WARNING

Trilafon, also known as Perphenazine, is an antipsychotic medication used to treat conditions such as schizophrenia and bipolar disorder. While it can be effective in managing symptoms, it also carries certain risks and side effects:

• Extrapyramidal Symptoms (EPS): Trilafon can cause movement disorders such as tremors, muscle stiffness, restlessness, and uncontrollable movements, which may be irreversible in some cases.
• Tardive Dyskinesia (TD): This is a potentially permanent condition characterized by repetitive, involuntary movements, especially of the face and tongue, which may occur with long-term use of Trilafon.
• Neuroleptic Malignant Syndrome (NMS): Although rare, Trilafon can lead to NMS, a severe and potentially life-threatening reaction characterized by high fever, muscle rigidity, altered mental status, and autonomic dysfunction.
• Metabolic Changes: Trilafon may cause metabolic changes such as weight gain, elevated blood sugar levels, and lipid abnormalities, increasing the risk of diabetes and cardiovascular disease.
• Sedation and Cognitive Impairment: Trilafon can cause drowsiness, dizziness, and impair cognitive function, affecting concentration and alertness.
• Orthostatic Hypotension: Some individuals may experience a drop in blood pressure upon standing, leading to dizziness or fainting.
• Anticholinergic Effects: Trilafon may cause dry mouth, constipation, blurred vision, urinary retention, and cognitive impairment due to its anticholinergic properties.
• Increased Prolactin Levels: Trilafon can elevate prolactin levels, leading to symptoms such as breast enlargement, lactation, and menstrual irregularities.
• Seizures: Trilafon may lower the seizure threshold, increasing the risk of seizures, particularly in individuals with a history of epilepsy or other predisposing factors.

It’s essential for individuals prescribed Trilafon to be closely monitored by their healthcare provider to manage these risks effectively and weigh them against the potential benefits of treatment. Always follow your healthcare provider’s instructions and report any concerning symptoms promptly.

Why is this medication prescribed?

Trilafon, also known as Perphenazine, is prescribed primarily for the treatment of certain mental health conditions, including:

• Schizophrenia: Trilafon is used to manage the symptoms of schizophrenia, including hallucinations, delusions, disorganized thinking, and emotional disturbances.
• Bipolar Disorder: It may also be prescribed as an adjunctive treatment for bipolar disorder, particularly for managing manic episodes.

Trilafon is typically prescribed as part of a comprehensive treatment plan that may include therapy and other medications.

How should this medicine be used?

As for how Trilafon should be used, it’s important to follow the prescribing healthcare provider’s instructions carefully. Here are some general guidelines:

• Dosage: The dosage of Trilafon can vary based on the individual’s condition, response to treatment, and other factors. It’s typically started at a low dose and gradually increased to achieve the desired therapeutic effect while minimizing side effects.
• Administration: Trilafon is usually taken orally in the form of tablets or liquid. It can be taken with or without food, but consistency in administration is important.
• Frequency: Trilafon is typically taken once or twice daily, as directed by the healthcare provider. It’s essential to take it regularly and at the same time each day to maintain steady blood levels of the medication.
• Duration: Treatment with Trilafon is often long-term, as discontinuing the medication abruptly can lead to a recurrence of symptoms. However, the duration of treatment should be individualized based on the patient’s response and ongoing assessment by the healthcare provider.
• Monitoring: During treatment with Trilafon, it’s important for patients to attend regular follow-up appointments with their healthcare provider for monitoring of symptoms, side effects, and medication efficacy. Adjustments to the dosage or treatment plan may be made as needed.

It’s crucial to never adjust the dosage or stop taking Trilafon without consulting the prescribing healthcare provider, as sudden changes can lead to worsening of symptoms or withdrawal effects. If you have any questions or concerns about how to use Trilafon, be sure to discuss them with your healthcare provider for personalized guidance.

Other uses for this medicine

Some healthcare providers may prescribe it for conditions such as:

• Severe Anxiety: Trilafon may be used in certain cases to manage severe anxiety or agitation, especially when other medications have not been effective.
• Nausea and Vomiting: In some instances, Trilafon may be prescribed off-label to help control severe nausea and vomiting, particularly in individuals who have not responded well to standard antiemetic medications.
• Tourette Syndrome: Trilafon might be used off-label to help manage tics associated with Tourette syndrome, although its efficacy for this purpose is not well-established.
• Behavioral Disorders: In certain situations, Trilafon may be used off-label to manage disruptive or aggressive behavior in individuals with developmental disorders or other psychiatric conditions.

What special precautions should I follow?

Regarding special precautions for Trilafon use, here are some key considerations:

• Medical History: Before starting Trilafon, inform your healthcare provider about any medical conditions you have, especially liver or kidney problems, heart disease, seizures, glaucoma, or a history of blood disorders.
• Allergies: Inform your healthcare provider about any allergies you have, particularly to medications.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Trilafon with your healthcare provider. Trilafon should only be used during pregnancy or breastfeeding if the potential benefits outweigh the potential risks.
• Driving and Operating Machinery: Trilafon may cause drowsiness, dizziness, or blurred vision, which can impair your ability to drive or operate machinery. Avoid these activities until you know how Trilafon affects you.
• Alcohol and Other Drugs: Avoid consuming alcohol or using other drugs that can cause drowsiness or respiratory depression while taking Trilafon, as it can increase the risk of adverse effects.
• Blood Tests: Your healthcare provider may perform regular blood tests to monitor your liver function, blood cell counts, and other parameters while you are taking Trilafon.

Always follow your healthcare provider’s instructions and communicate any concerns or unusual symptoms promptly. It’s essential to take Trilafon exactly as prescribed and attend regular follow-up appointments to monitor your response to treatment and manage any potential side effects.

What special dietary instructions should I follow?

Regarding special dietary instructions, there are no specific dietary restrictions associated with taking Trilafon. However, maintaining a healthy, balanced diet can support overall well-being and may complement your treatment.

What should I do if I forget a dose?

If you forget to take a dose of Trilafon, take it as soon as you remember, unless it’s close to the time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one. If you’re unsure about what to do, consult your healthcare provider or pharmacist for guidance. It’s important to maintain consistent levels of the medication in your system to ensure its effectiveness in managing your condition.

What side effects can this medication cause?

Trilafon (Perphenazine) can cause various side effects, ranging from mild to severe. Common side effects may include:

• Extrapyramidal Symptoms (EPS): These include tremors, muscle stiffness, restlessness, and involuntary movements such as tardive dyskinesia.
• Sedation: Trilafon can cause drowsiness or sleepiness, affecting concentration and alertness.
• Orthostatic Hypotension: Some individuals may experience a drop in blood pressure upon standing, leading to dizziness or fainting.
• Anticholinergic Effects: Trilafon may cause dry mouth, constipation, blurred vision, urinary retention, and cognitive impairment due to its anticholinergic properties.
• Metabolic Changes: Trilafon may lead to weight gain, elevated blood sugar levels, and lipid abnormalities, increasing the risk of diabetes and cardiovascular disease.
• Increased Prolactin Levels: Trilafon can elevate prolactin levels, resulting in symptoms such as breast enlargement, lactation, and menstrual irregularities.
• Neuroleptic Malignant Syndrome (NMS): Although rare, Trilafon can lead to NMS, a severe and potentially life-threatening reaction characterized by high fever, muscle rigidity, altered mental status, and autonomic dysfunction.
• Seizures: Trilafon may lower the seizure threshold, increasing the risk of seizures, particularly in individuals with a history of epilepsy or other predisposing factors.
• Other: Other potential side effects may include blurred vision, skin rash, sensitivity to sunlight, and changes in libido or sexual function.

It’s important to report any side effects or concerns to your healthcare provider promptly. They can help determine whether the side effects are manageable or require adjustments to your treatment plan. In some cases, your healthcare provider may recommend discontinuing Trilafon and trying a different medication. Never stop or adjust your medication without consulting your healthcare provider first.

What should I know about storage and disposal of this medication?

Storage and disposal of Trilafon:

• Storage: Keep Trilafon tablets or liquid at room temperature away from light and moisture. Avoid storing it in the bathroom. Follow any specific storage instructions provided by your pharmacist.
• Disposal: Dispose of any unused or expired Trilafon properly according to local regulations or guidelines. Do not flush medications down the toilet or pour them down the drain unless instructed to do so. Instead, take them to a medication take-back program or a pharmacy for proper disposal.

In case of emergency/overdose

In case of emergency or overdose of Trilafon, take the following steps:

• Seek Medical Assistance: If you suspect an overdose or experience severe symptoms such as difficulty breathing, loss of consciousness, seizures, or severe dizziness, seek immediate medical attention by calling emergency services or visiting the nearest emergency room.
• Poison Control: Contact your local poison control center or national poison helpline for guidance on how to handle the situation and what steps to take next. Be prepared to provide information about the medication ingested, the amount taken, and any symptoms experienced.

What other information should I know?

• Regular Monitoring: Attend regular follow-up appointments with your healthcare provider to monitor your response to Trilafon, adjust your dosage if needed, and address any concerns or side effects.
• Medication Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as they may interact with Trilafon and affect its effectiveness or increase the risk of side effects.
• Avoid Alcohol: Avoid consuming alcohol while taking Trilafon, as it can increase the risk of side effects such as drowsiness, dizziness, and impaired coordination.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Trilafon with your healthcare provider. Trilafon should only be used during pregnancy or breastfeeding if the potential benefits outweigh the potential risks.
• Driving and Operating Machinery: Trilafon may cause drowsiness, dizziness, or blurred vision, which can impair your ability to drive or operate machinery. Avoid these activities until you know how Trilafon affects you.
• Medication Adherence: Take Trilafon exactly as prescribed by your healthcare provider. Do not adjust your dosage or stop taking the medication without consulting your healthcare provider first.
• Communication: Openly communicate with your healthcare provider about your treatment experience, including any concerns, side effects, or changes in symptoms. This will help ensure that you receive the most appropriate care and support throughout your treatment journey.

Always follow your healthcare provider’s instructions regarding the use of Trilafon and consult them if you have any questions or concerns.