WARNING

Taking Videx (didanosine) for the treatment of HIV comes with certain risks, and it’s important for individuals prescribed this medication to be aware of them. Some of the risks associated with Videx include:

• Pancreatitis: Videx has been associated with an increased risk of pancreatitis, which is inflammation of the pancreas. Symptoms include severe abdominal pain, nausea, and vomiting.
• Liver Problems: Videx can affect liver function, and in some cases, it may lead to liver problems. Symptoms of liver issues may include yellowing of the skin or eyes (jaundice), dark urine, and persistent nausea.
• Peripheral Neuropathy: Some individuals may experience peripheral neuropathy, which can cause symptoms such as tingling, numbness, or pain in the extremities.
• Changes in Body Fat Distribution: Redistribution or accumulation of body fat can occur in individuals taking antiretroviral medications, including Videx.
• Lactic Acidosis: In rare cases, lactic acidosis, a serious metabolic condition, may occur. Symptoms include rapid breathing, muscle aches, and severe fatigue.
• Immune Reconstitution Syndrome: As the immune system improves with HIV treatment, individuals may experience inflammatory reactions to previously acquired infections. This is known as immune reconstitution syndrome.
• Allergic Reactions: While rare, allergic reactions to Videx can occur. Symptoms may include rash, fever, and swelling.
• Gastrointestinal Issues: Common side effects of Videx include nausea, vomiting, diarrhea, and abdominal pain.

It’s important to note that not everyone will experience these side effects, and some individuals may tolerate Videx well. Regular monitoring of blood counts, liver function, and pancreatic function is typically recommended during Videx therapy to detect and manage potential side effects. Adhering to the prescribed dosage, attending scheduled check-ups, and reporting any concerns or side effects to your healthcare provider will contribute to the effective and safe management of HIV with Videx.

Why is this medication prescribed?

Videx, the brand name for didanosine, is prescribed for the treatment of HIV (human immunodeficiency virus) infection. It is an antiretroviral medication belonging to the class of drugs known as nucleoside reverse transcriptase inhibitors (NRTIs).

The primary purpose of prescribing Videx is to inhibit the replication of the HIV virus within the body. By doing so, it helps control the progression of HIV infection and supports the immune system. Videx is typically part of a combination antiretroviral therapy (ART) regimen, where multiple drugs with different mechanisms of action are used simultaneously to maximize effectiveness and reduce the risk of developing drug-resistant strains of HIV.

How should this medicine be used?

Videx (didanosine) is an antiretroviral medication used in the treatment of HIV (human immunodeficiency virus) infection. Here are general guidelines on how Videx should be used:

Dosage and Administration:

• Consultation with Healthcare Provider: Before starting Videx or any antiretroviral therapy, consult with a healthcare professional experienced in the management of HIV. They will determine the most appropriate treatment plan based on your individual health status.
• Dosage: The dosage of Videx can vary based on factors such as your weight, age, and overall health. Take Videx exactly as prescribed by your healthcare provider.
• Formulations: Videx is available in different formulations, including chewable tablets, powder for oral solution, and delayed-release capsules. The choice of formulation depends on factors such as the patient’s age and ability to swallow tablets.
• Timing of Administration: Videx is usually taken on an empty stomach, at least 30 minutes before or 2 hours after a meal. Follow your healthcare provider’s specific instructions regarding the timing of Videx administration.
• Swallowing Tablets: If you are taking chewable tablets, chew them thoroughly before swallowing. If you are taking capsules, swallow them whole with water.
• Interaction with Antacids: Videx should not be taken with certain antacids containing aluminum, calcium, or magnesium, as they can interfere with the absorption of the medication. If antacids are needed, take them at least 1 hour before or after Videx.
• Stay Hydrated: Drink plenty of fluids unless otherwise directed by your healthcare provider. Staying hydrated can help prevent certain side effects.

It’s crucial to follow your healthcare provider’s instructions precisely, attend regular check-ups, and communicate any concerns or side effects promptly. Never adjust your medication regimen without consulting your healthcare provider.

Other uses for this medicine

Videx (didanosine) is primarily used in the treatment of HIV infection, and its use should be guided by a healthcare professional experienced in the management of HIV. There are no widely accepted alternative uses for Videx beyond its antiretroviral properties.

What special precautions should I follow?

As for special precautions when using Videx, it’s important to note the following:

• HIV Treatment Only: Videx is not a cure for HIV; it is used to manage the infection and reduce its progression. It is part of a comprehensive antiretroviral therapy (ART) regimen and should be used in combination with other HIV medications as prescribed by a healthcare provider.
• Consultation with Healthcare Provider: Before starting Videx or any antiretroviral therapy, it is crucial to consult with a healthcare professional. They will assess your overall health, conduct necessary tests, and consider potential drug interactions to determine the most appropriate treatment plan for you.
• Dosage and Administration Instructions: Videx should be taken according to the prescribed dosage and administration instructions provided by your healthcare provider. It is often taken on an empty stomach, and the specific formulation (chewable tablets, powder for oral solution, or delayed-release capsules) will be determined based on individual factors.
• Interaction with Antacids: As mentioned previously, Videx should not be taken with certain antacids containing aluminum, calcium, or magnesium. These can interfere with the absorption of the medication. If antacids are necessary, they should be taken at least 1 hour before or after Videx.
• Regular Monitoring: Regular monitoring of blood counts, liver function, and pancreatic function is typically required during Videx therapy. This helps detect and manage any potential side effects or complications promptly.
• Pancreatitis Risk: Videx has been associated with an increased risk of pancreatitis (inflammation of the pancreas). Inform your healthcare provider if you experience symptoms such as severe abdominal pain, nausea, or vomiting, as these may be signs of pancreatitis.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The potential benefits and risks of Videx during pregnancy and breastfeeding should be carefully evaluated.

It’s essential to communicate openly with your healthcare provider about your medical history, any medications you are taking, and any side effects or concerns you may have during Videx treatment. This helps ensure the most effective and safe management of your HIV infection. Never adjust your medication regimen without consulting your healthcare provider.

What special dietary instructions should I follow?

• Take on an Empty Stomach: Videx is usually taken on an empty stomach, at least 30 minutes before or 2 hours after a meal. This enhances its absorption.
• Stay Hydrated: Drink plenty of fluids while taking Videx, unless otherwise directed by your healthcare provider. Staying hydrated can help prevent certain side effects.

What should I do if I forget a dose?

• If It’s Almost Time for the Next Dose: If you miss a dose and it’s almost time for your next scheduled dose, skip the missed dose. Do not double up on doses to make up for the missed one.
• If It’s Not Almost Time for the Next Dose: If you remember a missed dose and it’s not nearly time for the next scheduled dose, take it as soon as you remember. Then, resume your regular dosing schedule.
• If You’re Unsure: If you’re unsure about what to do, contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Videx (didanosine) can cause various side effects, and it’s important for individuals taking this medication to be aware of them. Common side effects may include:

• Gastrointestinal Issues: Nausea, vomiting, diarrhea, and abdominal pain are common side effects. Taking Videx on an empty stomach may help reduce these symptoms.
• Pancreatitis: Videx has been associated with an increased risk of pancreatitis (inflammation of the pancreas). Symptoms include severe abdominal pain, nausea, and vomiting. If you experience these symptoms, notify your healthcare provider immediately.
• Peripheral Neuropathy: Some individuals may experience peripheral neuropathy, which can cause symptoms such as tingling, numbness, or pain in the extremities.
• Liver Problems: Videx can affect liver function. Signs of liver problems may include yellowing of the skin or eyes (jaundice), dark urine, and persistent nausea.
• Changes in Body Fat Distribution: Redistribution or accumulation of body fat can occur in individuals taking antiretroviral medications, including Videx.
• Immune Reconstitution Syndrome: As the immune system improves with HIV treatment, individuals may experience inflammatory reactions to previously acquired infections. This is known as immune reconstitution syndrome.
• Lactic Acidosis: In rare cases, lactic acidosis, a serious metabolic condition, may occur. Symptoms include rapid breathing, muscle aches, and severe fatigue.
• Allergic Reactions: Allergic reactions to Videx are rare but can occur. Symptoms may include rash, fever, and swelling.

It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects not listed here. Additionally, side effects can vary in severity from person to person. If you are prescribed Videx and experience any unusual or severe symptoms, it’s crucial to contact your healthcare provider promptly.

Regular monitoring of blood counts, liver function, and pancreatic function is typically recommended during Videx therapy to detect and manage potential side effects. Adhering to your healthcare provider’s instructions, attending scheduled check-ups, and reporting any concerns or side effects will contribute to the effective and safe management of HIV with Videx.

What should I know about storage and disposal of this medication?

Storage and Disposal of Videx:

• Storage:
  • Store Videx (didanosine) at room temperature, away from moisture and heat.
  • Keep the medication in its original container with the lid tightly closed.
  • Avoid storing Videx in the bathroom, as moisture can affect its stability.
• Disposal:
  • Dispose of expired or unused Videx according to local regulations and guidelines.
  • Do not flush medications down the toilet unless specifically instructed to do so.
  • Check with your healthcare provider or pharmacist for proper disposal methods.

In case of emergency/overdose

• Seek Medical Attention: In the case of a suspected overdose or if you experience severe side effects, seek emergency medical attention immediately. Call your local poison control center or emergency room for guidance.
• Symptoms of Overdose: Symptoms of Videx overdose may include nausea, vomiting, abdominal pain, numbness or tingling, and difficulty breathing. Provide healthcare professionals with as much information as possible, including the amount of Videx taken and the time of ingestion.

What other information should I know?

• Regular Monitoring: Videx therapy often requires regular monitoring of blood counts, liver function, and pancreatic function. Attend all scheduled check-ups as recommended by your healthcare provider.
• Adherence to Treatment: Adhere to the prescribed dosage and administration schedule for Videx. Missing doses or altering the regimen without consulting your healthcare provider can affect the effectiveness of the treatment.
• Consultation with Healthcare Provider: Inform your healthcare provider of all medications, supplements, and over-the-counter drugs you are taking, as well as any changes in your health status.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider to determine the appropriate course of action.
• Avoid Alcohol and Certain Substances: Limit or avoid alcohol while taking Videx, as alcohol can increase the risk of liver problems. Discuss with your healthcare provider before taking any new medications or substances to avoid potential interactions.
• Follow Dietary Instructions: Take Videx on an empty stomach, as instructed by your healthcare provider. Stay hydrated and follow any dietary recommendations provided by your healthcare provider.

Always follow your healthcare provider’s instructions and contact them with any concerns or questions you may have about Videx. It’s important to have open communication with your healthcare team to ensure the safe and effective management of your HIV treatment.