Why is this medication prescribed?

Larotrectinib is a medication that is prescribed for the treatment of certain types of cancers. It is a targeted therapy specifically designed for cancers that have a specific genetic alteration known as a neurotrophic receptor tyrosine kinase (NTRK) gene fusion. NTRK gene fusions can occur in various types of cancer and can lead to uncontrolled cell growth.

The cancers that Larotrectinib may be used to treat include solid tumors in adults and pediatric patients with NTRK gene fusion-positive tumors. These tumors can occur in various organs, such as the lungs, thyroid, and salivary glands.

How should this medicine be used?

Larotrectinib is typically prescribed by a healthcare professional, and its use should be closely supervised. The specific dosage and administration instructions can vary based on individual patient factors, such as weight, overall health, and the type of cancer being treated. It’s crucial to follow the healthcare provider’s recommendations and the instructions provided with the medication. Here are general guidelines for the use of Larotrectinib:

• Dosage: The healthcare provider will determine the appropriate dosage based on the patient’s characteristics and the specific type of cancer being treated.
• Administration: Larotrectinib is usually taken orally in the form of capsules. The capsules should be swallowed whole with water. It’s important not to crush, chew, or open the capsules, as this can affect the absorption of the medication.
• Timing: Larotrectinib can be taken with or without food. The healthcare provider will specify the recommended timing for taking the medication.
• Consistency: It’s important to take Larotrectinib consistently as prescribed by the healthcare provider. Missing doses or altering the schedule may impact the effectiveness of the treatment.
• Monitoring: Regular medical check-ups and laboratory tests may be scheduled to monitor the patient’s response to Larotrectinib and to manage any potential side effects. It’s essential to attend all appointments and follow-up visits.
• Adverse Effects: Patients should be aware of potential side effects and report any unusual symptoms to their healthcare provider promptly. Common side effects may include fatigue, nausea, vomiting, dizziness, and changes in liver function tests.
• Drug Interactions: Inform the healthcare provider about all medications, supplements, and over-the-counter drugs being taken, as some substances may interact with Larotrectinib.
• Pregnancy and Breastfeeding: Patients should notify their healthcare provider if they are pregnant, planning to become pregnant, or breastfeeding, as the safety of Larotrectinib during pregnancy and lactation is not well-established.

Patients should always refer to the specific instructions provided by their healthcare provider and the medication’s packaging. It’s important to communicate openly with the healthcare team and seek guidance on any questions or concerns about Larotrectinib therapy.

Other uses for this medicine

Larotrectinib is primarily indicated for the treatment of solid tumors that have a specific genetic alteration known as a neurotrophic receptor tyrosine kinase (NTRK) gene fusion. It is a targeted therapy for cancers with this specific genetic abnormality. However, it’s essential to note that new information or approvals may have emerged since then.

What special precautions should I follow?

Regarding special precautions for Larotrectinib, it’s crucial for patients to discuss their medical history, including any existing conditions or medications, with their healthcare provider. Here are some general precautions to consider:

• Pregnancy and Breastfeeding: The safety of Larotrectinib during pregnancy and breastfeeding is not well-established. Patients should inform their healthcare provider if they are pregnant, planning to become pregnant, or breastfeeding.
• Liver Function: Larotrectinib can affect liver function. Regular monitoring of liver function through blood tests may be necessary. Patients should promptly report any signs of liver problems, such as jaundice (yellowing of the skin or eyes), dark urine, or persistent abdominal pain.
• Other Medications: Inform your healthcare provider about all medications, including prescription and over-the-counter drugs, as well as dietary supplements and herbal products. Some medications may interact with Larotrectinib, potentially affecting its effectiveness or increasing the risk of side effects.
• Allergies: Individuals with known allergies or hypersensitivity to Larotrectinib or its components should avoid using the medication.
• Medical Conditions: Patients with certain medical conditions, such as pre-existing liver disease, should discuss their condition with their healthcare provider before starting Larotrectinib.
• Dizziness and Fatigue: Larotrectinib may cause dizziness and fatigue. Patients should exercise caution when performing activities that require alertness, such as driving or operating machinery.
• Routine Monitoring: Regular monitoring, including clinical evaluations and laboratory tests, may be necessary to assess the patient’s response to Larotrectinib and manage potential side effects.

It’s important for patients to communicate openly with their healthcare provider, adhere to the prescribed dosage and schedule, and promptly report any concerns or adverse effects. Since individual circumstances can vary, healthcare providers will tailor their recommendations based on the patient’s specific situation. Patients should follow the guidance provided by their healthcare team to optimize the safety and effectiveness of Larotrectinib therapy.

What special dietary instructions should I follow?

Larotrectinib does not typically come with specific dietary restrictions. However, it’s essential to follow a healthy and balanced diet to support overall well-being during cancer treatment. Discuss any specific dietary concerns with your healthcare provider or a registered dietitian, especially if you have pre-existing dietary restrictions or concerns about nutritional intake.

What should I do if I forget a dose?

If you forget to take a dose of Larotrectinib, it’s important to follow the guidance provided by your healthcare provider or the instructions on the medication label. In general:

• If it’s close to the time for your next dose: Take the missed dose as soon as you remember, and then continue with your regular schedule.
• If it’s almost time for your next dose: Skip the missed dose and take the next dose at the scheduled time.

Do not double up on doses to make up for a missed one. If you have concerns about missed doses or if you have any questions, contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Larotrectinib, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and some people may experience side effects that are not listed. Additionally, the severity of side effects can vary from person to person. Common side effects and less common but more serious side effects associated with Larotrectinib may include:

Common Side Effects:

• Fatigue
• Nausea
• Dizziness
• Vomiting
• Increased liver enzymes

Less Common but More Serious Side Effects:

• Neutropenia: A decrease in a type of white blood cell called neutrophils, which can increase the risk of infection.
• Elevated Liver Enzymes: In some cases, Larotrectinib may cause liver function abnormalities.
• Anemia: A reduction in red blood cells, which can lead to fatigue and weakness.
• Weight Gain
• Central Nervous System Effects: Such as dizziness or changes in mood.
• Allergic reactions: While rare, some people may experience allergic reactions to Larotrectinib. Seek medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.

It’s important to promptly report any side effects to your healthcare provider. They will be able to assess the severity of the side effects and determine the appropriate course of action. Your healthcare provider will also monitor your overall health and adjust your treatment plan as needed.

This list is not exhaustive, and it’s crucial to consult with your healthcare provider or pharmacist for comprehensive information tailored to your specific health condition and medical history. If you experience severe or life-threatening side effects, seek immediate medical attention.

What should I know about storage and disposal of this medication?

Storage:

• Temperature: Store Larotrectinib at room temperature, typically between 68°F to 77°F (20°C to 25°C).
• Container: Keep the medication in its original container, and make sure it is tightly closed.
• Protection from Light: Some medications are sensitive to light. Check the packaging or consult your pharmacist to see if Larotrectinib should be protected from light.
• Moisture: Avoid storing Larotrectinib in areas with excessive moisture. Bathrooms are generally not ideal for medication storage due to humidity.

Disposal:

• Follow Local Regulations: Dispose of Larotrectinib according to local regulations for medication disposal. Do not flush it down the toilet unless instructed to do so.
• Take-Back Programs: Some communities have drug take-back programs that allow you to return unused medications to a pharmacy or other designated location.
• Ask Your Pharmacist: If you are unsure about how to dispose of Larotrectinib, consult your pharmacist for guidance.

In case of emergency/overdose

• Seek Medical Attention: If you suspect an overdose or experience severe side effects, seek emergency medical attention immediately.
• Contact Poison Control: In the case of accidental ingestion or overdose, contact your local poison control center.

What other information should I know?

• Regular Follow-ups: Attend all scheduled appointments with your healthcare provider to monitor your progress and address any concerns or side effects.
• Inform Healthcare Providers: Make sure to inform all healthcare providers involved in your care about the use of Larotrectinib, including dentists and emergency room personnel.
• Side Effects: Be aware of potential side effects and contact your healthcare provider if you experience anything unusual or severe.
• Other Medications: Inform your healthcare provider of all medications (prescription and over-the-counter), vitamins, and supplements you are taking to avoid potential drug interactions.

Always follow your healthcare provider’s specific instructions, and do not hesitate to contact them with any questions or concerns. This information is not a substitute for professional medical advice.