some individuals may experience bone pain as a side effect of Zarxio treatment. This is a common side effect and is usually temporary. Inform your healthcare provider if you experience persistent or severe bone pain.
• Splenomegaly (Enlarged Spleen): Zarxio can lead to an enlargement of the spleen. Inform your healthcare provider if you experience symptoms such as left-sided abdominal pain or fullness.
• Leukocytosis (Increased White Blood Cell Count): Treatment with Zarxio can lead to an increase in white blood cell counts, including neutrophils. Regular monitoring is typically conducted to ensure that the counts do not become excessively high.
• Fluid Retention: In some cases, fluid retention can occur with Zarxio use. Individuals with pre-existing fluid retention conditions or a history of heart failure may need careful monitoring.
• Use During Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The use of Zarxio during pregnancy or breastfeeding should be carefully considered based on the potential risks and benefits.
• Other Medications: Inform your healthcare provider about all medications you are currently taking, including prescription and over-the-counter drugs, as well as any herbal supplements. Some medications may interact with Zarxio.
• Self-Administration: If Zarxio is prescribed for self-administration, individuals should receive proper training on the correct administration technique. Follow the prescribed dosage and administration schedule.

As always, individuals should follow their healthcare provider’s instructions and report any unusual or severe side effects promptly. If you have specific concerns or questions about Zarxio, it’s best to discuss them directly with your healthcare provider for personalized advice.

What special dietary instructions should I follow?

There were no specific dietary instructions associated with Zarxio. However, individual healthcare providers may provide personalized guidance based on the patient’s overall health and specific medical conditions. It’s generally advisable to maintain a balanced and healthy diet.

What should I do if I forget a dose?

Regarding a missed dose of Zarxio:

• Timing: If you miss a dose, contact your healthcare provider immediately for guidance on when to take the next dose.
• Don’t Double Dose: Do not double up on doses to make up for a missed one unless instructed by your healthcare provider.
• Follow Instructions: Follow your healthcare provider’s advice on how to proceed after a missed dose.

What side effects can this medication cause?

Zarxio (filgrastim-sndz) can cause side effects, and the severity and occurrence of these side effects can vary from person to person. It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects that are not listed here. If you are prescribed Zarxio, your healthcare provider will monitor you for potential side effects and provide guidance on managing them. Common side effects of Zarxio may include:

• Bone Pain: One of the most commonly reported side effects is bone pain, particularly in the lower back or pelvis. This pain is usually mild to moderate and tends to improve with continued use.
• Headache: Some individuals may experience headaches while using Zarxio.
• Redness or Swelling at the Injection Site: If Zarxio is administered as a subcutaneous injection, redness or swelling at the injection site may occur. Proper injection techniques, including site rotation, can help minimize these effects.
• Pain or Swelling in the Joints: Joint pain or swelling can occur in some individuals.
• Allergic Reactions: While uncommon, allergic reactions to Zarxio can occur. Symptoms may include difficulty breathing, swelling of the face or throat, and severe rash. Seek immediate medical attention if you experience any signs of an allergic reaction.
• Enlarged Spleen (Splenomegaly): Zarxio can cause an enlargement of the spleen. Inform your healthcare provider if you experience left-sided abdominal pain or fullness.
• Leukocytosis (Increased White Blood Cell Count): Treatment with Zarxio may lead to an increase in white blood cell counts, including neutrophils. Regular monitoring is typically conducted to ensure that counts do not become excessively high.
• Fluid Retention: Some individuals may experience fluid retention as a side effect of Zarxio.

It’s important to report any side effects or symptoms to your healthcare provider promptly. Your healthcare team will assess the risk-benefit profile of Zarxio for your specific situation and may adjust the dosage or provide additional recommendations based on your individual needs.

This list is not exhaustive, and there may be other side effects associated with Zarxio. Always refer to the prescribing information provided by your healthcare provider or the medication’s package insert for the most comprehensive and up-to-date information on potential side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal of Zarxio:

• Storage:
  • Follow the storage instructions provided by the pharmacist or healthcare provider. Zarxio may need to be stored in a refrigerator or at room temperature, depending on the specific formulation. Do not freeze.
  • Protect Zarxio from light.
  • Keep it out of reach of children and pets.
• Disposal:
  • Dispose of unused or expired Zarxio as directed by your healthcare provider or pharmacist.
  • Do not flush medications down the toilet unless specifically instructed to do so. Proper disposal helps prevent environmental contamination.

In case of emergency/overdose

In case of an emergency or overdose with Zarxio, seek medical attention immediately. If you suspect an overdose, contact your local poison control center at 1-800-222-1222 (in the United States) for guidance. Overdose symptoms may include an excessive increase in white blood cell counts, which may lead to complications. Emergency medical attention is crucial to manage any potential complications.

What other information should I know?

• Regular Monitoring: Your healthcare provider will monitor your blood counts regularly during Zarxio treatment to assess its effectiveness and adjust the dosage if necessary.
• Self-Administration: If you are instructed to self-administer Zarxio, ensure that you receive proper training on the correct administration technique.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care, including dentists and emergency room personnel, that you are receiving Zarxio.
• Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider to discuss your progress and address any concerns.
• Interactions with Other Medications: Inform your healthcare provider about all medications you are taking, as some drugs may interact with Zarxio.
• Allergic Reactions: Be aware of signs of an allergic reaction, such as difficulty breathing, swelling, or severe rash, and seek immediate medical attention if they occur.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The use of Zarxio during pregnancy or breastfeeding should be carefully considered based on potential risks and benefits.
• Keep Appointments: Stick to your scheduled appointments for blood tests and other monitoring to ensure the safe and effective use of Zarxio.

Always follow the specific instructions provided by your healthcare provider and refer to the medication’s package insert for comprehensive information. If you have any questions or concerns about Zarxio, do not hesitate to discuss them with your healthcare team.