WARNING

Tixagevimab and cilgavimab are monoclonal antibodies used in combination as a treatment for COVID-19. Like any medication, they come with potential risks and side effects. Here are some of the risks associated with taking tixagevimab and cilgavimab:

• Allergic reactions: Some individuals may experience allergic reactions to the medication, ranging from mild to severe. Symptoms may include rash, itching, swelling, difficulty breathing, or anaphylaxis.
• Infusion-related reactions: Since tixagevimab and cilgavimab are administered via infusion, there is a risk of infusion-related reactions such as fever, chills, nausea, headache, or low blood pressure.
• Reduced effectiveness: There’s a possibility that the treatment may not be as effective as expected, particularly against certain variants of the SARS-CoV-2 virus.
• Unknown long-term effects: As with any newly developed medication, the long-term effects of tixagevimab and cilgavimab are not yet fully understood. Further research and monitoring are needed to assess any potential long-term risks.
• Interactions with other medications: Tixagevimab and cilgavimab may interact with other medications, potentially leading to adverse effects or reduced efficacy. It’s important for healthcare providers to be aware of all medications a patient is taking to avoid potential interactions.
• Development of resistance: There’s a risk that the SARS-CoV-2 virus could develop resistance to tixagevimab and cilgavimab over time, which may reduce their effectiveness as treatments for COVID-19.

It’s essential for individuals considering or prescribed tixagevimab and cilgavimab to discuss the potential risks and benefits with their healthcare provider to make an informed decision about treatment.

Why is this medication prescribed?

Tixagevimab and cilgavimab are prescribed for the treatment of COVID-19. Specifically, they are used in combination as monoclonal antibodies to treat individuals who have tested positive for COVID-19 and are at high risk of developing severe illness from the virus. This includes individuals with certain underlying health conditions or compromised immune systems, as well as those who are elderly or have other risk factors for severe COVID-19.

The goal of prescribing tixagevimab and cilgavimab is to reduce the severity of illness and the risk of hospitalization in individuals with COVID-19 by providing targeted therapy against the SARS-CoV-2 virus. These monoclonal antibodies work by binding to the spike protein of the virus, which helps to neutralize it and prevent it from infecting cells in the body.

How should this medicine be used?

Tixagevimab and cilgavimab are typically administered together through intravenous (IV) infusion. The dosage and administration schedule are determined by healthcare professionals based on the specific protocol recommended for the individual patient. Here are some general guidelines on how tixagevimab and cilgavimab are used:

• Administration by healthcare professionals: Tixagevimab and cilgavimab are typically administered in a healthcare setting, such as a hospital, clinic, or infusion center. Trained medical staff will oversee the infusion process to ensure proper administration and monitor for any potential adverse reactions.
• Preparation: Before administering the medication, healthcare providers will prepare the infusion solution according to the manufacturer’s instructions. This may involve diluting the medication with a compatible solution and ensuring proper storage and handling to maintain its stability and efficacy.
• Infusion process: The infusion of tixagevimab and cilgavimab usually takes place over a specified period of time, often ranging from 30 minutes to several hours, depending on the dosage and protocol. The medication is delivered intravenously through a vein, typically in the arm.
• Monitoring: During the infusion, patients will be closely monitored by healthcare providers for any signs of allergic reactions, infusion-related adverse effects, or other potential complications. Vital signs such as blood pressure, heart rate, and oxygen levels may be monitored throughout the infusion process.
• Follow-up: After the infusion is complete, patients may be observed for a period of time to ensure they do not experience any delayed adverse reactions. Healthcare providers will provide instructions to patients regarding any additional follow-up care or monitoring that may be necessary.

It’s essential for individuals receiving tixagevimab and cilgavimab to follow the guidance and instructions provided by their healthcare provider regarding the dosage, administration, and monitoring of the medication. Any questions or concerns about the treatment should be discussed with a healthcare professional.

Other uses for this medicine

Tixagevimab and cilgavimab are primarily used as a combination treatment for COVID-19, specifically for individuals at high risk of developing severe illness from the virus. As of last update, their primary approved use is for this purpose, and they are not commonly prescribed for other conditions.

What special precautions should I follow?

Regarding special precautions for tixagevimab and cilgavimab, here are some important considerations:

• Allergy and hypersensitivity: Individuals with known allergies or hypersensitivity to tixagevimab, cilgavimab, or any of the ingredients in the medication should not receive this treatment. It’s crucial to inform healthcare providers of any known allergies before starting treatment.
• Monitoring for adverse reactions: During and after infusion, patients should be closely monitored for any signs of allergic reactions, infusion-related adverse effects, or other potential complications. Healthcare providers will be prepared to manage any adverse reactions that may occur.
• Interactions with other medications: Tixagevimab and cilgavimab may interact with other medications. Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking to avoid potential interactions that could affect the safety or efficacy of the treatment.
• Pregnancy and breastfeeding: The safety of tixagevimab and cilgavimab during pregnancy and breastfeeding has not been established. Healthcare providers will consider the potential risks and benefits before prescribing this treatment to pregnant or breastfeeding individuals.
• Immunosuppression: Tixagevimab and cilgavimab are designed to boost the immune response against the SARS-CoV-2 virus. However, individuals who are immunosuppressed or have compromised immune function may not respond as effectively to the treatment. Healthcare providers will evaluate the appropriateness of this treatment for individuals with immunocompromising conditions.
• Follow-up care: Patients receiving tixagevimab and cilgavimab should follow up with their healthcare provider as recommended for continued monitoring and assessment of their condition.

As always, it’s important for individuals to discuss any questions or concerns about tixagevimab and cilgavimab with their healthcare provider, who can provide personalized guidance based on their individual medical history and circumstances.

What special dietary instructions should I follow?

There are no specific dietary instructions associated with tixagevimab and cilgavimab. However, maintaining a healthy diet and staying hydrated can support your overall health and immune function, which may contribute to the effectiveness of the treatment.

What should I do if I forget a dose?

Since tixagevimab and cilgavimab are typically administered as a single infusion under medical supervision, there isn’t a concern about forgetting a dose in the same way as with oral medications taken daily. However, if you miss an appointment for your infusion, it’s important to reschedule it as soon as possible. Contact your healthcare provider to arrange another appointment and follow their guidance on the best course of action.

What side effects can this medication cause?

Tixagevimab and cilgavimab, like any medication, can cause side effects. Here are some potential side effects associated with these monoclonal antibodies:

• Allergic reactions: Some individuals may experience allergic reactions to tixagevimab and cilgavimab. Symptoms may include rash, itching, swelling, difficulty breathing, or anaphylaxis. These reactions typically occur during or shortly after the infusion and require immediate medical attention.
• Infusion-related reactions: Common side effects of infusion may include fever, chills, nausea, headache, or low blood pressure. These reactions are generally mild to moderate in severity and can often be managed with supportive care.
• Immune response-related effects: As these medications work by boosting the immune response against the SARS-CoV-2 virus, there is a potential for immune-related side effects. These may include symptoms such as fatigue, muscle aches, joint pain, or flu-like symptoms.
• Interference with laboratory tests: Tixagevimab and cilgavimab may interfere with certain laboratory tests, particularly those used to detect the presence of SARS-CoV-2 antibodies. This can potentially lead to false-positive or false-negative results in diagnostic testing.
• Other side effects: Other less common side effects may occur with tixagevimab and cilgavimab, although they are not as frequently reported. These may include gastrointestinal symptoms such as diarrhea or vomiting, as well as dizziness, or changes in blood pressure.

It’s important to note that not everyone will experience side effects, and the severity and frequency of side effects can vary from person to person. Additionally, the benefits of treatment with tixagevimab and cilgavimab in reducing the risk of severe COVID-19 may outweigh the potential side effects for many individuals. If you experience any concerning symptoms or side effects while receiving treatment, it’s essential to notify your healthcare provider promptly. They can provide guidance on managing side effects and may adjust your treatment plan if necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Tixagevimab and cilgavimab are typically supplied as a sterile solution for intravenous infusion and should be stored according to the manufacturer’s instructions. Generally, they are stored under refrigeration at a controlled temperature until they are ready for use. It’s essential to follow the storage guidelines provided by your healthcare provider or pharmacist to maintain the stability and efficacy of the medication.
• Disposal: Any unused or expired tixagevimab and cilgavimab should be disposed of properly. Do not dispose of them in household trash or wastewater. Follow local regulations for the disposal of medical waste or consult with your healthcare provider or pharmacist for guidance on proper disposal methods.

In case of emergency/overdose

In case of an emergency or overdose involving tixagevimab and cilgavimab, immediate medical attention should be sought. Contact your local emergency services or go to the nearest emergency room for evaluation and treatment. It’s important to inform healthcare providers about the specific medication involved and provide any relevant information about the circumstances of the overdose.

What other information should I know?

• Follow-up care: After receiving treatment with tixagevimab and cilgavimab, it’s essential to follow up with your healthcare provider as recommended for ongoing monitoring and assessment of your condition. They may recommend additional tests or follow-up appointments to evaluate your response to treatment and ensure your continued health.
• COVID-19 precautions: Tixagevimab and cilgavimab are used specifically for the treatment of COVID-19 in individuals at high risk of severe illness. It’s important to continue following public health guidelines and recommendations to reduce the risk of exposure to the virus, such as wearing masks, practicing social distancing, and getting vaccinated if eligible.
• Information for caregivers: If you’re a caregiver for someone receiving treatment with tixagevimab and cilgavimab, it’s essential to be aware of the medication’s administration, potential side effects, and any special instructions provided by healthcare providers. Be prepared to assist the individual with their treatment as needed and to seek medical attention in case of any concerns or emergencies.
• Patient assistance programs: Some pharmaceutical companies may offer patient assistance programs or support services for individuals receiving treatment with tixagevimab and cilgavimab. These programs may provide financial assistance, resources, or other support to help individuals access and afford their medication. You can inquire with your healthcare provider or pharmacist about available resources or contact the manufacturer directly for more information.

Always consult with your healthcare provider or pharmacist if you have any questions or concerns about tixagevimab and cilgavimab or its use. They can provide personalized guidance and address any specific considerations related to your treatment.