Why is this medication prescribed?

Tivozanib is a medication used in the treatment of advanced renal cell carcinoma (RCC), which is a type of kidney cancer. It belongs to a class of medications called tyrosine kinase inhibitors (TKIs), which work by blocking the action of certain proteins involved in the growth and spread of cancer cells.

Tivozanib is typically prescribed by oncologists or other specialized healthcare providers for patients who have already undergone treatment with other cancer therapies that were not effective, or for those who cannot tolerate other treatment options.

How should this medicine be used?

Tivozanib is typically prescribed for the treatment of advanced renal cell carcinoma (RCC), a type of kidney cancer. It is taken orally in the form of tablets. Here’s how Tivozanib is generally used:

• Dosage: The typical starting dose of Tivozanib is 1 tablet (1 mg) taken once daily.
• Administration: Tivozanib tablets should be swallowed whole with a glass of water. They can be taken with or without food, as directed by the healthcare provider.
• Timing: It’s important to take Tivozanib at the same time each day to maintain consistent levels of the medication in the body.
• Compliance: Patients should adhere to the prescribed dosage and schedule provided by their healthcare provider. It’s crucial not to adjust the dosage or stop taking Tivozanib without consulting the doctor, as this can impact the effectiveness of the treatment.
• Monitoring: Patients may require regular check-ups and monitoring by their healthcare provider while taking Tivozanib. This helps assess the response to treatment and manage any potential side effects.
• Side effects: Like many medications, Tivozanib may cause side effects. Common side effects include fatigue, diarrhea, high blood pressure, nausea, and decreased appetite. It’s important to report any persistent or severe side effects to the healthcare provider promptly.
• Interactions: Patients should inform their healthcare provider about all medications, supplements, and herbal products they are taking, as Tivozanib may interact with certain medications.
• Storage: Tivozanib tablets should be stored at room temperature, away from moisture and heat. They should be kept in their original container and out of reach of children.

Remember, these are general guidelines, and individual dosages and instructions may vary based on factors such as the patient’s overall health and response to treatment. Always follow the specific instructions provided by the prescribing healthcare provider.

Other uses for this medicine

Tivozanib is primarily used for the treatment of advanced renal cell carcinoma (RCC), but researchers are continually exploring potential uses for medications beyond their initial approved indications. However, it’s essential to note that using medications off-label (for purposes other than those approved by regulatory agencies) should only be done under the guidance and supervision of a qualified healthcare provider.

What special precautions should I follow?

As for special precautions to follow when taking Tivozanib:

• Medical History: Before starting Tivozanib treatment, it’s crucial to inform your healthcare provider about your complete medical history, including any pre-existing conditions, allergies, surgeries, or other medications you are taking.
• Pregnancy and Breastfeeding: Tivozanib can cause harm to an unborn baby if used during pregnancy. Therefore, it’s essential to avoid becoming pregnant while taking Tivozanib and to use effective contraception during treatment and for some time after the last dose. Additionally, breastfeeding while on Tivozanib is not recommended, as it may harm the nursing infant.
• Liver Function: Tivozanib may affect liver function, so regular monitoring of liver enzymes is usually recommended during treatment. Patients with pre-existing liver conditions may require special monitoring or dosage adjustments.
• Hypertension (High Blood Pressure): Tivozanib can cause high blood pressure (hypertension) as a side effect. Blood pressure should be monitored regularly during treatment, and antihypertensive medications may be prescribed if necessary.
• Cardiac Function: Tivozanib may also affect cardiac function. Patients with a history of heart disease or other cardiac conditions may require careful monitoring during treatment.
• Wound Healing: Tivozanib may impair wound healing. Patients scheduled for surgery should inform their surgeon about their Tivozanib treatment, as temporary discontinuation of the medication may be necessary before surgery.
• Drug Interactions: Tivozanib may interact with other medications, including over-the-counter drugs, supplements, and herbal products. It’s crucial to inform your healthcare provider about all medications you are taking to avoid potential interactions.
• Adverse Reactions: Be vigilant for any signs of allergic reactions, such as rash, itching, swelling, dizziness, or difficulty breathing, and seek immediate medical attention if they occur.

Always follow your healthcare provider’s instructions and guidance regarding the use of Tivozanib, including any specific precautions or monitoring requirements based on your individual health status and treatment plan.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Tivozanib. However, maintaining a healthy and balanced diet is generally recommended during cancer treatment to support overall health and well-being.

What should I do if I forget a dose?

If you forget to take a dose of Tivozanib at your usual time, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have any concerns or questions about missed doses, consult your healthcare provider for guidance.

What side effects can this medication cause?

Tivozanib, like many medications, can cause side effects. Not all people who take Tivozanib will experience these side effects, and the severity can vary from person to person. Some common side effects of Tivozanib include:

• High Blood Pressure (Hypertension): Tivozanib can increase blood pressure. Regular monitoring of blood pressure is typically recommended during treatment.
• Fatigue: Feeling tired or fatigued is a common side effect of Tivozanib.
• Diarrhea: Some patients may experience diarrhea while taking Tivozanib.
• Nausea and Vomiting: Tivozanib can cause nausea and vomiting in some individuals.
• Decreased Appetite: Loss of appetite is another possible side effect of Tivozanib.
• Headache: Some patients may experience headaches while taking Tivozanib.
• Dysphonia (Hoarseness): Tivozanib may cause changes in voice quality, such as hoarseness.
• Hand-Foot Syndrome: This condition involves redness, swelling, and pain on the palms of the hands and soles of the feet.
• Proteinuria (Increased Protein in Urine): Tivozanib can cause an increase in protein levels in the urine.
• Hypothyroidism: Some patients may experience low thyroid hormone levels while taking Tivozanib.
• Constipation: Difficulty passing stools may occur as a side effect of Tivozanib.
• Abdominal Pain: Some individuals may experience abdominal discomfort or pain.
• Nasopharyngitis (Common Cold): Symptoms such as a runny or stuffy nose may occur.
• Cough: Tivozanib may cause coughing in some patients.

It’s important to note that this list is not exhaustive, and other side effects may occur. Additionally, some side effects of Tivozanib can be severe or life-threatening. Patients should promptly report any new or worsening symptoms to their healthcare provider for evaluation and management.

What should I know about storage and disposal of this medication?

Storage and disposal of Tivozanib:

• Storage: Tivozanib tablets should be stored at room temperature, away from moisture and heat. Keep the medication in its original container with the lid tightly closed. Ensure that it is kept out of reach of children and pets.
• Disposal: Unused or expired Tivozanib tablets should be disposed of properly according to local regulations or guidelines. Do not flush them down the toilet or pour them into a drain unless instructed to do so. Contact your pharmacist or local waste disposal authority for information on how to safely dispose of medications.

In case of emergency/overdose

If you suspect an overdose of Tivozanib or experience severe symptoms, such as difficulty breathing, fainting, or severe dizziness, seek immediate medical attention or contact a poison control center right away. It’s important to provide as much information as possible about the medication ingested and the amount taken.

What other information should I know?

• Follow-up Appointments: Regular follow-up appointments with your healthcare provider are essential while taking Tivozanib. These appointments allow for monitoring of your response to treatment and the management of any potential side effects.
• Blood Tests: Your healthcare provider may order blood tests to monitor your liver function, kidney function, blood cell counts, and other parameters during treatment with Tivozanib. Attend all scheduled appointments for blood tests as recommended.
• Precautions During Surgery: Inform your surgeon or dentist that you are taking Tivozanib before undergoing any surgical or dental procedures. Temporary discontinuation of Tivozanib may be necessary before elective surgeries to reduce the risk of complications related to impaired wound healing.
• Avoid Grapefruit: Avoid consuming grapefruit or grapefruit juice while taking Tivozanib, as it may interact with the medication and increase the risk of side effects.
• Inform Healthcare Providers: Make sure that all healthcare providers involved in your care are aware that you are taking Tivozanib. This includes your primary care physician, specialists, dentists, and pharmacists.
• Patient Support: Consider joining support groups or seeking counseling to help cope with the emotional and psychological aspects of cancer treatment.

Always consult your healthcare provider or pharmacist if you have any questions or concerns about taking Tivozanib or its usage instructions. They can provide personalized advice based on your individual health status and treatment plan.