WARNING

Taking Xartemis XR involves certain risks that individuals and healthcare providers should be aware of. Here’s a brief overview of the risks associated with the use of Xartemis XR:

• Opioid Risks: Xartemis XR contains oxycodone, an opioid analgesic. Opioids carry the risk of abuse, addiction, and physical dependence. Prolonged use can lead to tolerance, where higher doses are needed for the same pain relief.
• Respiratory Depression: Opioids, including oxycodone, can cause respiratory depression, slowing down breathing. This is a serious risk, particularly at higher doses or in individuals with respiratory conditions.
• Liver Toxicity: Xartemis XR contains acetaminophen, and excessive intake can lead to liver damage. It’s important to follow the prescribed dosage and avoid other medications containing acetaminophen.
• Drug Interactions: Xartemis XR can interact with other medications, leading to potentially dangerous side effects or reduced efficacy of one or more drugs. Inform your healthcare provider about all medications you are taking.
• Central Nervous System Effects: Xartemis XR can cause drowsiness, dizziness, and impair cognitive function. This can affect the ability to perform activities that require mental alertness, such as driving or operating machinery.
• Gastrointestinal Effects: Constipation is a common side effect of opioid medications, and Xartemis XR is no exception. Adequate hydration and dietary fiber intake are often recommended to manage this side effect.
• Potential for Overdose: Taking too much Xartemis XR can lead to an overdose, which can be life-threatening. Overdose symptoms may include severe respiratory depression, unconsciousness, and difficulty breathing.
• Withdrawal Symptoms: Abruptly stopping Xartemis XR after prolonged use can lead to withdrawal symptoms, including anxiety, irritability, insomnia, nausea, vomiting, and flu-like symptoms.
• Tolerance and Dependence: Long-term use of Xartemis XR can lead to the development of tolerance, where higher doses are needed for the same pain relief. Physical dependence may occur, and abrupt discontinuation can lead to withdrawal symptoms.
• Misuse and Addiction: Opioids, including Xartemis XR, are sometimes misused for non-medical reasons. This misuse poses serious health risks and can contribute to the broader issue of opioid addiction.

It’s crucial for individuals to use Xartemis XR exactly as prescribed by their healthcare provider, to communicate openly about any concerns or side effects, and to be aware of the potential risks associated with opioid medications. Healthcare providers play a crucial role in monitoring and managing these risks, making informed decisions about pain management, and providing support for individuals using these medications.

Why is this medication prescribed?

Xartemis XR is a prescription medication that combines two active ingredients: oxycodone, an opioid analgesic, and acetaminophen, a non-opioid pain reliever. It is typically prescribed for the management of moderate to severe pain when other pain treatments are not sufficient. The extended-release formulation of Xartemis XR is designed to provide around-the-clock pain relief.

Xartemis XR is commonly prescribed for the treatment of pain associated with conditions such as:

• Chronic Pain: Xartemis XR may be used for the management of chronic pain conditions, including osteoarthritis and other musculoskeletal disorders.
• Post-Surgical Pain: It can be prescribed for the relief of pain following surgical procedures.
• Injury-Related Pain: Xartemis XR may be used to manage pain resulting from injuries, such as fractures or trauma.

How should this medicine be used?

It’s crucial to follow the specific instructions provided by your healthcare provider, and the dosing information on the prescription label. However, here are general guidelines for using Xartemis XR:

• Dosage: The dosage is determined based on the severity of the pain, the individual’s medical condition, and response to opioid medications. It is typically prescribed to be taken every 12 hours.
• Administration: Xartemis XR should be taken orally, with or without food, as directed by your healthcare provider.
• Swallow Whole: The extended-release tablets should be swallowed whole and not crushed, chewed, or broken. Breaking, crushing, or chewing the tablets can lead to a rapid release of the medication, increasing the risk of overdose.
• Avoid Alcohol: It’s advisable to avoid alcohol while taking Xartemis XR, as the combination of opioids and alcohol can lead to dangerous side effects, such as respiratory depression.
• Regular Follow-Up: Regular follow-up appointments with your healthcare provider are essential to monitor the effectiveness of the medication, assess for side effects, and make any necessary adjustments to the treatment plan.
• Tapering and Discontinuation: If the medication needs to be stopped, it is usually tapered gradually under the guidance of a healthcare provider to prevent withdrawal symptoms.
• Emergency Situations: In case of any adverse reactions, side effects, or concerns, contact your healthcare provider promptly. If there are signs of overdose, such as difficulty breathing or loss of consciousness, seek emergency medical attention.

It’s crucial to use Xartemis XR exactly as prescribed and to communicate openly with your healthcare provider about your pain levels and any side effects you may be experiencing. Additionally, given that Xartemis XR contains acetaminophen, it’s important to be mindful of the total acetaminophen intake from all sources to avoid the risk of liver damage. Always inform your healthcare provider about all medications, including over-the-counter drugs and supplements, that you are taking to avoid potential drug interactions.

Other uses for this medicine

Xartemis XR is primarily prescribed for the management of moderate to severe pain. It is not typically used for other purposes. The combination of oxycodone and acetaminophen provides analgesic effects, but its use is generally limited to pain relief.

What special precautions should I follow?

Special Precautions for Xartemis XR:

• Opioid Risks: Xartemis XR contains oxycodone, which is an opioid analgesic. It carries risks, including the potential for abuse, addiction, and physical dependence. It should be used cautiously and only under the supervision of a healthcare provider.
• Liver Function: The acetaminophen component of Xartemis XR can cause liver damage if taken in excessive amounts. It’s essential to follow the prescribed dosage and avoid other medications containing acetaminophen. Inform your healthcare provider if you have a history of liver disease or if you consume alcohol regularly.
• Kidney Function: Xartemis XR should be used with caution in individuals with impaired kidney function. Dose adjustments may be necessary in such cases.
• Respiratory Conditions: Caution is advised when prescribing Xartemis XR to individuals with respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD) because opioids can cause respiratory depression.
• Interaction with Other Medications: Inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter medications, and supplements. Xartemis XR can interact with other medications, potentially leading to adverse effects.
• Pregnancy and Breastfeeding: The safety of Xartemis XR during pregnancy and breastfeeding is not well-established. Consult with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding.
• Tolerance and Dependence: Long-term use of Xartemis XR can lead to tolerance, where higher doses are needed for the same pain relief. Abrupt discontinuation may result in withdrawal symptoms. Your healthcare provider will guide you through a tapering process if the medication needs to be stopped.
• Avoid Alcohol: Combining Xartemis XR with alcohol can increase the risk of side effects, including respiratory depression. Avoid alcohol while taking this medication.
• Central Nervous System Effects: Xartemis XR can cause drowsiness and impair cognitive function. Avoid activities that require mental alertness, such as driving or operating machinery, until you know how the medication affects you.
• Avoid Grapefruit Juice: Grapefruit juice may interact with the medication, potentially increasing the risk of side effects. It’s advisable to avoid consuming grapefruit or grapefruit juice while taking Xartemis XR.

Always follow your healthcare provider’s instructions and inform them of any pre-existing medical conditions or concerns you may have. If you experience severe or persistent side effects, contact your healthcare provider promptly. Do not self-adjust the dosage or discontinue the medication without consulting your healthcare provider.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions associated with Xartemis XR. However, considering the presence of acetaminophen, it’s essential to be mindful of your overall acetaminophen intake from all sources, including other medications or over-the-counter products containing acetaminophen. Excessive acetaminophen intake can lead to liver damage.

What should I do if I forget a dose?

If you forget to take a dose of Xartemis XR, take it as soon as you remember. However, if it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one, as this can increase the risk of side effects and complications.

What side effects can this medication cause?

Xartemis XR, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary from person to person. Common side effects of Xartemis XR include:

• Nausea: Feeling sick to the stomach is a common side effect of opioid medications.
• Vomiting: Some individuals may experience vomiting as a side effect.
• Constipation: Opioids, including oxycodone in Xartemis XR, are well-known for causing constipation. Maintaining adequate hydration and dietary fiber intake can help manage this side effect.
• Dizziness: Xartemis XR can cause dizziness, especially when standing up quickly. Avoid sudden movements, and rise slowly from a sitting or lying position.
• Drowsiness: Opioid medications can cause drowsiness or sedation. It’s important to avoid activities that require alertness, such as driving or operating heavy machinery, until you know how the medication affects you.
• Headache: Some individuals may experience headaches while taking Xartemis XR.
• Itching or Rash: Allergic reactions can manifest as itching or a rash. Seek medical attention if you notice signs of an allergic reaction.
• Difficulty Breathing: In rare cases, opioid medications like Xartemis XR can cause respiratory depression, which is a serious side effect that requires immediate medical attention.
• Dry Mouth: Some people may experience a dry mouth sensation.
• Sleep Disturbances: Changes in sleep patterns, including difficulty sleeping or excessive drowsiness, can occur.
• Mood Changes: Opioids can affect mood, potentially leading to euphoria or dysphoria.
• Urinary Retention: Difficulty urinating or incomplete emptying of the bladder may occur.

It’s important to contact your healthcare provider if you experience severe or persistent side effects. Additionally, if you notice signs of an allergic reaction (such as difficulty breathing, swelling of the face or throat, or severe rash), seek emergency medical attention.

Long-term use of opioids like Xartemis XR can lead to the development of tolerance, physical dependence, and addiction. It’s crucial to use these medications exactly as prescribed by your healthcare provider and to communicate openly about any concerns or side effects you may be experiencing. If you have any questions or concerns about the side effects of Xartemis XR, consult with your healthcare provider for personalized advice and guidance.

What should I know about storage and disposal of this medication?

Storage and Disposal of Xartemis XR:

• Storage: Keep Xartemis XR in a secure place, out of the reach of children and pets. Store it at room temperature, away from moisture, heat, and light. Follow any specific storage instructions provided by your pharmacist or healthcare provider.
• Disposal: Unused or expired medications, including Xartemis XR, should be disposed of properly to prevent accidental ingestion, misuse, or environmental contamination. Many communities have drug take-back programs or pharmacies that accept unused medications. If such options are not available, follow specific disposal instructions provided by your pharmacist or check with your local waste management authorities.

In case of emergency/overdose

If you suspect an overdose or experience signs of overdose with Xartemis XR, such as severe respiratory depression, unconsciousness, or difficulty breathing, seek emergency medical attention immediately. In the case of an overdose, it’s important to:

• Call Emergency Services: Dial emergency services (911 in the United States) for immediate assistance.
• Provide Information: Be prepared to provide information about the person’s age, weight, symptoms, and the amount of Xartemis XR ingested (if known).
• Do Not Wait: Time is critical in cases of overdose. Do not wait for symptoms to worsen; seek help promptly.

What other information should I know?

• Avoid Alcohol: Combining Xartemis XR with alcohol can increase the risk of side effects, including respiratory depression. Avoid alcohol while taking this medication.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Xartemis XR with your healthcare provider.
• Tolerance and Dependence: Long-term use of Xartemis XR can lead to the development of tolerance, where higher doses are needed for the same pain relief. Abrupt discontinuation may result in withdrawal symptoms.
• Driving and Operating Machinery: Xartemis XR can cause drowsiness and impair cognitive function. Avoid activities that require mental alertness, such as driving or operating machinery, until you know how the medication affects you.
• Regular Follow-Up: If you are prescribed Xartemis XR for pain management, your healthcare provider will likely schedule regular follow-up appointments to monitor your progress, assess for side effects, and make any necessary adjustments to the treatment plan.
• Interaction with Other Medications: Inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter medications, and supplements, to avoid potential interactions.

Always follow the specific instructions provided by your healthcare provider and pharmacist. If you have any questions or concerns about Xartemis XR, its use, or potential side effects, consult with your healthcare provider for personalized guidance.