Why is this medication prescribed?

Alpelisib is a medication used in the treatment of certain types of breast cancer. It is specifically indicated for use in postmenopausal women and men with hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer, in combination with fulvestrant, after the disease has progressed on or following endocrine therapy.

Alpelisib is a type of medication known as a phosphatidylinositol-3-kinase (PI3K) inhibitor. It works by inhibiting a specific pathway involved in the growth and survival of cancer cells.

How should this medicine be used?

The information provided here is based on general guidelines for alpelisib. However, specific instructions may vary, and it’s crucial to follow your healthcare provider’s recommendations. Always refer to the latest information from your healthcare team or the medication’s official prescribing information for the most accurate guidance. Here are general guidelines for the use of alpelisib:

• Dosage: Alpelisib is typically prescribed by a healthcare provider. The recommended dosage can vary based on individual factors, such as the patient’s overall health, the specific type of cancer being treated, and other medications being taken.
• Administration: Alpelisib is usually taken orally, with or without food. It is often prescribed in combination with fulvestrant.
• Timing: Take alpelisib at the same time each day to maintain a consistent level of the medication in your body. Follow your healthcare provider’s instructions regarding the timing of doses.
• Missed Dose: If a dose is missed, follow your healthcare provider’s guidance on whether to take the missed dose or wait until the next scheduled dose. Do not double the dose to make up for a missed one without consulting your healthcare provider.
• Precautions: Avoid grapefruit or grapefruit juice while taking alpelisib, as they may interact with the medication.
• Monitoring: Your healthcare provider may perform regular blood tests to monitor your liver function and other parameters during treatment.
• Side Effects: Be aware of potential side effects and report any unusual symptoms or severe reactions to your healthcare provider promptly.
• Contraception: If you are of childbearing potential, use effective contraception during treatment with alpelisib, as the medication may harm an unborn baby.
• Interactions: Inform your healthcare provider about all medications, supplements, and vitamins you are taking, as alpelisib may interact with other drugs.

Always consult with your healthcare provider for personalized instructions regarding the use of alpelisib. They will consider your specific health condition, potential interactions, and other individual factors to provide the most accurate guidance. If there have been updates or changes in guidelines since my last knowledge update, your healthcare provider will have the latest information.

Other uses for this medicine

Alpelisib is primarily approved for the treatment of advanced or metastatic breast cancer as described above. It’s important to consult with a healthcare professional for the most up-to-date information on approved uses or any off-label uses.

What special precautions should I follow?

If you are prescribed alpelisib or any medication, it’s crucial to follow your healthcare provider’s instructions and ask any questions you may have about the medication. Here are some general precautions that are often recommended for alpelisib:

• Pre-existing Conditions: Inform your healthcare provider about any pre-existing medical conditions you may have, including allergies, liver problems, or any other significant health issues.
• Other Medications: Provide a list of all medications, supplements, and vitamins you are currently taking, including prescription and over-the-counter drugs. Some medications may interact with alpelisib.
• Pregnancy and Breastfeeding: Discuss the potential risks and benefits of alpelisib if you are pregnant or breastfeeding. It’s essential to use effective contraception during treatment, as the drug may harm the unborn baby.
• Monitoring: Your healthcare provider may conduct regular blood tests to monitor your liver function and other parameters during alpelisib treatment.
• Side Effects: Be aware of potential side effects and report any unusual symptoms or severe reactions to your healthcare provider promptly.
• Dietary Considerations: Some medications interact with certain foods or require specific dietary considerations. Check with your healthcare provider to see if there are any dietary restrictions or recommendations while taking alpelisib.

Remember, these are general precautions, and your healthcare provider will provide you with specific guidance based on your individual health status. Always consult with your healthcare team for the most accurate and up-to-date information regarding the use of alpelisib or any other medication.

What special dietary instructions should I follow?

Special Dietary Instructions:

• Grapefruit Interaction: Avoid grapefruit or grapefruit juice while taking alpelisib, as they may interact with the medication.
• General Diet: Follow a balanced and healthy diet unless your healthcare provider provides specific dietary instructions based on your individual health condition.

What should I do if I forget a dose?

• Missed Dose: If you forget to take a dose of alpelisib, follow your healthcare provider’s guidance on whether to take the missed dose or wait until the next scheduled dose.
• Do Not Double Dose: Do not take a double dose to make up for a missed one without consulting your healthcare provider.
• Consult Your Healthcare Provider: If you are unsure about what to do after missing a dose, contact your healthcare provider for guidance.

What side effects can this medication cause?

Alpelisib, like many medications, can cause side effects. It’s important to note that the severity and occurrence of side effects can vary from person to person. Common side effects and some less common, but more serious, side effects associated with alpelisib may include:

Common Side Effects:

• Hyperglycemia (High Blood Sugar): Alpelisib may lead to increased blood sugar levels, which can cause symptoms like increased thirst, frequent urination, or unexplained weight loss.
• Skin Rash: Some individuals may experience a rash as a side effect of alpelisib.
• Diarrhea: Diarrhea is a common side effect of alpelisib.
• Nausea and Vomiting: Some people may experience nausea or vomiting.
• Fatigue: Fatigue or weakness may occur during treatment.
• Decreased Appetite: A decrease in appetite is another potential side effect.

Less Common but Serious Side Effects:

• Hyperglycemic Crisis: In some cases, alpelisib can cause severe hyperglycemia, leading to a hyperglycemic crisis, which requires immediate medical attention.
• Pneumonitis: Rarely, alpelisib may cause inflammation of the lungs (pneumonitis), which can lead to difficulty breathing.
• Hepatotoxicity (Liver Problems): Alpelisib may cause liver problems, and symptoms such as yellowing of the skin or eyes (jaundice) should be reported to a healthcare provider.
• Infections: There may be an increased risk of certain infections during treatment with alpelisib.
• Allergic Reactions: Severe allergic reactions are rare but can occur.

It’s important to promptly report any unusual or severe symptoms to your healthcare provider. Additionally, routine monitoring, including blood tests to assess liver function and blood sugar levels, is often conducted during treatment.

Always consult with your healthcare provider for the most up-to-date information on side effects associated with alpelisib. They can provide guidance on managing side effects and make adjustments to the treatment plan if necessary. If you are prescribed alpelisib, your healthcare provider will discuss potential side effects and monitor your response to the medication closely.

What should I know about storage and disposal of this medication?

Storage and Disposal of alpelisib:

Storage:

• Room Temperature: Alpelisib is typically stored at room temperature. Avoid extreme temperatures or direct sunlight unless otherwise specified.
• Original Container: Keep alpelisib in its original container to protect it from light and moisture.
• Childproof Container: Ensure that the medication is stored in a childproof container, out of the reach of children.

Disposal:

• Follow Local Guidelines: Dispose of alpelisib according to local regulations and guidelines for medication disposal. Do not flush it down the toilet unless instructed to do so.
• Take-Back Programs: Check if there are any medication take-back programs or community disposal programs in your area.
• Consult with Pharmacist: If you are unsure about how to dispose of alpelisib, consult with your pharmacist or healthcare provider.

In case of emergency/overdose

Emergency/Overdose:

• Seek Immediate Medical Attention: If you suspect an overdose or experience severe side effects, seek immediate medical attention or contact your local poison control center.
• Symptoms of Overdose: Symptoms of overdose may include severe hyperglycemia (high blood sugar), gastrointestinal symptoms, and other adverse reactions.
• Provide Information: When seeking emergency help, provide information about the medication, its dosage, and the time it was taken.

What other information should I know?

• Regular Follow-ups: Attend all scheduled appointments with your healthcare provider for regular check-ups and monitoring.
• Lab Tests: Your healthcare provider may conduct regular blood tests to monitor your liver function, blood sugar levels, and other parameters during treatment.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care that you are taking alpelisib, including dentists and emergency medical personnel.
• Medication Interactions: Inform your healthcare provider about all medications, supplements, and vitamins you are taking to avoid potential interactions.

Always follow your healthcare provider’s instructions and consult with them or your pharmacist for any specific details regarding the storage, disposal, or emergency procedures for alpelisib. This information is general, and individual circumstances may warrant different recommendations.