WARNING

Tasigna (nilotinib) is a medication used to treat certain types of leukemia, but like any drug, it comes with potential risks and side effects. Some of the risks associated with taking Tasigna include:

• Cardiac Issues: Tasigna may cause QT prolongation, affecting the heart’s electrical activity, which could lead to an irregular heartbeat. Regular cardiac monitoring is typically required.
• Blood Count Changes: Tasigna can affect blood cell counts, increasing the risk of infections, anemia, or bleeding. Regular blood tests are necessary to monitor these changes.
• Liver Function: Elevated liver enzymes may occur, requiring regular liver function tests to monitor for potential liver-related issues.
• Fluid Retention: Tasigna may cause fluid retention, leading to swelling in the hands, ankles, or feet.
• Gastrointestinal Effects: Common side effects include nausea, vomiting, diarrhea, and abdominal pain.
• Skin Reactions: Some individuals may experience skin rash or itching.
• Muscle and Joint Pain: Tasigna can cause muscle or joint pain in some cases.
• Interactions: Tasigna may interact with other medications, and avoiding certain substances like grapefruit is recommended.
• Pregnancy and Breastfeeding: The risks and benefits of Tasigna during pregnancy and breastfeeding should be carefully discussed with a healthcare provider.

It’s important to note that not everyone will experience these side effects, and the severity can vary. Patients taking Tasigna should have regular check-ups and communicate any concerns or side effects to their healthcare provider promptly. Always follow the prescribed dosage and guidelines provided by your healthcare team. This information is a brief overview, and individuals should consult with their healthcare professionals for personalized advice based on their specific medical history and condition.

Why is this medication prescribed?

Tasigna (nilotinib) is a prescription medication used in the treatment of a type of blood cancer called chronic myeloid leukemia (CML). It specifically targets the abnormal protein produced by the Philadelphia chromosome, which plays a key role in the development of CML.

How should this medicine be used?

Here are some general guidelines on how Tasigna is typically used:

• Dosage: The recommended dose of Tasigna can vary depending on the specific condition being treated and individual patient factors. It is crucial to follow the dosage prescribed by your healthcare provider.
• Administration: Tasigna is usually taken orally, with or without food. It’s important to swallow the capsules whole with a glass of water.
• Timing: Tasigna is typically taken twice a day, about 12 hours apart. It’s important to take the medication at the same times each day.
• Avoiding Food: Taking Tasigna with food can increase its absorption, but it should be taken at least 2 hours after eating. It’s essential to follow your healthcare provider’s instructions regarding food restrictions.
• Interactions: Certain medications, foods, and supplements can interact with Tasigna. Inform your healthcare provider about all the medications and supplements you are taking to avoid potential interactions.
• Monitoring: Regular monitoring of blood counts and other relevant parameters is usually done during Tasigna treatment to assess its effectiveness and manage any potential side effects.
• Duration of Treatment: Treatment duration with Tasigna varies based on the individual’s response to the medication and the stage of the disease. It’s important to continue taking the medication as prescribed by your healthcare provider, even if you start feeling better.

Always follow your healthcare provider’s instructions and consult them if you have any questions or concerns about your medication. They will provide you with specific guidance based on your medical history and the stage of your condition.

Other uses for this medicine

Tasigna (nilotinib) is primarily approved for the treatment of chronic myeloid leukemia (CML). It is not FDA-approved for other uses. It’s essential to follow your healthcare provider’s recommendations and only use Tasigna for the specific condition it has been prescribed for.

What special precautions should I follow?

Regarding special precautions, here are some important considerations:

• Medical History: Inform your healthcare provider about your complete medical history, including any pre-existing conditions, allergies, or medications you are currently taking.
• Liver Function: Tasigna may affect liver function, so your healthcare provider may monitor your liver enzymes regularly. Inform your doctor if you have a history of liver problems.
• Cardiovascular Issues: Tasigna may cause QT prolongation, which is a disturbance in the heart’s electrical activity. Inform your healthcare provider if you have a history of heart problems or if you are taking medications that can also cause QT prolongation.
• Blood Counts: Regular monitoring of blood counts is essential during Tasigna treatment. This helps assess the impact of the medication on your blood cells and allows for prompt intervention if any issues arise.
• Fluid Retention: Tasigna may cause fluid retention. Inform your healthcare provider if you experience swelling, rapid weight gain, or shortness of breath.
• Pancreatitis: There have been reports of pancreatitis in patients taking Tasigna. Notify your healthcare provider if you experience symptoms such as severe abdominal pain that may radiate to the back.
• Pregnancy and Breastfeeding: Tasigna may harm an unborn baby, so it is important to use effective contraception during treatment. It is not recommended for use during pregnancy. Additionally, breastfeeding is not recommended while taking Tasigna.
• Drug Interactions: Inform your healthcare provider about all the medications, supplements, and herbal products you are taking, as certain drugs may interact with Tasigna.

It’s crucial to attend all scheduled medical appointments and laboratory tests as recommended by your healthcare provider. If you experience any side effects or have concerns about the medication, contact your healthcare provider promptly.

Keep in mind that this information is based on knowledge, and there may have been updates or changes in guidelines. Always consult with your healthcare provider for the most current and personalized information.

What special dietary instructions should I follow?

• Avoid Grapefruit: Grapefruit and grapefruit juice can interact with Tasigna, and their consumption should be avoided.
• Take on an Empty Stomach: Tasigna should be taken on an empty stomach, at least 2 hours before or 1 hour after eating.

What should I do if I forget a dose?

If you forget to take a dose of Tasigna, follow these general guidelines:

• If you forget a dose, take it as soon as you remember unless it is close to the time for your next scheduled dose.
• Do not double up on doses to make up for a missed one.
• If you have concerns about missed doses, contact your healthcare provider for guidance.

What side effects can this medication cause?

Tasigna (nilotinib) is a medication primarily used in the treatment of chronic myeloid leukemia (CML). Like any medication, Tasigna can cause side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary from person to person. Some common side effects of Tasigna include:

• Nausea and vomiting: Some people may experience nausea and vomiting while taking Tasigna.
• Diarrhea: Diarrhea is a common side effect of Tasigna.
• Headache: Headaches may occur as a side effect of the medication.
• Muscle and joint pain: Tasigna can cause muscle and joint pain in some individuals.
• Fatigue: Feeling tired or fatigued is another potential side effect.
• Skin rash: Some people may develop a rash on their skin while taking Tasigna.
• Itching: Itching or skin irritation may occur.
• Abdominal pain: Pain or discomfort in the abdominal area is a reported side effect.
• Elevated liver enzymes: Tasigna can affect liver function, leading to elevated liver enzymes.
• Low blood counts: Tasigna may cause a decrease in red blood cells, white blood cells, and platelets.
• QT prolongation: There is a risk of QT interval prolongation, which can affect the heart’s rhythm.

It’s important to notify your healthcare provider if you experience any side effects while taking Tasigna. Additionally, there are more serious and less common side effects associated with the medication, so it’s crucial to follow your healthcare provider’s guidance and undergo regular monitoring during treatment.

This list is not exhaustive, and individual responses to medication can vary. Always consult with your healthcare professional for personalized advice and information based on your specific health condition and medical history.

What should I know about storage and disposal of this medication?

Storage and Disposal of Tasigna:

• Storage Conditions: Store Tasigna (nilotinib) at room temperature, away from light and moisture.
• Keep Out of Reach of Children and Pets: Store Tasigna in a location inaccessible to children and pets to prevent accidental ingestion.
• Original Container: Keep Tasigna in its original container, and use the provided desiccant packets to help absorb moisture.
• Do Not Use Expired Medication: Check the expiration date on the medication, and do not use Tasigna if it has expired. Dispose of any expired medication properly.
• Disposal: Follow your healthcare provider’s or pharmacist’s instructions on how to dispose of unused or expired Tasigna. Do not flush it down the toilet or throw it in the trash without proper guidance.

In case of emergency/overdose

In the case of an emergency or overdose, contact your local poison control center or emergency room immediately. Overdose symptoms may include severe nausea, vomiting, and rapid heartbeat. It’s important to seek medical attention promptly.

What other information should I know?

• Medical History: Inform your healthcare provider of your complete medical history, including any pre-existing conditions, allergies, or medications you are currently taking.
• Interactions: Tasigna may interact with other medications, including over-the-counter drugs and herbal supplements. Inform your healthcare provider of all the medications and supplements you are taking to avoid potential interactions.
• Regular Monitoring: Your healthcare team will regularly monitor your blood counts, liver function, and cardiac function during Tasigna treatment. Attend all scheduled appointments and laboratory tests.
• Pregnancy and Breastfeeding: Discuss with your healthcare provider the potential risks and benefits of Tasigna if you are pregnant, planning to become pregnant, or breastfeeding.
• Avoid Grapefruit: As mentioned earlier, avoid grapefruit and grapefruit juice while taking Tasigna, as they can interact with the medication.

Always follow your healthcare provider’s instructions and communicate any concerns or side effects promptly. If you have questions about Tasigna or your treatment plan, consult with your healthcare team for personalized guidance based on your specific medical condition.