Why is this medication prescribed?

Ubrogepant is a medication that belongs to a class of drugs known as calcitonin gene-related peptide (CGRP) receptor antagonists. It is primarily prescribed for the acute treatment of migraine headaches in adults. Migraines are severe headaches that are often accompanied by other symptoms such as nausea, vomiting, and sensitivity to light and sound.

Ubrogepant works by blocking the action of CGRP, a neuropeptide that is involved in the dilation of blood vessels in the brain. By inhibiting CGRP, ubrogepant helps to reduce the inflammation and dilation of blood vessels, which are believed to contribute to the pain associated with migraines.

How should this medicine be used?

Ubrogepant is typically prescribed for the acute treatment of migraine headaches in adults. It comes in tablet form, and the recommended dosage is usually a single dose taken orally.

Here are general guidelines for the use of ubrogepant:

• Dosage: The typical recommended dose is 50 mg or 100 mg, as prescribed by your healthcare provider. The choice of dosage may depend on the severity of your migraine and how well you respond to the medication.
• Administration: Take ubrogepant by mouth with or without food. It can be taken at any time during a migraine attack.
• Limitations on Use: Do not take more than the recommended dose in a 24-hour period. If the initial dose does not provide relief, it is generally not recommended to take a second dose for the same migraine attack.
• Avoid in Certain Conditions: Ubrogepant is not recommended for use in certain situations. For example, it should not be used concomitantly with strong CYP3A4 inhibitors, as this can increase ubrogepant concentrations and the risk of adverse effects.
• Medical Advice: Before starting ubrogepant or any new medication, it’s important to inform your healthcare provider about your medical history, including any allergies, current medications, and existing health conditions.
• Side Effects and Monitoring: Be aware of potential side effects, and contact your healthcare provider if you experience any unusual or severe symptoms. Common side effects may include nausea and tiredness.

Always follow your healthcare provider’s instructions and do not self-adjust the dosage without consulting them. If you have any questions or concerns about the use of ubrogepant, discuss them with your healthcare provider for personalized advice.

Other uses for this medicine

Ubrogepant is primarily approved for the acute treatment of migraine headaches in adults, and its usage for other conditions is not established. It is essential to use ubrogepant only as prescribed by your healthcare provider and for the specific purpose for which it was prescribed.

What special precautions should I follow?

Special precautions and considerations for the use of ubrogepant include:

• Medical History: Inform your healthcare provider about your complete medical history, including any allergies, existing health conditions, and medications you are currently taking. This information helps your doctor determine if ubrogepant is a suitable and safe option for you.
• Liver Impairment: Ubrogepant should be used with caution in individuals with severe hepatic impairment. If you have liver problems, discuss this with your healthcare provider before starting ubrogepant.
• Interactions with Other Medications: Ubrogepant may interact with certain medications, including strong CYP3A4 inhibitors. Inform your healthcare provider about all the medications you are taking, including prescription and over-the-counter drugs, as well as any herbal supplements.
• Pregnancy and Breastfeeding: The safety of ubrogepant during pregnancy and breastfeeding has not been established. Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before using ubrogepant.
• Allergic Reactions: If you have had an allergic reaction to ubrogepant or any of its components, you should not take the medication. Allergic reactions can include symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Driving and Operating Machinery: Ubrogepant can cause dizziness and fatigue. Avoid driving or operating heavy machinery until you know how the medication affects you.
• Alcohol Consumption: Limit or avoid alcohol while taking ubrogepant, as it may intensify the drowsiness or dizziness caused by the medication.

Always follow your healthcare provider’s instructions and guidelines for the use of ubrogepant. If you have any concerns or experience adverse effects, contact your healthcare provider promptly. It’s crucial to attend regular follow-up appointments to monitor your response to the medication and address any issues that may arise.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions associated with ubrogepant. However, it’s important to follow your healthcare provider’s advice and maintain a healthy lifestyle. If you have concerns or questions about diet and ubrogepant, discuss them with your healthcare provider.

What should I do if I forget a dose?

If you forget to take a dose of ubrogepant, take it as soon as you remember. However, if it is close to the time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses to make up for a missed one. If you are unsure about what to do or if you have concerns, contact your healthcare provider for guidance. They can provide specific instructions based on your individual circumstances.

What side effects can this medication cause?

Ubrogepant, like any medication, may cause side effects. It’s important to be aware of potential side effects and to promptly report any unusual or severe symptoms to your healthcare provider. Common side effects of ubrogepant include:

• Nausea: Feeling sick to your stomach.
• Somnolence (Sleepiness or Drowsiness): Ubrogepant can cause drowsiness, so it’s important to avoid activities that require alertness, such as driving or operating machinery, until you know how the medication affects you.
• Dry Mouth: A sensation of dryness or discomfort in the mouth.
• Fatigue: Feeling unusually tired or lacking in energy.

These side effects are generally mild and may subside on their own. However, if you experience persistent or severe symptoms, contact your healthcare provider.

In some cases, individuals may experience more serious side effects. Seek immediate medical attention if you experience:

• Allergic Reactions: Symptoms may include rash, itching, swelling, severe dizziness, or difficulty breathing.
• Chest Pain or Pressure: Ubrogepant may cause an increase in blood pressure, and in rare cases, this can lead to chest pain or pressure. Seek medical attention if you experience such symptoms.

It’s important to note that this is not a comprehensive list of side effects, and individual responses to medications can vary. Always consult with your healthcare provider for personalized information about the potential risks and benefits of ubrogepant based on your medical history and current health status. If you have concerns about side effects, discuss them with your healthcare provider before starting the medication.

What should I know about storage and disposal of this medication?

Storage and Disposal of Ubrogepant:

• Storage:
  • Store ubrogepant at room temperature between 68°F to 77°F (20°C to 25°C).
  • Keep it in its original packaging to protect it from light and moisture.
  • Store the medication out of reach of children and pets.
• Disposal:
  • Dispose of ubrogepant as per the instructions provided by your healthcare provider or pharmacist.
  • Do not flush medications down the toilet unless instructed to do so.
  • Check with your local pharmacy or healthcare provider for guidance on safe disposal options.

In case of emergency/overdose

If you suspect an overdose or experience severe symptoms, seek emergency medical attention or contact your local poison control center at 1-800-222-1222. Overdose symptoms may include:

• Severe dizziness or lightheadedness
• Loss of consciousness
• Difficulty breathing

What other information should I know?

• Follow-Up Appointments: Attend regular follow-up appointments with your healthcare provider to monitor your response to ubrogepant and address any concerns.
• Medical Alert: Inform healthcare providers, including dentists and emergency personnel, about your use of ubrogepant before any medical procedures or treatments.
• Avoid Alcohol: Limit or avoid alcohol while taking ubrogepant, as it may intensify drowsiness or dizziness.
• Inform Healthcare Provider: Keep your healthcare provider informed about all medications, including over-the-counter drugs and supplements, that you are taking.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the use of ubrogepant with your healthcare provider.
• Drowsiness and Dizziness: Ubrogepant may cause drowsiness and dizziness. Avoid activities that require alertness until you know how the medication affects you.
• Allergic Reactions: Be aware of signs of allergic reactions, such as rash, itching, swelling, severe dizziness, or difficulty breathing. Seek medical attention if these occur.

Always adhere to your healthcare provider’s instructions and guidelines for the use of ubrogepant. If you have questions or concerns, consult your healthcare provider for personalized advice.