Why is this medication prescribed?

Renagel is a brand name for the medication sevelamer hydrochloride. It is primarily prescribed for the management of high levels of phosphate in the blood, a condition known as hyperphosphatemia, in individuals with chronic kidney disease (CKD) who are on dialysis.

The kidneys play a crucial role in removing waste products from the body, including phosphate. In individuals with CKD, especially those undergoing dialysis, the kidneys may not function properly, leading to an accumulation of phosphate in the blood. Elevated phosphate levels can contribute to complications such as bone problems, cardiovascular issues, and other complications associated with kidney disease.

Sevelamer hydrochloride, the active ingredient in Renagel, is a phosphate binder. It works by binding to phosphate in the digestive tract, preventing its absorption into the bloodstream. This helps to reduce the overall phosphate levels in the body.

How should this medicine be used?

Renagel (sevelamer hydrochloride) is usually prescribed to be taken with meals, or as directed by your healthcare provider. Here are general guidelines for using Renagel:

• Dosage: Follow your doctor’s prescription regarding the dosage. The typical starting dose for adults is often based on the level of phosphorus in your blood. Your doctor may adjust the dose over time.
• Take with Meals: Renagel is typically taken with meals to bind to the phosphate present in food. This helps prevent the absorption of phosphate from the digestive tract.
• Swallow Whole: Swallow the Renagel tablets whole with a sufficient amount of water. Do not crush, chew, or break the tablets unless your healthcare provider advises otherwise.
• Consistent Timing: Try to take Renagel at the same times each day to maintain a consistent level of the medication in your body.
• Follow Dietary Guidelines: Along with taking Renagel, your healthcare provider may recommend dietary restrictions to help control your phosphate intake. It’s important to follow these dietary guidelines for effective management of hyperphosphatemia.
• Regular Monitoring: Attend regular follow-up appointments with your healthcare provider to monitor your phosphate levels and overall kidney function. Your doctor may adjust the dosage based on your response to the medication and any changes in your condition.
• Missed Dose: If you miss a dose, take it with your next meal. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular dosing schedule. Do not double up on doses to make up for a missed one.

It’s crucial to communicate openly with your healthcare provider, informing them of any side effects, concerns, or changes in your health. Renagel is a part of a comprehensive treatment plan for managing chronic kidney disease, and its effectiveness can be optimized when used in conjunction with lifestyle modifications and other prescribed medications. Always follow your healthcare provider’s instructions and attend regular check-ups to ensure the safe and effective use of Renagel.

Other uses for this medicine

Sevelamer hydrochloride, sold under the brand name Renagel, is primarily used to manage high levels of phosphate in the blood in individuals with chronic kidney disease (CKD) who are on dialysis. However, it’s essential to note that medications should only be used for the specific purposes for which they are prescribed by a healthcare professional. Off-label use or self-prescribing can lead to serious health risks.

What special precautions should I follow?

As for special precautions when using Renagel, consider the following:

• Medical History: Inform your healthcare provider about your complete medical history, especially if you have a history of gastrointestinal disorders or difficulties swallowing.
• Allergies: If you are allergic to sevelamer hydrochloride or any other ingredients in Renagel, inform your doctor.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of Renagel during pregnancy and breastfeeding is not well established, and your doctor will weigh the potential benefits against the risks.
• Interactions with Other Medications: Provide a list of all prescription and over-the-counter medications, as well as any herbal supplements or vitamins you are taking. Some medications may interact with Renagel, affecting its effectiveness or increasing the risk of side effects.
• Phosphate Levels Monitoring: Your healthcare provider will monitor your phosphate levels regularly and may adjust the dosage of Renagel as needed. Follow-up appointments are crucial for assessing the medication’s effectiveness and making any necessary adjustments.
• Dietary Considerations: Follow any dietary guidelines provided by your healthcare provider. Renagel is often part of a comprehensive treatment plan that includes dietary restrictions to manage phosphate intake.
• Calcium Levels: Since Renagel does not contain calcium, your doctor may prescribe a calcium supplement if needed. It’s important to maintain appropriate levels of calcium in the body.
• Side Effects: Be aware of potential side effects of Renagel, such as gastrointestinal issues (e.g., constipation, nausea, vomiting). If you experience severe or persistent side effects, contact your healthcare provider.
• Routine Check-ups: Attend regular follow-up appointments with your healthcare provider to monitor your overall kidney function and assess the effectiveness of the treatment plan.

Always take Renagel exactly as prescribed by your healthcare provider. If you have any questions or concerns about the medication, discuss them with your doctor. This information is not exhaustive, and individual circumstances may vary, so it’s crucial to rely on professional medical advice for your specific situation.

What special dietary instructions should I follow?

• Take with Meals: Renagel is typically taken with meals to bind to phosphate in food. Follow your healthcare provider’s instructions regarding meal timing.
• Phosphate-Restricted Diet: Follow any dietary restrictions recommended by your healthcare provider to limit phosphate intake. Foods high in phosphate include dairy products, nuts, and certain processed foods.

What should I do if I forget a dose?

• Take It with the Next Meal: If you forget a dose, take it with your next scheduled meal. If it’s almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
• Do Not Double Dose: Do not take a double dose to make up for a missed one. Taking more than the prescribed amount can increase the risk of side effects.

What side effects can this medication cause?

Renagel (sevelamer hydrochloride) can cause side effects, and it’s important to be aware of them. Not everyone will experience these side effects, and their severity can vary. Common side effects include:

• Gastrointestinal Issues: The most common side effects are related to the digestive system and may include:
  • Nausea
  • Vomiting
  • Constipation
  • Diarrhea
  • Abdominal pain
• Difficulty Swallowing: Some people may experience difficulty swallowing the Renagel tablets.
• Allergic Reactions: While rare, allergic reactions can occur. Seek medical attention immediately if you experience symptoms such as:
  • Rash
  • Itching
  • Swelling (especially of the face, tongue, or throat)
  • Severe dizziness
  • Difficulty breathing
• Low Blood Calcium Levels (Hypocalcemia): Since Renagel does not contain calcium, there may be a risk of low blood calcium levels, especially in patients with low calcium diets or those not taking calcium supplements as prescribed. Symptoms may include muscle spasms or contractions, numbness or tingling in the fingers and toes, or seizures.
• Low Blood Phosphate Levels (Hypophosphatemia): In some cases, Renagel may cause low blood phosphate levels. This can lead to symptoms such as weakness, bone pain, and fractures.
• Other Potential Side Effects: Less common side effects may include inflammation of the stomach lining (gastritis) and inflammation of the peritoneum (peritonitis).

It’s important to note that this is not an exhaustive list of side effects, and individual reactions can vary. If you experience any unusual or severe side effects while taking Renagel, contact your healthcare provider promptly.

Patients should follow up with their healthcare providers regularly to monitor for side effects, assess the effectiveness of the medication, and make any necessary adjustments to the treatment plan. Additionally, if you have any concerns or questions about the side effects of Renagel, discuss them with your healthcare provider for personalized advice.

What should I know about storage and disposal of this medication?

Storage and Disposal of Renagel:

• Storage Instructions:
  • Store Renagel at room temperature, away from excessive heat and moisture.
  • Keep the medication in its original container with the lid tightly closed.
  • Do not transfer the tablets to another container unless instructed by your healthcare provider or pharmacist.
• Disposal:
  • Dispose of Renagel according to local regulations or guidelines.
  • Do not flush medications down the toilet unless specifically instructed to do so.
  • Consult with your pharmacist or local waste disposal facility about the proper way to dispose of unused or expired medications.

In case of emergency/overdose

• Emergency Medical Attention: In case of suspected overdose or emergency, call your local emergency services or poison control center immediately.
• Symptoms of Overdose: Overdose symptoms may include severe gastrointestinal symptoms such as vomiting, difficulty swallowing, or severe constipation. Seek prompt medical attention if you suspect an overdose.

What other information should I know?

• Regular Follow-up Appointments: Attend regular follow-up appointments with your healthcare provider to monitor your kidney function, phosphate levels, and the overall effectiveness of the treatment plan.
• Lab Tests: Your doctor may order regular blood tests to monitor phosphate levels and adjust the Renagel dosage as needed.
• Comprehensive Treatment Plan: Renagel is often part of a comprehensive treatment plan for managing chronic kidney disease. Follow your healthcare provider’s recommendations, including dietary guidelines and other prescribed medications.
• Inform Healthcare Providers: Inform all healthcare providers (including dentists and surgeons) about your use of Renagel before undergoing any procedures or surgeries.
• Adherence to Prescription: Take Renagel exactly as prescribed by your healthcare provider. Do not change the dosage or stop taking the medication without consulting your doctor.
• Communication with Healthcare Provider: If you experience any new or worsening symptoms, side effects, or have concerns about Renagel, promptly communicate with your healthcare provider.
• Phosphate Restriction: Follow any dietary restrictions recommended by your healthcare provider to manage phosphate intake effectively.
• Calcium Supplementation: If prescribed, take any calcium supplements as directed by your healthcare provider to maintain adequate calcium levels.

Always follow your healthcare provider’s instructions and seek professional medical advice for specific concerns or questions related to your use of Renagel. This information is not exhaustive, and individual circumstances may vary.