Why is this medication prescribed?

Tresiba (insulin degludec) is a long-acting insulin analog prescribed to control blood sugar levels in people with diabetes. It is used by individuals with type 1 diabetes (in which the body does not produce insulin) and type 2 diabetes (in which the body does not use insulin properly).

Tresiba works by replacing the insulin that the body would normally make. It helps to lower blood sugar levels by facilitating the uptake of glucose into cells for energy.

How should this medicine be used?

Here’s how Tresiba is typically used:

• Dosage: The dosage of Tresiba varies depending on individual factors such as age, weight, and the severity of diabetes. Your healthcare provider will determine the appropriate dosage for you.
• Administration: Tresiba is injected subcutaneously (under the skin), usually once a day at the same time each day. It can be injected into the thigh, abdomen, or upper arm. It’s important to rotate injection sites to prevent tissue damage.
• Timing:Tresiba can be administered at any time of the day, but it should be taken consistently at the same time each day to maintain stable blood sugar control.
• Adjustments: Your doctor may adjust your dose of Tresiba based on your blood sugar levels, diet, exercise, and other factors. It’s essential to follow their instructions closely and not change your dosage without consulting them.
• Combination therapy: Tresiba can be used alone or in combination with other diabetes medications, including short-acting insulins or oral antidiabetic drugs.
• Storage: Tresiba should be stored in the refrigerator when not in use. Once a Tresiba FlexTouch pen is in use, it can be kept at room temperature (below 86°F or 30°C) for up to 56 days.

Always follow your healthcare provider’s instructions regarding the use of Tresiba, and don’t hesitate to ask them any questions or seek clarification on how to properly administer the medication.

Other uses for this medicine

Tresiba (insulin degludec) is primarily used for the management of diabetes mellitus. However, there are no significant alternative uses for Tresiba approved by regulatory agencies like the FDA. Its main function is to help regulate blood sugar levels in individuals with diabetes.

What special precautions should I follow?

As for special precautions when using Tresiba, here are some important points to keep in mind:

• Hypoglycemia: Tresiba, like all insulin medications, can cause low blood sugar levels (hypoglycemia). It’s important to monitor your blood sugar levels regularly and be aware of the symptoms of hypoglycemia, which can include sweating, shakiness, confusion, dizziness, and hunger. You should always have a source of fast-acting sugar (such as glucose tablets or juice) on hand to treat low blood sugar if it occurs.
• Hyperglycemia: On the other hand, if your blood sugar levels become too high (hyperglycemia), Tresiba dosage adjustments or additional medications may be necessary. It’s crucial to work closely with your healthcare provider to manage your blood sugar levels effectively.
• Allergic reactions: Some people may experience allergic reactions to Tresiba. Signs of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. Seek immediate medical attention if you experience any of these symptoms.
• Hypokalemia: Insulin therapy, including Tresiba, can cause potassium levels in the blood to decrease (hypokalemia). Your doctor may monitor your potassium levels and adjust your treatment if necessary.
• Pregnancy and breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, it’s essential to discuss the risks and benefits of using Tresiba with your healthcare provider. Your insulin requirements may change during pregnancy, and close monitoring is necessary to ensure optimal blood sugar control for both you and your baby.
• Medication interactions: Inform your doctor about all medications, supplements, and herbal products you are taking, as they may interact with Tresiba. This includes other diabetes medications, especially oral antidiabetic drugs or other insulin preparations.

Always follow your healthcare provider’s instructions and recommendations regarding the use of Tresiba, and don’t hesitate to ask any questions or express concerns you may have about the medication.

What special dietary instructions should I follow?

Special dietary instructions:

• Consistency: Try to eat meals at consistent times each day to help maintain stable blood sugar levels.
• Balanced diet: Follow a healthy, balanced diet rich in fruits, vegetables, lean proteins, and whole grains. Monitor your carbohydrate intake and distribute it evenly throughout the day.
• Alcohol consumption: Limit alcohol consumption, as it can affect blood sugar levels and increase the risk of hypoglycemia.

What should I do if I forget a dose?

If you forget to take your dose of Tresiba:

• Take the missed dose as soon as you remember, unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule.
• Do not take a double dose to make up for a missed one.
• Monitor your blood sugar levels closely after missing a dose and follow any additional instructions from your healthcare provider.

What side effects can this medication cause?

Tresiba (insulin degludec) is generally well-tolerated, but like all medications, it can cause side effects in some individuals. Common side effects of Tresiba may include:

• Hypoglycemia: Low blood sugar levels (hypoglycemia) are the most common side effect of insulin therapy, including Tresiba. Symptoms of hypoglycemia include sweating, shakiness, confusion, dizziness, hunger, irritability, and rapid heartbeat.
• Injection site reactions: Some people may experience redness, itching, or swelling at the injection site. These reactions are usually mild and temporary.
• Weight gain: Insulin therapy can sometimes lead to weight gain, especially if blood sugar levels are not well-controlled.
• Allergic reactions: Although rare, some individuals may experience allergic reactions to Tresiba. Signs of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing. Seek immediate medical attention if you experience any of these symptoms.
• Hypokalemia: Insulin therapy, including Tresiba, can cause potassium levels in the blood to decrease (hypokalemia), which may lead to symptoms such as muscle weakness or irregular heartbeat.
• Edema: Fluid retention (edema) may occur as a side effect of insulin therapy, leading to swelling in the feet, ankles, or hands.
• Injection site lipodystrophy: Prolonged use of insulin injections at the same site may cause fat tissue to shrink or thicken at the injection site, known as lipodystrophy.
• Vision changes: Some individuals may experience changes in vision, including blurriness, as a result of fluctuations in blood sugar levels.

It’s important to note that this list is not exhaustive, and other side effects may occur. If you experience any persistent or bothersome side effects while taking Tresiba, contact your healthcare provider for further evaluation and guidance. They can help determine whether any adjustments to your treatment plan are necessary.

What should I know about storage and disposal of this medication?

Storage and disposal of Tresiba:

• Storage:
  • Before opening, Tresiba should be stored in the refrigerator at a temperature of 36°F to 46°F (2°C to 8°C). Do not freeze it.
  • Once a Tresiba FlexTouch pen is in use, it can be kept at room temperature (below 86°F or 30°C) for up to 56 days. Do not expose it to heat or direct sunlight.
  • Store unused Tresiba pens in the refrigerator, and protect them from light.
• Disposal:
  • Dispose of used needles and pens in a puncture-resistant container, such as a sharps disposal container.
  • Do not throw needles or pens in the household trash where they can pose a risk of injury to others.
  • Follow local regulations or guidelines for proper disposal of medical waste.

In case of emergency/overdose

In case of emergency or overdose of Tresiba:

• Hypoglycemia: If you experience symptoms of low blood sugar (hypoglycemia), such as sweating, shakiness, confusion, or dizziness, consume a fast-acting source of glucose (such as glucose tablets or juice) to raise your blood sugar levels. Follow up with a snack or meal containing carbohydrates and protein to help stabilize your blood sugar.
• Hyperglycemia: If you experience symptoms of high blood sugar (hyperglycemia), such as increased thirst, frequent urination, or fruity breath odor, monitor your blood sugar levels closely and follow your healthcare provider’s instructions for managing hyperglycemia. Seek medical attention if necessary.
• Contact emergency services: If you or someone else has overdosed on Tresiba or is experiencing severe symptoms, such as loss of consciousness or difficulty breathing, call emergency services immediately or go to the nearest emergency room for evaluation and treatment.

What other information should I know?

• Regular monitoringv Monitor your blood sugar levels regularly as directed by your healthcare provider. Keep track of your results and share them with your doctor during follow-up appointments.
• Medical alert: Wear a medical alert bracelet or carry a medical identification card indicating that you have diabetes and are being treated with insulin.
• Follow-up appointments: Attend scheduled follow-up appointments with your healthcare provider to monitor your diabetes management and adjust your treatment plan as needed.
• Travel considerations: When traveling, keep your insulin and supplies with you in your carry-on luggage to prevent exposure to extreme temperatures or loss of luggage. Familiarize yourself with local medical facilities and pharmacies at your destination in case you need assistance.
• Lifestyle modifications: Maintain a healthy lifestyle by following a balanced diet, engaging in regular physical activity, and managing stress to help optimize your diabetes management.

Always consult your healthcare provider for personalized advice and guidance regarding the use of Tresiba and management of your diabetes.