WARNING

While Remicade (infliximab) can be effective in treating various autoimmune conditions, it is essential to be aware of potential risks and side effects associated with its use. It’s important to note that not everyone will experience these risks, and the benefits of the medication should be weighed against the potential risks. Here’s a brief overview of some of the risks associated with Remicade:

• Infections: Remicade suppresses the immune system, which can increase the risk of infections. Serious infections, including bacterial, viral, and fungal infections, have been reported. Patients should be monitored for signs of infection, and it’s important to notify healthcare providers if any symptoms, such as fever or persistent cough, develop.
• Infusion Reactions: Some individuals may experience infusion reactions during or after receiving Remicade infusions. These reactions can include fever, chills, headache, and difficulty breathing. Healthcare providers typically monitor patients closely during infusions to address any immediate reactions.
• Allergic Reactions: Allergic reactions, including hypersensitivity and anaphylaxis, are possible with Remicade. Patients should be monitored for signs of allergic reactions, such as hives, itching, swelling, and difficulty breathing.
• Malignancies: There may be an increased risk of certain types of cancers, such as lymphoma, associated with the use of TNF inhibitors like Remicade. The overall risk is generally considered low, but it’s important to discuss any concerns with your healthcare provider.
• Heart Failure: Remicade has been associated with an increased risk of heart failure. Patients with pre-existing heart conditions should be closely monitored, and the medication should be used with caution in this population.
• Hepatitis B Reactivation: Remicade may lead to the reactivation of hepatitis B in individuals who are carriers of the virus. Screening for hepatitis B before starting treatment is recommended.
• Neurological Reactions: Rare neurological events, including multiple sclerosis-like symptoms, seizures, and peripheral neuropathy, have been reported with Remicade use.

It’s crucial for patients to discuss their medical history and any concerns with their healthcare provider before starting Remicade treatment. Regular monitoring and communication with healthcare professionals are essential to manage potential risks and ensure the safe and effective use of the medication. If any unexpected or severe side effects occur, prompt medical attention should be sought.

Why is this medication prescribed?

Remicade (infliximab) is a prescription medication primarily used to treat certain autoimmune conditions, particularly those related to inflammation. It belongs to a class of drugs known as tumor necrosis factor (TNF) inhibitors. Remicade is commonly prescribed for the following conditions:

• Rheumatoid Arthritis (RA): Remicade is used to treat moderate to severe rheumatoid arthritis, helping to reduce joint inflammation and damage.
• Crohn’s Disease: It is prescribed for adults and children with moderately to severely active Crohn’s disease, an inflammatory bowel disease affecting the digestive tract.
• Ulcerative Colitis: Remicade is used for the treatment of moderately to severely active ulcerative colitis, another inflammatory bowel disease that primarily affects the colon and rectum.
• Ankylosing Spondylitis: This medication is used to manage the symptoms of ankylosing spondylitis, a type of arthritis that primarily affects the spine.
• Psoriatic Arthritis: Remicade is prescribed for treating psoriatic arthritis, an inflammatory arthritis associated with psoriasis.
• Plaque Psoriasis: In some cases, Remicade may be used to treat moderate to severe plaque psoriasis, a skin condition characterized by red, itchy, and scaly patches.

How should this medicine be used?

Remicade (infliximab) is typically administered as an intravenous (IV) infusion by healthcare professionals in a medical setting. Here are general guidelines on how Remicade is used:

• Dosage and Frequency: The dosage and frequency of Remicade infusions vary depending on the condition being treated and the individual patient. Your healthcare provider will determine the appropriate dosage and schedule for your specific situation.
• Administration: Remicade is administered through an IV line, usually in a vein in your arm. The infusion is typically given over a period of several hours. Healthcare professionals, such as nurses or doctors, will administer the infusion in a medical facility, such as a clinic or hospital.
• Preparation: Before the infusion, the healthcare team will assess your overall health and may perform certain tests to monitor for any potential issues. The medication is prepared by diluting the concentrated Remicade solution in an appropriate intravenous fluid.
• Monitoring: During the infusion, you will be monitored closely for any adverse reactions or side effects. Vital signs, such as blood pressure and heart rate, may be checked regularly.
• Duration of Treatment: The duration of Remicade treatment varies, and your healthcare provider will determine how long you should continue the therapy based on your response and the specific condition being treated.
• Follow-up Appointments: After each infusion, your healthcare provider may schedule follow-up appointments to monitor your progress, assess the effectiveness of the medication, and address any concerns or side effects.

It’s essential to adhere to the prescribed dosage and infusion schedule recommended by your healthcare provider. Do not change the dosage or frequency without consulting your healthcare professional.

As with any medication, it’s crucial to communicate openly with your healthcare provider about your medical history, any potential side effects, and any other medications or supplements you may be taking. This information helps ensure safe and effective treatment with Remicade. If you have any questions or concerns about the administration of Remicade, be sure to discuss them with your healthcare provider.

Other uses for this medicine

Remicade is primarily used to treat autoimmune conditions characterized by inflammation. Common indications include:

• Rheumatoid arthritis
• Crohn’s disease
• Ulcerative colitis
• Ankylosing spondylitis
• Psoriatic arthritis
• Plaque psoriasis

In some cases, Remicade may be considered for off-label use or in investigational settings for conditions like hidradenitis suppurativa and certain eye conditions.

What special precautions should I follow?

As for special precautions when using Remicade, it’s crucial to follow your healthcare provider’s guidance and inform them about your complete medical history. Here are some general precautions:

• Infections: Remicade can increase the risk of infections. Before starting treatment, your healthcare provider may test for tuberculosis and other infections. It’s important to inform your healthcare provider if you have any signs of infection, and you should avoid receiving live vaccines while on Remicade.
• Allergic Reactions: Individuals with known hypersensitivity or allergic reactions to Remicade or its components should not use the medication.
• Heart Failure: Remicade has been associated with an increased risk of heart failure. It should be used with caution in individuals with pre-existing heart conditions.
• Hepatitis B: Before starting Remicade, your healthcare provider may test for hepatitis B, as the medication may lead to the reactivation of hepatitis B in carriers of the virus.
• Neurological Disorders: Remicade may be associated with rare neurological events. If you have a history of neurological disorders, seizures, or multiple sclerosis, inform your healthcare provider.
• Pregnancy and Breastfeeding: The safety of Remicade during pregnancy and breastfeeding is not well-established. Discuss the potential risks and benefits with your healthcare provider if you are pregnant or planning to become pregnant, or if you are breastfeeding.
• Monitoring: Regular monitoring is essential to assess the medication’s effectiveness and manage any potential side effects. This may include routine blood tests and other assessments.

Always take Remicade as prescribed by your healthcare provider, and do not make any changes to your treatment plan without consulting them. If you experience any unusual or severe side effects, contact your healthcare provider promptly. Open communication with your healthcare team is key to managing your condition effectively while minimizing risks.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Remicade. However, maintaining a healthy and balanced diet is generally advisable for overall well-being. If you have specific dietary concerns or restrictions, discuss them with your healthcare provider or a registered dietitian.

What should I do if I forget a dose?

Remicade is typically administered in a healthcare setting by healthcare professionals, so the likelihood of an individual forgetting a dose is minimal. However, if there are any concerns or changes to the treatment plan, it’s crucial to communicate with your healthcare provider promptly. They can provide guidance on the next steps, whether it involves rescheduling an appointment or adjusting the treatment plan.

What side effects can this medication cause?

Remicade (infliximab) may cause side effects, and it’s important to note that not everyone will experience these effects. Common side effects, as well as more serious and rare complications, can occur. It’s essential to discuss any concerns or potential side effects with your healthcare provider. Here is a list of potential side effects associated with Remicade:

Common Side Effects:

• Infusion Reactions: Many people experience mild to moderate reactions during or after the infusion, such as fever, chills, headache, and skin reactions at the infusion site.
• Respiratory Infections: Cough, sinus infections, and respiratory tract infections may occur.
• Gastrointestinal Issues: Nausea, abdominal pain, and diarrhea are possible side effects.
• Upper Respiratory Tract Infections: Symptoms like a runny nose or sore throat may occur.

Serious Side Effects:

• Infections: Remicade can increase the risk of serious infections, including bacterial, viral, and fungal infections. Symptoms may include fever, fatigue, cough, or flu-like symptoms.
• Hepatitis B Reactivation: Reactivation of hepatitis B in individuals who are carriers of the virus is possible.
• Heart Failure: There may be an increased risk of heart failure, particularly in individuals with pre-existing heart conditions.
• Neurological Disorders: Rare neurological events, including multiple sclerosis-like symptoms, seizures, and peripheral neuropathy, have been reported.
• Allergic Reactions: Hypersensitivity reactions, including anaphylaxis, are possible. Symptoms may include hives, itching, swelling, and difficulty breathing.

Other Considerations:

• Malignancies: There may be a slightly increased risk of certain types of cancers, such as lymphoma.
• Blood Disorders: Rare cases of blood disorders, including leukopenia and thrombocytopenia, have been reported.

It’s important to report any unusual or severe symptoms to your healthcare provider promptly. Keep in mind that the benefits of Remicade in managing autoimmune conditions often outweigh the potential risks for many individuals. Your healthcare provider will carefully monitor you during treatment to manage and mitigate potential side effects.

This list is not exhaustive, and individual responses to Remicade can vary. Always consult with your healthcare provider for personalized information based on your medical history and specific circumstances.

What should I know about storage and disposal of this medication?

Storage and Disposal of Remicade:

• Storage:
  • Remicade is typically stored by healthcare professionals in a medical setting, and the medication is prepared just before administration.
  • If Remicade is prescribed for home use (rare), your healthcare provider will provide specific instructions on storage. Generally, it may be stored in a refrigerator, and you should follow any storage guidelines provided by the manufacturer or your healthcare provider.
• Disposal:
  • Remicade is administered in a medical setting by healthcare professionals, and any unused or expired medication will be handled by the healthcare facility. If you have concerns about the disposal of medical waste, consult your healthcare provider or local regulations for guidance.
  • Do not attempt to dispose of Remicade or any medical waste on your own without proper guidance.

In case of emergency/overdose

In the case of an emergency or suspected overdose, contact emergency services (such as 911 in the United States) immediately. It’s crucial to seek professional medical help if you believe you have received too much Remicade or are experiencing severe adverse reactions.

What other information should I know?

• Follow-up Appointments: Attend all scheduled follow-up appointments with your healthcare provider. Regular monitoring is important to assess the effectiveness of Remicade and manage any potential side effects.
• Communication with Healthcare Provider: Inform your healthcare provider about any changes in your health, including new symptoms or concerns, during the course of Remicade treatment.
• Medication Interactions: Inform your healthcare provider about all medications, including over-the-counter drugs, supplements, and herbal products, that you are currently taking. Some medications may interact with Remicade.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss this with your healthcare provider. The safety of Remicade during pregnancy and breastfeeding is not well-established.
• Travel Considerations: If you plan to travel, ensure that you have an adequate supply of Remicade and discuss any travel plans with your healthcare provider. If you are receiving infusions at a medical facility, arrangements may need to be made for treatment while away from home.
• Patient Assistance Programs: If you have concerns about the cost of Remicade, inquire about patient assistance programs or financial assistance options that may be available.

Always follow your healthcare provider’s instructions regarding the use of Remicade, and do not make any changes to your treatment plan without consulting them. If you have specific questions or concerns about Remicade, your healthcare provider is the best source of information based on your individual health circumstances.