Tolmetin is used for:

Treating
rheumatoid arthritis, osteoarthritis, or juvenile arthritis. It may
also be used for other conditions as determined by your doctor.

Tolmetin is an NSAID. Exactly how it works is not known. It
may block certain substances in thebodythat are linked
to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not
treat the disease that causes those symptoms.

Do NOT use Tolmetin if:

• you are allergic to any
  ingredient in Tolmetin
• you have had a severe allergic
  reaction (eg, severe rash, hives, trouble breathing, growths in the nose,
  dizziness) to aspirin or a nonsteroidal anti-inflammatory drug (NSAID) (eg,
  ibuprofen, celecoxib)
• you have recently had or will be
  having bypass heart surgery
• you are in the last 3 months of
  pregnancy

Before using Tolmetin :

Some medical conditions may interact with Tolmetin . Tell
your doctor or pharmacist if you have any medical conditions, especially if any
of the following apply to you:

• if you are pregnant, planning to
  become pregnant, or are breast-feeding
• if you are taking any
  prescription or nonprescription medicine, herbal preparation, or dietary
  supplement
• if you have allergies to
  medicines,foods,
  or other substances
• if you have a history of kidney
  or liver disease, diabetes, or stomach or bowel problems (eg, bleeding,
  perforation, ulcers)
• if you have a history of swelling
  or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth
  inflammation
• if you have highblood
  pressure,
  blood disorders, bleeding or clotting problems, heart problems (eg, heart
  failure), or blood vessel disease, or if you are at risk for any of these
  diseases
• if you have poor health,
  dehydration or low fluid volume, or low blood sodium levels, you drink
  alcohol, or you have a history of alcohol abuse

Some MEDICINES MAY INTERACT with Tolmetin . Tell your health
care provider if you are taking any other medicines, especially any of the
following:

• Anticoagulants (eg, warfarin),
  corticosteroids (eg, prednisone), heparin, salicylates (eg, aspirin), or
  selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the
  risk of stomach bleeding may be increased
• Probenecid because it may
  increase the risk of Tolmetin ‘s side effects
• Cyclosporine, lithium,
  methotrexate, or quinolones (eg, ciprofloxacin) because the risk of their
  side effects may be increased by Tolmetin
• Angiotensin-converting enzyme
  (ACE) inhibitors (eg, enalapril), beta-blockers (eg, propranolol), or
  diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness
  may be decreased by Tolmetin

How to use Tolmetin :

Use Tolmetin as directed by your doctor. Check the label on
the medicine for exact dosing instructions.

• Tolmetin comes with an extra
  patient information sheet called a Medication Guide. Read it carefully. Read
  it again each time you get Tolmetin refilled.
• Take Tolmetin by mouth. It may be
  taken withfood
  if it upsets your stomach. Taking it with food may not lower the risk of
  stomach or bowel problems (eg, bleeding, ulcers). Talk with your doctor or
  pharmacist if you have persistent stomach upset.
• If Tolmetin upsets your stomach,
  you may take it with an antacid. Do not take it with sodium bicarbonate.
• Take Tolmetin with a full glass
  of water (8 oz/240 mL) as directed by your doctor.
• If you miss a dose of Tolmetin
  and you are taking it regularly, take it as soon as possible. If it is
  almost time for your next dose, skip the missed dose. Go back to your
  regular dosing schedule. Do not take 2 doses at once.

Important safety information:

• Tolmetin may cause dizziness or
  drowsiness. These effects may be worse if you take it with alcohol or
  certain medicines. Use Tolmetin with caution. Do not drive or perform other
  possibly unsafe tasks until you know how you react to it.
• Serious stomach ulcers or
  bleeding can occur with the use of Tolmetin . Taking it in high doses or for
  a long time, smoking, or drinking alcohol increases the risk of these side
  effects. Taking Tolmetin with food will NOT reduce the risk of these
  effects. Contact your doctor oremergency
  roomat once if you develop severe stomach or back pain; black,
  tarry stools; vomit that looks like blood or coffee grounds; or unusual
  weight gain or swelling.
• Do NOT take more than the
  recommended dose or use for longer than prescribed without checking with
  your doctor.
• Tolmetin is an NSAID. Before you
  start any new medicine, check the label to see if it has an NSAID (eg,
  ibuprofen) in it too. If it does or if you are not sure, check with your
  doctor or pharmacist.
• Do not take aspirin while you are
  using Tolmetin unless your doctor tells you to.
• Tolmetin may interfere with
  certain lab tests. Be sure your doctor and lab personnel know that you take
  Tolmetin .
• Lab tests, including kidney
  function, complete blood cell counts, and blood pressure, may be performed
  while you use Tolmetin . These tests may be used to monitor your condition
  or check for side effects. Be sure to keep all doctor and lab appointments.
• Use Tolmetin with caution in the
  ELDERLY; they may be more sensitive to its effects, especially stomach
  bleeding and kidney problems.
• Tolmetin should be used with
  extreme caution inCHILDRENyounger than 2 years old;
  safety and effectiveness in these children have not been confirmed.
• PREGNANCY and BREAST-FEEDING:
  Tolmetin may cause harm to the fetus. Do not use it during the last 3 months
  of pregnancy. If you think you may be pregnant, contact your doctor. You
  will need to discuss the benefits and risks of using Tolmetin while you are
  pregnant. Tolmetin is found in breast milk. Do not breast-feed while taking
  Tolmetin .

Possible side effects of Tolmetin :

All medicines may cause side effects, but many people have
no, or minor, side effects. Check with your doctor if any
of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; gas; headache;
heartburn; nausea; stomach upset; weakness.

Seek medical attention right away if any of these SEVERE
side effects occur:

Severe allergic reactions (rash; hives; itching; trouble
breathing; tightness in the chest; swelling of the mouth, face, lips, or
tongue); bloody or black, tarry stools; change in the amount of urine
produced; chest pain; confusion; dark urine; depression; fainting; fast or
irregular heartbeat; fever, chills, or persistent sore throat; mental or mood
changes; numbness of an arm or leg; one-sided weakness; red, swollen,
blistered, or peelingskin;
ringing in the ears; seizures; severe headache or dizziness; severe or
persistent stomach pain or nausea; severe vomiting; shortness of breath;
sudden or unexplained weight gain; swelling of hands, legs, or feet; unusual
bruising or bleeding; unusual joint or muscle pain; unusual tiredness or
weakness; vision or speech changes; vomit that looks like coffee grounds;
yellowing of the skin or eyes.