Why is this medication prescribed?

Ustekinumab injection is prescribed primarily for the treatment of certain immune-mediated inflammatory conditions. The main indications for prescribing Ustekinumab include:

• Psoriasis: Ustekinumab is used for the treatment of moderate to severe plaque psoriasis in adults and children who are at least 6 years old. Psoriasis is a chronic skin condition characterized by red, thickened patches covered with silvery scales.
• Psoriatic Arthritis: This medication is indicated for the treatment of active psoriatic arthritis in adults. Psoriatic arthritis is a form of arthritis that affects some people with psoriasis and can cause joint pain, stiffness, and swelling.
• Crohn’s Disease: Ustekinumab is prescribed for the treatment of moderate to severe Crohn’s disease in adults. Crohn’s disease is a type of inflammatory bowel disease (IBD) that can affect any part of the gastrointestinal tract, leading to symptoms such as abdominal pain, diarrhea, weight loss, and fatigue.

Ustekinumab is classified as a biologic medication and works by targeting specific proteins in the immune system that are involved in the inflammatory response. By modulating the immune system, Ustekinumab helps to reduce inflammation and alleviate symptoms associated with these conditions.

How should this medicine be used?

Ustekinumab is typically administered as a subcutaneous injection, meaning it is injected under the skin. The specific instructions for using Ustekinumab can vary, so it is crucial to follow the guidance provided by your healthcare provider. Here is a general overview of how Ustekinumab injection is commonly used:

• Training: Patients are often trained by healthcare professionals on how to self-administer Ustekinumab injections. This training may include proper injection technique, site rotation, and other important aspects of medication administration.
• Injection Sites: Ustekinumab is usually injected into the thigh or abdomen. It’s important to rotate injection sites to avoid irritation or reactions at the injection site. Your healthcare provider will provide guidance on the specific areas where injections should be administered.
• Dosage: The dosage of Ustekinumab can vary based on the specific condition being treated, the patient’s weight, and other factors. Your healthcare provider will determine the appropriate dosage for your individual case.
• Frequency: The frequency of Ustekinumab injections also depends on the specific treatment plan prescribed by your healthcare provider. It may be administered as a single dose or in multiple doses over a specified period. Follow the prescribed schedule to ensure the medication’s effectiveness.
• Preparation of the Injection: Ustekinumab is often supplied as a prefilled syringe or autoinjector. Follow the instructions provided with the medication for proper preparation. This may include removing the cap, attaching the needle, and priming the syringe or autoinjector.
• Administration: Once the injection is prepared, administer it according to the training provided by your healthcare provider. This may involve pinching the skin and injecting the medication at a 45 to 90-degree angle, depending on the specific instructions.
• Storage: Follow the storage guidelines provided with the medication. Ustekinumab may need to be refrigerated, and it should be protected from light. Do not freeze the medication.

It’s crucial to adhere to the prescribed dosing schedule and not to adjust the dosage or frequency without consulting your healthcare provider. If you have any questions or concerns about the administration of Ustekinumab, don’t hesitate to contact your healthcare team for guidance. Regular follow-up appointments are also important to monitor your response to the medication and address any potential side effects or concerns.

Other uses for this medicine

As of last update, the primary approved uses for Ustekinumab include:

• Psoriasis: Treatment of moderate to severe plaque psoriasis.
• Psoriatic Arthritis: Treatment of active psoriatic arthritis.
• Crohn’s Disease: Treatment of moderate to severe Crohn’s disease.

Ongoing research and clinical trials may explore additional uses for Ustekinumab, but it’s important to consult with a healthcare professional for the most up-to-date information.

What special precautions should I follow?

Regarding special precautions for Ustekinumab injection, it’s important to consider the following:

• Infections: Ustekinumab can affect the immune system, potentially increasing the risk of infections. Before starting treatment, inform your healthcare provider about any existing infections or conditions that may increase the risk of infection. Report any signs of infection during treatment.
• Live Vaccines: Avoid live vaccines while receiving Ustekinumab, as immunosuppressive medications may interfere with vaccine effectiveness. Before starting Ustekinumab, discuss your vaccination schedule with your healthcare provider.
• Tuberculosis (TB): Before starting treatment, your healthcare provider may perform a TB test. If you have a history of TB or have been in contact with someone with TB, discuss this with your healthcare provider.
• Allergies: Inform your healthcare provider about any known allergies or hypersensitivity reactions to Ustekinumab or its components.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Ustekinumab during pregnancy and breastfeeding is not well established, and the potential benefits and risks should be discussed with your healthcare provider.
• Monitoring: Regularly attend follow-up appointments as recommended by your healthcare provider. Monitoring may include assessing your response to treatment, checking for potential side effects, and conducting laboratory tests.
• Other Medications: Inform your healthcare provider about all medications, including prescription, over-the-counter, and herbal supplements, that you are taking. Some medications may interact with Ustekinumab.

It’s crucial to follow your healthcare provider’s instructions and communicate openly about your medical history and any concerns you may have. If you experience any unusual or severe side effects while using Ustekinumab, contact your healthcare provider promptly.

What special dietary instructions should I follow?

As of last update, there are no specific dietary restrictions associated with Ustekinumab. However, it’s essential to maintain a healthy and balanced diet to support overall well-being.

What should I do if I forget a dose?

If you forget to take a dose of Ustekinumab, contact your healthcare provider for guidance. It’s important not to double up on doses to make up for a missed one without consulting your healthcare provider first. They can provide specific instructions based on your treatment plan and the length of time since your last dose.

If you are administering the injections yourself and you miss a dose, follow your healthcare provider’s guidance on when and how to administer the missed dose. If in doubt, contact your healthcare provider or seek advice from a healthcare professional.

What side effects can this medication cause?

Ustekinumab, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects that are not listed. If you are prescribed Ustekinumab, your healthcare provider will closely monitor you for any potential side effects. Common side effects and less common but more serious side effects associated with Ustekinumab include:

Common Side Effects:

• Upper respiratory tract infections: This includes symptoms like a sore throat, runny nose, and sinus infections.
• Headache: Some individuals may experience headaches as a side effect of Ustekinumab.
• Fatigue: Feeling tired or experiencing fatigue is a common side effect.
• Injection site reactions: This can include redness, swelling, or itching at the injection site.

Less Common but Serious Side Effects:

• Infections: Ustekinumab may increase the risk of serious infections. Contact your healthcare provider if you notice signs of infection, such as fever, chills, or persistent cough.
• Allergic reactions: Serious allergic reactions are rare but can occur. Seek medical attention if you experience symptoms such as difficulty breathing, swelling of the face or throat, or severe itching.
• Liver problems: Ustekinumab may affect liver function. Contact your healthcare provider if you experience symptoms such as yellowing of the skin or eyes (jaundice), dark urine, or persistent abdominal pain.
• Neurological symptoms: In rare cases, Ustekinumab has been associated with neurological symptoms such as seizures or problems with coordination. Seek medical attention if you experience these symptoms.
• Blood disorders: Ustekinumab may affect blood cell counts. Contact your healthcare provider if you notice signs of blood disorders, such as persistent fatigue, easy bruising, or bleeding.

It’s crucial to report any side effects or concerns to your healthcare provider promptly. They can provide guidance on managing side effects or adjust your treatment plan if needed. It’s important not to discontinue or adjust your medication without consulting your healthcare provider. If you experience severe or life-threatening symptoms, seek emergency medical attention.

This information is based on my knowledge as of January 2022, and it’s recommended to consult with a healthcare professional or refer to the latest medical information for any updates or changes.

What should I know about storage and disposal of this medication?

Storage and Disposal of Ustekinumab Injection:

• Storage: Follow the storage instructions provided with the specific Ustekinumab product you have been prescribed. In general, Ustekinumab is often stored in the refrigerator, but it should not be frozen. Protect it from light. Do not use Ustekinumab that has been frozen or exposed to excessive heat.
• Handling: Handle the medication with care, and avoid shaking the vial or prefilled syringe vigorously.
• Disposal: Dispose of used needles and syringes in a puncture-resistant container. Your healthcare provider or pharmacist can provide guidance on proper disposal procedures. Do not dispose of Ustekinumab in household waste or sharps containers.

In case of emergency/overdose

If you suspect an overdose or experience severe side effects, seek emergency medical attention immediately. The specific symptoms of an overdose can vary, and it’s crucial to get prompt medical help in such situations.

What other information should I know?

• Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. Regular monitoring is important to assess your response to Ustekinumab and address any concerns or adjustments to your treatment plan.
• Inform Healthcare Providers: Inform all healthcare providers, including dentists and specialists, about your use of Ustekinumab. This includes any upcoming surgeries or dental procedures.
• Vaccinations: Discuss your vaccination schedule with your healthcare provider. Live vaccines are generally not recommended while on Ustekinumab.
• Communication: Report any new or worsening symptoms, changes in your health, or side effects to your healthcare provider. Open communication is essential for effective management of your condition.
• Patient Assistance Programs: If cost is a concern, inquire about patient assistance programs or financial assistance options that may be available for Ustekinumab.
• Travel: If you plan to travel, make sure to bring an adequate supply of Ustekinumab and any necessary supplies. Consider contacting your healthcare provider before traveling for additional guidance.

Remember, the information provided here is general, and individual circumstances may vary. Always follow your healthcare provider’s specific instructions, and if you have any questions or concerns, consult with your healthcare team.