WARNING

While Xiaflex (collagenase clostridium histolyticum) is generally considered safe and effective when used under the guidance of a healthcare professional, it does carry certain risks and potential side effects. Some of the risks associated with taking Xiaflex include:

• Injection Site Reactions: Common side effects include swelling, bruising, pain, redness, or itching at the injection site.
• Nodule Formation: Formation of small lumps or nodules in the treated area may occur.
• Tendon Rupture: In some cases, there have been reports of tendon rupture or other serious injuries to the treated area.
• Nerve Injury: There is a risk of nerve injury in the treated area.
• Allergic Reactions: Although rare, allergic reactions can occur. Signs of an allergic reaction may include rash, itching, swelling, severe dizziness, or difficulty breathing.
• Bleeding: Xiaflex may increase the risk of bleeding. This is particularly important for individuals with a history of bleeding disorders or those taking medications that affect blood clotting.
• Infection: There is a risk of infection at the injection site. If you notice signs of infection, such as redness, swelling, or increased pain, it’s important to contact your healthcare provider promptly.
• Pain or Discomfort: Pain or discomfort at the injection site is a common side effect.

It’s important to note that the severity and likelihood of these side effects can vary among individuals. Before starting Xiaflex treatment, healthcare providers will assess the individual’s medical history and overall health to determine the appropriateness of the medication. Patients should communicate any concerns or unusual symptoms to their healthcare provider promptly.

This information is a brief overview, and it’s essential to consult with a healthcare professional for a comprehensive understanding of the potential risks and benefits of Xiaflex based on individual health conditions. Additionally, healthcare providers will provide guidance on how to manage and minimize these risks during treatment.

Why is this medication prescribed?

Xiaflex is prescribed for the treatment of specific medical conditions, and its use is typically determined by a healthcare professional. Xiaflex is used in the following conditions:

• Dupuytren’s Contracture:
  • Condition: Dupuytren’s contracture is a condition in which the connective tissue under the skin in the palm of the hand becomes thickened and shortened. This can result in the fingers being pulled towards the palm, leading to difficulty straightening them.
  • Purpose of Xiaflex: Xiaflex is used to break down the excess collagen that causes the contraction, helping to straighten the affected fingers.
• Peyronie’s Disease:
  • Condition: Peyronie’s disease involves the development of fibrous scar tissue inside the penis, leading to curvature and sometimes pain during erections.
  • Purpose of Xiaflex: Xiaflex is used to break down the collagen plaque in the penis, aiming to reduce curvature and improve symptoms associated with Peyronie’s disease.

How should this medicine be used?

Xiaflex (collagenase clostridium histolyticum) is a prescription medication used to treat Dupuytren’s contracture and Peyronie’s disease. The following information is a general guideline, and it’s crucial to follow your healthcare provider’s specific instructions for using Xiaflex.

For Dupuytren’s Contracture:

• Administration by Healthcare Professional: Xiaflex should be administered by a healthcare professional in a medical office or clinic setting.
• Treatment Schedule: Typically, Xiaflex is injected into the affected cords in the hand. The injection is followed by a procedure in which the healthcare provider manipulates or stretches the cord to help break it apart.
• Treatment Sessions: The treatment may involve multiple injection and manipulation sessions separated by about 4 weeks.
• Rest and Hand Care: After each injection, you may be instructed to rest your hand and avoid strenuous activities to allow the medication to work effectively.

For Peyronie’s Disease:

• Administration by Healthcare Professional: Similar to Dupuytren’s contracture, Xiaflex is administered by a healthcare professional, specifically into the plaque (scar tissue) in the penis.
• Treatment Schedule: Xiaflex treatment for Peyronie’s disease also involves multiple injection sessions. These sessions are usually spaced about 6 weeks apart.
• Post-Injection Care: After each injection, your healthcare provider may recommend specific post-treatment care, which may include avoiding sexual activity for a certain period.

It’s important to note that Xiaflex treatment is not suitable for everyone, and its use should be discussed thoroughly with your healthcare provider. They will consider factors such as your medical history, the severity of your condition, and potential risks and benefits.

Always follow your healthcare provider’s instructions regarding the use of Xiaflex. If you have any questions or concerns about the medication, its administration, or potential side effects, be sure to discuss them with your healthcare provider. They can provide personalized guidance based on your specific health needs and circumstances.

Other uses for this medicine

Xiaflex (collagenase clostridium histolyticum) was primarily indicated for the treatment of Dupuytren’s contracture and Peyronie’s disease. However, it’s important to note that new uses or indications for medications may have been approved since then, and it’s advisable to consult the most recent medical literature or your healthcare provider for the latest information.

What special precautions should I follow?

Regarding special precautions for Xiaflex, it’s crucial to follow the guidance provided by your healthcare professional. Here are some general precautions and considerations:

• Allergies: Inform your healthcare provider about any known allergies or adverse reactions to collagenase or other components of Xiaflex.
• Medical History: Provide a comprehensive medical history, including information about any existing health conditions, especially bleeding disorders or problems with blood clotting.
• Medication Interactions: Inform your healthcare provider about all the medications, supplements, or herbal products you are currently taking. Some medications may interact with Xiaflex.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Xiaflex with your healthcare provider. The safety of Xiaflex in pregnancy and breastfeeding has not been well studied.
• Infection Risk: There is a risk of infection associated with Xiaflex injections. If you have any signs of infection, such as redness, swelling, or increased pain at the injection site, contact your healthcare provider promptly.
• Bleeding Risk: Xiaflex may increase the risk of bleeding. Inform your healthcare provider if you have a history of bleeding disorders or if you are taking medications that affect blood clotting.
• Manipulation After Injection: After the injection of Xiaflex, the affected area may be manipulated to help break down the collagen. It’s important to follow your healthcare provider’s instructions regarding post-injection care.
• Monitoring and Follow-up: Regular follow-up appointments may be necessary to monitor your progress and address any concerns or side effects.

Remember, the information provided here is based on knowledge, and there may have been updates or changes in guidelines since then. Always consult your healthcare provider for the most current and personalized information regarding Xiaflex and its use.

What special dietary instructions should I follow?

As of my last update, there were no specific dietary restrictions associated with Xiaflex. However, it’s essential to maintain a healthy and balanced diet to support overall well-being and recovery.

What should I do if I forget a dose?

Xiaflex is typically administered as an injection by a healthcare professional. Since it’s not a medication that you administer to yourself, the concept of “forgetting a dose” is less applicable. However, if you have concerns or questions about your treatment plan, contact your healthcare provider for guidance.

What side effects can this medication cause?

Xiaflex (collagenase clostridium histolyticum) may cause side effects, and it’s important to be aware of these potential reactions. Keep in mind that not everyone will experience these side effects, and some individuals may experience them to varying degrees. Common side effects include:

• Swelling and Bruising: Injection site reactions are common, including swelling, bruising, and pain. This is a normal response to the injection.
• Pain or Discomfort: Pain or discomfort at the injection site is a common side effect.
• Itching or Redness: Some individuals may experience itching or redness at the injection site.
• Nodule Formation: Formation of small lumps or nodules in the treated area may occur. This is a part of the body’s response to the breakdown of collagen.
• Allergic Reactions: Although rare, allergic reactions can occur. Signs of an allergic reaction may include rash, itching, swelling, severe dizziness, or difficulty breathing. Seek medical attention if you experience these symptoms.
• Tendon Rupture: In some cases, there have been reports of tendon rupture or other serious injuries to the treated area. This risk is higher in individuals with a history of tendon disorders.
• Nerve Injury: There is a risk of nerve injury in the treated area.
• Bleeding: Xiaflex may increase the risk of bleeding. Inform your healthcare provider if you have a history of bleeding disorders or if you are taking medications that affect blood clotting.

It’s important to note that the above list is not exhaustive, and other side effects may occur. Additionally, the severity of side effects can vary among individuals. If you experience any unusual or severe side effects after receiving Xiaflex, contact your healthcare provider promptly.

This information is based on knowledge, and it’s essential to consult with your healthcare provider for the most current and personalized information regarding Xiaflex and its potential side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal of Xiaflex:

• Storage:
  • Xiaflex should be stored as directed by your healthcare provider or pharmacist.
  • Generally, it is stored in a refrigerator.
  • Keep it out of reach of children.
• Disposal:
  • Unused or expired Xiaflex should be disposed of properly.
  • Follow local regulations or guidelines for the disposal of medications.
  • Do not dispose of Xiaflex in household trash unless specifically instructed to do so.

In case of emergency/overdose

If you suspect an overdose or experience severe side effects after receiving Xiaflex, seek emergency medical attention or contact your local poison control center immediately.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Follow your healthcare provider’s instructions carefully regarding the administration of Xiaflex, post-injection care, and any other specific guidance.
• Regular Follow-up: Attend regular follow-up appointments with your healthcare provider to monitor your progress and address any concerns.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care about your Xiaflex treatment, including surgeons and dentists, as the medication may affect your response to anesthesia.
• Potential for Allergic Reactions: Be aware of the signs of allergic reactions, such as rash, itching, swelling, severe dizziness, or difficulty breathing. Seek medical attention if you experience these symptoms.
• Tendon Rupture Risk:Be cautious about activities that may put stress on the treated area, as there is a risk of tendon rupture.
• Bleeding Risk: Inform healthcare providers about a history of bleeding disorders or the use of medications that affect blood clotting.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Xiaflex with your healthcare provider.
• Stay Informed: Stay informed about any updates or changes in the safety information or guidelines for Xiaflex.

Always consult with your healthcare provider or pharmacist for the most up-to-date and personalized information regarding the storage, disposal, and use of Xiaflex.