WARNING

Velmanase alfa, like any medication, carries certain risks. It’s crucial to note that individual responses to the medication can vary, and the information provided here is based on general considerations. Specific risks should be discussed with your healthcare provider, and you should refer to the most recent prescribing information. Here are some potential risks associated with Velmanase alfa:

• Infusion-Related Reactions: There is a risk of infusion-related reactions, which may include symptoms such as fever, chills, flushing, shortness of breath, chest tightness, nausea, vomiting, or dizziness during or after the infusion.
• Hypersensitivity Reactions: Allergic reactions may occur in individuals, particularly those with known allergies or hypersensitivity to Velmanase alfa or its components.
• Headache: Headache is a reported side effect in some individuals receiving Velmanase alfa.
• Abdominal Pain: Abdominal pain or discomfort may occur in some cases.
• Nausea: Some individuals may experience nausea or gastrointestinal discomfort.
• Fatigue: Fatigue or tiredness has been reported as a side effect.

It’s important to promptly report any unusual or severe side effects to your healthcare provider. In some cases, the healthcare team may need to adjust the dosage or provide additional medical support to manage side effects. Regular monitoring and follow-up appointments are essential to assess your response to Velmanase alfa and address any concerns.

As with any medication, the benefits and risks should be carefully considered, and treatment decisions should be made in consultation with your healthcare provider. The information provided here is a general overview, and specific risks may vary based on individual health factors and medical history. Always consult with your healthcare team for personalized information based on your specific circumstances.

Why is this medication prescribed?

Velmanase alfa is an enzyme replacement therapy used in the treatment of alpha-mannosidosis. Alpha-mannosidosis is a rare genetic disorder characterized by the deficiency of an enzyme called alpha-mannosidase. This enzyme is necessary for the breakdown of complex sugars in the body.

Velmanase alfa is designed to replace the missing or deficient alpha-mannosidase enzyme, helping to break down and remove certain complex sugars that would otherwise accumulate in the body. By addressing the enzyme deficiency, Velmanase alfa aims to alleviate some of the symptoms associated with alpha-mannosidosis.

How should this medicine be used?

The specific dosage and administration of Velmanase alfa can vary based on individual factors, such as the patient’s age, weight, and the severity of the alpha-mannosidosis. The prescribing healthcare provider will determine the appropriate dose and administration schedule for each patient.

As of last update, Velmanase alfa is typically administered by intravenous (IV) infusion. The healthcare provider will administer the infusion in a clinical setting, such as a hospital or specialized treatment center. The infusion process may take several hours.

It’s crucial for patients to follow the healthcare provider’s instructions regarding the frequency and duration of Velmanase alfa infusions. Regular monitoring and follow-up appointments will likely be scheduled to assess the patient’s response to the treatment and make any necessary adjustments to the treatment plan.

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Here are some general considerations:

• Allergies and Hypersensitivity: Inform your healthcare provider of any known allergies or hypersensitivity reactions to Velmanase alfa or its components.
• Medical History: Provide a comprehensive medical history to your healthcare provider, including information about any existing health conditions, ongoing medications, or surgeries.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Velmanase alfa with your healthcare provider.
• Interactions with Other Medications: Inform your healthcare provider about all medications, supplements, or herbal products you are taking, as there may be potential interactions with Velmanase alfa.

Always consult with your healthcare provider for personalized advice and information regarding the use of Velmanase alfa or any other medication. Additionally, updates or changes to medication guidelines may have occurred since last update.

What special dietary instructions should I follow?

As of last update, there weren’t specific dietary instructions provided for Velmanase alfa. However, it’s essential to follow any dietary recommendations or restrictions given by your healthcare provider. They may advise on general nutritional considerations or modifications based on your individual health needs.

What should I do if I forget a dose?

If you forget to receive a scheduled dose of Velmanase alfa, it’s crucial to contact your healthcare provider promptly. Missing a dose may affect the effectiveness of the treatment, and your healthcare team can provide guidance on how to proceed. Do not attempt to administer extra doses without consulting your healthcare provider.

What side effects can this medication cause?

Velmanase alfa, like any medication, may cause side effects. The side effects listed below are not exhaustive, and individual responses to medication can vary. Common side effects of Velmanase alfa may include:

• Infusion-Related Reactions: Some patients may experience reactions during or after the infusion, such as fever, chills, flushing, shortness of breath, chest tightness, nausea, vomiting, or dizziness.
• Hypersensitivity Reactions: Allergic reactions may occur, and individuals with known allergies or hypersensitivity to Velmanase alfa or its components should exercise caution.
• Headache: Headache is a reported side effect in some individuals receiving Velmanase alfa.
• Nausea: Nausea or gastrointestinal discomfort may occur in some patients.
• Fatigue: Some individuals may experience fatigue or tiredness.
• Abdominal Pain: Abdominal pain or discomfort has been reported as a side effect in some cases.

It’s important to report any unusual or severe side effects to your healthcare provider promptly. In some cases, the healthcare team may adjust the dosage or provide additional medical support to manage side effects. It’s crucial to attend regular follow-up appointments to monitor your response to Velmanase alfa and address any concerns.

Since information can change, and new developments may have occurred, it’s advisable to consult the most recent prescribing information, medical literature, or your healthcare provider for the latest information on Velmanase alfa and its potential side effects.

What should I know about storage and disposal of this medication?

Storage:

• Refrigeration: Velmanase alfa is often stored in the refrigerator. Follow the storage instructions provided by the manufacturer or your healthcare provider.
• Protect from Light: Some medications are sensitive to light. Check if Velmanase alfa should be protected from light and stored in its original packaging.
• Do Not Freeze: Avoid freezing Velmanase alfa, as freezing can affect its stability.

Disposal:

• Consult Healthcare Provider: Follow your healthcare provider’s instructions for the proper disposal of any unused or expired Velmanase alfa.
• Special Disposal Instructions: Some medications require special disposal procedures. Check if there are specific guidelines for Velmanase alfa disposal in your region.

In case of emergency/overdose

In case of an emergency or overdose, it is essential to seek immediate medical attention. Contact your local poison control center or emergency room. Provide them with information about the medication, the amount taken (if known), and any symptoms experienced.

What other information should I know?

• Regular Monitoring: Attend regular follow-up appointments with your healthcare provider for monitoring of your condition and response to Velmanase alfa.
• Communication with Healthcare Team: Keep open communication with your healthcare team. Report any side effects, changes in symptoms, or concerns promptly.
• Medication Records: Maintain accurate records of your medication schedule, including the dates and times of Velmanase alfa administrations.
• Interaction with Other Medications: Inform your healthcare provider about all medications, including over-the-counter drugs, supplements, or herbal products, to avoid potential interactions.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider to determine the potential risks and benefits of Velmanase alfa.

Always follow the specific guidance provided by your healthcare provider, and consult with them or a pharmacist if you have any questions or concerns about the storage, disposal, or other aspects of Velmanase alfa use. Additionally, check for any updates or changes in information since last update.