Why is this medication prescribed?

Talzenna (talazoparib) is a medication used for the treatment of certain types of breast cancer. It falls into the class of drugs known as poly (ADP-ribose) polymerase (PARP) inhibitors. These drugs work by interfering with the ability of cancer cells to repair their damaged DNA, leading to the death of the cancer cells.

Talzenna is typically prescribed for individuals with advanced or metastatic breast cancer who have specific mutations in the BRCA1 or BRCA2 genes. These mutations make the cancer cells more susceptible to the effects of PARP inhibitors.

How should this medicine be used?

The information provided here is a general guideline and may not cover all individual cases. Always consult with your healthcare professional for personalized advice. Here are some general guidelines for using Talzenna:

• Dosage: The recommended dosage of Talzenna can vary based on individual factors and the specific characteristics of the cancer being treated. Follow your healthcare provider’s instructions carefully regarding the correct dosage.
• Administration: Talzenna is typically taken orally in the form of tablets. Swallow the tablets whole with water. Do not crush, chew, or break them.
• Schedule: Take Talzenna according to the schedule prescribed by your healthcare provider. It is important to take the medication consistently and at the same time each day.
• Food Interactions: Talzenna can be taken with or without food. However, it’s important to follow your healthcare provider’s guidance regarding food and medication interactions.
• Missed Dose: If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.
• Side Effects: Be aware of potential side effects, and promptly report any unusual or severe symptoms to your healthcare provider.
• Regular Monitoring: Your healthcare provider may schedule regular check-ups and laboratory tests to monitor your response to the medication and assess any potential side effects.
• Precautions: Inform your healthcare provider about any other medications, supplements, or herbal products you are taking, as they may interact with Talzenna. Notify your healthcare provider of any allergies or pre-existing medical conditions.

It’s crucial to maintain open communication with your healthcare provider throughout the treatment process. They can provide personalized guidance based on your specific health status and response to the medication. If you have any questions or concerns about the use of Talzenna, do not hesitate to discuss them with your healthcare professional.

Other uses for this medicine

As for other uses, the primary indication for Talzenna is advanced or metastatic breast cancer with germline BRCA1/2 mutations. The drug’s usage may be determined based on the specific characteristics of the cancer and the patient’s medical history. However, it’s important to note that medication indications can evolve, and new uses may have been identified since last update. Always consult with a healthcare professional for the latest and most accurate information.

What special precautions should I follow?

Regarding special precautions for Talzenna, it’s crucial to discuss your medical history and any current medications with your healthcare provider before starting treatment. Special precautions and considerations may include:

• Allergies: Inform your healthcare provider about any known allergies or hypersensitivity reactions.
• Pregnancy and Breastfeeding: Talzenna may cause harm to an unborn baby, so it is important to discuss pregnancy plans with your healthcare provider before starting treatment. Breastfeeding is not recommended while taking Talzenna, as the drug may be present in breast milk.
• Liver Function: Individuals with pre-existing liver conditions may require special monitoring while taking Talzenna.
• Blood Disorders: Talzenna can affect blood cell counts. Regular blood tests may be required to monitor for any changes.
• Interactions with Other Medications: Inform your healthcare provider about all the medications, supplements, and herbal products you are currently taking, as some substances may interact with Talzenna.
• Potential Side Effects: Be aware of potential side effects, including nausea, fatigue, anemia, and others. Report any unusual or severe side effects to your healthcare provider promptly.
• Regular Monitoring: Your healthcare provider may conduct regular check-ups and tests to monitor your response to Talzenna and manage any potential side effects.

It’s crucial to have a comprehensive discussion with your healthcare provider about the specific precautions, potential side effects, and any other relevant considerations based on your individual health profile. This information is not exhaustive, and the most up-to-date guidance should be obtained from your healthcare professional or the prescribing information for Talzenna.

What special dietary instructions should I follow?

There were no specific dietary restrictions mentioned in the prescribing information for Talzenna. However, it’s crucial to follow your healthcare provider’s advice regarding diet and nutrition. Some medications may be taken with or without food, and your healthcare provider can provide specific instructions based on your individual needs.

What should I do if I forget a dose?

If you forget to take a dose of Talazoparib, follow these general guidelines:

• Take the Missed Dose As Soon As Possible: If you forget a dose, take it as soon as you remember.
• Skip the Missed Dose If It’s Almost Time for the Next Dose: If it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
• Do Not Double Up on Doses: Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Talzenna (talazoparib) is a medication used for the treatment of certain types of breast cancer, particularly in individuals with specific mutations in the BRCA1 or BRCA2 genes. Like any medication, Talzenna may cause side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary among individuals. Additionally, some side effects may be temporary or may require medical attention. Common side effects of Talzenna may include:

• Hematologic (Blood-related) Side Effects:
  • Anemia (low red blood cell count)
  • Neutropenia (low white blood cell count)
  • Thrombocytopenia (low platelet count)
• Gastrointestinal Side Effects:
  • Nausea
  • Fatigue
  • Diarrhea
  • Vomiting
• Musculoskeletal Side Effects:
  • Joint pain
  • Muscle pain
• Laboratory Abnormalities:
  • Elevated liver enzymes (as seen in blood tests)
• Respiratory Side Effects:
  • Shortness of breath
• Cardiovascular Side Effects:
  • Palpitations (feeling of rapid or strong heartbeats)
• Central Nervous System Side Effects:
  • Headache
  • Dizziness

It’s important to report any side effects to your healthcare provider, especially if they are severe, persistent, or affecting your quality of life. Additionally, contact your healthcare provider immediately if you experience signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing.

Keep in mind that this list is not exhaustive, and other side effects may occur. Your healthcare provider will provide you with more detailed information about potential side effects based on your individual health status. They will also monitor you for any adverse effects during your treatment with Talzenna. If you have specific concerns or questions about the side effects of Talzenna, it’s best to discuss them with your healthcare provider for personalized advice.

What should I know about storage and disposal of this medication?

Storage and Disposal of Talzenna:

• Storage:
  • Store Talzenna (talazoparib) at room temperature, away from excessive heat, light, and moisture.
  • Keep the medication in its original packaging.
  • Store it in a place that is out of reach of children and pets.
• Disposal:
  • Dispose of unused or expired medication properly and according to local regulations.
  • Consult with your healthcare provider, pharmacist, or local waste disposal facility for guidance on how to safely dispose of Talzenna.

In case of emergency/overdose

• If you suspect an overdose or experience severe adverse effects, seek emergency medical attention or contact your local poison control center immediately.
• Be prepared to provide information about the medication, dosage, and any symptoms experienced.

What other information should I know?

• Regular Monitoring: Your healthcare provider may schedule regular check-ups, blood tests, or other monitoring to assess your response to Talzenna and manage any potential side effects.
• Follow-Up Appointments: Attend all follow-up appointments with your healthcare provider. These visits are essential for monitoring your progress and adjusting the treatment plan if necessary.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care, including dentists and surgeons, that you are taking Talzenna. This is important for proper coordination of care.
• Inform About Other Medications: Inform your healthcare provider about all medications, supplements, and herbal products you are taking, as they may interact with Talzenna.
• Medical Alert Bracelet/ID: Consider wearing a medical alert bracelet or carrying an identification card indicating that you are taking Talzenna. This can be helpful in case of emergencies.
• Patient Education: Understand the potential side effects of Talzenna and report any unusual or severe symptoms to your healthcare provider promptly.
• Pregnancy and Contraception: Discuss family planning and contraception options with your healthcare provider, as Talzenna may cause harm to an unborn baby.
• Patient Assistance Programs: Explore patient assistance programs or support services that may be available to help with the cost of medication, if needed.

Always follow your healthcare provider’s instructions and guidance regarding the use of Talzenna. If you have any questions or concerns, do not hesitate to discuss them with your healthcare professional or pharmacist. This information is not exhaustive, and the most up-to-date guidance should be obtained from your healthcare provider or the prescribing information for Talzenna.