WARNING

Triumeq is a medication used to treat HIV infection. Like all medications, Triumeq carries certain risks and potential side effects. Some of the risks associated with taking Triumeq include:

• Allergic reactions: Some individuals may experience allergic reactions to the components of Triumeq, which can be severe and even life-threatening. Symptoms may include rash, fever, swelling of the face or throat, and difficulty breathing.
• Liver problems: Triumeq can sometimes cause liver problems, including elevated liver enzymes or inflammation of the liver. Signs of liver issues may include yellowing of the skin or eyes (jaundice), dark urine, and abdominal pain.
• Lactic acidosis: This is a rare but serious side effect of Triumeq, characterized by the buildup of lactic acid in the bloodstream. Symptoms may include weakness, muscle pain, difficulty breathing, stomach pain, and feeling cold or dizzy.
• Immune reconstitution syndrome: When starting HIV treatment, including Triumeq, some individuals may experience an inflammatory response from the recovering immune system. This can lead to the worsening of pre-existing infections or the development of new ones.
• Bone problems: Long-term use of Triumeq may be associated with bone density loss or osteoporosis, which can increase the risk of fractures.
• Weight gain: Some individuals may experience weight gain while taking Triumeq, although the exact reason for this is not fully understood.
• Mood changes: Mood changes, including depression and anxiety, have been reported by some individuals taking Triumeq. It’s important to monitor mental health while on this medication.
• Drug interactions: Triumeq can interact with other medications, including over-the-counter drugs and herbal supplements, potentially affecting their effectiveness or increasing the risk of side effects.

It’s essential for individuals taking Triumeq to be monitored regularly by a healthcare provider for any signs of adverse effects or complications. Additionally, any concerns or questions about the risks and benefits of Triumeq should be discussed with a healthcare professional.

Why is this medication prescribed?

Triumeq is prescribed as a treatment for HIV-1 infection in adults and pediatric patients weighing at least 40 kg (approximately 88 pounds). It is a fixed-dose combination medication containing three active ingredients:

• Abacavir: This is a nucleoside reverse transcriptase inhibitor (NRTI) that helps to block the action of an enzyme called reverse transcriptase, which is necessary for HIV to replicate.
• Dolutegravir: This is an integrase strand transfer inhibitor (INSTI) that works by blocking another enzyme called integrase, which is also necessary for HIV replication.
• Lamivudine: Another nucleoside reverse transcriptase inhibitor (NRTI) that works similarly to abacavir, blocking the action of reverse transcriptase.

Triumeq is used as part of a combination regimen for the treatment of HIV infection. It’s important to note that Triumeq is not a cure for HIV or AIDS, but rather helps to control the virus, reduce its replication, and maintain the health of the immune system. It is typically used in combination with other antiretroviral medications as part of a comprehensive HIV treatment plan.

How should this medicine be used?

Triumeq is typically taken orally as a tablet once daily, with or without food. Here’s a general guide on how to use Triumeq:

• Follow Prescribing Instructions: Always follow the dosage instructions provided by your healthcare provider. Do not change the dosage or frequency of taking Triumeq without consulting your doctor.
• Swallow Whole: Swallow the tablet whole with a glass of water. Do not crush, chew, or break the tablet, as this may affect its effectiveness.
• Consistency: Take Triumeq at the same time each day to maintain a consistent level of medication in your body.
• With or Without Food: Triumeq can be taken with or without food. You can choose a time that best fits your daily routine.
• Do Not Miss Doses: It’s important to take Triumeq regularly as prescribed by your doctor. Missing doses can decrease the effectiveness of the medication and increase the risk of developing drug resistance.
• Avoid Alcohol and Grapefruit: Avoid consuming alcohol and grapefruit or grapefruit juice while taking Triumeq, as they may interact with the medication.
• Keep Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. These visits are important for monitoring your response to the medication, checking for any side effects, and adjusting your treatment plan if necessary.
• Continue Other HIV Medications: If you are taking other HIV medications along with Triumeq, continue taking them as prescribed unless otherwise instructed by your doctor.
• Store Properly: Store Triumeq tablets at room temperature away from moisture and heat. Keep the medication in its original packaging, and close the container tightly after each use.

Always consult your healthcare provider if you have any questions or concerns about how to use Triumeq properly. They can provide personalized guidance based on your individual health needs and circumstances.

Other uses for this medicine

Triumeq is primarily used for the treatment of HIV-1 infection, and its use for other purposes is not recommended unless specifically prescribed by a healthcare provider. It’s essential to follow your doctor’s instructions regarding the use of Triumeq and not to use it for any other condition without their guidance.

What special precautions should I follow?

As for special precautions to follow when taking Triumeq, here are some important points to keep in mind:

• HIV Testing and Monitoring: Triumeq should only be used by individuals who have tested positive for HIV-1 infection. Regular monitoring of HIV viral load and CD4 cell count is necessary to assess the effectiveness of treatment and to detect any signs of treatment failure or drug resistance.
• Allergy Screening: Before starting Triumeq, it’s crucial to undergo screening for HLA-B5701 allele. This genetic test helps identify individuals at higher risk of developing a severe hypersensitivity reaction to abacavir, one of the components of Triumeq. If you test positive for HLA-B5701, you should not take Triumeq or any other medication containing abacavir.
• Medical History: Inform your healthcare provider about your complete medical history, including any past or present medical conditions, allergies, and medications you are currently taking. This information can help your doctor determine if Triumeq is safe and appropriate for you.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Triumeq with your doctor. While Triumeq is generally considered safe to use during pregnancy, it’s essential to weigh the potential risks to the fetus against the benefits of HIV treatment. Pregnant individuals with HIV should receive specialized prenatal care to optimize both maternal and infant health.
• Liver and Kidney Function: Triumeq can affect liver function, so your doctor may perform regular liver function tests while you are taking the medication. If you have pre-existing liver or kidney problems, your doctor may adjust your dosage or monitor you more closely.
• Drug Interactions: Triumeq can interact with other medications, including over-the-counter drugs, supplements, and herbal products. Inform your healthcare provider about all the medications and supplements you are currently taking to avoid potential interactions.
• Adherence: It’s essential to take Triumeq exactly as prescribed by your doctor. Missing doses or not following the prescribed regimen can lead to treatment failure, drug resistance, and reduced effectiveness in controlling HIV.
• Side Effects: Be aware of potential side effects of Triumeq and report any new or worsening symptoms to your healthcare provider promptly.

By following these precautions and guidelines, you can help ensure the safe and effective use of Triumeq in the treatment of HIV infection. Always consult your healthcare provider if you have any questions or concerns about your medication regimen.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with taking Triumeq. You can take Triumeq with or without food, according to your preference.

What should I do if I forget a dose?

If you miss a dose of Triumeq, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the regular scheduled time. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Triumeq, like any medication, can cause side effects, although not everyone experiences them. Common side effects of Triumeq may include:

• Headache: Mild to moderate headaches are among the most commonly reported side effects of Triumeq.
• Nausea: Some individuals may experience feelings of nausea or upset stomach while taking Triumeq.
• Diarrhea: Diarrhea is another gastrointestinal side effect that may occur with Triumeq.
• Fatigue: Feelings of tiredness or fatigue are reported by some individuals taking Triumeq.
• Insomnia: Difficulty sleeping or insomnia may occur as a side effect of Triumeq.
• Dizziness: Some individuals may experience dizziness or lightheadedness while taking Triumeq.
• Rash: Skin rash is a possible side effect of Triumeq. In some cases, this rash may be severe and require medical attention.
• Abnormal Dreams: Some people may experience unusual or vivid dreams while taking Triumeq.
• Depression: Changes in mood, including symptoms of depression, have been reported by some individuals taking Triumeq.
• Liver Problems: Triumeq can sometimes cause liver problems, including elevated liver enzymes or inflammation of the liver. Signs of liver issues may include yellowing of the skin or eyes (jaundice), dark urine, and abdominal pain.
• Lactic Acidosis: This is a rare but serious side effect of Triumeq, characterized by the buildup of lactic acid in the bloodstream. Symptoms may include weakness, muscle pain, difficulty breathing, stomach pain, and feeling cold or dizzy.
• Immune Reconstitution Syndrome: When starting HIV treatment, including Triumeq, some individuals may experience an inflammatory response from the recovering immune system. This can lead to the worsening of pre-existing infections or the development of new ones.

It’s important to note that this list is not exhaustive, and other side effects may occur. If you experience any persistent or severe side effects while taking Triumeq, it’s essential to contact your healthcare provider for further evaluation and guidance. They can help determine the best course of action, which may include adjusting your treatment regimen or addressing any specific symptoms you may be experiencing.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Store Triumeq tablets at room temperature, away from moisture and heat. Keep the medication in its original container, tightly closed. Do not store Triumeq in the bathroom. Keep it out of reach of children and pets.
• Disposal: Dispose of unused or expired Triumeq tablets properly according to local regulations or guidelines. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Consult your pharmacist or healthcare provider for guidance on proper disposal methods.

In case of emergency/overdose

In case of emergency or overdose of Triumeq:

• Emergency: In case of a medical emergency, such as severe allergic reactions (anaphylaxis), difficulty breathing, or other serious symptoms, call emergency services or seek immediate medical attention.
• Overdose: If you suspect an overdose of Triumeq or experience symptoms such as nausea, vomiting, dizziness, or unusual fatigue, contact your healthcare provider, poison control center, or emergency room immediately. Do not attempt to treat an overdose on your own without medical guidance.

What other information should I know?

• Adherence: It’s crucial to take Triumeq exactly as prescribed by your healthcare provider. Do not skip doses or stop taking the medication without consulting your doctor, even if you feel well. Skipping doses or discontinuing treatment can lead to treatment failure, drug resistance, and HIV progression.
• Regular Monitoring: Your healthcare provider will likely schedule regular follow-up appointments to monitor your response to Triumeq treatment. This may include blood tests to check HIV viral load, CD4 cell count, and liver function. Attend all scheduled appointments and discuss any concerns or changes in your health with your doctor.
• Drug Interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as Triumeq can interact with certain drugs. Your doctor can help you manage potential interactions and adjust your treatment plan if necessary.
• Precautions: Follow all special precautions provided by your healthcare provider, including allergy screening, monitoring for liver function, and discussing any medical conditions or concerns you may have.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Triumeq with your doctor. Pregnant individuals with HIV require specialized prenatal care, and decisions about HIV treatment during pregnancy should be made in consultation with a healthcare provider.

By following these guidelines and communicating openly with your healthcare provider, you can ensure the safe and effective use of Triumeq in the treatment of HIV infection.