Why is this medication prescribed?

Selexipag is a medication prescribed for the treatment of pulmonary arterial hypertension (PAH). PAH is a condition characterized by high blood pressure in the arteries that supply blood to the lungs. Selexipag belongs to a class of drugs known as prostacyclin receptor agonists, and it works by dilating the blood vessels in the lungs to reduce the strain on the heart and improve blood flow.

How should this medicine be used?

When using Selexipag, it’s important to follow the prescribing doctor’s instructions carefully. Typically, the medication is taken orally with or without food, as directed by the healthcare provider. The dosage may be gradually increased over time to help the patient tolerate the medication better.

Here are some general guidelines for using Selexipag:

• Starting Dosage: The initial dosage is usually low, and it is increased gradually. This helps to minimize potential side effects.
• Titration: Titration involves adjusting the dosage based on the individual patient’s response and tolerance. This is typically done under the supervision of a healthcare professional.
• Administration: Selexipag tablets should be taken whole and swallowed with water. They should not be crushed, broken, or chewed.
• Consistency: It’s important to take Selexipag consistently at the same time each day to maintain a steady level of the medication in the body.
• Missed Dose: If a dose is missed, the patient should take it as soon as they remember. However, if it is almost time for the next dose, they should skip the missed dose and continue with the regular dosing schedule.
• Adverse Effects: Patients should be aware of potential side effects and report any unusual symptoms or concerns to their healthcare provider promptly.
• Regular Monitoring: Patients taking Selexipag may require regular monitoring of blood pressure and other relevant parameters. Follow-up appointments with the healthcare provider are crucial to assess the effectiveness of the medication and manage any potential side effects.

It’s essential for patients to communicate openly with their healthcare providers regarding their symptoms, any side effects experienced, and any other medications or supplements they are taking. Only a qualified healthcare professional can determine the appropriate dosage and monitor the patient’s response to Selexipag effectively.

Other uses for this medicine

Selexipag is primarily approved for the treatment of pulmonary arterial hypertension (PAH), and its use for other conditions is not common. The medication works specifically by targeting the prostacyclin pathway to dilate blood vessels in the lungs. Therefore, its use is generally limited to the management of PAH.

What special precautions should I follow?

Special precautions should be taken when using Selexipag, and it’s crucial to follow the advice of your healthcare provider. Here are some general precautions associated with Selexipag use:

• Liver Function Monitoring: Selexipag may have an impact on liver function. Regular monitoring of liver enzymes is often recommended during treatment. If there are signs of liver problems, such as persistent nausea, vomiting, abdominal pain, fatigue, or jaundice, it’s important to notify your healthcare provider.
• Pregnancy and Breastfeeding: Selexipag may cause harm to a developing fetus, so it’s important to use effective contraception during treatment. If you become pregnant while taking Selexipag, inform your healthcare provider immediately. It is not known whether Selexipag passes into breast milk, so breastfeeding is not recommended during treatment.
• Hypotension (Low Blood Pressure): Selexipag can cause a decrease in blood pressure. It’s important to monitor blood pressure regularly, especially during the titration phase. Dizziness or fainting may occur, and patients should be cautious when standing up, especially after sitting or lying down.
• Drug Interactions: Selexipag may interact with other medications, including those metabolized by certain enzymes (e.g., CYP2C8 and CYP3A4). Inform your healthcare provider about all the medications, including prescription, over-the-counter, and herbal supplements, that you are taking.
• Dosage Titration: The dosage of Selexipag is typically titrated gradually to minimize potential side effects. It’s important to follow the prescribed titration schedule and not to adjust the dosage without consulting your healthcare provider.
• Adverse Effects: Report any unusual or severe side effects to your healthcare provider promptly. This includes symptoms such as severe headache, jaw pain, diarrhea, nausea, vomiting, or any signs of liver problems.
• Regular Follow-up: Regular follow-up appointments with your healthcare provider are essential to monitor your response to Selexipag, adjust the dosage as needed, and address any concerns or side effects.

Always consult with your healthcare provider for personalized advice and information regarding the use of Selexipag, especially if you have any pre-existing medical conditions or are taking other medications.

What special dietary instructions should I follow?

Regarding special dietary instructions for Selexipag, there are no specific dietary restrictions mentioned in the prescribing information. However, it’s advisable to maintain a healthy and balanced diet as part of an overall healthy lifestyle, especially considering the impact of diet on general cardiovascular health.

What should I do if I forget a dose?

If you forget to take a dose of Selexipag:

• Take It as Soon as You Remember: If you miss a dose, take it as soon as you remember. If it’s almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do Not Double Up: Do not take a double dose to make up for a missed one. Taking extra medication may increase the risk of side effects.
• Contact Your Healthcare Provider: If you have questions about what to do when you miss a dose, or if you consistently have difficulty remembering to take your medication, contact your healthcare provider for guidance.

What side effects can this medication cause?

Selexipag, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may tolerate the medication well. If you are prescribed Selexipag, your healthcare provider will weigh the potential benefits against the risks based on your individual health profile. Common side effects and adverse reactions associated with Selexipag may include:

• Headache: Headache is a common side effect of Selexipag. It may be more pronounced during the initial titration phase.
• Jaw Pain: Some individuals may experience jaw pain, which could be a symptom of increased jaw muscle tension.
• Diarrhea: Gastrointestinal symptoms, including diarrhea, have been reported by some patients taking Selexipag.
• Nausea and Vomiting: These symptoms may occur, particularly during the initial period of treatment.
• Pain in Extremities: Pain in the arms or legs has been reported as a side effect.
• Flushing: Skin flushing, or redness, may occur due to the vasodilatory effects of Selexipag.
• Decreased Appetite: Some individuals may experience a decrease in appetite.
• Fatigue: Fatigue or weakness may occur as a side effect.
• Anemia: Selexipag can lead to a decrease in red blood cell count, resulting in anemia. Regular monitoring of blood parameters is typically recommended.
• Nasal Congestion: Stuffy or congested nose may occur.
• Lightheadedness: Selexipag may cause lightheadedness or dizziness, especially when standing up.
• Liver Enzyme Elevation: Elevated liver enzymes may occur, and regular monitoring of liver function is usually recommended.

It’s essential to report any unusual or severe side effects to your healthcare provider promptly. Additionally, if you experience symptoms such as severe headache, jaw pain, diarrhea, nausea, vomiting, or signs of liver problems (such as yellowing of the skin or eyes), seek medical attention.

This list is not exhaustive, and individual responses to medications can vary. Your healthcare provider can provide more detailed information about potential side effects based on your medical history and current health status. If you have concerns or questions about the side effects of Selexipag, discuss them with your healthcare provider.

What should I know about storage and disposal of this medication?

Storage of Selexipag:

• Room Temperature: Selexipag tablets should be stored at room temperature, typically between 20°C to 25°C (68°F to 77°F).
• Protect from Moisture and Light: Keep the medication in its original packaging and protect it from moisture and light.
• Keep Out of Reach of Children: Store Selexipag in a location where it is inaccessible to children and pets.
• Avoid Extreme Conditions: Do not store Selexipag in extreme temperatures or conditions. Avoid exposure to excessive heat or cold.

Disposal of Selexipag:

• Follow Local Regulations: Dispose of unused or expired Selexipag according to local regulations and guidelines. Check with your local pharmacy or healthcare provider for guidance on proper disposal.
• Do Not Flush Medications: Do not flush Selexipag tablets down the toilet or drain unless specifically instructed to do so. Check with your pharmacist or local waste disposal facility for safe disposal methods.

In case of emergency/overdose

In the event of an overdose or if someone has ingested more Selexipag than prescribed, seek emergency medical attention immediately. Symptoms of an overdose may include severe headache, flushing, nausea, vomiting, diarrhea, jaw pain, and other side effects.

What other information should I know?

• Regular Follow-Up: Attend scheduled follow-up appointments with your healthcare provider to monitor your response to Selexipag and make any necessary adjustments to your treatment plan.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care, including dentists and surgeons, that you are taking Selexipag. They should be aware of all the medications you are using to prevent potential interactions.
• Medication Compliance: Take Selexipag as prescribed by your healthcare provider. Do not adjust the dosage or stop taking the medication without consulting your doctor.
• Medical Alert Bracelet/ID: Consider wearing a medical alert bracelet or carrying an ID card indicating that you are taking Selexipag. This information can be crucial in case of emergencies.
• Patient Education: Educate yourself about the medication, its potential side effects, and the signs of adverse reactions. Report any concerns or unusual symptoms to your healthcare provider promptly.

Always consult with your healthcare provider or pharmacist for personalized advice and information related to your specific situation. They can provide guidance on proper medication storage, disposal, and what to do in case of emergencies.