WARNING

Retacrit is a medication that contains epoetin alfa, a synthetic form of erythropoietin, a hormone that stimulates the production of red blood cells. It is commonly used to treat anemia, especially in patients with chronic kidney disease or those undergoing certain medical treatments.

Like any medication, Retacrit comes with potential risks and side effects. It’s important to note that individual responses to the medication can vary, and not everyone will experience these risks. Some potential risks associated with taking Retacrit include:

• Blood Clots: Epoetin alfa can increase the risk of blood clots, especially in patients with a history of cardiovascular disease or those on dialysis.
• Hypertension (High Blood Pressure): Retacrit may cause an increase in blood pressure, and this effect should be monitored and managed appropriately.
• Pure Red Cell Aplasia (PRCA): This is a rare but serious condition where the body stops producing red blood cells in response to erythropoietin. Although rare, it’s a severe side effect that requires immediate medical attention.
• Seizures: Some patients may experience seizures as a side effect of Retacrit.
• Allergic Reactions: Allergic reactions, including anaphylaxis, can occur in some individuals. Symptoms may include difficulty breathing, swelling, and severe rash.
• Bone Marrow Suppression: Retacrit can suppress bone marrow function, leading to a decrease in the production of blood cells.

It’s crucial to use Retacrit under the supervision of a healthcare professional who can monitor your response to the medication and adjust the dosage as needed. Before starting Retacrit, discuss your medical history, current medications, and any concerns with your healthcare provider to determine if it is the right treatment for you. If you experience any unusual or severe side effects while taking Retacrit, seek medical attention promptly. This information is a brief overview, and it does not replace professional medical advice.

Why is this medication prescribed?

Retacrit is a prescription medication that contains epoetin alfa, a synthetic form of erythropoietin. Erythropoietin is a hormone produced by the kidneys that stimulates the production of red blood cells in the bone marrow. Retacrit is typically prescribed for the following purposes:

• Anemia due to Chronic Kidney Disease (CKD): Retacrit is often prescribed to treat anemia in patients with chronic kidney disease, especially those on dialysis or not on dialysis.
• Anemia in Cancer Patients: It may be used in cancer patients undergoing chemotherapy whose anemia is caused by the effect of chemotherapy on the bone marrow.
• Reduction of Blood Transfusions: Retacrit may be prescribed to reduce the need for blood transfusions in certain medical conditions or surgical procedures where there is a risk of significant blood loss.
• Anemia in HIV-infected Patients: In some cases, Retacrit might be prescribed to treat anemia in patients with HIV who are taking zidovudine, an antiretroviral medication associated with anemia.

How should this medicine be used?

The dosage and administration of Retacrit are specific to each patient and depend on factors such as the underlying medical condition, the severity of anemia, and individual patient response. It is administered as an injection under the skin (subcutaneous) or into a vein (intravenous) by a healthcare professional.

It’s important to follow the prescribed dosage and administration schedule provided by the healthcare provider. Self-administration may be an option for some patients after proper training.

Here are general guidelines for the use of Retacrit:

• Dosage: The dosage is determined by the healthcare provider based on the patient’s condition and needs.
• Administration: Retacrit is usually injected under the skin (subcutaneously) or into a vein (intravenously). The healthcare provider will determine the appropriate route of administration.
• Frequency: The frequency of administration may vary but is often a few times per week. Follow the prescribed schedule.
• Monitoring: Regular monitoring of hemoglobin levels and other blood parameters is essential to adjust the dosage and assess the effectiveness of treatment.

Patients should not self-adjust the dosage without consulting their healthcare provider. It’s crucial to communicate any concerns or side effects to the healthcare team promptly.

As always, this information provides a general overview, and individual circumstances may vary. Patients should consult their healthcare provider for personalized advice and guidance regarding the use of Retacrit.

Other uses for this medicine

While Retacrit is primarily prescribed for the treatment of anemia associated with chronic kidney disease, cancer chemotherapy, HIV therapy, and certain surgical procedures, there may be other off-label uses based on a healthcare provider’s judgment and assessment of an individual patient’s needs. Off-label use refers to the prescription of a medication for a purpose other than the one officially approved by regulatory authorities. It’s important for patients to follow their healthcare provider’s guidance regarding the specific use of Retacrit.

What special precautions should I follow?

Regarding special precautions when using Retacrit, it’s crucial to consider the following:

• Allergies: Inform your healthcare provider of any allergies you may have, especially if you are allergic to erythropoietin products or any other ingredients in Retacrit. Allergic reactions can be serious and require immediate medical attention.
• High Blood Pressure: Retacrit can increase blood pressure. Your healthcare provider will monitor your blood pressure regularly and may need to manage it with medication or adjust the Retacrit dosage.
• Blood Clots: Epoetin alfa medications, including Retacrit, may increase the risk of blood clots. Inform your healthcare provider if you have a history of blood clots or if you are at an increased risk.
• Seizures: Retacrit may trigger seizures in some individuals. If you have a history of seizures, discuss this with your healthcare provider.
• Pure Red Cell Aplasia (PRCA): Although rare, PRCA is a severe condition where the body stops producing red blood cells in response to erythropoietin. Regular monitoring is essential to detect and manage this condition promptly.
• Bone Marrow Suppression: Retacrit can suppress bone marrow function, leading to a decrease in the production of blood cells. Regular blood tests will be conducted to monitor your blood cell counts.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The use of Retacrit during pregnancy or breastfeeding should be discussed with your healthcare provider, weighing the potential benefits against the risks.
• Iron Levels: Adequate iron levels are necessary for the effectiveness of Retacrit. Your healthcare provider may recommend iron supplements if needed.

It’s essential to attend all scheduled appointments with your healthcare provider for monitoring and follow-up. If you experience any side effects, unusual symptoms, or changes in your health, notify your healthcare provider promptly.

Always take Retacrit as prescribed, and do not adjust the dosage without consulting your healthcare provider. This information is a general overview, and individual circumstances may vary, so it’s important to discuss any concerns with your healthcare team.

What special dietary instructions should I follow?

• Iron-Rich Diet: Consuming iron-rich foods can support the effectiveness of Retacrit. Good sources of iron include red meat, poultry, fish, beans, lentils, tofu, and fortified cereals.
• Vitamin B12 and Folate: Ensure you have an adequate intake of vitamin B12 and folate, which are important for red blood cell production. These can be found in meat, dairy products, eggs, leafy green vegetables, and fortified cereals.
• Hydration: Maintain good hydration, as it can contribute to overall health and support the circulatory system.

What should I do if I forget a dose?

• Contact Your Healthcare Provider: If you forget a dose, contact your healthcare provider for guidance. Do not try to compensate by taking extra doses on your own.
• Follow Instructions: Your healthcare provider will provide specific instructions on what to do if you miss a dose. They may adjust the schedule or dosage accordingly.
• Avoid Double Dosing: Do not take a double dose to make up for a missed one unless explicitly instructed by your healthcare provider.

What side effects can this medication cause?

Retacrit, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary from person to person. Common and serious side effects of Retacrit may include:

Common Side Effects:

• Hypertension (High Blood Pressure): Retacrit can increase blood pressure. Regular monitoring is essential, and your healthcare provider may adjust your antihypertensive medication if needed.
• Headache: Some individuals may experience headaches as a side effect of Retacrit.
• Nausea and Vomiting: Gastrointestinal symptoms such as nausea and vomiting may occur.
• Joint or Muscle Pain: Some individuals may experience joint or muscle pain.
• Redness or Itching at the Injection Site: For individuals receiving subcutaneous injections, redness, or itching at the injection site may occur.
• Fever: In some cases, patients may experience a fever.

Serious Side Effects:

• Blood Clots: Retacrit may increase the risk of blood clots, which can be a serious and potentially life-threatening side effect. Seek medical attention if you experience symptoms such as shortness of breath, chest pain, leg swelling, or persistent headaches.
• Pure Red Cell Aplasia (PRCA): PRCA is a rare but severe condition where the body stops producing red blood cells in response to erythropoietin. This condition requires immediate medical attention.
• Seizures: Some individuals may experience seizures as a side effect of Retacrit.
• Serious Allergic Reactions: Allergic reactions, including anaphylaxis, are rare but can occur. Seek emergency medical attention if you experience difficulty breathing, swelling, or severe rash.
• Worsening of Hypertension: In some cases, Retacrit may exacerbate existing hypertension.
• Bone Marrow Suppression: Retacrit can suppress bone marrow function, leading to a decrease in the production of blood cells.

It’s crucial to report any side effects or concerns to your healthcare provider promptly. They can help assess the severity of the side effects and determine whether any adjustments to your treatment plan are necessary.

This list is not exhaustive, and individual responses to medication can vary. Your healthcare provider will provide specific information based on your medical history and current health status. Always follow your healthcare provider’s advice and attend regular check-ups while using Retacrit.

What should I know about storage and disposal of this medication?

Storage and Disposal of Retacrit:

• Storage Conditions: Store Retacrit as directed by your healthcare provider or as indicated on the medication’s packaging. Typically, it is stored in the refrigerator at a specific temperature. Do not freeze.
• Protect from Light: Some formulations may be sensitive to light. Follow any specific instructions regarding protection from light.
• Do Not Shake: Avoid shaking the medication. Gently rotate or invert the vial to mix the solution if necessary.
• Expiration Date: Check the expiration date on the packaging and do not use the medication if it has expired.
• Keep Out of Reach of Children: Store Retacrit in a secure place, out of the reach of children and pets.
• Unused Medication: If you have unused or expired Retacrit, follow proper disposal procedures. Do not dispose of it in household waste unless instructed to do so. Your healthcare provider or pharmacist can provide guidance on proper disposal.

In case of emergency/overdose

In case of an emergency or suspected overdose, seek immediate medical attention. Symptoms of an overdose may include:

• Severe headache
• Dizziness
• Seizures
• Blurred vision
• Nausea or vomiting
• Trouble breathing

What other information should I know?

• Regular Monitoring: Attend all scheduled appointments with your healthcare provider for regular monitoring. Blood tests may be conducted to assess your response to Retacrit and make any necessary adjustments to your treatment plan.
• Medical History: Inform your healthcare provider about your complete medical history, including any pre-existing conditions, allergies, or medications you are currently taking.
• Follow Healthcare Provider’s Instructions: Follow your healthcare provider’s instructions carefully regarding dosage, administration, and any precautions related to Retacrit.
• Inform Healthcare Providers: Inform other healthcare providers, including dentists and surgeons, about your use of Retacrit before undergoing any procedures or surgeries.
• Travel: If you need to travel, plan ahead to ensure you have an adequate supply of Retacrit. Follow any specific travel instructions provided by your healthcare provider.
• Patient Education: Educate yourself about the potential side effects and warning signs associated with Retacrit. Report any unusual symptoms or concerns promptly to your healthcare provider.

Always consult with your healthcare provider or pharmacist if you have any questions or concerns about the storage, disposal, or usage of Retacrit. This information is a general guide, and individual recommendations may vary based on your specific medical condition and needs.