Why is this medication prescribed?

Tedizolid injection is prescribed for the treatment of certain bacterial infections. It belongs to a class of antibiotics called oxazolidinones and works by stopping the growth of bacteria.

It is commonly used to treat infections such as skin and skin structure infections (SSSIs) caused by susceptible bacteria including Staphylococcus aureus (including methicillin-resistant strains) and Streptococcus pyogenes.

How should this medicine be used?

The dosage and administration of Tedizolid injection are typically determined by a healthcare professional based on the specific infection being treated, the patient’s medical history, and other factors. However, a general guideline for the use of Tedizolid injection is as follows:

• The usual recommended dosage for adults is 200 mg administered once daily for 6 days. It can be administered either intravenously (IV) or orally.
• For patients with renal impairment or end-stage renal disease (ESRD) requiring hemodialysis, the recommended dosage is 200 mg once daily after dialysis on hemodialysis days.
• Tedizolid injection should be administered over a period of 1 hour if given intravenously.
• For oral administration, Tedizolid can be taken with or without food.
• It is essential to complete the full course of treatment as prescribed by the healthcare provider, even if the symptoms improve before the treatment course is completed. Stopping the medication prematurely may lead to the re-emergence of the infection or the development of antibiotic resistance.
• If a dose is missed, it should be taken as soon as remembered unless it is close to the time for the next scheduled dose. In that case, the missed dose should be skipped, and the regular dosing schedule should be resumed. Double doses should not be taken to make up for a missed dose.
• It’s important to follow all instructions provided by the healthcare provider regarding the use of Tedizolid injection, including any precautions or special considerations.

As with any antibiotic treatment, it’s crucial to use Tedizolid injection only as prescribed and to consult a healthcare professional if there are any concerns or questions about its use or potential side effects.

Other uses for this medicine

Some potential off-label uses of Tedizolid injection may include:

• Treatment of other bacterial infections: In addition to skin and soft tissue infections, Tedizolid may be considered for the treatment of other bacterial infections caused by susceptible organisms. This could include pneumonia, bloodstream infections, and other severe infections.
• Prophylaxis: Tedizolid may be used prophylactically to prevent bacterial infections in certain high-risk patients undergoing surgical procedures or immunocompromised individuals.

What special precautions should I follow?

Special precautions should be taken when using Tedizolid injection to ensure its safe and effective use. Here are some important precautions to consider:

• Allergies: Before using Tedizolid injection, inform your healthcare provider about any known allergies to Tedizolid or other antibiotics in the oxazolidinone class.
• Pregnancy and breastfeeding: It’s important to discuss the risks and benefits of using Tedizolid injection during pregnancy or while breastfeeding with your healthcare provider. They can provide guidance on whether the benefits outweigh the potential risks.
• Renal impairment: Tedizolid is primarily eliminated through the kidneys. Patients with renal impairment may require dosage adjustments, and those with severe renal impairment may need to be monitored closely while receiving Tedizolid injection.
• Hepatic impairment: Tedizolid is primarily metabolized in the liver. Patients with moderate to severe hepatic impairment may require dosage adjustments or closer monitoring while receiving Tedizolid injection.
• Drug interactions: Tedizolid may interact with other medications, including certain antidepressants (MAO inhibitors), serotonergic agents, and other antibiotics. Inform your healthcare provider about all medications, supplements, and herbal products you are taking before starting Tedizolid injection.
• Clostridium difficile infection: Antibiotic therapy, including Tedizolid, may increase the risk of developing Clostridium difficile-associated diarrhea. If you experience persistent diarrhea or abdominal pain while receiving Tedizolid injection, contact your healthcare provider immediately.
• Neurologic effects: Some patients may experience neurologic adverse reactions, including peripheral and optic neuropathy, while receiving Tedizolid injection. If you experience symptoms such as numbness, tingling, or visual disturbances, notify your healthcare provider promptly.

Always follow your healthcare provider’s instructions and guidance regarding the use of Tedizolid injection, including any special precautions or considerations specific to your individual circumstances.

What special dietary instructions should I follow?

Regarding special dietary instructions for Tedizolid injection, it can be taken with or without food, so there are typically no specific dietary restrictions. However, it’s essential to follow any dietary advice provided by your healthcare provider or pharmacist.

What should I do if I forget a dose?

If you forget a dose of Tedizolid injection, take it as soon as you remember unless it’s almost time for your next scheduled dose. In that case, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for a missed one. If you have any concerns or questions about missed doses, consult your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Tedizolid injection, like any medication, can cause side effects, although not everyone will experience them. Some common side effects of Tedizolid injection may include:

• Nausea
• Headache
• Diarrhea
• Vomiting
• Dizziness
• Insomnia
• Constipation
• Fatigue
• Rash
• Itching

These side effects are usually mild to moderate and may go away on their own as your body adjusts to the medication. However, if any of these side effects persist or worsen, it’s essential to inform your healthcare provider.

In addition to the common side effects mentioned above, Tedizolid injection may also cause more serious side effects in some individuals. These could include:

• Allergic reactions: Some people may experience allergic reactions to Tedizolid, which could manifest as rash, itching, swelling, severe dizziness, or difficulty breathing. Seek immediate medical attention if you experience any signs of an allergic reaction.
• Clostridium difficile-associated diarrhea: Antibiotic use, including Tedizolid, may lead to the overgrowth of Clostridium difficile bacteria, resulting in diarrhea. If you experience severe or persistent diarrhea, abdominal pain, or blood in stool while using Tedizolid injection, notify your healthcare provider immediately.
• Peripheral and optic neuropathy: Tedizolid use has been associated with peripheral neuropathy (nerve damage) and optic neuropathy (damage to the optic nerve), leading to symptoms such as numbness, tingling, weakness, or visual disturbances. Inform your healthcare provider promptly if you experience any neurologic symptoms.

It’s essential to report any side effects or adverse reactions you experience while using Tedizolid injection to your healthcare provider. They can provide guidance on managing side effects and determine whether any further action is necessary.

What should I know about storage and disposal of this medication?

When it comes to the storage and disposal of Tedizolid injection, here are some important considerations:

Storage:

• Store Tedizolid injection vials at room temperature between 20°C to 25°C (68°F to 77°F).
• Protect Tedizolid injection from light.
• Do not freeze Tedizolid injection.
• Keep Tedizolid injection out of reach of children and pets.

Disposal:

• Dispose of unused or expired Tedizolid injection properly according to local regulations or guidelines.
• Do not flush Tedizolid injection down the toilet or pour it into a drain unless instructed to do so by your healthcare provider or pharmacist.
• Consult your healthcare provider or pharmacist for information on how to safely dispose of Tedizolid injection.

In case of emergency/overdose

In case of emergency or overdose of Tedizolid injection, it’s important to seek immediate medical attention. You can contact your local poison control center or go to the nearest emergency room. Be sure to bring the Tedizolid injection packaging or container with you to provide information to healthcare professionals about the medication and its dosage.

What other information should I know?

• Follow all instructions provided by your healthcare provider or pharmacist regarding the use of Tedizolid injection, including dosage, administration, and duration of treatment.
• Finish the full course of treatment prescribed by your healthcare provider, even if your symptoms improve before the treatment is completed.
• Inform your healthcare provider about any medical conditions you have, including allergies, kidney or liver problems, and any medications or supplements you are taking.
• Report any side effects or adverse reactions to your healthcare provider promptly.
• Keep all appointments for follow-up care and monitoring as recommended by your healthcare provider.

By following these guidelines and staying informed about the proper use, storage, and disposal of Tedizolid injection, you can help ensure safe and effective treatment while minimizing potential risks.