Why is this medication prescribed?

Reyvow (lasmiditan) is a medication used for the acute treatment of migraine with or without aura in adults. Migraine is a neurological condition characterized by severe headaches, often accompanied by other symptoms such as nausea, vomiting, and sensitivity to light and sound.

Reyvow is classified as a selective serotonin 5-HT1F receptor agonist. It works by binding to serotonin receptors in the brain and reducing the release of inflammatory substances that can cause migraines.

How should this medicine be used?

Here are some key points regarding the use of Reyvow:

• Prescription: Reyvow is available only by prescription, and it should be used under the supervision and guidance of a healthcare professional.
• Dosage: The recommended dose of Reyvow is usually a single dose of 50 mg, 100 mg, or 200 mg, depending on the severity of the migraine and the individual’s response to the medication.
• Administration: Reyvow is taken orally with or without food. It should be swallowed whole with water and should not be split, crushed, or chewed.
• Timing: Reyvow should be taken as soon as the migraine headache begins. It can be taken at any time during a migraine attack.
• Frequency: It is important to note that Reyvow should not be used for the preventive treatment of migraines. It is specifically intended for the acute treatment of migraine attacks.
• Limitations: Reyvow is not recommended for the prevention of migraines, and it should not be used for the treatment of other types of headaches.
• Caution: Reyvow may cause dizziness and sedation, so individuals are advised to avoid activities that require mental alertness, such as driving or operating machinery, until they know how the medication affects them.

It’s crucial for individuals to discuss their medical history, including any other medications they may be taking, with their healthcare provider before starting Reyvow. This helps ensure that there are no potential interactions or contraindications that could affect the safety and effectiveness of the medication for that specific individual. Always follow the healthcare provider’s instructions and dosage recommendations.

Other uses for this medicine

Reyvow (lasmiditan) is specifically approved for the acute treatment of migraine headaches in adults and is not indicated for other uses. Its mechanism of action as a selective serotonin 5-HT1F receptor agonist makes it effective in targeting migraines, but it does not have broader applications.

What special precautions should I follow?

Special precautions should be taken when using Reyvow, and it’s important to discuss your medical history and any potential risk factors with your healthcare provider before starting this medication. Here are some key precautions:

• Cardiovascular Issues: Reyvow can cause an increase in blood pressure. It should be used with caution in individuals with a history of cardiovascular disease, including coronary artery disease, heart attacks, and stroke.
• Liver Impairment: Reyvow is metabolized in the liver, so individuals with moderate to severe liver impairment should use it with caution. The dosage may need to be adjusted in such cases.
• Alcohol and Sedative Effects: Reyvow may cause dizziness and sedation. It’s important to avoid alcohol and other central nervous system depressants while taking Reyvow, as these substances can enhance these effects.
• Serotonin Syndrome Risk: Reyvow interacts with serotonin receptors. Concurrent use with other medications that increase serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs), may increase the risk of serotonin syndrome.
• Pregnancy and Breastfeeding: The safety of Reyvow during pregnancy and breastfeeding has not been established, and it should be used with caution in these situations. The potential benefits should be weighed against the potential risks.
• Driving and Operating Machinery: Reyvow may cause dizziness and sedation. Patients should be cautious when driving or operating machinery until they know how the medication affects them.
• Allergies: Individuals with a known hypersensitivity or allergy to Reyvow or its components should not use this medication.

Always follow your healthcare provider’s instructions and inform them of any other medications or supplements you are taking. It’s important to attend follow-up appointments to monitor the effectiveness and safety of Reyvow for your specific condition. If you experience any concerning side effects or have questions about the medication, contact your healthcare provider promptly.

What special dietary instructions should I follow?

There are generally no specific dietary instructions for Reyvow. It can be taken with or without food. However, it’s essential to discuss any dietary considerations or restrictions with your healthcare provider, as individual health conditions may warrant specific advice.

What should I do if I forget a dose?

Reyvow is typically taken as needed at the onset of a migraine attack. If you forget to take a dose and your migraine persists, contact your healthcare provider for guidance. It’s important not to double the dose to make up for a missed one.

What side effects can this medication cause?

Reyvow (lasmiditan) may cause side effects, and it’s important to be aware of them. Not everyone will experience these side effects, and some individuals may tolerate the medication well. Common side effects of Reyvow include:

• Dizziness: Reyvow can cause dizziness. It’s recommended to avoid activities that require mental alertness, such as driving or operating machinery, until you know how the medication affects you.
• Fatigue: Some people may experience fatigue or a feeling of tiredness after taking Reyvow.
• Paresthesia (tingling or prickling sensations): Reyvow may cause paresthesia in some individuals.
• Sedation: Reyvow can cause a feeling of sedation or sleepiness. It’s important to be cautious, especially when combined with other medications that can cause sedation.
• Nausea: Nausea is a potential side effect of Reyvow.
• Muscle Weakness: Some individuals may experience muscle weakness as a side effect of the medication.
• Increased Blood Pressure: Reyvow can cause a temporary increase in blood pressure. Blood pressure should be monitored during treatment, especially in individuals with a history of cardiovascular issues.
• Chest Discomfort or Tightness: Chest discomfort or tightness has been reported in some users.
• Serotonin Syndrome (rare): In rare cases, Reyvow can lead to serotonin syndrome, especially when used in combination with other medications that increase serotonin levels.

It’s important to note that this is not a complete list of side effects, and individuals may experience side effects not listed here. If you experience severe or persistent side effects, contact your healthcare provider promptly.

Discuss any concerns or questions about Reyvow and its potential side effects with your healthcare provider before starting the medication. They can provide personalized guidance based on your medical history and overall health.

What should I know about storage and disposal of this medication?

Storage and Disposal of Reyvow:

• Storage: Store Reyvow at room temperature, away from excessive heat and moisture. Keep it in its original packaging and out of reach of children.
• Disposal: Dispose of unused or expired Reyvow properly according to local regulations or guidelines. Do not flush medications down the toilet or pour them down the drain unless instructed to do so. Consult with your healthcare provider or pharmacist on the appropriate way to dispose of medications.

In case of emergency/overdose

In case of an emergency or suspected overdose of Reyvow, seek medical attention immediately. Symptoms of an overdose may include severe dizziness, fainting, or loss of consciousness. It’s important to contact your local poison control center (1-800-222-1222 in the United States) for guidance.

What other information should I know?

• Follow Instructions: Take Reyvow exactly as prescribed by your healthcare provider. Do not exceed the recommended dosage or frequency.
• Alcohol and Other Medications: Inform your healthcare provider about all medications, including over-the-counter drugs, supplements, and herbal products, that you are taking. Reyvow may interact with certain medications, and alcohol should be avoided while taking Reyvow.
• Driving and Operating Machinery: Reyvow may cause dizziness and sedation. Avoid driving or operating machinery until you know how Reyvow affects you.
• Regular Follow-up: Attend follow-up appointments with your healthcare provider to monitor the effectiveness and safety of Reyvow for your specific condition.
• Allergic Reactions: Seek medical attention if you experience signs of an allergic reaction, such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Reyvow during pregnancy and lactation has not been established.

Always consult with your healthcare provider or pharmacist for specific guidance and information based on your individual health status and needs. If you have any questions or concerns about Reyvow, do not hesitate to discuss them with your healthcare provider.