WARNING

Xeloda is an oral chemotherapy medication that contains the active ingredient capecitabine. It is commonly used in the treatment of certain types of cancer, such as breast, colorectal, and gastric cancers. Like any medication, Xeloda has potential risks and side effects. It’s important to note that the information provided here is a general overview, and individual responses to the medication can vary. Always consult with a healthcare professional for personalized advice.

• Common Side Effects: Xeloda can cause common side effects, including nausea, vomiting, diarrhea, and fatigue. Hand-foot syndrome is a specific side effect characterized by redness, swelling, and pain on the palms of the hands and the soles of the feet.
• Hematological Side Effects: Xeloda may affect blood cell counts, leading to conditions like anemia, neutropenia (low white blood cell count), and thrombocytopenia (low platelet count).
• Gastrointestinal Issues: Diarrhea is a common side effect, and in severe cases, it can lead to dehydration. Patients need to stay well-hydrated during treatment.
• Liver Dysfunction: Xeloda can cause liver dysfunction, which may manifest as elevated liver enzymes. Regular monitoring of liver function is often required during treatment.
• Cardiotoxicity: Some patients may experience cardiovascular side effects, including chest pain and, rarely, more serious conditions like heart attack or angina.
• Increased Risk of Blood Clots: Xeloda has been associated with an increased risk of blood clots (thromboembolism), which can be a serious concern.
• Allergic Reactions: While uncommon, allergic reactions to Xeloda can occur. Symptoms may include rash, itching, and difficulty breathing.
• Pregnancy and Breastfeeding: Xeloda can cause harm to a developing fetus, so it is not recommended during pregnancy. Breastfeeding is also contraindicated while taking Xeloda.
• Interactions with Other Medications: Xeloda may interact with other medications, potentially affecting their efficacy or increasing the risk of side effects.
• Bone Marrow Suppression: Xeloda can suppress bone marrow function, leading to a decrease in blood cell production.

It’s crucial for patients to communicate openly with their healthcare team about any side effects or concerns during Xeloda treatment. The benefits and risks of the medication should be thoroughly discussed, and patients should be monitored closely for potential adverse effects. Always follow the prescribed dosage and schedule provided by the healthcare provider.

Why is this medication prescribed?

Xeloda (capecitabine) is a prescription medication used in the treatment of certain types of cancer, particularly breast cancer and colorectal cancer. It is classified as an antimetabolite, a type of chemotherapy drug that interferes with the growth of cancer cells.

The active ingredient in Xeloda, capecitabine, is converted to 5-fluorouracil (5-FU) in the body. 5-FU is a substance that inhibits the growth of cancer cells and interferes with the synthesis of DNA.

How should this medicine be used?

Here are some general guidelines on how Xeloda is typically used, but it’s crucial to follow the specific instructions provided by your healthcare provider:

• Dosage: The dosage of Xeloda can vary depending on the type of cancer being treated and individual patient factors. It’s usually taken twice daily, with approximately 12 hours between doses.
• Administration: Xeloda is usually taken with food or within 30 minutes after a meal, as this can help improve its absorption.
• Duration of Treatment: Treatment with Xeloda is often organized into cycles, with each cycle lasting several weeks. The number of cycles and the overall duration of treatment depend on the specific cancer being treated and the individual’s response to the medication.
• Swallowing the Tablets: Xeloda tablets should be swallowed whole with water. Do not crush or cut the tablets unless specifically instructed by your healthcare provider.
• Adherence to Schedule: It’s important to take Xeloda exactly as prescribed by your healthcare provider. If you miss a dose, you should not take a double dose to make up for the missed one. Instead, continue with the regular dosing schedule.
• Monitoring: During treatment with Xeloda, your healthcare provider will monitor your blood counts and liver function regularly to ensure the medication is being tolerated and is effective.
• Potential Side Effects: Xeloda, like many chemotherapy drugs, can cause side effects. Common side effects include hand-foot syndrome (redness, swelling, and pain on the palms of the hands and/or soles of the feet), diarrhea, nausea, and fatigue. It’s important to communicate any side effects to your healthcare provider.

Always consult with your healthcare provider for personalized advice and guidance based on your specific medical condition. If you have any questions or concerns about Xeloda or its use, it’s crucial to discuss them with your oncologist or healthcare professional.

Other uses for this medicine

Some off-label uses of Xeloda may include:

• Gastric Cancer: Xeloda may be used in the treatment of advanced or metastatic gastric (stomach) cancer.
• Pancreatic Cancer: In some cases, Xeloda may be considered for the treatment of pancreatic cancer.
• Ovarian Cancer: Xeloda may be used in combination with other medications for the treatment of ovarian cancer.

What special precautions should I follow?

As for special precautions when using Xeloda, here are some key considerations:

• Pregnancy and Breastfeeding: Xeloda can cause harm to a developing fetus. If you are pregnant or planning to become pregnant, or if you are breastfeeding, you should discuss this with your healthcare provider. Adequate contraception should be used during treatment with Xeloda.
• Liver and Kidney Function: Xeloda is metabolized in the liver, and its dosage may need adjustment in individuals with impaired liver function. It’s important to inform your healthcare provider about any pre-existing liver or kidney conditions.
• Blood Counts: Xeloda can affect blood cell counts, including white blood cells, red blood cells, and platelets. Regular monitoring of blood counts is typically performed during treatment.
• Hand-Foot Syndrome: Xeloda is associated with a side effect known as hand-foot syndrome, which involves redness, swelling, and pain on the palms of the hands and/or soles of the feet. Patients should be advised on how to manage and report these symptoms.
• Diarrhea: Diarrhea is a common side effect of Xeloda. It’s important to stay hydrated, and your healthcare provider may recommend medications to manage diarrhea.
• Interactions with Other Medications: Xeloda can interact with other medications, so it’s essential to inform your healthcare provider about all the medications, supplements, and herbal products you are taking.
• Dose Adjustments: Your healthcare provider may need to adjust the dosage of Xeloda based on how well your body tolerates the medication and how effective it is in treating the cancer.

Always follow your healthcare provider’s instructions and guidelines for taking Xeloda, and don’t hesitate to ask questions if you have any concerns or experience side effects. It’s crucial to have regular check-ups and communicate openly with your healthcare team throughout the course of treatment.

What special dietary instructions should I follow?

• Food Intake: You can take Xeloda with or without food, but it’s important to take it consistently the same way each time.
• Grapefruit Juice: Avoid consuming grapefruit or grapefruit juice while taking Xeloda, as it can interact with the medication.

What should I do if I forget a dose?

If you miss a dose of Xeloda, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Xeloda (capecitabine) is a chemotherapy medication commonly used in the treatment of certain types of cancer, including breast, colorectal, and gastric cancers. Like many chemotherapy drugs, Xeloda can cause side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary from person to person. Here are some common side effects associated with Xeloda:

• Gastrointestinal Issues:
  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach pain or discomfort
• Hand-Foot Syndrome (Palmar-Plantar Erythrodysesthesia):
  • Redness, swelling, and pain on the palms of the hands and the soles of the feet
  • Tingling or numbness
• Fatigue:
  • General tiredness and weakness
• Mucositis:
  • Inflammation of the mucous membranes, which can lead to mouth sores and irritation
• Loss of Appetite:
  • Changes in taste or a metallic taste in the mouth
• Changes in Blood Cell Counts:
  • Decreased levels of red blood cells (anemia)
  • Decreased levels of white blood cells (neutropenia), which can increase the risk of infection
  • Decreased levels of platelets (thrombocytopenia), which can lead to easy bruising and bleeding
• Liver Enzyme Changes:
  • Elevated liver enzymes (as seen in blood tests)
• Allergic Reactions:
  • Allergic reactions are possible, although they are rare. Seek medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s crucial to report any side effects or symptoms to your healthcare provider promptly. Your healthcare team will monitor your response to the medication and may adjust the dosage or provide supportive care to manage side effects. In some cases, side effects may be severe enough to require a change in treatment.

If you are prescribed Xeloda or any other chemotherapy drug, your healthcare provider will discuss the potential side effects with you and provide guidance on managing them. Additionally, they will monitor your overall health and adjust your treatment plan as needed.

What should I know about storage and disposal of this medication?

Storage and Disposal of Xcopri:

• Storage:
  • Temperature: Store Xeloda at room temperature, away from light and moisture. Do not refrigerate.
  • Keep Out of Reach of Children: Store the medication in a secure place, out of the reach of children and pets.
  • Original Container: Keep Xeloda in its original container. Do not transfer the medication to another container unless directed to do so by your pharmacist or healthcare provider.
• Disposal:
  • Follow Local Regulations: Dispose of Xeloda according to local regulations. Do not flush medications down the toilet unless instructed to do so.
  • Pharmacy or Take-Back Programs: Many pharmacies and local government agencies have programs for the safe disposal of medications. Check with your pharmacist or local health department for information about take-back programs in your area.
  • Do Not Keep Expired Medication: Discard any remaining medication after the prescribed duration, and do not use Xeloda after its expiration date.

In case of emergency/overdose

If you suspect an overdose or experience severe side effects, seek emergency medical attention immediately. The symptoms of an overdose may include:

• Severe nausea, vomiting, or diarrhea
• Unexplained bleeding or bruising
• Unusual tiredness or weakness
• Signs of infection (e.g., fever, chills)

What other information should I know?

• Inform Healthcare Providers: Make sure all your healthcare providers, including doctors, dentists, and pharmacists, are aware that you are taking Xeloda. Provide a list of all medications you are currently taking, including prescription, over-the-counter, and herbal supplements.
• Regular Monitoring: Your healthcare provider will likely monitor your blood cell counts and liver function regularly while you are taking Xeloda.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Xeloda may harm an unborn baby.
• Avoid Grapefruit: While Xeloda is not known to interact with grapefruit, it’s a good practice to avoid grapefruit or grapefruit juice during chemotherapy treatment, as grapefruit can interact with various medications.

Always follow your healthcare provider’s instructions carefully and reach out to them with any questions or concerns you may have. They can provide you with the most accurate and personalized information based on your health status and the specifics of your treatment plan.