WARNING

Trulance (plecanatide) is a medication primarily prescribed for the treatment of chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C). While it can be effective for some individuals, like any medication, it carries potential risks and side effects. Here are some of the risks associated with taking Trulance:

• Gastrointestinal Side Effects: Common side effects of Trulance include diarrhea, abdominal pain, flatulence, and bloating. These symptoms may occur especially at the beginning of treatment and may lessen over time.
• Dehydration: Excessive diarrhea caused by Trulance can lead to dehydration if not managed properly. It’s important to stay adequately hydrated while taking this medication.
• Hypersensitivity Reactions: Some individuals may experience allergic reactions to Trulance, characterized by symptoms such as rash, itching, swelling, dizziness, or difficulty breathing. Seek medical attention if you experience any of these symptoms.
• Severe Diarrhea: While diarrhea is a common side effect, in some cases, it can be severe and lead to complications such as electrolyte imbalances or dehydration, especially in vulnerable populations such as the elderly or those with pre-existing health conditions.
• Interactions with Other Medications: Trulance may interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects. It’s essential to inform your healthcare provider about all the medications you’re taking before starting Trulance.
• Pregnancy and Breastfeeding: The safety of Trulance during pregnancy and breastfeeding has not been established. Consult with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before using Trulance.
• Intestinal Obstruction: In rare cases, Trulance may cause severe diarrhea or exacerbate symptoms in individuals with certain intestinal conditions, such as bowel obstructions. If you have a history of such conditions, inform your doctor before starting Trulance.
• Adverse Reactions: In addition to the common side effects mentioned, some individuals may experience other adverse reactions while taking Trulance. If you notice any unusual symptoms or reactions, consult your healthcare provider promptly.

It’s crucial to discuss the potential risks and benefits of Trulance with your healthcare provider before starting this medication, especially if you have any underlying medical conditions or are taking other medications. Your doctor can provide personalized guidance based on your individual health profile.

Why is this medication prescribed?

Trulance (plecanatide) is prescribed primarily for the treatment of two gastrointestinal conditions:

• Chronic Idiopathic Constipation (CIC): This condition is characterized by infrequent bowel movements and difficulty passing stool without a known underlying cause. Trulance helps to increase bowel movements and alleviate constipation symptoms.
• Irritable Bowel Syndrome with Constipation (IBS-C): IBS-C is a gastrointestinal disorder that involves abdominal pain or discomfort, along with constipation. Trulance can help improve bowel movements and relieve symptoms such as abdominal discomfort associated with IBS-C.

How should this medicine be used?

Here are general guidelines for using Trulance:

• Dosage: Trulance is typically available as oral tablets in strengths of 3 mg and 6 mg. The usual recommended dose for adults with either CIC or IBS-C is 3 mg once daily.
• Administration: Trulance tablets should be taken orally with water, with or without food.
• Follow Doctor’s Instructions: It’s important to follow your healthcare provider’s instructions regarding the dosage and duration of Trulance treatment. Do not exceed the prescribed dose unless instructed by your doctor.
• Constancy: Trulance should be taken consistently every day to achieve the best results. If a dose is missed, it should be taken as soon as remembered, unless it is almost time for the next scheduled dose. In such cases, the missed dose should be skipped, and the regular dosing schedule resumed.
• Adjustments: Your doctor may adjust the dosage of Trulance based on your individual response to the medication and any side effects experienced.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using Trulance, as its safety during pregnancy and breastfeeding has not been established.
• Monitoring: While taking Trulance, it’s essential to monitor for any side effects or adverse reactions. If you experience severe or persistent diarrhea, allergic reactions, or other concerning symptoms, contact your healthcare provider promptly.

Always communicate openly with your healthcare provider regarding your symptoms, treatment effectiveness, and any concerns you may have about Trulance. They can provide personalized guidance and adjustments to ensure the best outcomes while minimizing potential risks.

Other uses for this medicine

While Trulance is primarily indicated for CIC and IBS-C, it is sometimes used off-label for other gastrointestinal conditions. However, any such use should be strictly guided by a healthcare professional.

What special precautions should I follow?

Special Precautions for Trulance:

• Medical History: Before starting Trulance, inform your healthcare provider about your medical history, including any gastrointestinal conditions, allergies, surgeries, and current medications or supplements you are taking.
• Allergies: If you are allergic to plecanatide or any other ingredients in Trulance, inform your doctor before using this medication.
• Pregnancy and Breastfeeding: The safety of Trulance during pregnancy and breastfeeding has not been established. Consult with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding before using Trulance.
• Pediatric Use: The safety and effectiveness of Trulance in pediatric patients have not been established. It is not recommended for use in children under 18 years of age.
• Renal Impairment: Trulance should be used with caution in patients with severe renal impairment. Dose adjustment may be necessary in these individuals.
• Severe Diarrhea: Trulance may cause diarrhea, which can be severe in some cases. If you experience severe or persistent diarrhea, contact your healthcare provider, as it may require medical attention.
• Interactions: Trulance may interact with other medications, potentially affecting their effectiveness or increasing the risk of side effects. It’s essential to inform your doctor about all the medications you are taking before starting Trulance.
• Monitoring: While taking Trulance, it’s important to monitor for any side effects or adverse reactions. Contact your healthcare provider if you experience any concerning symptoms.

By following these precautions and consulting with your healthcare provider, you can ensure the safe and effective use of Trulance for your specific condition.

What special dietary instructions should I follow?

There are no specific dietary instructions that need to be followed while taking Trulance. However, it’s important to maintain a healthy, balanced diet and drink plenty of fluids to help manage constipation and maintain overall gastrointestinal health.

What should I do if I forget a dose?

If you forget to take a dose of Trulance, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

What side effects can this medication cause?

Trulance (plecanatide) can cause various side effects, although not everyone experiences them. Common side effects of Trulance include:

• Diarrhea: Diarrhea is the most common side effect of Trulance. It may occur during the first few days or weeks of treatment and typically resolves over time. However, some individuals may experience severe or persistent diarrhea, which requires medical attention.
• Abdominal Pain: Some people may experience abdominal discomfort or pain while taking Trulance. This may include cramping, bloating, or discomfort in the stomach area.
• Flatulence (Gas): Trulance can cause increased gas production in some individuals, leading to flatulence or passing gas more frequently than usual.
• Headache: Headaches are another common side effect reported by some individuals taking Trulance. These headaches may be mild to moderate in intensity.
• Nausea: Some people may experience nausea or feelings of queasiness while taking Trulance. This side effect is usually mild and temporary.
• Vomiting: In some cases, Trulance may cause vomiting as a side effect. If vomiting occurs frequently or is severe, medical attention may be needed.
• Dehydration: Excessive diarrhea caused by Trulance can lead to dehydration if not managed properly. It’s essential to drink plenty of fluids while taking this medication to prevent dehydration.
• Hypersensitivity Reactions: Rarely, some individuals may experience allergic reactions to Trulance. Symptoms may include rash, itching, swelling, dizziness, or difficulty breathing. Seek medical attention immediately if you experience any signs of an allergic reaction.

It’s important to note that this list does not include all possible side effects of Trulance. Some individuals may experience other side effects not listed here. If you experience any concerning symptoms or side effects while taking Trulance, contact your healthcare provider for further evaluation and guidance. Additionally, if you have any questions or concerns about potential side effects, discuss them with your doctor or pharmacist.

What should I know about storage and disposal of this medication?

Storage and Disposal of Trulance:

• Storage: Trulance should be stored at room temperature between 68°F to 77°F (20°C to 25°C) in its original container. Keep the medication away from moisture and heat, and store it out of reach of children and pets.
• Disposal: Dispose of unused or expired Trulance tablets according to local regulations or guidelines. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Instead, consult your pharmacist or local waste disposal company for proper disposal instructions.

In case of emergency/overdose

In case of an overdose or emergency related to Trulance, such as severe diarrhea or adverse reactions, seek immediate medical attention or contact your local poison control center at 1-800-222-1222 (in the United States). Be prepared to provide information about the amount of medication ingested, symptoms experienced, and any other relevant details.

What other information should I know?

• Follow Instructions: Take Trulance exactly as prescribed by your healthcare provider. Do not exceed the recommended dosage or frequency of administration.
• Regular Follow-up: Attend follow-up appointments with your doctor to monitor your response to Trulance and assess any side effects or changes in your condition.
• Stay Hydrated: Drink plenty of fluids while taking Trulance to prevent dehydration, especially if you experience diarrhea.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using Trulance, as its safety during pregnancy and breastfeeding has not been established.
• Driving and Operating Machinery: Trulance is not expected to impair your ability to drive or operate machinery. However, if you experience dizziness or other side effects that may affect your ability to perform these activities safely, use caution.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care, including dentists and pharmacists, that you are taking Trulance. This medication may interact with other drugs or medical procedures.
• Medication Review: Periodically review your medication list with your doctor or pharmacist to check for potential drug interactions or changes in your treatment plan.

By following these guidelines and staying informed about Trulance, you can ensure safe and effective use of this medication for the treatment of chronic idiopathic constipation or irritable bowel syndrome with constipation.