WARNING

Turalio (pexidartinib) is a medication used to treat a type of cancer called tenosynovial giant cell tumor (TGCT). While it can be effective, there are several risks associated with taking Turalio:

• Liver toxicity: Turalio can cause liver damage, which may be severe or fatal. Regular monitoring of liver function is required during treatment.
• QT interval prolongation: Turalio can affect the heart’s electrical activity, leading to a potentially dangerous condition called QT interval prolongation, which can cause irregular heartbeats.
• Hypertension: Turalio may increase blood pressure, which can lead to complications such as stroke or heart attack.
• Risk of infections: Turalio can suppress the immune system, increasing the risk of infections. Patients should be monitored for signs of infection during treatment.
• Gastrointestinal perforation: Turalio may cause perforation (a hole) in the stomach or intestines, which can be life-threatening.
• Embryo-fetal toxicity: Turalio can harm a developing fetus if taken during pregnancy. It is important for women of childbearing potential to use effective contraception during treatment.
• Other common side effects: These may include fatigue, nausea, vomiting, diarrhea, hair color changes, and changes in laboratory tests.

Patients taking Turalio should be closely monitored by their healthcare provider for these potential risks and side effects. It’s essential to weigh the benefits of treatment against the potential risks and discuss any concerns with a healthcare professional.

Why is this medication prescribed?

Turalio (pexidartinib) is prescribed to treat a specific type of cancer called tenosynovial giant cell tumor (TGCT) in adults. TGCT is a rare tumor that affects the synovium, which is the lining of joints, tendon sheaths, and bursae. Turalio is indicated for patients with TGCT that is not amenable to surgical removal (resection).

The primary goal of Turalio treatment is to reduce tumor size and alleviate symptoms associated with TGCT, such as pain and limited mobility. It works by inhibiting certain enzymes involved in the growth and survival of tumor cells.

How should this medicine be used?

Turalio is available in capsule form and is typically taken orally with or without food. The recommended dosage is usually determined by a healthcare provider based on factors such as the patient’s weight and overall health. Patients should follow their healthcare provider’s instructions carefully and take Turalio exactly as prescribed.

During treatment, regular monitoring of liver function is necessary due to the risk of liver toxicity. Blood pressure should also be monitored regularly, and patients should report any signs of infection or gastrointestinal issues to their healthcare provider.

It’s essential for patients to communicate openly with their healthcare team about any concerns or side effects experienced while taking Turalio. Additionally, women of childbearing potential should use effective contraception during treatment, as Turalio can cause harm to a developing fetus if taken during pregnancy.

Other uses for this medicine

Turalio (pexidartinib) is primarily used to treat tenosynovial giant cell tumor (TGCT) in adults. However, there may be other potential uses for Turalio that are being investigated in clinical trials or off-label uses. It’s important to note that using Turalio for any condition other than TGCT should only be done under the supervision of a healthcare professional.

What special precautions should I follow?

Some special precautions to follow when taking Turalio include:

• Liver function monitoring: Regular monitoring of liver function tests is essential during Turalio treatment due to the risk of liver toxicity. Your healthcare provider will likely perform liver function tests before starting treatment and periodically throughout.
• Blood pressure monitoring: Turalio may increase blood pressure, so regular monitoring of blood pressure is recommended during treatment. Your healthcare provider may adjust your blood pressure medications as needed.
• QT interval monitoring: Turalio can prolong the QT interval, which may increase the risk of abnormal heart rhythms. Your healthcare provider may perform electrocardiograms (ECGs) before and during treatment to monitor your heart’s electrical activity.
• Risk of infections: Turalio can suppress the immune system, increasing the risk of infections. It’s important to report any signs of infection, such as fever or persistent cough, to your healthcare provider promptly.
• Gastrointestinal perforation: Turalio may increase the risk of gastrointestinal perforation (a hole in the stomach or intestines), which can be life-threatening. Contact your healthcare provider immediately if you experience severe abdominal pain, vomiting, or other signs of gastrointestinal issues.
• Embryo-fetal toxicity: Turalio can harm a developing fetus if taken during pregnancy. Women of childbearing potential should use effective contraception during treatment and for at least one month after the last dose of Turalio.
• Interactions with other medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting Turalio, as it may interact with certain medications.
• Adherence to treatment: Take Turalio exactly as prescribed by your healthcare provider. Do not adjust your dosage or stop taking the medication without consulting your healthcare provider first.

By following these precautions and working closely with your healthcare provider, you can help ensure the safe and effective use of Turalio for the treatment of TGCT or any other condition for which it is prescribed.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Turalio. However, maintaining a healthy and balanced diet is always beneficial for overall health. If you have any concerns or questions about dietary considerations while taking Turalio, consult your healthcare provider or a registered dietitian for personalized guidance.

What should I do if I forget a dose?

If you forget to take a dose of Turalio at the scheduled time, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you are unsure about what to do, contact your healthcare provider or pharmacist for advice.

What side effects can this medication cause?

Turalio (pexidartinib) can cause various side effects, ranging from mild to severe. It’s essential to be aware of these potential side effects and to promptly report any concerning symptoms to your healthcare provider. Common side effects of Turalio may include:

• Liver toxicity: Turalio can cause liver damage, which may manifest as elevated liver enzymes, jaundice (yellowing of the skin or eyes), abdominal pain, or dark urine.
• QT interval prolongation: Turalio may affect the heart’s electrical activity, leading to QT interval prolongation, which can result in irregular heart rhythms.
• Hypertension: Turalio can increase blood pressure, which may lead to symptoms such as headaches, dizziness, or blurred vision.
• Infections: Turalio can suppress the immune system, increasing the risk of infections. Symptoms of infection may include fever, chills, sore throat, or cough.
• Gastrointestinal perforation: Turalio may increase the risk of gastrointestinal perforation, which can cause severe abdominal pain, nausea, vomiting, or fever.
• Fatigue: Turalio treatment may cause fatigue or weakness.
• Nausea and vomiting: Some patients may experience nausea, vomiting, or diarrhea while taking Turalio.
• Hair color changes: Turalio may cause changes in hair color, such as graying or lightening of the hair.
• Laboratory abnormalities: Turalio can affect laboratory test results, including changes in blood cell counts, electrolyte levels, and kidney function tests.

It’s essential to communicate openly with your healthcare provider about any side effects or symptoms you experience while taking Turalio. Your healthcare provider can provide guidance on managing side effects and may adjust your treatment regimen if necessary. Additionally, if you experience any severe or concerning symptoms, seek medical attention promptly.

What should I know about storage and disposal of this medication?

Storage and disposal of Turalio:

• Storage: Store Turalio capsules at room temperature, away from light and moisture. Keep the medication in its original container, and ensure it is tightly closed when not in use.
• Disposal: Dispose of unused or expired Turalio capsules according to local regulations or guidelines. Do not flush them down the toilet or pour them down the drain unless instructed to do so. Contact your pharmacist or local waste disposal facility for proper disposal instructions.

In case of emergency/overdose

In case of emergency or overdose of Turalio, seek immediate medical attention or contact a poison control center right away. Symptoms of overdose may include severe dizziness, fainting, or difficulty breathing. Be prepared to provide information about the amount of medication ingested and any symptoms experienced.

What other information should I know?

• Keep all appointments: Attend all scheduled appointments with your healthcare provider for monitoring and follow-up during Turalio treatment.
• Laboratory tests: Your healthcare provider may order regular blood tests to monitor liver function, blood cell counts, and other parameters during Turalio treatment.
• Avoid grapefruit and grapefruit juice: Grapefruit and grapefruit juice may interact with Turalio and increase the risk of side effects. Avoid consuming grapefruit products while taking Turalio.
• Inform healthcare providers: Inform all healthcare providers involved in your care, including dentists and specialists, that you are taking Turalio. This includes providing a list of all medications, supplements, and herbal products you are taking.
• Supportive care: Seek support from healthcare professionals, family members, or support groups if you experience any challenges or concerns related to Turalio treatment.
• Pregnancy and breastfeeding: Turalio may cause harm to a developing fetus if taken during pregnancy. Women of childbearing potential should use effective contraception during treatment and discuss breastfeeding considerations with their healthcare provider.
• Carry identification: Consider carrying a medical identification card or wearing a bracelet indicating that you are taking Turalio in case of emergency situations.

By following these guidelines and staying informed about Turalio treatment, you can help ensure safe and effective use of the medication under the guidance of your healthcare provider.