WARNING

Taking Tivdak (tivozanib) for the treatment of advanced renal cell carcinoma (RCC) comes with certain risks. Some of the potential risks associated with Tivdak include:

• Hypertension (high blood pressure): Tivdak can cause an increase in blood pressure, which may require monitoring and management by your healthcare provider.
• Liver problems: Tivdak may lead to liver problems, including liver failure. Your healthcare provider may monitor your liver function through blood tests during treatment.
• Wound healing: Tivdak may interfere with wound healing, which is important to consider before and after surgery or dental procedures.
• Thyroid function: Tivdak can affect thyroid function, potentially leading to hypothyroidism or thyroiditis.
• Hand-foot syndrome: This condition may cause redness, swelling, pain, or blisters on the palms of the hands and/or soles of the feet.
• Proteinuria: Tivdak may result in an increased level of protein in the urine.
• Fatigue, nausea, diarrhea: These are some common side effects associated with Tivdak.

It’s crucial to discuss these risks with your healthcare provider before starting Tivdak treatment. They can provide personalized guidance based on your medical history and individual circumstances and monitor you closely for any potential complications during treatment.

Why is this medication prescribed?

Tivdak (tivozanib) is a prescription medication used for the treatment of adults with advanced renal cell carcinoma (RCC), which is a type of kidney cancer. It is specifically indicated for individuals who have received prior systemic therapy.

Tivdak is a tyrosine kinase inhibitor (TKI) that works by blocking certain proteins in cancer cells, which can slow down or stop the growth of cancer cells.

How should this medicine be used?

Tivdak (tivozanib) is typically taken orally, usually once daily, with or without food. The dosage prescribed by the healthcare provider may vary depending on factors such as the patient’s overall health, kidney function, and any other medications they may be taking. Here are some general guidelines for the use of Tivdak:

• Follow the prescription exactly as directed by your healthcare provider. Do not take more or less of the medication than prescribed.
• Take Tivdak at approximately the same time each day to maintain a consistent level of the medication in your bloodstream.
• Swallow the Tivdak tablets whole with a glass of water. Do not crush, chew, or break the tablets before swallowing.
• It is generally recommended to take Tivdak either at least one hour before or at least two hours after eating. However, follow your healthcare provider’s specific instructions regarding food and Tivdak administration.
• If you miss a dose of Tivdak, take it as soon as you remember, unless it is almost time for your next dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one.
• Keep track of your medication schedule and attend all follow-up appointments with your healthcare provider. They may adjust your dosage or monitor you for any potential side effects.
• Store Tivdak tablets at room temperature away from moisture and heat. Keep them in their original packaging and out of reach of children and pets.

As with any prescription medication, it’s important to discuss any questions or concerns you may have about the use of Tivdak with your healthcare provider. They can provide personalized guidance based on your medical history and individual needs.

Other uses for this medicine

Tivdak (tivozanib) is primarily used for the treatment of advanced renal cell carcinoma (RCC), a type of kidney cancer, in adults who have received prior systemic therapy. Tivdak’s primary indication is for RCC, and its use for other conditions is not well established. It’s crucial to follow your healthcare provider’s guidance regarding the prescribed use of Tivdak.

What special precautions should I follow?

Regarding special precautions for Tivdak, here are some important points to consider:

• Pregnancy and breastfeeding: Tivdak can harm an unborn baby, so it is not recommended for use during pregnancy. Additionally, breastfeeding is not recommended while taking Tivdak, as it may pass into breast milk and harm the nursing infant. If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of Tivdak with your healthcare provider.
• Liver problems: Tivdak can cause liver problems, including liver failure. Your healthcare provider may perform blood tests to monitor your liver function before and during treatment with Tivdak. Inform your healthcare provider if you have a history of liver disease or experience symptoms such as yellowing of the skin or eyes, abdominal pain, or dark urine.
• Hypertension (high blood pressure): Tivdak can increase blood pressure, which may lead to serious complications. Your healthcare provider may monitor your blood pressure regularly during treatment with Tivdak. Inform your healthcare provider if you experience symptoms such as severe headache, blurred vision, chest pain, or shortness of breath.
• Wound healing: Tivdak may interfere with wound healing. If you have surgery or dental procedures planned, inform your healthcare provider that you are taking Tivdak. Your healthcare provider may recommend temporarily stopping Tivdak before and after surgery or dental procedures to reduce the risk of complications.
• Thyroid function: Tivdak can affect thyroid function, leading to hypothyroidism (low thyroid hormone levels) or thyroiditis (inflammation of the thyroid gland). Your healthcare provider may monitor your thyroid function during treatment with Tivdak. Inform your healthcare provider if you experience symptoms such as fatigue, weight gain, constipation, or sensitivity to cold.
• Other medications and supplements: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Tivdak and affect its effectiveness or increase the risk of side effects.

It’s essential to communicate openly with your healthcare provider about any concerns or questions you have regarding Tivdak. They can provide personalized guidance based on your medical history and individual needs.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Tivdak. However, it’s essential to maintain a healthy and balanced diet as recommended by your healthcare provider. Drinking plenty of fluids is generally advised to stay hydrated, especially if you experience diarrhea or other side effects.

What should I do if I forget a dose?

If you forget to take a dose of Tivdak, take it as soon as you remember, unless it is almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not double the dose to make up for the missed one.

What side effects can this medication cause?

Tivdak (tivozanib) may cause several side effects, some of which can be serious. It’s essential to be aware of these potential side effects and to promptly report any concerning symptoms to your healthcare provider. Common side effects of Tivdak include:

• High blood pressure (hypertension): Tivdak can increase blood pressure, which may require monitoring and management by your healthcare provider.
• Fatigue: Feeling tired or lethargic is a common side effect of Tivdak.
• Diarrhea: Tivdak can cause diarrhea, which may range from mild to severe. It’s important to stay hydrated and inform your healthcare provider if diarrhea persists or becomes severe.
• Nausea and vomiting: Some individuals may experience nausea and vomiting while taking Tivdak.
• Decreased appetite: Tivdak may decrease appetite in some patients, leading to weight loss or nutritional deficiencies.
• Hand-foot syndrome: This condition causes redness, swelling, and pain on the palms of the hands and/or soles of the feet. It may also cause blisters or peeling skin in severe cases.
• Hoarseness or voice changes: Tivdak can cause changes in voice quality or hoarseness.
• Hypothyroidism: Tivdak may affect thyroid function, leading to symptoms such as fatigue, weight gain, and sensitivity to cold.
• Proteinuria: Some patients may experience an increased level of protein in the urine while taking Tivdak.
• Headache: Headaches are a common side effect of Tivdak.
• Dizziness: Tivdak may cause dizziness or lightheadedness in some individuals.
• Cough: Tivdak may lead to a persistent cough in some patients.

It’s essential to inform your healthcare provider about any side effects you experience while taking Tivdak. They can provide guidance on managing side effects and may adjust your treatment plan if necessary. Additionally, contact your healthcare provider immediately if you experience any severe or concerning symptoms while taking Tivdak.

What should I know about storage and disposal of this medication?

Storage and disposal of Tivdak:

• Storage: Store Tivdak tablets at room temperature, away from moisture and heat. Keep the medication in its original packaging and out of reach of children and pets.
• Disposal: Dispose of unused or expired Tivdak tablets properly, following the instructions provided by your healthcare provider or local pharmacy. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Proper disposal helps prevent accidental ingestion by children or pets and protects the environment.

In case of emergency/overdose

In case of an overdose of Tivdak or if you suspect an overdose, seek emergency medical attention or contact a poison control center immediately. Overdose symptoms may include severe dizziness, fainting, or difficulty breathing.

What other information should I know?

• Regular monitoring: Your healthcare provider will likely monitor your condition and conduct regular blood tests to check for any potential side effects or complications during Tivdak treatment.
• Follow-up appointments: Attend all scheduled follow-up appointments with your healthcare provider to assess the effectiveness of Tivdak and address any concerns or side effects.
• Medication interactions: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Tivdak and affect its effectiveness or increase the risk of side effects.
• Driving and operating machinery: Tivdak may cause dizziness or fatigue, which can impair your ability to drive or operate machinery safely. Use caution when engaging in activities that require mental alertness or coordination until you know how Tivdak affects you.
• Patient support: Consider joining a support group for individuals with renal cell carcinoma or seeking support from friends, family, or mental health professionals to cope with the emotional and psychological aspects of cancer treatment.

Always follow your healthcare provider’s instructions and guidelines regarding the use of Tivdak, including storage, disposal, and what to do in case of emergency or overdose. If you have any questions or concerns, do not hesitate to reach out to your healthcare provider for clarification and guidance.