Why is this medication prescribed?

Ursodiol, also known by its brand names Urso and Actigall, is a medication primarily prescribed for the treatment of certain liver diseases. The most common use of ursodiol is in the management of gallstones and certain liver conditions, such as primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC).

• Gallstones: Ursodiol is often prescribed to dissolve cholesterol gallstones in patients who are not suitable candidates for surgery or who prefer a non-surgical approach. It works by reducing the production of cholesterol and by promoting the dissolution of cholesterol in bile, which can help prevent the formation of new gallstones.
• Primary Biliary Cholangitis (PBC): Ursodiol is used in the treatment of PBC, a chronic liver disease where the small bile ducts in the liver become damaged, leading to a buildup of bile and damage to liver cells.
• Primary Sclerosing Cholangitis (PSC): Ursodiol may also be used in the treatment of PSC, another chronic liver disease characterized by inflammation and scarring of the bile ducts.

How should this medicine be used?

The usage of Ursodiol, or any medication, should be in accordance with your healthcare provider’s instructions. Below are general guidelines on how Ursodiol is typically used, but it’s important to note that individual dosages and instructions may vary based on your specific medical condition. Always follow the recommendations of your healthcare provider.

• Dosage: The typical dosage of Ursodiol can vary depending on the condition being treated. It is important to take the medication exactly as prescribed by your healthcare provider.
• Administration: Ursodiol is usually taken orally, and it is commonly available in capsule form. It is generally taken with food to enhance its absorption.
• Consistency: Take Ursodiol regularly at the same times each day. This helps to maintain a consistent level of the medication in your body.
• Follow Healthcare Provider’s Instructions: Always follow the specific instructions given by your healthcare provider regarding the use of Ursodiol. Do not adjust the dosage or stop taking the medication without consulting your healthcare provider.
• Monitoring: Your healthcare provider may conduct regular tests to monitor the effectiveness of the medication and to check for any potential side effects. Attend all scheduled appointments and laboratory tests as recommended.
• Missed Dose: If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
• Storage: Store Ursodiol at room temperature, away from moisture and heat. Follow any specific storage instructions provided by your pharmacist.
• Additional Considerations: Inform your healthcare provider about any other medications, supplements, or herbal products you are taking, as they may interact with Ursodiol. If you experience any side effects or have concerns about the medication, contact your healthcare provider promptly.

Remember, these guidelines are general and may not cover all individual cases. Always consult your healthcare provider for personalized advice based on your medical history and current health status.

Other uses for this medicine

While Ursodiol is primarily prescribed for the treatment of gallstones, primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC), there may be instances where healthcare providers consider it for off-label use. Off-label use refers to the use of a medication for a purpose other than its approved indications. However, any off-label use should be done under the guidance and supervision of a healthcare professional.

What special precautions should I follow?

It’s important to take Ursodiol with certain precautions to ensure its safe and effective use. Here are some special precautions:

• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The use of Ursodiol during pregnancy and breastfeeding should be carefully considered, and your healthcare provider will weigh the potential benefits against the risks.
• Allergies: If you are allergic to Ursodiol or any of its components, inform your healthcare provider. Allergic reactions can be serious and may require immediate medical attention.
• Liver Function: Since Ursodiol is primarily used in the treatment of liver conditions, your healthcare provider may monitor your liver function regularly while you are on this medication. Inform your healthcare provider of any existing liver conditions.
• Gallbladder Function: Ursodiol is used for gallstone dissolution, so it’s important to assess gallbladder function before initiating treatment. In some cases, gallbladder function tests may be performed.
• Pancreatitis: If you have a history of pancreatitis or are at an increased risk, discuss this with your healthcare provider. Ursodiol may be used cautiously in such cases.
• Interactions with Other Medications: Inform your healthcare provider about all medications, including over-the-counter drugs, supplements, and herbal products, that you are currently taking. Ursodiol can interact with certain medications, and your healthcare provider will consider potential drug interactions.
• Bowel Issues: If you have a history of bowel issues, discuss this with your healthcare provider. Ursodiol may cause or worsen certain bowel conditions, and its use should be monitored in such cases.
• Pancreatic Insufficiency: If you have a history of pancreatic insufficiency, use Ursodiol with caution, as it may affect fat absorption.
• Pediatric Use: The safety and efficacy of Ursodiol in pediatric patients may vary, and its use in children should be based on the healthcare provider’s assessment.

Always follow your healthcare provider’s instructions and communicate any concerns or changes in your health status during the course of Ursodiol treatment. If you experience unexpected side effects or have questions about the medication, contact your healthcare provider promptly.

What special dietary instructions should I follow?

• Ursodiol is generally taken with food to enhance its absorption.
• Follow any specific dietary instructions provided by your healthcare provider.
• Maintain a healthy and balanced diet as recommended by your healthcare provider, especially if you are taking Ursodiol for liver conditions.

What should I do if I forget a dose?

• If you forget to take a dose of Ursodiol, take it as soon as you remember.
• If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
• Do not double up on doses to make up for a missed one.
• If you are unsure about what to do, contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Ursodiol is generally well-tolerated, but like any medication, it can cause side effects in some individuals. It’s important to note that not everyone will experience these side effects, and some people may experience side effects that are not listed. If you are prescribed Ursodiol, it’s essential to discuss any concerns or symptoms with your healthcare provider. Common side effects of Ursodiol may include:

• Digestive System Issues:
  • Diarrhea
  • Upset stomach
  • Constipation
  • Nausea
• Musculoskeletal Issues:
  • Back pain
  • Joint pain
• Central Nervous System Issues:
  • Dizziness
• Respiratory System Issues:
  • Cough
• Skin Issues:
  • Rash
• General Issues:
  • Headache

While the above side effects are common, there are more serious side effects that require immediate medical attention. If you experience any of the following, contact your healthcare provider or seek emergency medical attention:

• Allergic Reaction:
  • Difficulty breathing
  • Swelling of the face, lips, tongue, or throat
  • Severe itching or rash
• Liver Issues:
  • Yellowing of the skin or eyes (jaundice)
  • Severe stomach or abdominal pain
  • Persistent nausea or vomiting
  • Dark urine
• Pancreatitis:
  • Severe abdominal pain
  • Persistent nausea or vomiting
• Serious Digestive System Issues:
  • Severe diarrhea

It’s important to report any unusual or severe side effects to your healthcare provider promptly. Additionally, inform your healthcare provider of any other medications, supplements, or herbal products you are taking, as there may be potential interactions.

This list is not exhaustive, and individual responses to medication can vary. Always follow your healthcare provider’s instructions, and if you have questions or concerns about the side effects of Ursodiol, discuss them with your healthcare provider.

What should I know about storage and disposal of this medication?

Storage and Disposal of Ursodiol:

• Storage:
  • Store Ursodiol at room temperature away from moisture and heat.
  • Keep the medication in its original container, tightly closed.
  • Do not store Ursodiol in the bathroom.
  • Keep the medication out of reach of children and pets.
• Disposal:
  • Dispose of unused or expired medication according to local regulations and guidelines.
  • Do not flush medications down the toilet unless instructed to do so. Check with your pharmacist or local waste disposal facility for proper disposal instructions.

In case of emergency/overdose

In case of an overdose or emergency, contact your local poison control center at 1-800-222-1222 (in the United States). If someone has collapsed or is not breathing, call emergency services immediately.

What other information should I know?

• Regular Monitoring: Your healthcare provider may conduct regular tests to monitor the effectiveness of Ursodiol and to check for any potential side effects. Attend all scheduled appointments and laboratory tests.
• Follow Healthcare Provider’s Instructions: Always follow the instructions given by your healthcare provider regarding the use of Ursodiol. Do not adjust the dosage or stop taking the medication without consulting your healthcare provider.
• Communication with Healthcare Provider: Inform your healthcare provider about any changes in your health status, new symptoms, or concerns related to Ursodiol.
• Interactions with Other Medications: Inform your healthcare provider about all medications, including over-the-counter drugs, supplements, and herbal products, that you are currently taking. Ursodiol can interact with certain medications.
• Allergic Reactions: If you experience signs of an allergic reaction (difficulty breathing, swelling of the face or throat, severe itching, or rash), seek immediate medical attention.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of Ursodiol with your healthcare provider. The decision to use Ursodiol during pregnancy and breastfeeding should be made in consultation with a healthcare professional.
• Dietary Considerations: Take Ursodiol with food as directed by your healthcare provider. Follow any specific dietary instructions provided by your healthcare provider.
• Missed Dose: If you miss a dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses.

Always consult with your healthcare provider or pharmacist if you have questions or concerns about the storage, disposal, or usage of Ursodiol. It’s important to have a clear understanding of how to use the medication safely and effectively.