Why is this medication prescribed?

Venclexta (venetoclax) is a prescription medication used to treat certain types of cancer. Specifically, it is approved for the treatment of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) in combination with other medications.

• Chronic Lymphocytic Leukemia (CLL): Venclexta is often prescribed in combination with obinutuzumab or rituximab for the treatment of CLL in adults who have received at least one prior therapy.
• Small Lymphocytic Lymphoma (SLL): Venclexta is also used in combination with obinutuzumab for the treatment of SLL in adults who have not received prior treatment.

Venclexta works by inhibiting a protein called BCL-2, which helps cancer cells survive. By blocking this protein, Venclexta promotes the death of cancer cells.

How should this medicine be used?

It’s crucial to follow your healthcare provider’s instructions and the dosing schedule provided with the medication. The typical dosing schedule involves a gradual increase in the dose over several weeks, known as a “ramp-up” or titration phase. This is done to reduce the risk of a condition called tumor lysis syndrome, which can occur when a large number of cancer cells are rapidly destroyed.

Here are some general guidelines, but remember to follow the specific instructions given by your healthcare provider:

• Initial Dose: The initial dose is usually a low amount, and it is gradually increased over time. This process is typically done in an outpatient setting, and your healthcare provider will monitor you closely.
• Regular Dosing: After the ramp-up phase, you will reach a steady or maintenance dose. This dose will be determined by your healthcare provider based on your individual response and tolerability.
• Administration: Venclexta is usually taken orally once daily with a meal and a glass of water. Swallow the tablets whole; do not break, crush, or chew them.
• Monitoring: Your healthcare provider will monitor your blood counts and other parameters regularly during treatment to assess the medication’s effectiveness and detect any potential side effects.

It’s essential to inform your healthcare provider about any other medications, supplements, or medical conditions you have before starting Venclexta, as certain drugs may interact with it. Additionally, be sure to report any side effects or concerns promptly to your healthcare team.

Always consult with your healthcare provider for personalized advice and guidance based on your specific medical condition and history.

Other uses for this medicine

Venclexta (venetoclax) is primarily indicated for the treatment of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL). However, ongoing research and clinical trials may explore its potential uses in other types of cancer or conditions. It’s important to check with healthcare professionals or reliable medical sources for the most current information on approved uses.

What special precautions should I follow?

Regarding special precautions for Venclexta, it’s crucial to follow your healthcare provider’s guidance closely. Here are some general precautions:

• Tumor Lysis Syndrome (TLS): Venclexta can cause TLS, a condition where there is a rapid breakdown of cancer cells, leading to the release of substances that can be harmful to the body. To minimize the risk, your healthcare provider will carefully manage the dosage, often starting with a lower dose and gradually increasing it. Monitoring for signs of TLS and providing supportive care are essential.
• Hepatitis B Reactivation: Venclexta may cause reactivation of hepatitis B virus in individuals who have been previously infected. Before starting treatment, your healthcare provider may test for hepatitis B infection. If you have a history of hepatitis B, your provider will monitor you closely during and after treatment.
• Drug Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as some drugs may interact with Venclexta, potentially affecting its effectiveness or increasing the risk of side effects.
• Pregnancy and Breastfeeding: Venclexta may cause harm to an unborn baby, so it’s important to use effective contraception during treatment and for a certain period after the last dose. If you are pregnant or planning to become pregnant, discuss the risks and benefits with your healthcare provider. It is not known whether Venclexta passes into breast milk, so breastfeeding is generally not recommended during treatment.
• Side Effects: Report any side effects or unusual symptoms to your healthcare provider promptly. Common side effects may include nausea, diarrhea, upper respiratory tract infection, and low white blood cell counts.

Always consult with your healthcare provider for personalized advice and information based on your specific health condition and medical history. If you have questions or concerns about Venclexta or its potential uses, your healthcare team can provide the most accurate and up-to-date information.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Venclexta. However, it’s important to follow your healthcare provider’s advice and any instructions provided with the medication. If you have concerns or questions about your diet while taking Venclexta, it’s best to discuss them with your healthcare team.

What should I do if I forget a dose?

If you forget to take a dose of Venclexta, the general recommendation is to take it as soon as you remember, but only if it’s within 8 hours of the scheduled time. If more than 8 hours have passed, skip the missed dose and take the next scheduled dose at the regular time. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Venclexta (venetoclax) can cause various side effects, and it’s essential to be aware of them and promptly report any unusual symptoms to your healthcare provider. Keep in mind that not everyone will experience these side effects, and their severity can vary. Common side effects may include:

• Nausea: Feeling sick to your stomach is a common side effect. Taking Venclexta with food may help alleviate nausea.
• Diarrhea: Diarrhea is another frequently reported side effect. Staying hydrated and notifying your healthcare provider if diarrhea persists or becomes severe is important.
• Upper Respiratory Tract Infection: Infections of the upper respiratory tract, such as the common cold, may occur.
• Fatigue: Feeling tired or having a lack of energy can be a side effect of Venclexta.
• Low Blood Cell Counts: Venclexta may cause low levels of red blood cells (anemia), white blood cells (neutropenia), and platelets (thrombocytopenia). This can increase the risk of infections, fatigue, and easy bruising or bleeding. Regular blood tests are typically conducted to monitor blood cell counts.
• Muscle and Joint Pain: Some people may experience muscle or joint pain as a side effect of Venclexta.
• Fever: Developing a fever is a possible side effect, and it’s important to inform your healthcare provider if you experience this symptom.
• Cough: A persistent or bothersome cough can occur.
• Headache: Some individuals may experience headaches while taking Venclexta.
• Tumor Lysis Syndrome (TLS): As mentioned earlier, Venclexta has the potential to cause TLS, which is characterized by the rapid breakdown of cancer cells. Symptoms may include nausea, vomiting, diarrhea, lethargy, and in severe cases, kidney failure. Your healthcare provider will monitor and manage the risk of TLS.

It’s important to note that this is not an exhaustive list, and other side effects may occur. Additionally, each person’s response to medication is unique, so individual experiences may vary. If you experience any side effects or have concerns while taking Venclexta, it’s crucial to communicate with your healthcare provider. They can provide guidance, adjust your treatment plan if necessary, or recommend supportive measures to manage side effects.

What should I know about storage and disposal of this medication?

Storage and Disposal of Venclexta:

• Storage: Store Venclexta (venetoclax) at room temperature between 68°F to 77°F (20°C to 25°C). Keep the medication in its original container, away from excessive heat and moisture. Do not store it in the bathroom. Ensure that it is out of reach of children and pets.
• Disposal: Dispose of any unused or expired Venclexta according to local regulations or guidelines. Do not flush medications down the toilet or pour them down the drain unless instructed to do so. Contact your healthcare provider or a local pharmacy to inquire about proper disposal methods.

In case of emergency/overdose

In case of an emergency or suspected overdose, seek medical attention immediately. The symptoms of an overdose with Venclexta are not well-documented, and it’s crucial to have prompt medical evaluation if there are concerns. If possible, bring the medication container or packaging to the healthcare facility to assist healthcare providers in assessing the situation.

What other information should I know?

• Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. Regular monitoring is important to assess the effectiveness of the treatment and manage any potential side effects.
• Lab Tests: Your healthcare provider will likely order regular blood tests to monitor your blood cell counts and other relevant parameters. Keep all scheduled laboratory appointments.
• Medical Alert: Inform healthcare providers, including dentists and emergency personnel, that you are taking Venclexta. It’s a good idea to carry a medical alert card or wear a medical alert bracelet indicating that you are on this medication.
• Pregnancy/Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss these situations with your healthcare provider. Venclexta may cause harm to a developing fetus, and the use of effective contraception is usually recommended during treatment.
• Drug Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as some drugs may interact with Venclexta.
• Missed Dose: If you miss a dose, follow the instructions provided by your healthcare provider. Do not double up on doses to make up for a missed one.

Always follow the specific instructions provided by your healthcare provider and the medication’s packaging. If you have any questions or concerns, do not hesitate to contact your healthcare team for clarification and guidance.