WARNING

While RU-486 (mifepristone) is generally considered safe and effective for medical abortion when used under the supervision of a healthcare professional, it is important to be aware of potential risks and complications. Some of the risks associated with taking RU-486 include:

• Incomplete Abortion: In some cases, the abortion may be incomplete, requiring additional medical or surgical intervention to remove any remaining pregnancy tissue.
• Heavy Bleeding: Excessive bleeding is a potential risk, and individuals should be monitored for signs of severe bleeding or hemorrhage.
• Infection: There is a risk of infection, although it is relatively low. Signs of infection, such as fever, should be promptly reported to a healthcare provider.
• Allergic Reactions: While rare, allergic reactions to the medication can occur. Any signs of an allergic reaction, such as difficulty breathing or swelling, should be addressed immediately.
• Ectopic Pregnancy: If a woman has an ectopic pregnancy (a pregnancy outside the uterus, usually in the fallopian tube), RU-486 is not effective and can lead to complications. Therefore, it is crucial to confirm the intrauterine location of the pregnancy before administering the medication.
• Emotional Impact: Undergoing a medical abortion can have emotional and psychological effects. It is important for individuals to have access to counseling and support if needed.

It’s important to note that the risks associated with RU-486 are generally lower when the medication is administered under the supervision of a qualified healthcare professional. Additionally, healthcare providers will assess individual health conditions and medical history to determine the appropriateness of the medication for a particular patient.

Anyone considering a medical abortion with RU-486 should consult with a healthcare provider to discuss their specific situation, potential risks, and any contraindications. Medical abortion is subject to legal and regulatory considerations in different regions, and healthcare providers follow established protocols to ensure the safety and well-being of the patient.

Why is this medication prescribed?

RU-486, also known as mifepristone, is a medication used for medical abortion (termination of pregnancy). It is prescribed to induce a miscarriage in the early stages of pregnancy. RU-486 is typically used within the first 7 to 9 weeks of pregnancy. RU-486 is not prescribed for contraception or other purposes. Here’s why RU-486 is prescribed:

• Termination of Pregnancy: RU-486 is primarily prescribed for the purpose of inducing a medical abortion. It is used to terminate pregnancies within the first 7 to 9 weeks. This method provides an alternative to surgical abortion for individuals who prefer a non-invasive option.
• Mechanism of Action: RU-486 works by blocking the hormone progesterone, which is necessary for the maintenance of pregnancy. By interfering with progesterone, RU-486 causes the lining of the uterus to break down, making it difficult for the pregnancy to continue. The subsequent administration of another medication, misoprostol, induces uterine contractions, leading to the expulsion of the pregnancy.
• Non-Surgical Option: Some individuals may choose medical abortion over surgical procedures for personal or medical reasons. It allows women to terminate a pregnancy in a more private and non-invasive manner.
• Supervision of Healthcare Provider: RU-486 is prescribed and administered under the supervision of a qualified healthcare professional. This ensures that the medication is used appropriately, and the individual’s health is monitored throughout the process.

How should this medicine be used?

Here is a general overview of how RU-486 is typically used:

• Consultation with Healthcare Provider: Before obtaining and using RU-486, you should have a consultation with a healthcare provider. This is important to determine if medical abortion is suitable for your specific situation and to ensure that you understand the process and potential risks.
• Confirmation of Pregnancy: Confirm that you are pregnant and determine the gestational age. RU-486 is generally effective up to around 10 weeks of pregnancy.
• Administration of Mifepristone: The process typically begins with the administration of mifepristone. This is usually done under the supervision of a healthcare provider in a medical setting. Mifepristone works by blocking the hormone progesterone, which is necessary for maintaining pregnancy.
• Follow-up Visit: A follow-up visit is usually scheduled about 24 to 48 hours after taking mifepristone. This is to assess the response to the medication and confirm that the pregnancy has not continued.
• Administration of Misoprostol: If the pregnancy has not ended, the second medication, misoprostol, is usually administered. This can be done at a healthcare provider’s office or at home, depending on the specific protocol and legal regulations in your region.
• Monitoring and Follow-up: After taking misoprostol, expect symptoms such as cramping and bleeding. It’s important to have access to medical care during this time and to follow the healthcare provider’s instructions. A follow-up visit is usually scheduled to confirm the completion of the abortion.

It is crucial to follow the healthcare provider’s instructions closely and to seek immediate medical attention if you experience severe pain, heavy bleeding, or other concerning symptoms.

Please keep in mind that medical abortion with RU-486 should only be done under the guidance and supervision of a qualified healthcare professional. If you are considering a medical abortion, consult with your healthcare provider to discuss your individual circumstances and receive appropriate care and guidance.

Other uses for this medicine

Some of the investigational uses of RU-486 include:

• Cushing’s Syndrome: RU-486 has been studied for its potential in treating Cushing’s syndrome, a hormonal disorder characterized by high levels of cortisol in the blood.
• Endometriosis: There has been research exploring the use of mifepristone for the management of endometriosis, a condition where tissue similar to the lining of the uterus grows outside the uterus.
• Breast Cancer: Some studies have investigated the use of mifepristone in combination with other medications for the treatment of certain types of breast cancer.

What special precautions should I follow?

Regarding special precautions for the use of RU-486 for its approved indication (medical abortion), individuals should follow these guidelines:

• Medical Supervision: RU-486 should only be used under the supervision of a qualified healthcare provider who can assess the appropriateness of the medication for a particular patient.
• Pregnancy Confirmation: Before administering RU-486, it is crucial to confirm the intrauterine location of the pregnancy to avoid complications in the case of an ectopic pregnancy.
• Follow-up Care: A follow-up visit with the healthcare provider is essential to ensure the completion of the abortion and to address any potential complications.
• Emergency Care: Individuals should be aware of the signs of complications, such as heavy bleeding or infection, and seek prompt medical attention if they occur.
• Emotional Support: Given the nature of the procedure, emotional and psychological support should be available, and individuals should be informed about potential emotional impacts.
• Contraindications: There are certain contraindications, such as a known or suspected ectopic pregnancy, that should be considered before prescribing RU-486.

It’s crucial for individuals considering the use of RU-486 to discuss their specific situation, medical history, and any concerns with their healthcare provider. Medical abortion is subject to legal and regulatory considerations in different regions, and healthcare providers adhere to established protocols to ensure patient safety.

What special dietary instructions should I follow?

There are usually no specific dietary restrictions associated with RU-486. However, individuals should follow their healthcare provider’s advice regarding general health and well-being during the abortion process. Staying well-hydrated and maintaining a balanced diet can contribute to overall health.

What should I do if I forget a dose?

For medical abortion with RU-486, the dosing regimen involves taking mifepristone followed by misoprostol after a specific interval. It’s crucial to follow the prescribed schedule as closely as possible. If a dose is missed, individuals should contact their healthcare provider immediately for guidance. It may be necessary to adjust the timing of subsequent doses or take additional precautions based on the specific circumstances.

What side effects can this medication cause?

RU-486, or mifepristone, can cause side effects as part of the medical abortion process. It’s important to note that not everyone will experience these side effects, and their severity can vary from person to person. Additionally, side effects can depend on individual health, gestational age, and other factors. Common side effects include:

• Bleeding and Cramping: Vaginal bleeding and uterine cramping are expected side effects of the medication. This is the body’s natural response to expel the pregnancy.
• Nausea and Vomiting: Some individuals may experience nausea or vomiting after taking mifepristone or misoprostol (the second medication in the regimen).
• Fatigue: Feelings of tiredness or fatigue are common during and after the medical abortion process.
• Abdominal Pain: Pain or discomfort in the abdominal area can occur as the uterus contracts to expel the pregnancy.
• Headache: Headaches are a potential side effect of the medication.
• Dizziness: Some individuals may feel lightheaded or dizzy.
• Diarrhea: Diarrhea can occur as a side effect, particularly after taking misoprostol.
• Fever: A mild fever is a common side effect, usually as a response to the abortion process.

It’s important to seek medical attention if any of the following occur:

• Heavy bleeding (soaking more than two sanitary pads per hour for two consecutive hours).
• Severe abdominal pain that does not respond to over-the-counter pain medications.
• High fever persisting more than 24 hours after taking misoprostol.
• Signs of infection, such as foul-smelling vaginal discharge or persistent fever.

Additionally, individuals should contact their healthcare provider if they have concerns about the severity or duration of any side effects. It’s crucial to follow up with the healthcare provider for a post-abortion checkup to ensure the abortion is complete and to address any ongoing concerns.

As with any medication, individual responses can vary, and this information is not exhaustive. Healthcare providers will provide specific guidance based on the individual’s health, medical history, and the gestational age of the pregnancy.

What should I know about storage and disposal of this medication?

Here are some important considerations regarding the storage and disposal of RU-486 (mifepristone):

Storage:

• Follow Instructions: Always follow the storage instructions provided by your healthcare provider or on the medication packaging.
• Room Temperature: In general, medications are stored at room temperature, away from excessive heat, moisture, and light. However, specific storage recommendations may vary, so it’s crucial to adhere to the instructions.
• Keep Out of Reach of Children: Store medications in a secure location out of reach of children and pets.

Disposal:

• Follow Guidelines: Dispose of unused or expired medications according to local guidelines. Some areas have specific instructions for safe drug disposal to minimize environmental impact.
• Do Not Flush: Do not flush medications down the toilet unless instructed to do so. This helps prevent contamination of water sources.
• Take-Back Programs: Check if there are medication take-back programs or collection sites in your area where you can safely dispose of medications.

In case of emergency/overdose

In the case of an emergency or suspected overdose, it’s crucial to seek immediate medical attention. Emergency services should be contacted, and you can also contact your local poison control center.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Always take RU-486 exactly as prescribed by your healthcare provider. Do not alter the dosage or the schedule without consulting your healthcare professional.
• Keep Follow-Up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. These visits are important to ensure the completion of the abortion and monitor for any complications.
• Communicate Openly: Report any unusual symptoms, side effects, or concerns to your healthcare provider promptly. Open communication is essential for your safety and well-being.
• Emotional Support: Recognize that undergoing a medical abortion can have emotional and psychological effects. Seek emotional support from friends, family, or counseling services if needed.
• Legal Considerations: Be aware of the legal and regulatory considerations regarding medical abortion in your region. Follow all applicable laws and regulations.

Remember, the information provided here is general, and individual circumstances may vary. Always consult with your healthcare provider for personalized guidance based on your health, medical history, and specific situation.