WARNING

Belzutifan (MK-6482) is a hypoxia-inducible factor prolyl hydroxylase inhibitor that was under investigation for the treatment of certain types of cancer, such as renal cell carcinoma (RCC). It was designed to work by blocking the activity of proteins involved in the response to low oxygen levels, thereby inhibiting the growth of cancer cells.

However, it’s crucial to note that information about medications can change over time as new research findings emerge. For the most up-to-date and accurate information on belzutifan or any other medication, you should consult a healthcare professional or refer to the latest medical literature and official prescribing information.

Some potential risks and side effects associated with belzutifan included:

• Hypertension (High Blood Pressure): Belzutifan has been associated with an increased risk of hypertension. Blood pressure should be monitored regularly during treatment.
• Liver Enzyme Elevations: Elevated liver enzymes may occur, and liver function should be monitored.
• Thyroid Abnormalities: Belzutifan may affect thyroid function, leading to changes in thyroid hormone levels. Thyroid function should be monitored.
• Gastrointestinal Issues: Gastrointestinal adverse reactions, such as nausea, diarrhea, and constipation, may occur.
• Central Nervous System Effects: Some patients may experience fatigue or changes in cognition.
• Other Side Effects: Other potential side effects include anemia, decreased appetite, and rash.

It’s important for individuals considering or currently using belzutifan to discuss its potential risks and benefits with their healthcare provider. Only a qualified healthcare professional can provide personalized advice based on an individual’s medical history and specific circumstances. Additionally, ongoing research and clinical trials may provide more insights into the long-term safety and efficacy of belzutifan.

Why is this medication prescribed?

Belzutifan is a medication used for the treatment of a rare genetic disorder called von Hippel-Lindau (VHL) disease. VHL disease is characterized by the formation of tumors and cysts in various parts of the body, including the kidneys, pancreas, and adrenal glands. Belzutifan is specifically indicated for the treatment of certain renal cell carcinomas associated with VHL disease.

Belzutifan works by inhibiting the activity of hypoxia-inducible factor (HIF)-2α, which is involved in the growth and development of tumors. By targeting HIF-2α, belzutifan aims to suppress the formation of tumors associated with VHL disease.

How should this medicine be used?

Here are some general steps for using belzutifan:

• Dosage: The dosage of belzutifan is determined by a healthcare professional based on the patient’s individual characteristics and health condition.
• Administration: Belzutifan is typically taken orally in the form of tablets.
• Timing: The medication may be taken with or without food. Patients should follow the specific instructions provided by their healthcare provider or pharmacist.
• Adherence: It is essential to take belzutifan as prescribed by the healthcare provider. Do not alter the dosage or stop taking the medication without consulting your doctor.
• Regular Monitoring: Patients prescribed belzutifan may need regular medical check-ups to monitor the response to treatment and assess for any potential side effects.
• Interaction with Other Medications: Inform your healthcare provider about all medications, including prescription and over-the-counter drugs, as well as any herbal supplements, to avoid potential interactions.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The use of certain medications may need to be adjusted in these situations.

It’s important to note that this information is general, and individualized guidance should be obtained from a healthcare professional. Always follow the specific instructions provided by your healthcare provider and refer to the most recent prescribing information for belzutifan for the most accurate and up-to-date details.

Other uses for this medicine

Belzutifan was primarily being investigated and used for the treatment of von Hippel-Lindau (VHL) disease-associated renal cell carcinoma. It’s important to note that information about new uses or precautions for medications can change over time, and it’s crucial to consult with a healthcare professional or refer to the most recent medical literature for the latest information.

What special precautions should I follow?

Regarding special precautions for belzutifan, the following are general considerations based on its mechanism of action and its use in clinical trials for VHL-associated renal cell carcinoma. However, it’s essential to consult with a healthcare provider for personalized guidance:

• Pregnancy and Breastfeeding: Pregnant or breastfeeding individuals should inform their healthcare provider before using belzutifan, as the safety of the medication during pregnancy and breastfeeding may not be well-established.
• Liver Function: Belzutifan may impact liver function, and periodic monitoring of liver function tests may be necessary during treatment.
• Blood Pressure: Belzutifan may affect blood pressure. Blood pressure should be monitored regularly, and adjustments to antihypertensive medications may be necessary.
• Drug Interactions: Inform your healthcare provider about all medications, including prescription and over-the-counter drugs, as well as any herbal supplements. There may be potential interactions with other medications.
• Adverse Reactions: Like any medication, belzutifan can cause side effects. Common side effects reported in clinical trials may include anemia, fatigue, and increased liver enzymes. If you experience any unexpected or severe side effects, contact your healthcare provider.
• Hypersensitivity: Individuals with a known hypersensitivity to belzutifan or any of its components should avoid its use.
• Special Populations: Limited information may be available regarding the use of belzutifan in certain populations, such as pediatric patients or individuals with severe hepatic impairment. Consultation with a healthcare provider is necessary in such cases.

It’s important to understand that this information is not exhaustive, and specific precautions may vary based on individual health conditions. Patients should always follow their healthcare provider’s instructions and inform them of any changes in health status or concerns about the medication. Additionally, there may be new developments or updates in the information about belzutifan, and it’s recommended to consult with a healthcare professional for the latest guidance.

What special dietary instructions should I follow?

There were no specific dietary instructions associated with belzutifan. However, it’s crucial to discuss any dietary concerns or restrictions with your healthcare provider. Certain medications may be affected by food, and your healthcare provider can provide guidance on whether belzutifan should be taken with or without food.

What should I do if I forget a dose?

If you forget to take a dose of belzutifan, it’s important to follow the guidance provided by your healthcare provider or the prescribing information. Generally, if you miss a dose:

• Take It as Soon as Possible: If it is not too close to the time for your next scheduled dose, take the missed dose as soon as you remember.
• Do Not Double Up: Do not take a double dose to make up for a missed one. If it’s close to the time for your next dose, skip the missed dose and continue with your regular schedule.
• Consult Healthcare Provider: If you have questions about what to do when you miss a dose, contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Belzutifan was a relatively new medication, and information about its side effects was based on clinical trials and studies. Keep in mind that side effect profiles can be subject to updates, and it’s important to consult with a healthcare professional or refer to the most recent prescribing information for the latest details. The following are some common side effects that were reported in clinical trials:

• Anemia: A decrease in the number of red blood cells, which can lead to fatigue and weakness.
• Increased Liver Enzymes: Elevated levels of liver enzymes in blood tests.
• Edema: Swelling caused by the accumulation of fluid in the tissues.
• Fatigue: Feeling tired or weak.
• Nausea: Feeling queasy or experiencing an urge to vomit.
• Headache: Pain or discomfort in the head.
• Dizziness: Feeling lightheaded or unsteady.

It’s important to note that not everyone will experience these side effects, and their severity can vary from person to person. Additionally, other side effects not mentioned here may occur, and individual responses to medications can differ.

Patients taking belzutifan should promptly report any unusual or severe side effects to their healthcare provider. In some cases, side effects may necessitate adjustments to the treatment plan or medical intervention.

There may have been new developments or updates in the information about belzutifan. Therefore, individuals considering or currently using belzutifan should consult with their healthcare provider and refer to the most recent prescribing information for the most accurate and up-to-date information on potential side effects.

What should I know about storage and disposal of this medication?

Storage:

• Follow Instructions: Always follow the storage instructions provided by your healthcare provider or the medication’s packaging.
• Temperature: Medications are often stored at room temperature, away from direct sunlight and moisture. However, specific requirements can vary.
• Keep Out of Reach of Children: Store medications in a secure place, out of reach of children and pets.

Disposal:

• Follow Local Regulations: Dispose of medications according to local regulations. Some areas have specific guidelines for medication disposal to protect the environment.
• Do Not Flush: Avoid flushing medications down the toilet unless explicitly instructed to do so.
• Take-Back Programs: Check if there are any local take-back programs or disposal sites for unused medications.

In case of emergency/overdose

• Seek Medical Attention: In case of a suspected overdose or emergency, seek medical attention immediately. Call emergency services or a poison control center.
• Provide Information: Be prepared to provide information on the medication, dosage, and any symptoms observed.

What other information should I know?

• Compliance: Take the medication exactly as prescribed by your healthcare provider. Do not alter the dosage or stop taking it without consulting your doctor.
• Regular Check-ups: Attend scheduled check-ups with your healthcare provider to monitor your response to the medication and address any concerns.
• Inform Healthcare Providers: Make sure to inform all healthcare providers about the medications you are taking, including belzutifan, to avoid potential drug interactions.
• Pregnancy/Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The use of certain medications may need to be adjusted in these situations.

Remember, the information provided here is general and not specific to belzutifan. Always consult the prescribing information or contact your healthcare provider for detailed and accurate guidance based on the latest information available. If there have been updates or changes, your healthcare provider will have the most current information.