Why is this medication prescribed?

Tafenoquine is a medication used for the prevention of malaria. Malaria is a serious and potentially life-threatening disease caused by the Plasmodium parasite, which is transmitted to humans through the bites of infected mosquitoes. Tafenoquine is specifically prescribed to prevent relapse of Plasmodium vivax malaria.

How should this medicine be used?

Here’s how Tafenoquine is typically used:

• Dosage: The dosage of Tafenoquine can vary based on factors such as the individual’s weight, age, and other medical conditions. It is usually taken as a single dose after completing the treatment for the acute infection.
• Timing: Tafenoquine is taken once a week, on the same day each week, for the duration of the prescribed period. It is essential to follow the prescribed schedule precisely.
• Duration: The duration for which Tafenoquine is prescribed can vary. It is commonly used in combination with other antimalarial medications. The exact duration will depend on the specific circumstances and the healthcare provider’s recommendations.
• Take with Food: Tafenoquine should be taken with food to improve its absorption and reduce the risk of stomach upset.
• Compliance: It’s crucial to take the full course of Tafenoquine as prescribed by the healthcare provider. Skipping doses or stopping the medication prematurely may reduce its effectiveness and increase the risk of malaria.
• Not for Treatment: Tafenoquine is primarily used for prevention and should not be used to treat an acute malaria infection. If malaria is suspected or diagnosed, a different antimalarial treatment will be prescribed.

It’s important to note that Tafenoquine, like any medication, may have potential side effects and interactions with other drugs. Therefore, it should only be taken under the supervision and prescription of a qualified healthcare professional. Additionally, the use of Tafenoquine may not be suitable for everyone, and individuals with certain medical conditions or a history of certain disorders may need special considerations or alternative malaria prevention strategies. Always consult with a healthcare provider for personalized advice and guidance.

Other uses for this medicine

Tafenoquine is primarily used for the prevention of relapse of Plasmodium vivax malaria. As of last update, its approved use is limited to this indication, and it may not have been widely explored or approved for other uses. It’s important to note that new information may have emerged since then, so consulting with a healthcare professional or checking the latest medical guidelines is advisable.

What special precautions should I follow?

Regarding special precautions for Tafenoquine use, the following considerations are important:

• Medical History: Inform your healthcare provider about your complete medical history, including any pre-existing conditions, allergies, or other medications you are taking.
• G6PD Deficiency: Tafenoquine may cause hemolysis (breakdown of red blood cells) in individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency. Your healthcare provider may need to test for G6PD deficiency before prescribing Tafenoquine.
• Pregnancy and Breastfeeding: The safety of Tafenoquine during pregnancy and breastfeeding is not well-established. It should be used with caution, and the potential risks and benefits should be discussed with a healthcare professional.
• Drug Interactions: Tafenoquine may interact with other medications. Inform your healthcare provider about all prescription and over-the-counter medications, as well as any supplements, you are taking to avoid potential interactions.
• Liver Function: Tafenoquine is metabolized in the liver. If you have liver problems, your healthcare provider may need to adjust the dosage or monitor you more closely.
• Psychiatric Effects: Tafenoquine has been associated with neuropsychiatric events in some individuals. Inform your healthcare provider if you have a history of psychiatric disorders.
• Allergic Reactions: If you have experienced an allergic reaction to Tafenoquine or any similar medications in the past, inform your healthcare provider.
• Adherence to Dosage Schedule: It’s crucial to take Tafenoquine according to the prescribed schedule and complete the full course. Skipping doses may reduce its effectiveness and increase the risk of malaria.

Always follow your healthcare provider’s instructions and ask any questions you may have about the medication. If you experience any unusual or severe side effects while taking Tafenoquine, contact your healthcare provider promptly. As medical information can change, consult with a healthcare professional for the most up-to-date and personalized advice.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Tafenoquine. However, taking the medication with food is recommended to improve its absorption and reduce the risk of stomach upset. Therefore, it’s generally advisable to take Tafenoquine with a meal.

What should I do if I forget a dose?

• Take it as soon as you remember: If you forget to take a scheduled dose, take it as soon as you remember. However, if it’s close to the time for your next dose, skip the missed dose and resume your regular dosing schedule.
• Do not double up: Do not take a double dose to make up for a missed one. Taking more than the prescribed amount can increase the risk of side effects without providing additional benefits.
• Consult your healthcare provider: If you have questions or concerns about a missed dose, contact your healthcare provider for guidance. They can provide specific instructions based on your individual circumstances.

What side effects can this medication cause?

Tafenoquine, like any medication, can cause side effects. Not everyone will experience these side effects, and their severity can vary from person to person. Common side effects and potential adverse reactions associated with Tafenoquine include:

• Gastrointestinal Disturbances: Nausea, vomiting, diarrhea, and abdominal pain are common side effects. Taking Tafenoquine with food may help reduce these symptoms.
• Dizziness or Vertigo: Some individuals may experience dizziness or a spinning sensation (vertigo).
• Headache: Headaches are reported by some individuals taking Tafenoquine.
• Neuropsychiatric Effects: Tafenoquine has been associated with neuropsychiatric events, including anxiety, depression, and vivid dreams. Individuals with a history of psychiatric disorders should inform their healthcare provider.
• Hemolysis in G6PD-Deficient Individuals: In individuals with glucose-6-phosphate dehydrogenase (G6PD) deficiency, Tafenoquine may cause hemolysis (breakdown of red blood cells), leading to anemia. G6PD deficiency should be tested for before prescribing Tafenoquine.
• Hypersensitivity Reactions: Allergic reactions, including rash and itching, may occur.
• Electrocardiogram (ECG) Changes: Tafenoquine may lead to changes in the electrical activity of the heart, as observed in ECG readings.
• Liver Enzyme Elevations: There have been reports of elevated liver enzymes in some individuals taking Tafenoquine.

It’s important to note that these side effects are not exhaustive, and individual reactions can vary. Additionally, newer information may have emerged since last update. Always consult with your healthcare provider for the most up-to-date information and guidance.

If you experience severe or persistent side effects, contact your healthcare provider promptly. In case of a medical emergency, such as difficulty breathing or a severe allergic reaction, seek immediate medical attention. Healthcare providers weigh the potential benefits of Tafenoquine in preventing malaria against the risks of side effects, and decisions are made based on individual health circumstances.

What should I know about storage and disposal of this medication?

Storage of Tafenoquine:

• Store Tafenoquine at room temperature, away from excessive heat and moisture.
• Keep the medication in its original packaging, and protect it from light.
• Store it out of reach of children and pets.

Disposal of Tafenoquine:

• Follow specific disposal instructions provided by your healthcare provider or pharmacist.
• Do not flush Tafenoquine down the toilet or pour it down the drain unless instructed to do so.
• Check with your local pharmacy or healthcare facility for medication disposal programs in your area.

In case of emergency/overdose

• In case of an overdose or emergency, contact your local poison control center or emergency room immediately.
• Symptoms of an overdose may include severe dizziness, difficulty breathing, or loss of consciousness.
• Provide healthcare professionals with details about the amount of Tafenoquine ingested and any other relevant information.

What other information should I know?

• Regular Follow-ups: Attend regular follow-up appointments with your healthcare provider to monitor your response to Tafenoquine and address any concerns or side effects.
• Medical Alert Bracelet: If you have G6PD deficiency, consider wearing a medical alert bracelet to inform healthcare providers in case of emergencies.
• Inform Healthcare Providers: Inform all healthcare providers, including dentists and surgeons, about your use of Tafenoquine. It’s crucial to disclose this information before undergoing any medical procedures or surgeries.
• Avoid Alcohol: Limit or avoid alcohol consumption while taking Tafenoquine, as alcohol may interact with the medication and increase the risk of side effects.
• Travel Considerations: If using Tafenoquine for malaria prevention during travel, adhere to the prescribed schedule and take necessary precautions to avoid mosquito bites.
• Follow Healthcare Provider’s Advice: Follow your healthcare provider’s instructions regarding dosing, scheduling, and any additional precautions or recommendations.

Always consult with your healthcare provider or pharmacist for specific guidance related to your individual circumstances. If you have any questions or concerns, don’t hesitate to seek professional advice. Additionally, keep in mind that medical information can change, so it’s essential to stay informed about any updates related to the use of Tafenoquine.