Why is this medication prescribed?

Rydapt was primarily prescribed for the treatment of certain types of cancer, specifically acute myeloid leukemia (AML) and advanced systemic mastocytosis (ASM). Midostaurin is a kinase inhibitor that works by blocking the action of certain proteins involved in the growth and spread of cancer cells.

How should this medicine be used?

Here are general guidelines for using Rydapt:

• Dosage: The dosage of Rydapt can vary based on the specific condition being treated (e.g., acute myeloid leukemia or systemic mastocytosis) and individual patient factors. The recommended dosage and schedule will be determined by the treating healthcare provider.
• Administration: Rydapt is typically taken orally with food to improve absorption. It is important to take the medication exactly as prescribed by your doctor. Swallow the capsules whole with a glass of water; do not crush, break, or chew the capsules.
• Schedule: Follow the prescribed dosing schedule provided by your healthcare provider. Stick to the same schedule every day to ensure a consistent level of the medication in your system.
• Other Medications: Inform your healthcare provider about all other medications, including prescription and over-the-counter drugs, as well as any supplements or herbal products you may be taking. Certain medications may interact with Rydapt, so your doctor needs a complete list of everything you are using.
• Monitoring: Regular follow-up appointments with your healthcare provider are essential to monitor your response to Rydapt and to address any potential side effects or concerns. Your doctor may order blood tests or other diagnostic tests to assess your condition during treatment.
• Side Effects: Be aware of potential side effects and report any unusual symptoms or severe reactions to your healthcare provider promptly. Common side effects may include nausea, vomiting, diarrhea, fatigue, and respiratory symptoms.
• Pregnancy and Contraception: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. Rydapt may cause harm to a developing fetus, so appropriate contraception methods may be recommended.
• Missed Dose: If you miss a dose, follow your doctor’s instructions on what to do. Do not double up on doses unless specifically instructed.

It’s important to note that this information is based on knowledge, and there may have been updates or changes. Always consult your healthcare provider and refer to the prescribing information for the most accurate and current guidance on using Rydapt.

Other uses for this medicine

Rydapt is primarily used for the treatment of AML and advanced systemic mastocytosis. It is not typically used for other conditions unless specifically prescribed by a healthcare provider.

What special precautions should I follow?

Special precautions and considerations for using Rydapt include:

• Pregnancy and Contraception: Rydapt may cause harm to a developing fetus. It is important to inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. Adequate contraception methods should be discussed and used during treatment.
• Drug Interactions: Inform your healthcare provider about all medications you are taking, including prescription drugs, over-the-counter medications, supplements, and herbal products. Rydapt may interact with other medications, potentially affecting their effectiveness or leading to adverse effects.
• Liver Function: Rydapt is metabolized in the liver. Patients with hepatic impairment may require dosage adjustments or careful monitoring. Liver function tests may be conducted regularly to assess how the liver is processing the medication.
• Heart Function: Rydapt may affect the heart’s electrical activity (QT prolongation). Inform your healthcare provider if you have a history of heart problems or if you are taking medications that can affect the heart’s rhythm. Electrocardiograms (ECGs) may be performed to monitor cardiac function.
• Allergic Reactions: Inform your healthcare provider of any known allergies or hypersensitivity reactions. Watch for signs of allergic reactions, such as rash, itching, swelling, severe dizziness, or difficulty breathing, and seek medical attention if they occur.
• Gastrointestinal Issues: Rydapt is generally taken with food to improve absorption and reduce the risk of gastrointestinal side effects.
• Side Effect Monitoring: Regular monitoring for side effects, including blood counts and organ function tests, may be necessary during treatment.
• Special Populations: The safety and efficacy of Rydapt in pediatric populations and elderly patients may differ. Special considerations may be needed based on age and health status.

It’s crucial to consult with your healthcare provider for personalized advice and guidance based on your specific medical history and condition. Additionally, because medical information can evolve, it’s recommended to refer to the most recent prescribing information for Rydapt or consult with a healthcare professional for the latest updates and precautions.

What special dietary instructions should I follow?

• Rydapt is generally taken orally with food to enhance absorption.
• Follow your healthcare provider’s instructions regarding the specific dietary recommendations while taking Rydapt.

What should I do if I forget a dose?

• Follow Healthcare Provider Instructions: If you forget a dose, follow the specific instructions provided by your healthcare provider. Do not double up on doses unless your healthcare provider advises you to do so.
• Contact Your Healthcare Provider: If you miss a dose and are unsure about what to do, contact your healthcare provider or the healthcare team promptly for guidance.
• Regular Schedule: Try to take the missed dose as soon as you remember, and then continue with your regular dosing schedule.

What side effects can this medication cause?

Rydapt (midostaurin) may cause various side effects, and it’s important for patients to be aware of potential reactions. Keep in mind that the specific side effects can vary from person to person, and not everyone will experience the same symptoms. Additionally, new information may have emerged since last update. Always consult with your healthcare provider for the most accurate and up-to-date information. Here are some common side effects associated with Rydapt:

• Gastrointestinal Issues:
  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
• Dermatological Reactions:
  • Rash
  • Itching (pruritus)
  • Redness of the skin (erythema)
• Fatigue: Tiredness or weakness
• Respiratory Symptoms:Shortness of breath
• Edema: Swelling, typically of the hands, feet, or ankles
• Fever: Elevated body temperature
• Headache: Pain or discomfort in the head
• Anorexia: Loss of appetite
• Bone Marrow Suppression: Decreased blood cell counts, including low levels of red blood cells (anemia), white blood cells (neutropenia), and platelets (thrombocytopenia)
• Liver Enzyme Elevations: Increased levels of liver enzymes in blood tests
• QT Prolongation: Prolongation of the QT interval on electrocardiogram (ECG), which may affect the heart’s electrical activity
• Infections: Increased susceptibility to infections
• Allergic Reactions: Hypersensitivity reactions, such as allergic skin reactions

It’s crucial to report any side effects or unusual symptoms to your healthcare provider promptly. Additionally, some side effects may require immediate medical attention, so it’s important to seek medical help if you experience severe or emergent symptoms.

This list is not exhaustive, and there may be additional side effects or rare reactions associated with Rydapt. Patients should discuss potential side effects with their healthcare provider before starting treatment, and regular monitoring will be conducted during the course of therapy. If you have specific concerns or questions about Rydapt and its side effects, consult with your healthcare provider for personalized guidance.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage:
  • Store Rydapt (midostaurin) at room temperature, away from excessive heat and moisture.
  • Keep the medication in its original packaging to protect it from light.
• Keep Out of Reach of Children:
  • Store Rydapt in a location that is out of reach of children and pets.
• Disposal:
  • Dispose of unused or expired medication in accordance with local regulations.
  • Do not flush Rydapt down the toilet or pour it into a drain unless instructed to do so.

In case of emergency/overdose

• Seek Medical Attention: In case of a suspected overdose or if you experience severe symptoms, seek immediate medical attention or contact your local poison control center.
• Symptoms of Overdose: Overdose symptoms may include nausea, vomiting, diarrhea, fever, confusion, and other adverse reactions. It’s important to communicate all details about the suspected overdose to healthcare providers.

What other information should I know?

• Regular Monitoring: Regular monitoring, including blood tests and other diagnostic measures, may be necessary during Rydapt treatment.
• Follow Healthcare Provider Instructions: Always take Rydapt exactly as prescribed by your healthcare provider. Do not adjust the dosage or stop taking the medication without consulting your healthcare provider.
• Drug Interactions: Inform your healthcare provider about all medications, including prescription drugs, over-the-counter medications, supplements, and herbal products, to avoid potential drug interactions.
• Regular Appointments: Attend all scheduled appointments with your healthcare provider to monitor your response to treatment and address any concerns.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care (dentists, surgeons, etc.) that you are taking Rydapt.
• Travel Precautions: Inform healthcare providers before any surgical or dental procedures, as adjustments to Rydapt dosing may be necessary.
• Allergies: Inform your healthcare provider of any known allergies or hypersensitivity reactions.

Always consult with your healthcare provider or pharmacist for personalized advice, and keep them informed about any changes in your health status. For the most accurate and up-to-date information, refer to the prescribing information provided with Rydapt or consult with your healthcare professional.