WARNING

Triumeq PD is a medication used to treat HIV infection. Like any medication, it comes with potential risks and side effects. Some common risks associated with Triumeq PD include:

• Allergic Reactions: Some individuals may experience severe allergic reactions to Triumeq PD, which can manifest as rash, fever, nausea, vomiting, or difficulty breathing. These reactions require immediate medical attention.
• Liver Problems: Triumeq PD can cause liver problems, including elevated liver enzymes and liver damage. Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, or unusual fatigue.
• Lactic Acidosis: This is a rare but serious condition characterized by the buildup of lactic acid in the bloodstream. Symptoms include weakness, muscle pain, trouble breathing, stomach pain, nausea, vomiting, irregular heartbeat, or feeling cold.
• Immune Reconstitution Syndrome (IRIS): Some patients may experience an inflammatory response to latent infections as their immune system improves while taking Triumeq PD. This can lead to the worsening of pre-existing infections or the appearance of new ones.
• Bone Problems: Long-term use of Triumeq PD may be associated with bone loss or osteoporosis, increasing the risk of fractures.
• Weight Gain: Some individuals may experience weight gain while taking Triumeq PD.
• Metabolic Effects: Triumeq PD may affect glucose metabolism and lipid levels, potentially leading to diabetes or dyslipidemia.

It’s crucial for individuals taking Triumeq PD to be monitored regularly by their healthcare provider to assess for any potential adverse effects and to ensure the medication’s efficacy in controlling HIV infection. It’s also essential to adhere to prescribed dosages and follow-up appointments to minimize risks and optimize health outcomes.

Why is this medication prescribed?

Triumeq PD is prescribed for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 40 kg (about 88 pounds). It is typically used in combination with other antiretroviral medications as part of a comprehensive HIV treatment regimen. Triumeq PD contains three active ingredients: abacavir, dolutegravir, and lamivudine. Abacavir and lamivudine belong to a class of medications called nucleoside reverse transcriptase inhibitors (NRTIs), while dolutegravir is an integrase strand transfer inhibitor (INSTI). These drugs work together to inhibit the replication of the HIV virus, thereby reducing viral load and slowing the progression of HIV infection.

How should this medicine be used?

Triumeq PD is a medication used for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 40 kg. It contains a combination of three active ingredients: abacavir, dolutegravir, and lamivudine. Here’s how Triumeq PD should be used:

• Dosage: The usual recommended dosage for adults and pediatric patients weighing at least 40 kg is one tablet once daily.
• Administration: Triumeq PD tablets should be swallowed whole with water. They should not be crushed, chewed, or divided.
• Timing: Triumeq PD can be taken with or without food. It’s essential to take the medication consistently and at the same time each day to maintain steady levels of the drug in the body.
• Follow Healthcare Provider’s Instructions: It’s crucial to follow the dosage instructions provided by a healthcare provider. The prescribed dosage may vary depending on individual factors such as age, weight, other medications being taken, and overall health status.
• Regular Monitoring: Individuals taking Triumeq PD should attend regular follow-up appointments with their healthcare provider for monitoring of HIV viral load, CD4 cell count, and any potential side effects.
• Do Not Stop Without Consulting: It’s important not to discontinue Triumeq PD without consulting a healthcare provider, even if feeling better. Stopping the medication abruptly can lead to a rebound in HIV viral load and potentially compromise the effectiveness of future treatment regimens.
• Adherence: Adherence to the prescribed dosage and schedule is essential for the effectiveness of HIV treatment. Missing doses or inconsistent use can lead to the development of drug resistance and treatment failure.
• Storage: Triumeq PD should be stored at room temperature (between 68°F to 77°F or 20°C to 25°C) in its original container, away from moisture and heat. Keep the medication out of reach of children.

It’s crucial for individuals prescribed Triumeq PD to communicate with their healthcare provider regarding any questions or concerns about the medication, including potential side effects or interactions with other drugs.

Other uses for this medicine

Other Uses for Triumeq PD:

• Triumeq PD is specifically approved for the treatment of HIV-1 infection and should not be used for other purposes unless prescribed by a healthcare professional.
• The combination of abacavir, dolutegravir, and lamivudine in Triumeq PD is formulated to effectively suppress the HIV virus and reduce its replication in the body, helping to control the infection and improve immune function.

What special precautions should I follow?

Special precautions for Triumeq PD include:

• Hypersensitivity: Some individuals may have a hypersensitivity reaction to abacavir, a component of Triumeq PD. Before starting treatment, patients should undergo testing for the HLA-B*5701 allele, which is associated with an increased risk of hypersensitivity to abacavir.
• Lactic Acidosis and Hepatomegaly with Steatosis: Lactic acidosis, a potentially life-threatening condition, has been reported with the use of nucleoside analogs, including abacavir and lamivudine, which are components of Triumeq PD. Hepatomegaly with steatosis, including fatal cases, has also been reported. Patients should be monitored for signs and symptoms of lactic acidosis and hepatotoxicity.
• Immune Reconstitution Syndrome: In HIV-infected patients with severe immune deficiency at the time of initiation of antiretroviral therapy, an inflammatory reaction to asymptomatic or residual opportunistic infections may arise. Autoimmune disorders (such as Graves’ disease) have also been reported to occur in the setting of immune reconstitution; however, the time to onset is more variable and can occur many months after initiation of treatment.
• Risk of Transmission: Triumeq PD is not a cure for HIV infection and does not prevent transmission of HIV to others. Patients should continue to practice safe sex and take other precautions to prevent transmission of HIV to others.
• Drug Interactions: Triumeq PD may interact with other medications, including certain antacids, iron supplements, calcium supplements, and medications that affect kidney function. Patients should inform their healthcare provider about all medications they are taking, including prescription drugs, over-the-counter medications, and herbal supplements.

As always, it’s essential for individuals prescribed Triumeq PD to discuss any questions or concerns with their healthcare provider and to follow their provider’s instructions closely for safe and effective treatment.

What special dietary instructions should I follow?

Regarding special dietary instructions for Triumeq PD, there are no specific dietary restrictions associated with this medication. However, it’s essential to maintain a healthy and balanced diet as part of overall HIV management. Eating a nutritious diet can help support immune function, manage potential side effects of HIV medications, and promote general well-being.

What should I do if I forget a dose?

If you forget a dose of Triumeq PD, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and take your next dose at the regular time. Do not take a double dose to make up for a missed one. If you are unsure about what to do, consult your healthcare provider or pharmacist for guidance. Consistent adherence to your prescribed dosing schedule is crucial for the effectiveness of HIV treatment and to reduce the risk of developing drug resistance.

What side effects can this medication cause?

Triumeq PD, like any medication, can cause side effects. Not everyone will experience these side effects, and their severity can vary from person to person. Common side effects of Triumeq PD may include:

• Headache: Some individuals may experience headaches while taking Triumeq PD.
• Nausea: Nausea, sometimes accompanied by vomiting, can occur as a side effect of Triumeq PD.
• Diarrhea: Some people may experience diarrhea while taking Triumeq PD.
• Fatigue: Feelings of tiredness or fatigue are common side effects of Triumeq PD.
• Insomnia: Difficulty sleeping or insomnia may occur in some individuals.
•  Dizziness: Triumeq PD can cause dizziness or lightheadedness in some people.
• Rash: Skin rash is a potential side effect of Triumeq PD. It’s important to report any rash to your healthcare provider, as it could be a sign of an allergic reaction.
• Liver Problems: Triumeq PD can sometimes cause liver problems, including elevated liver enzymes and liver damage. Symptoms may include yellowing of the skin or eyes (jaundice), dark urine, abdominal pain, or unusual fatigue.
• Allergic Reactions: Some individuals may experience severe allergic reactions to Triumeq PD, which can manifest as rash, fever, nausea, vomiting, or difficulty breathing. These reactions require immediate medical attention.
• Lactic Acidosis: This is a rare but serious condition characterized by the buildup of lactic acid in the bloodstream. Symptoms include weakness, muscle pain, trouble breathing, stomach pain, nausea, vomiting, irregular heartbeat, or feeling cold.

It’s important to report any side effects experienced while taking Triumeq PD to your healthcare provider. They can provide guidance on managing side effects and may recommend adjustments to your treatment regimen if necessary. Additionally, it’s essential to attend regular follow-up appointments for monitoring of HIV viral load, CD4 cell count, and overall health while taking Triumeq PD.

What should I know about storage and disposal of this medication?

Storage and Disposal:

Storage:

• Store Triumeq PD at room temperature, between 68°F to 77°F (20°C to 25°C).
• Keep the medication in its original container, tightly closed, and away from moisture and heat.
• Do not store Triumeq PD in the bathroom.
• Keep Triumeq PD out of reach of children and pets.

Disposal:

• Dispose of unused or expired Triumeq PD tablets properly.
• Follow local regulations or guidelines for medication disposal.
• Do not flush Triumeq PD down the toilet or pour it down the drain unless instructed to do so by your healthcare provider or pharmacist.

In case of emergency/overdose

In case of emergency or overdose of Triumeq PD:

• In case of an overdose or emergency, such as accidentally taking too much Triumeq PD, contact your local poison control center (1-800-222-1222 in the United States) or go to the nearest emergency room immediately.
• Symptoms of overdose may include nausea, vomiting, abdominal pain, dizziness, weakness, and confusion.

What other information should I know?

• Triumeq PD is not a cure for HIV infection. It is essential to continue taking it as prescribed, even if you feel well, to control the infection and prevent the development of drug resistance.
• Triumeq PD does not prevent the transmission of HIV to others. Practice safe sex and take other preventive measures to reduce the risk of transmitting HIV to sexual partners or through blood contact.
• Inform your healthcare provider about all other medications you are taking, including prescription drugs, over-the-counter medications, vitamins, and herbal supplements, as they may interact with Triumeq PD.
• Attend all scheduled appointments with your healthcare provider for monitoring of HIV viral load, CD4 cell count, and overall health.
• Contact your healthcare provider if you experience any side effects or have concerns about taking Triumeq PD.

Remember to always follow your healthcare provider’s instructions and guidelines for the safe and effective use of Triumeq PD. If you have any questions or concerns, do not hesitate to discuss them with your healthcare provider or pharmacist.