WARNING

Reslizumab is a medication used to treat severe asthma with an eosinophilic phenotype. It is typically administered as an intravenous injection. As with any medication, there are potential risks and side effects associated with Reslizumab. It’s crucial to discuss these risks with your healthcare provider before starting the treatment. Here is a brief overview:

• Hypersensitivity Reactions: There is a risk of hypersensitivity reactions, including anaphylaxis, with Reslizumab. This can cause severe allergic symptoms and requires immediate medical attention.
• Parasitic Infections: Reslizumab may increase the risk of helminth (parasitic worm) infections. It’s important to be vigilant for any signs of parasitic infections and to seek medical attention if such symptoms occur.
• Upper Respiratory Tract Infections: Some individuals may experience upper respiratory tract infections while using Reslizumab.
• Herpes Zoster (Shingles): There is a potential increased risk of herpes zoster (shingles) with Reslizumab treatment.
• Malignancy: As with some immunomodulatory medications, there may be an increased risk of malignancies (cancers). This risk should be carefully evaluated against the potential benefits of the medication.
• Elevated Liver Enzymes: Reslizumab may lead to elevated liver enzymes, and liver function should be monitored during treatment.
• Pregnancy and Breastfeeding: The safety of Reslizumab during pregnancy and breastfeeding is not well-established. The potential benefits and risks should be discussed with a healthcare provider in these situations.
• Blood Eosinophil Counts: Monitoring blood eosinophil counts is essential during Reslizumab treatment, as the medication is specifically indicated for individuals with eosinophilic asthma.

It’s crucial to communicate openly with your healthcare provider about your medical history, current medications, and any concerns you may have about potential risks. Your healthcare provider will assess your individual health situation and determine whether Reslizumab is an appropriate and safe treatment for you. Additionally, they will monitor you for any signs of adverse reactions during the course of treatment.

Why is this medication prescribed?

Reslizumab is a medication that belongs to a class of drugs known as monoclonal antibodies. It is prescribed to treat severe asthma in adults and children aged 6 years and older who have an eosinophilic phenotype. Eosinophils are a type of white blood cell that plays a role in allergic reactions and asthma. Elevated levels of eosinophils in the blood and airways are often associated with certain types of asthma.

How should this medicine be used?

Reslizumab is typically prescribed when asthma symptoms are not well controlled with standard asthma medications, such as inhaled corticosteroids and long-acting beta-agonists.

• Mechanism of Action: Reslizumab works by binding to and inhibiting interleukin-5 (IL-5), a protein involved in the production and activation of eosinophils. By reducing the number of eosinophils, Reslizumab helps to decrease inflammation and improve asthma symptoms.
• Dosage and Administration: The dosage of Reslizumab is determined by the healthcare provider based on the patient’s weight. It is administered as an intravenous (IV) infusion over a specified period of time in a healthcare setting, such as a clinic or hospital. The frequency of infusions can vary, but they are typically given every 4 weeks. It’s crucial to follow the healthcare provider’s instructions regarding the dosage and administration schedule. The first dose may be administered over a longer period of time, and subsequent doses may have shorter infusion times.

• Monitoring: Patients receiving Reslizumab may be monitored for a period of time after each infusion to watch for any potential allergic reactions or side effects.

It’s important for individuals prescribed Reslizumab to communicate with their healthcare provider about their asthma symptoms, any side effects experienced, and any other medications they may be taking.

As with any prescription medication, the decision to use Reslizumab should be made in consultation with a healthcare professional who can assess the individual’s specific medical condition and needs. This information is a general overview, and the specifics may vary based on the patient’s situation and the prescribing healthcare provider’s recommendations.

Other uses for this medicine

Reslizumab is primarily indicated for the treatment of severe asthma in adults. It is not typically used for other medical conditions. Always use the medication as prescribed by your healthcare provider and do not attempt to self-diagnose or self-treat with Reslizumab.

What special precautions should I follow?

As for special precautions, here are some general considerations:

• Allergies: Individuals with known hypersensitivity or allergic reactions to Reslizumab or any of its components should avoid its use.
• Infections: Like many immunomodulatory medications, Reslizumab may increase the risk of infections. Patients should be monitored for signs of infections, and healthcare providers should be informed if any occur.
• Pre-existing Conditions: It’s important for healthcare providers to know about any pre-existing medical conditions, including infections or other health concerns, before prescribing Reslizumab.
• Pregnancy and Breastfeeding: The safety of Reslizumab during pregnancy and breastfeeding may not be well established. It’s essential to discuss the potential risks and benefits with a healthcare provider if there is a possibility of pregnancy or if breastfeeding.
• Immunizations: Patients receiving Reslizumab should discuss their immunization status with their healthcare provider. Live vaccines are generally not recommended while on immunosuppressive medications.
• Monitoring: Regular monitoring may be necessary to assess the effectiveness of Reslizumab and watch for any potential side effects.

It’s crucial to follow the specific guidance provided by the prescribing healthcare professional and to report any unusual symptoms or side effects promptly. Additionally, since medical information can change over time, consulting a healthcare provider for the most up-to-date information is important.

What special dietary instructions should I follow?

There were no specific dietary restrictions associated with Reslizumab. However, it’s important to follow a healthy and balanced diet as advised by your healthcare provider. If there have been updates or changes since then, your healthcare provider will provide you with the most current information.

What should I do if I forget a dose?

Reslizumab is typically administered by healthcare professionals through intravenous infusion, and the schedule is determined by your healthcare provider. It’s important to attend all scheduled appointments for your infusions. If, for any reason, you miss an appointment, contact your healthcare provider’s office as soon as possible to reschedule. It’s crucial not to skip doses without consulting your healthcare provider, as this can impact the effectiveness of the treatment.

What side effects can this medication cause?

Reslizumab, like any medication, can cause side effects. It’s important to note that not everyone will experience these side effects, and the severity can vary among individuals. Additionally, the benefits of the medication in managing a specific medical condition are weighed against the potential risks.

Common side effects of Reslizumab may include:

• Headache
• Sore throat
• Myalgia (muscle pain)
• Upper respiratory tract infections

Serious side effects are less common but may include:

• Hypersensitivity reactions: This can include severe allergic reactions. Seek medical attention immediately if you experience symptoms such as difficulty breathing, swelling of the face, lips, or tongue, or severe itching.
• Infusion-related reactions: Some individuals may experience reactions during or after the infusion, such as flushing, rash, itching, or dizziness. These reactions should be reported to healthcare providers.
• Parasitic (helminth) infections: Reslizumab suppresses eosinophils, which play a role in the body’s defense against certain parasites. Therefore, there may be an increased risk of parasitic infections.

It’s essential to promptly report any unexpected or severe symptoms to your healthcare provider. If you experience a medical emergency or severe allergic reaction, seek immediate medical attention.

This list is not exhaustive, and other side effects may occur. Always consult with your healthcare provider for a complete understanding of potential side effects, especially if you have specific health concerns or conditions. It’s also important to attend all scheduled follow-up appointments so that your healthcare provider can monitor your response to the medication and address any emerging issues.

What should I know about storage and disposal of this medication?

Storage of Reslizumab Injection:

• Reslizumab is typically administered in a healthcare setting, and the storage and handling of the medication are the responsibility of the healthcare provider.
• If you are given a prescription to take home (unlikely with Reslizumab), follow your healthcare provider’s instructions for storage. In most cases, it may require refrigeration.
• Keep the medication out of reach of children and pets.

Disposal of Reslizumab Injection:

• Dispose of unused or expired Reslizumab in accordance with local regulations and guidelines.
• If you have unused medication at home, consult with your healthcare provider or pharmacist on how to properly dispose of it.

In case of emergency/overdose

• In case of an emergency or suspected overdose, contact your local poison control center or emergency room immediately.
• It’s important to seek medical attention right away, even if there are no immediate symptoms. Emergency medical personnel will be able to provide appropriate care.

What other information should I know?

• Inform all healthcare providers involved in your care about any medications you are taking, including Reslizumab.
• Attend all scheduled appointments for Reslizumab infusions as directed by your healthcare provider.
• Keep a list of all your medications, including prescription and over-the-counter drugs, and share it with your healthcare providers.

Always follow your healthcare provider’s instructions and guidance regarding the use, storage, and disposal of Reslizumab. If you have specific questions or concerns, discuss them with your healthcare provider or pharmacist. Additionally, be vigilant about reporting any unusual symptoms or side effects to your healthcare provider promptly.