Tamoxifen Citrate 10mg Tablets – Generic Nolvadex
Actual product appearance may differ slightly.
Women taking Tamoxifen to decrease the risk of developing
breast cancer have developed cancer of the uterus, stroke, and blood clots in
the lung. Some of these events have been fatal. Contact your doctor right away
if you develop any of the following: unusual vaginal bleeding or discharge;
abnormal menstrual period; groin pressure or pain; chest pain; shortness of
up blood; confusion; one-sided weakness; vision or speech problems.
at high risk of breast cancer or with ductal carcinoma in situ (DCIS) should
discuss the use of Tamoxifen with their doctor. Decide if the possible
benefits (reducing the risk of breast cancer) outweigh the risk of these
events. The benefits of Tamoxifen outweigh the risks in women who already have
Tamoxifen is used for:
Treating breast cancer that has spread to other sites in thebody.
It is also used along with other medicines to treat other types of breast
cancer. It is used in women who are at high risk for breast cancer and in women
with DCIS (after surgery and radiation) to decrease the risk of developing
breast cancer. It may also be used for other conditions as determined by your
Tamoxifen is an antiestrogen. It works by blocking the effect
of estrogen on certain tumors. This may prevent the growth of tumors that are
activated by estrogen.
Do NOT use Tamoxifen if:
- you areallergic
to any ingredient in Tamoxifen
- you are using Tamoxifen to reduce
your risk of breast cancer and you have a history of blood clots in the lung
- you are using Tamoxifen to reduce
your risk of breast cancer and you also take certain anticoagulants (eg,
- you are taking anastrozole
Before using Tamoxifen :
Some medical conditions may interact with Tamoxifen . Tell
your doctor or pharmacist if you have any medical conditions, especially if any
of the following apply to you:
- if you are pregnant, planning to
become pregnant, or are breast-feeding
- if you are taking any
prescription or nonprescription medicine, herbal preparation, ordietary
- if you have allergies to
or other substances
- if you have a history of blood
clots in the legs or lungs
- if you have high levels of
calcium in your blood, a weakened immune system, or low levels of white
blood cells or platelets in your blood
- if you have high cholesterol or
- if you have cataracts or other
- if you are using cytotoxic cancer
- if you are confined to a bed or
Some MEDICINES MAY INTERACT with Tamoxifen . Tell your health
care provider if you are taking any other medicines, especially any of the
- Anticoagulants (eg, warfarin)
because the risk of bleeding may be increased
- Cytotoxic cancer medicines (eg,
cisplatin) because the risk of developing blood clots may be increased
- Rifampin because it may decrease
Tamoxifen ‘s effectiveness
- Fluorouracil or mitomycin C
because they may increase the risk of Tamoxifen ‘s side effects
- Aromatase inhibitors (eg,
anastrozole, letrozole) because their effectiveness may be decreased by
How to use Tamoxifen :
Use Tamoxifen as directed by your doctor. Check the label on
the medicine for exact dosing instructions.
- Tamoxifen comes with an extra
patient information sheet called a Medication Guide. Read it carefully. Read
it again each time you get Tamoxifen refilled.
- Tamoxifen may be taken by mouth
with or withoutfood.
- Take Tamoxifen with water or
another nonalcoholic liquid.
- Swallow this medication whole. Do
not break, crush, or chew before swallowing.
- Continue to take Tamoxifen even
if you feel well. Do not miss any doses. Taking Tamoxifen at the same time
each day will help you to remember to take it.
- If you miss a dose of Tamoxifen ,
take it as soon as possible. If it is almost time for your next dose, skip
the missed dose and go back to your regular dosing schedule. Do not take 2
doses at once.
Important safety information:
- Tamoxifen may cause dizziness.
These effects may be worse if you take it with alcohol or certain medicines.
Use Tamoxifen with caution. Do not drive or perform other possibly unsafe
tasks until you know how you react to it.
- Tamoxifen may reduce the number
of clot-forming cells (platelets) in your blood. Avoid activities that may
cause bruising or injury. Tell your doctor if you have unusual bruising or
bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Tamoxifen may lower the ability
of your body to fight infection. Avoid contact with people who have colds or
infections. Tell your doctor if you notice signs of infection like fever,
sore throat, rash, or chills.
- New tumors have occurred in body
sites other than the uterus in patients taking Tamoxifen . It is unknown if
Tamoxifen may be the cause. Discuss any questions or concerns with your
- Women who take Tamoxifen to
reduce the risk of breast cancer should have a breast exam, mammogram, and
gynecological exam before starting and during treatment with Tamoxifen .
- Women who may become pregnant
should begin taking Tamoxifen during a menstrual period. Women who have
irregular menstrual periods should have a pregnancy test immediately before
starting Tamoxifen . Talk to your doctor if you have any questions about how
to begin taking Tamoxifen .
- Women who may become pregnant
must use effective nonhormonal birth control (eg, condoms, diaphragm) during
sexual intercourse while they are taking Tamoxifen and for 2 months after
they stop taking it. Do not use hormonal birth control (eg, birth control
pills); it may not work as well while you are taking Tamoxifen . Discuss any
questions about effective nonhormonal birth control with your doctor.
- Tamoxifen will not prevent you
from becoming pregnant.
- Lab tests, including breast
exams, mammograms, gynecologic exams, complete blood counts, and liver
function tests, may be performed while you use Tamoxifen . These tests may
be used to monitor your condition or check for side effects. Be sure to keep
all doctor and lab appointments.
- Tamoxifen should be used with
extreme caution inCHILDREN;
safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING:
Tamoxifen may cause harm to the fetus. Do not become pregnant while you are
using it and for 2 months after you stop using it. If you think you may be
pregnant, contact your doctor. You will need to discuss the benefits and
risks of using Tamoxifen while you are pregnant. It is not known if
Tamoxifen is found in breastmilk.
Do not breast-feed while taking Tamoxifen .
Possible side effects of Tamoxifen :
All medicines may cause side effects, but many people have
no, or minor side effects. Check with your doctor if any
of these most COMMON side effects persist or become bothersome:
Bone pain; constipation; coughing; hot flashes; muscle
pain; nausea; tiredness; vaginal discharge;weight
Seek medical attention right away if any of these SEVERE
side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty
breathing; tightness in the chest; swelling of the mouth, face, lips, or
tongue; unexplained hoarseness); abnormal menstrual periods; abnormal vaginal
bleeding or bloody discharge; chest pain; coughing up blood; dark urine;
decreased sexual desire or ability; depression; fever, chills, or persistent
sore throat; groin or pelvic pain or pressure; loss of appetite; loss of
balance or coordination; missed menstrual period; new or increased breast
tumor or pain; new or unusual lumps; one-sided weakness; pain or swelling in
one or both legs; red, swollen, blistered, or peeling skin; severe or
persistent tiredness or weakness; shortness of breath; skin changes;stomach
pain; sudden severe headache; swelling of the arms or the legs;
unusual bleeding or bruising; vision or speech problems; yellowing of the eyes