WARNING

Targiniq ER is a prescription medication that combines oxycodone, an opioid analgesic, with naloxone, which is included to help deter abuse. While it can effectively manage pain, it comes with certain risks and potential side effects. It’s essential to note that this information is not exhaustive, and you should always consult with a healthcare professional for personalized advice. Here are some potential risks associated with Targiniq ER:

• Opioid Side Effects: Common side effects may include drowsiness, constipation, nausea, and dizziness. These side effects can impact daily activities and quality of life.
• Risk of Dependence and Addiction: Opioids like oxycodone have the potential for dependence and addiction. Prolonged use or misuse can lead to physical and psychological dependence.
• Respiratory Depression: Opioids can cause respiratory depression, which is a serious and potentially life-threatening side effect. This risk is higher when the medication is misused or taken in high doses.
• Naloxone Interaction: Naloxone is included in Targiniq ER to deter abuse. If the medication is crushed or broken, the naloxone can counteract the opioid effects and induce withdrawal symptoms.
• Constipation: Opioids often cause constipation, which can be a persistent issue for some individuals. Adequate hydration and dietary measures may be needed to manage this side effect.
• Interaction with Other Medications: Targiniq ER may interact with other medications, including sedatives and certain antidepressants, potentially causing adverse effects or reducing the effectiveness of one or more drugs.
• Hypotension: Opioids can cause low blood pressure, leading to dizziness or fainting. This risk may be higher in individuals with pre-existing cardiovascular conditions.
• Central Nervous System Effects: Targiniq ER can impair cognitive and motor skills, affecting the ability to drive or operate machinery. Alcohol and other central nervous system depressants can enhance these effects.

It is crucial to use Targiniq ER as prescribed by a healthcare professional, closely monitor for any side effects, and promptly report any concerns to your doctor. Additionally, discussions about potential alternative pain management strategies should be explored to minimize the risks associated with long-term opioid use.

Why is this medication prescribed?

Targiniq ER is prescribed for the management of severe pain in situations where other treatments have proven insufficient. It contains two active ingredients: oxycodone, which is an opioid analgesic, and naloxone, which is an opioid antagonist. The naloxone component is added to deter abuse of the medication.

How should this medicine be used?

Here are some general guidelines for the use of Targiniq ER:

• Prescription and Dosage: Targiniq ER is available only by prescription, and the dosage is determined by a healthcare professional based on the individual’s pain severity, medical history, and response to other pain management strategies.
• Administration: Targiniq ER comes in extended-release tablet form, which means it provides a controlled release of medication over an extended period. It is usually taken orally, with or without food, typically every 12 hours.
• Swallow Whole: The tablets should be swallowed whole and not crushed, chewed, or broken. Breaking the tablet can lead to the release of a potentially dangerous amount of oxycodone.
• Avoid Alcohol: Patients are advised to avoid consuming alcohol while taking Targiniq ER, as it can increase the risk of side effects, including respiratory depression.
• Follow Doctor’s Instructions: It is crucial to follow the healthcare provider’s instructions regarding dosage adjustments, frequency of administration, and any other specific guidelines for use.
• Monitoring and Follow-Up: Regular follow-up appointments with the prescribing healthcare professional are essential for monitoring the medication’s effectiveness, assessing side effects, and making any necessary adjustments to the treatment plan.
• Naloxone Deterrence: Naloxone is included in Targiniq ER to deter abuse. If the medication is crushed or injected, the naloxone component can counteract the opioid effects, potentially causing withdrawal symptoms.

It’s important for individuals prescribed Targiniq ER to communicate openly with their healthcare provider, report any side effects or concerns promptly, and strictly adhere to the prescribed dosage and instructions. Additionally, individuals should not stop taking the medication suddenly without consulting their healthcare provider, as abrupt discontinuation can lead to withdrawal symptoms.

Other uses for this medicine

Targiniq ER is primarily prescribed for the management of severe pain, particularly when other treatments have proven inadequate. It contains a combination of oxycodone and naloxone. However, it’s essential to note that medications should only be used for the specific purposes approved by healthcare professionals. Using Targiniq ER for purposes other than prescribed can lead to serious health risks and complications.

What special precautions should I follow?

Special precautions and considerations for Targiniq ER use:

• Medical History: Before taking Targiniq ER, inform your healthcare provider about your complete medical history, including any allergies, respiratory conditions, liver or kidney problems, history of substance abuse, or mental health issues.
• Current Medications: Provide a list of all the medications, including prescription and over-the-counter drugs, herbal supplements, and vitamins, that you are currently taking. Targiniq ER may interact with certain medications.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Targiniq ER during pregnancy and lactation is not well-established, and the potential benefits should be weighed against the potential risks.
• Avoid Alcohol: It is generally advised to avoid alcohol while taking Targiniq ER, as it can increase the risk of side effects, including respiratory depression.
• Driving and Operating Machinery: Targiniq ER can cause drowsiness and dizziness. Avoid driving, operating heavy machinery, or engaging in activities that require alertness until you know how the medication affects you.
• Naloxone Effect: Understand the role of naloxone in Targiniq ER. Naloxone is included to deter abuse, and if the medication is crushed or injected, naloxone can counteract the opioid effects, potentially leading to withdrawal symptoms.
• Follow Prescribed Dosage: Take Targiniq ER exactly as prescribed by your healthcare provider. Do not change the dosage or frequency without consulting your doctor.
• Regular Monitoring: Regularly attend follow-up appointments with your healthcare provider for monitoring, evaluation of the medication’s effectiveness, and adjustment of the treatment plan as needed.
• Withdrawal Risks: Abruptly stopping Targiniq ER can lead to withdrawal symptoms. Consult your healthcare provider for guidance on tapering off the medication if needed.

Always follow your healthcare provider’s advice and guidance for the safe and effective use of Targiniq ER, and do not hesitate to seek medical attention if you experience any concerning side effects or have questions about your treatment.

What special dietary instructions should I follow?

There are generally no specific dietary restrictions associated with Targiniq ER. However, staying well-hydrated and maintaining a healthy diet with adequate fiber can help alleviate constipation, a common side effect of opioids.

What should I do if I forget a dose?

If you forget to take a dose of Targiniq ER, take it as soon as you remember. However, if it is close to the time of your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not double up on doses to make up for a missed one. If you have concerns or questions about missed doses, consult with your healthcare provider for guidance.

What side effects can this medication cause?

Targiniq ER, like any medication, can cause side effects. It’s important to be aware of potential side effects and promptly report any unusual or severe symptoms to your healthcare provider. Common side effects of Targiniq ER may include:

• Constipation: Opioids, such as those found in Targiniq ER, commonly cause constipation. Maintaining a high-fiber diet, staying hydrated, and using over-the-counter stool softeners or laxatives under medical guidance may help manage this side effect.
• Nausea and Vomiting: Some individuals may experience nausea and vomiting, especially when starting the medication. Taking Targiniq ER with food or as directed by your healthcare provider may help reduce these symptoms.
• Dizziness or Lightheadedness: Targiniq ER can cause drowsiness, dizziness, or lightheadedness. Avoid activities requiring mental alertness, such as driving or operating machinery, until you know how the medication affects you.
• Sedation: Opioids can cause sedation or drowsiness. It’s important to avoid alcohol and other medications that can enhance this effect.
• Headache: Some individuals may experience headaches as a side effect of Targiniq ER.
• Dry Mouth: Opioids may lead to dry mouth. Staying hydrated and using sugar-free gum or candies may help alleviate this symptom.
• Itching or Sweating: Some individuals may experience itching or increased sweating while taking Targiniq ER.
• Respiratory Depression: In high doses or in individuals with specific medical conditions, opioids can suppress respiratory function, leading to slow or shallow breathing. Seek immediate medical attention if you experience difficulty breathing.
• Withdrawal Symptoms: If Targiniq ER is abruptly discontinued or if naloxone is activated due to misuse (crushing or injecting the medication), withdrawal symptoms may occur. These can include restlessness, irritability, anxiety, sweating, chills, and more.
• Serious Side Effects: While less common, Targiniq ER can lead to serious side effects, such as severe allergic reactions, low blood pressure, or adrenal insufficiency. Seek medical attention if you experience severe or concerning symptoms.

It’s crucial to communicate openly with your healthcare provider about any side effects you may be experiencing. They can provide guidance on managing side effects and may adjust the dosage or recommend alternative treatments if necessary. It’s also important to follow the prescribed dosage and not make any changes to your medication regimen without consulting your healthcare provider.

What should I know about storage and disposal of this medication?

Storage and Disposal of Targiniq ER:

• Storage:
  • Keep Targiniq ER in its original packaging, away from moisture and direct sunlight.
  • Store at room temperature, avoiding extreme temperatures.
  • Keep the medication out of reach of children and pets.
• Disposal:
  • Dispose of Targiniq ER in accordance with local regulations or as advised by your healthcare provider or pharmacist.
  • Do not flush medications down the toilet unless instructed to do so.
  • Use a drug take-back program if available or follow specific disposal instructions provided by your healthcare provider.

In case of emergency/overdose

In case of an emergency or suspected overdose, seek immediate medical attention. Symptoms of overdose may include extreme drowsiness, slow or shallow breathing, unconsciousness, or pinpoint pupils. Call emergency services or the Poison Control Center at 1-800-222-1222 (United States) for assistance.

What other information should I know?

• Follow Prescribed Dosage: Take Targiniq ER exactly as prescribed by your healthcare provider. Do not change the dosage or frequency without consulting your doctor.
• Avoid Alcohol and Other Substances: Limit or avoid alcohol consumption while taking Targiniq ER, as it can increase the risk of side effects, including respiratory depression. Inform your healthcare provider of any other medications or substances you are taking.
• Regular Monitoring: Attend follow-up appointments with your healthcare provider for regular monitoring of the medication’s effectiveness and any potential side effects.
• Withdrawal Risks: Do not abruptly stop taking Targiniq ER without consulting your healthcare provider. Sudden discontinuation can lead to withdrawal symptoms.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care about your use of Targiniq ER, including dentists or emergency medical professionals.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Discuss the risks and benefits of using Targiniq ER during these periods.
• Driving and Operating Machinery: Targiniq ER can cause drowsiness and dizziness. Avoid activities requiring mental alertness until you know how the medication affects you.
• Allergies: Inform your healthcare provider of any known allergies or adverse reactions to medications.

Always consult with your healthcare provider or pharmacist for personalized advice and additional information about Targiniq ER based on your specific health condition and circumstances.