Why is this medication prescribed?

Pacritinib is a medication primarily used for the treatment of certain types of myelofibrosis, a rare and serious bone marrow disorder. Myelofibrosis is characterized by the abnormal production and growth of blood cells in the bone marrow, leading to scarring (fibrosis) of the marrow and other complications.

Pacritinib is a tyrosine kinase inhibitor that works by targeting specific enzymes involved in the growth and development of blood cells. By inhibiting these enzymes, pacritinib helps to regulate the production of blood cells in the bone marrow and manage the symptoms associated with myelofibrosis.

How should this medicine be used?

Pacritinib is typically taken orally in the form of capsules. Here are some general guidelines for using pacritinib:

• Dosage: The prescribed dosage of pacritinib will depend on various factors, including the specific medical condition being treated, the patient’s overall health, and other medications they may be taking. Follow your healthcare provider’s instructions regarding the correct dosage.
• Administration: Pacritinib is usually taken with food. Swallow the capsules whole with a glass of water. Do not crush, break, or chew the capsules unless specifically instructed to do so by your healthcare provider.
• Schedule: Take pacritinib regularly at the same time(s) each day to maintain a consistent level of the medication in your body.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
• Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as pacritinib may interact with other substances.
• Monitoring: Your healthcare provider may perform regular blood tests to monitor your response to pacritinib and adjust the dosage if necessary.
• Adverse Effects: Be aware of any potential side effects and report any unusual symptoms or reactions to your healthcare provider promptly.

It’s important to note that the information provided here is based on general guidelines, and specific instructions may differ. Always consult with your healthcare provider for personalized advice regarding the use of pacritinib and any specific considerations based on your medical history and condition. Additionally, information on medications can change, so it’s advisable to refer to the most recent prescribing information or consult a healthcare professional for the latest guidance.

Other uses for this medicine

As of last knowledge update, pacritinib is primarily indicated for the treatment of myelofibrosis. It is a tyrosine kinase inhibitor that targets specific enzymes involved in the growth and development of blood cells. The use of pacritinib for other conditions would be considered off-label and should only be done under the guidance and prescription of a qualified healthcare professional.

What special precautions should I follow?

Regarding special precautions for pacritinib, individuals should be aware of the following:

• Pregnancy and Breastfeeding: Pacritinib may cause harm to a developing fetus, so it’s important to inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. A discussion of the potential risks and benefits with your healthcare provider is essential in such cases.
• Liver Function: Pacritinib is metabolized in the liver, and individuals with liver impairment may require dose adjustments. It’s crucial to inform your healthcare provider about any pre-existing liver conditions or changes in liver function during treatment.
• Cardiovascular Risks: Tyrosine kinase inhibitors, including pacritinib, have been associated with cardiovascular risks. Individuals with a history of cardiovascular disease should be closely monitored, and the decision to use pacritinib should be made in consultation with a healthcare provider.
• Blood Counts: Pacritinib may affect blood cell counts, so regular monitoring of blood counts is typically required during treatment. Your healthcare provider will assess the need for dosage adjustments based on these monitoring results.
• Drug Interactions: Pacritinib may interact with other medications, including those metabolized by certain liver enzymes. Inform your healthcare provider about all medications, supplements, and herbal products you are taking to avoid potential interactions.
• Allergies: Inform your healthcare provider about any known allergies or hypersensitivity reactions to pacritinib or its components.

It’s important to consult with your healthcare provider for personalized advice and to discuss any specific precautions or considerations based on your individual health profile. Additionally, be aware that information on medications can change, so referring to the most recent prescribing information or consulting a healthcare professional for the latest guidance is advisable.

What special dietary instructions should I follow?

There were no specific dietary restrictions associated with pacritinib. However, it’s essential to follow a balanced and healthy diet unless your healthcare provider advises otherwise. If there are any dietary considerations specific to your health condition or medications, your healthcare provider will provide guidance.

What should I do if I forget a dose?

• Take it as Soon as You Remember: If you forget a dose, take it as soon as you remember. If it’s almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
• Do Not Double Up: Do not take a double dose to make up for a missed one. Taking extra medication can increase the risk of side effects.
• Inform Your Healthcare Provider: If you consistently forget doses or have difficulty adhering to the prescribed schedule, inform your healthcare provider. They can provide guidance on how to manage missed doses.

What side effects can this medication cause?

Pacritinib, like any medication, can cause side effects. The severity and specific side effects can vary from person to person. It’s important to note that the information provided here is based on knowledge, and there may be updates or additional information since then. Always consult your healthcare provider for the most current and personalized information.

Common side effects of pacritinib may include:

• Low Blood Cell Counts: Pacritinib may cause a decrease in blood cell counts, including red blood cells, white blood cells, and platelets. This can result in anemia, increased risk of infection, and bleeding.
• Nausea and Vomiting: Some individuals may experience nausea and vomiting as side effects of pacritinib.
• Headache: Headache is a reported side effect of pacritinib.
• Dizziness: Dizziness or lightheadedness may occur in some individuals.
• Fatigue: Feeling tired or fatigued is a common side effect.
• Diarrhea: Some people may experience diarrhea while taking pacritinib.
• Muscle Aches: Muscle aches or pain may occur.
• Edema (Swelling): Swelling, especially in the ankles and feet, is a reported side effect.
• Constipation: Constipation may occur as a side effect.
• Elevated Liver Enzymes: Pacritinib can affect liver function, leading to elevated liver enzyme levels.

It’s important to report any side effects or unusual symptoms to your healthcare provider promptly. In some cases, dosage adjustments or additional medical interventions may be necessary.

Additionally, serious side effects may occur, and while less common, they can be severe. These can include:

• Cardiovascular Events: Pacritinib has been associated with cardiovascular risks, and serious events such as heart attack or stroke may occur.
• Hepatotoxicity: Severe liver problems, including hepatotoxicity, have been reported.
• Hemorrhage: In some cases, pacritinib may increase the risk of bleeding.
• Infections: Due to its effects on the immune system, pacritinib may increase the risk of infections.
• Other Severe Adverse Reactions: Rare but serious adverse reactions may occur. Always seek medical attention if you experience severe or persistent symptoms.

This is not an exhaustive list of side effects, and the information provided here is general. Individual responses to medication can vary, so it’s crucial to communicate any concerns or symptoms to your healthcare provider. If you are prescribed pacritinib, your healthcare provider will discuss the potential risks and benefits with you, taking into account your specific health status and medical history.

What should I know about storage and disposal of this medication?

Storage and disposal of medications, including pacritinib, are important aspects of medication safety. Here are general guidelines, but it’s crucial to follow the specific instructions provided by your healthcare provider and on the medication packaging:

Storage of Pacritinib:

• Room Temperature: Store pacritinib at room temperature, away from excessive heat and moisture.
• Original Packaging: Keep the medication in its original packaging to protect it from light and moisture.
• Childproof Container: Store pacritinib in a childproof container and keep it out of reach of children and pets.
• Avoid Exposure: Avoid exposing pacritinib to extreme temperatures, and do not freeze the medication.

Disposal of Pacritinib:

• Follow Guidelines: Follow any specific disposal instructions provided by your healthcare provider, pharmacist, or on the medication packaging.
• Take-back Programs: Check if there are any medication take-back programs or community disposal programs in your area. Many communities have specific locations where medications can be safely disposed of.
• Do Not Flush: Do not flush pacritinib down the toilet unless instructed to do so by specific disposal instructions. Flushing medications can potentially contaminate water sources.
• Mix with Unpalatable Substance: If no specific disposal instructions are given, mix pacritinib with an unpalatable substance (e.g., coffee grounds, kitty litter) in a sealed plastic bag before disposing of it in the trash. This helps prevent accidental ingestion.

In case of emergency/overdose

In case of an emergency or overdose, contact your local poison control center at 1-800-222-1222 or seek emergency medical attention immediately. Provide them with as much information as possible, including the medication name (pacritinib), the amount ingested, and any other relevant details.

What other information should I know?

• Regular Follow-ups: Attend regular follow-up appointments with your healthcare provider. They will monitor your response to pacritinib, perform necessary tests, and adjust your treatment plan as needed.
• Lab Tests: Your healthcare provider may order regular blood tests to monitor your blood cell counts and liver function.
• Communication: Keep an open line of communication with your healthcare provider. Inform them of any changes in your health, including new symptoms or side effects.
• Inform Other Healthcare Providers: Ensure that all your healthcare providers are aware of your pacritinib treatment, including dentists and specialists.
• Avoid Grapefruit: Some medications, including pacritinib, may interact with grapefruit. Avoid consuming grapefruit or grapefruit juice unless your healthcare provider advises otherwise.

Always follow your healthcare provider’s advice and instructions for the safe and effective use of pacritinib. If you have specific questions or concerns, don’t hesitate to discuss them with your healthcare team.