Why is this medication prescribed?

Belumosudil is a drug primarily used for the treatment of chronic graft-versus-host disease (cGVHD). Graft-versus-host disease is a complication that can occur after a stem cell or bone marrow transplant, where the transplanted cells attack the recipient’s body.

Belumosudil is a kinase inhibitor that works by targeting a specific enzyme called Rho-associated coiled-coil kinase 2 (ROCK2), which plays a role in the inflammatory process associated with cGVHD.

How should this medicine be used?

Belumosudil is typically administered orally. The usual dosage and administration may involve taking the medication once or twice daily. The specific dose and schedule will be determined by your healthcare provider based on factors such as the severity of your condition, your response to the treatment, and any other medical considerations.

Here are some general guidelines for the use of Belumosudil:

• Take as Prescribed: Follow your healthcare provider’s instructions and take Belumosudil exactly as prescribed. Do not change the dosage or stop taking the medication without consulting your healthcare provider.
• Take with or without Food: Belumosudil can be taken with or without food, but it’s important to be consistent with your choice to maintain a steady level of the medication in your body.
• Swallow Whole: Swallow the tablets whole with a glass of water. Do not crush, chew, or break the tablets unless directed otherwise by your healthcare provider.
• Missed Dose: If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take extra doses to make up for missed ones.
• Side Effects: Be aware of potential side effects and report any unusual or severe reactions to your healthcare provider promptly.
• Regular Monitoring: Your healthcare provider may conduct regular monitoring, including laboratory tests, to assess the effectiveness of the medication and to check for any adverse effects.

Always consult with your healthcare provider or pharmacist for the most accurate and up-to-date information on the use of Belumosudil, as guidelines and recommendations may change over time. If you have specific questions about your prescription or concerns about the medication, discuss them with your healthcare provider.

Other uses for this medicine

Belumosudil (also known as Rezurock) is primarily indicated for the treatment of chronic graft-versus-host disease (cGVHD) after failure of at least two prior lines of systemic therapy. However, it’s essential to note that new uses or indications for drugs may have emerged since then, and the prescribing information may have been updated.

What special precautions should I follow?

What special dietary instructions should I follow?

As of last knowledge update, there are no specific dietary restrictions associated with Belumosudil. However, always follow the instructions provided by your healthcare provider and consult them if you have any concerns about your diet while taking this medication.

What should I do if I forget a dose?

If you forget to take a dose of Belumosudil, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not take extra doses to make up for missed ones. If you have any concerns about missed doses or if you are unsure what to do, contact your healthcare provider or pharmacist for guidance.

What side effects can this medication cause?

Belumosudil (brand name Rezurock) can cause various side effects. It’s important to note that the list of side effects is not exhaustive, and individuals may experience different reactions. Additionally, new information may have emerged since my last update, so it’s crucial to consult with your healthcare provider and refer to the most recent prescribing information for the drug.

Common side effects of Belumosudil may include:

• Peripheral Edema: Swelling in the arms, hands, legs, or feet.
• Nausea: A feeling of discomfort or queasiness in the stomach.
• Fatigue: Feeling tired or having low energy levels.
• Diarrhea: Frequent and loose bowel movements.

More serious side effects may include:

• Hepatotoxicity: Belumosudil may affect liver function, leading to elevated liver enzymes. Regular liver function tests may be necessary.
• Infections: Belumosudil may increase the risk of infections, and severe infections have been reported. Notify your healthcare provider if you experience signs of infection, such as fever, chills, or persistent sore throat.
• Hypertension: High blood pressure may occur during Belumosudil treatment. Blood pressure should be monitored regularly, and antihypertensive medications may be required.
• Gastrointestinal Perforation: Rare cases of gastrointestinal perforation have been reported. Seek medical attention if you experience severe abdominal pain.
• Risk of Malignancies: Belumosudil may increase the risk of developing certain cancers. Regular monitoring is essential.
• Embryo-Fetal Toxicity: Belumosudil may cause harm to a developing fetus. Effective contraception is recommended during treatment, and pregnancy should be avoided.
• Other Adverse Reactions: Other potential side effects include muscle spasms, headache, respiratory tract infections, and changes in kidney function.

It’s crucial to report any unusual or severe side effects to your healthcare provider promptly. Your healthcare provider will assess the risk-benefit profile of the medication and determine the most appropriate course of action based on your individual health status.

This information is not a substitute for professional medical advice. Always consult with your healthcare provider for personalized guidance and the most up-to-date information on potential side effects associated with Belumosudil. If there have been updates or changes to the prescribing information since my last knowledge update, your healthcare provider will have the latest information.

What should I know about storage and disposal of this medication?

Storage of Belumosudil:

• Store as Directed: Keep Belumosudil in its original packaging and store it as directed by the prescribing information. Typically, it is stored at room temperature, away from excessive heat and moisture.
• Keep Out of Reach of Children: Store medications in a location that is out of reach of children and pets.
• Avoid Sunlight: Protect the medication from direct sunlight.
• Do Not Freeze: Do not freeze Belumosudil unless instructed otherwise.

Disposal of Belumosudil:

• Follow Local Guidelines: Dispose of unused or expired medications following local guidelines or regulations for medication disposal. Do not flush medications down the toilet unless instructed to do so.
• Take-Back Programs: Some communities or pharmacies may have take-back programs for the safe disposal of medications. Check with your local authorities or pharmacy to see if such programs are available.
• Ask Your Pharmacist: Your pharmacist can provide guidance on the proper disposal of Belumosudil.

In case of emergency/overdose

In case of an emergency or suspected overdose, seek immediate medical attention or contact your local poison control center. Be prepared to provide information about the medication, the amount taken, and any symptoms experienced.

What other information should I know?

• Regular Monitoring: Your healthcare provider may schedule regular check-ups, including laboratory tests, to monitor your response to Belumosudil and detect any potential side effects.
• Follow-Up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. These visits are essential for monitoring your progress and adjusting treatment if necessary.
• Communication with Healthcare Provider: Keep an open line of communication with your healthcare provider. Report any side effects, changes in symptoms, or concerns promptly.
• Compliance: Take Belumosudil exactly as prescribed by your healthcare provider. If you have any concerns about the medication or experience difficulties with adherence, discuss them with your healthcare provider.
• Inform Other Healthcare Providers: Make sure to inform other healthcare providers, including dentists and specialists, about your use of Belumosudil before any medical procedures or treatments.

Always consult with your healthcare provider or pharmacist for the most accurate and up-to-date information on the storage, disposal, and emergency procedures associated with Belumosudil. If there have been updates or changes to the prescribing information since my last knowledge update, your healthcare provider will have the latest information.