Why is this medication prescribed?

Fostemsavir is a medication used in the treatment of human immunodeficiency virus (HIV) infection. It belongs to a class of antiretroviral drugs known as attachment inhibitors. Fostemsavir is prescribed for the following purposes:

• HIV Infection: Fostemsavir is used in combination with other antiretroviral medications to treat HIV-1 infection in adults who have tried multiple HIV medications in the past (treatment-experienced) and whose current regimen is no longer effective due to resistance, intolerance, or safety issues.
• Treatment-Experienced Patients: This medication is specifically approved for individuals who have a history of resistance to several different classes of HIV medications. It works by inhibiting the attachment of the virus to the host CD4 cells, preventing the virus from entering and infecting the immune cells.

How should this medicine be used?

Here are some key points regarding the use of Fostemsavir:

• Prescription: Fostemsavir is available only with a prescription from a healthcare professional. It is not a first-line treatment for HIV but is typically prescribed for individuals who have developed resistance to other HIV medications.
• Combination Therapy: Fostemsavir is usually used as part of a combination antiretroviral therapy (ART) regimen. It is important to take it in combination with other HIV medications as prescribed by your healthcare provider.
• Dosage: The specific dosage of Fostemsavir can vary based on individual factors such as the patient’s medical history, other medications they are taking, and the extent of drug resistance. Your healthcare provider will determine the appropriate dosage for you.
• Administration: Fostemsavir is typically taken orally in the form of tablets. It can be taken with or without food. It’s important to follow the instructions provided by your healthcare provider and the medication’s packaging.
• Adherence: Consistent and regular adherence to the prescribed dosing schedule is crucial for the effectiveness of Fostemsavir and other HIV medications. Missing doses or not taking the medication as directed can contribute to the development of drug resistance.
• Monitoring: Your healthcare provider will regularly monitor your response to Fostemsavir and may perform laboratory tests to assess the level of the virus in your blood and other relevant parameters.

It’s essential to communicate openly with your healthcare provider about any concerns, side effects, or challenges you may face with your HIV treatment. They can provide guidance and adjustments to your treatment plan as needed. Additionally, patients should not adjust their medication regimen without consulting their healthcare provider.

Other uses for this medicine

Fostemsavir is primarily indicated for the treatment of HIV-1 infection in adults who have resistance to other antiretroviral medications. There may not be approved or established alternative uses for Fostemsavir beyond its use in the management of HIV. It’s crucial to consult with a healthcare professional for the most up-to-date and accurate information regarding medication uses and indications.

What special precautions should I follow?

Regarding special precautions for Fostemsavir, it’s important to note the following:

• Prescription Only: Fostemsavir is available only with a prescription from a healthcare provider who is experienced in the management of HIV infection.
• Adherence: Adherence to the prescribed dosage and schedule is critical for the effectiveness of Fostemsavir. Missing doses or not taking the medication as directed can lead to treatment failure and the development of drug-resistant HIV strains.
• Allergies: Inform your healthcare provider about any known allergies or adverse reactions to medications, as well as any other health conditions you may have.
• Drug Interactions: Fostemsavir can interact with other medications. Inform your healthcare provider about all the medications, including prescription and over-the-counter drugs, supplements, and herbal products, that you are currently taking. This is important to avoid potential drug interactions that could affect the efficacy and safety of your treatment.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the potential risks and benefits of Fostemsavir with your healthcare provider. They will help determine the most appropriate course of action considering your individual circumstances.
• Liver Function: Fostemsavir may affect liver function. Regular monitoring of liver function through blood tests may be necessary during treatment. Inform your healthcare provider of any history of liver disease or abnormal liver function.
• Side Effects: Be aware of potential side effects associated with Fostemsavir. Common side effects may include headache, diarrhea, nausea, and rash. Contact your healthcare provider if you experience any severe or persistent side effects.
• Resistance Testing: Before starting Fostemsavir, your healthcare provider may conduct resistance testing to assess the susceptibility of the HIV virus to the medication.

It’s important to follow your healthcare provider’s instructions and attend scheduled follow-up appointments for monitoring and adjustments to your treatment plan. Any concerns or questions about Fostemsavir should be discussed with your healthcare provider for personalized guidance based on your medical history and current health status.

What special dietary instructions should I follow?

Dietary Instructions for Fostemsavir:

• Food Intake: Fostemsavir can be taken with or without food. Follow your healthcare provider’s instructions regarding food intake when taking Fostemsavir.
• Grapefruit Interaction: Some medications can interact with grapefruit or grapefruit juice, affecting their absorption or metabolism. Check with your healthcare provider if there are any specific dietary restrictions related to grapefruit while taking Fostemsavir.

What should I do if I forget a dose?

If you forget to take a dose of Fostemsavir, follow these general guidelines:

• If a Dose is Missed: If you forget to take a dose of Fostemsavir, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule.
• Do Not Double Dose: Do not take a double dose to make up for a missed one. Taking more than the prescribed amount can increase the risk of side effects without providing additional benefits.
• Consult Your Healthcare Provider: If you have questions or concerns about missed doses, contact your healthcare provider for guidance. They can provide specific advice based on your individual circumstances.

What side effects can this medication cause?

Fostemsavir, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary. Common side effects may go away on their own as your body adjusts to the medication. However, if you experience persistent or severe side effects, it’s essential to contact your healthcare provider. Here are some potential side effects associated with Fostemsavir:

• Headache: Headaches are a common side effect reported by individuals taking Fostemsavir.
• Diarrhea: Some people may experience diarrhea as a side effect of Fostemsavir.
• Nausea: Nausea is another gastrointestinal side effect that may occur.
• Rash: Skin rash is a possible side effect. If you notice a rash or any skin changes, inform your healthcare provider.
• Abnormal Liver Function Tests: Fostemsavir may affect liver function, and an increase in liver enzymes can occur. Regular monitoring of liver function through blood tests is typically recommended.
• Allergic Reactions: Serious allergic reactions are rare but possible. Seek immediate medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Changes in Fat Distribution: Antiretroviral medications, including Fostemsavir, have been associated with changes in body fat distribution, such as fat accumulation or loss.
• Immune Reconstitution Syndrome: In some cases, individuals starting antiretroviral therapy may experience an inflammatory response to previously hidden infections (immune reconstitution syndrome). This can manifest as fever, inflammation, and worsening of pre-existing infections.

It’s important to report any unusual or severe symptoms to your healthcare provider promptly. Additionally, keep in mind that this is not an exhaustive list of potential side effects, and individual reactions can vary.

If you are prescribed Fostemsavir, your healthcare provider will discuss potential side effects with you and monitor your response to the medication. Adhering to your prescribed treatment plan, attending follow-up appointments, and communicating openly with your healthcare provider are crucial for managing potential side effects and optimizing the effectiveness of your HIV treatment.

What should I know about storage and disposal of this medication?

Storage of Fostemsavir:

• Room Temperature: Store Fostemsavir at room temperature, typically between 68°F to 77°F (20°C to 25°C).
• Original Container: Keep the medication in its original container with the lid tightly closed.
• Protect from Light and Moisture: Protect the medication from light and moisture. Do not store it in the bathroom.
• Keep Out of Reach of Children: Store Fostemsavir in a location where it is out of reach of children and pets.

Disposal of Fostemsavir:

• Follow Local Guidelines: Follow local guidelines and regulations for the disposal of medications. Do not flush medications down the toilet unless instructed to do so.
• Take-Back Programs: Many communities have drug take-back programs that allow for safe disposal of unused or expired medications. Check with local pharmacies or law enforcement for information on available programs.
• Dispose in Household Trash: If no take-back programs are available, you can dispose of Fostemsavir in your household trash. Mix the medication with an undesirable substance (e.g., coffee grounds, cat litter) in a sealed plastic bag before throwing it away.

In case of emergency/overdose

• Seek Medical Attention: If you suspect an overdose or experience severe side effects, seek emergency medical attention immediately.
• Symptoms of Overdose: Symptoms of overdose may include severe dizziness, fainting, or difficulty breathing.

What other information should I know?

• Regular Monitoring: Your healthcare provider will monitor your response to Fostemsavir through regular check-ups and laboratory tests.
• Follow Healthcare Provider’s Instructions: Follow your healthcare provider’s instructions regarding dosing, scheduling, and any other specific recommendations related to your HIV treatment.
• Inform Healthcare Provider: Keep your healthcare provider informed about any changes in your health, other medications you are taking, or any concerns or side effects you may be experiencing.
• Adherence is Key: Consistent adherence to your prescribed treatment plan is crucial for the effectiveness of Fostemsavir and the management of HIV.

Always consult with your healthcare provider or pharmacist if you have specific questions about the storage, disposal, or any other aspect of your medication. They can provide personalized guidance based on your individual health status and needs.