Why is this medication prescribed?

Questran is a brand name for cholestyramine, a medication used to lower high levels of cholesterol in the blood. It belongs to a class of drugs known as bile acid sequestrants. Cholestyramine works by binding to bile acids in the intestine, preventing them from being reabsorbed into the bloodstream. This leads to an increased excretion of bile acids in the feces, and the liver responds by using more cholesterol to produce new bile acids. As a result, the overall cholesterol levels in the blood decrease.

The main causes for prescribing Questran are listed below:

• High Cholesterol Levels: Questran is often prescribed to individuals with high levels of LDL (low-density lipoprotein) cholesterol, also known as “bad” cholesterol.
• Pruritus (Itching) Due to Biliary Obstruction: In certain cases of liver disease, Questran may be used to alleviate itching associated with the buildup of bile salts in the bloodstream.

How should this medicine be used?

Here are some general guidelines:

• Formulation: Questran is available as a powder that must be mixed with a liquid before consumption.
• Dosage: The dosage is typically determined by a healthcare professional based on the individual’s condition and response to treatment.
• Administration: It is usually taken one to six times per day with meals. The powder should be thoroughly mixed with water, non-carbonated beverages, or a highly liquid soup.
• Consistency: It’s important to take Questran exactly as prescribed by the healthcare provider. The consistency of taking the medication is crucial for its effectiveness.
• Other Medications: Questran may interfere with the absorption of other medications, so it’s important to take other drugs at least 1 hour before or 4 to 6 hours after taking Questran.
• Monitoring: Regular monitoring of cholesterol levels and liver function may be necessary during treatment with Questran.

Always follow the instructions provided by your healthcare provider and the specific guidance on the medication’s label. If you have any concerns or experience side effects, it’s crucial to communicate with your healthcare professional promptly. Do not alter the dosage or stop taking Questran without consulting your doctor.

Other uses for this medicine

While the primary use of Questran is to lower cholesterol, it may also be used in the treatment of certain other conditions:

• Bile Acid Diarrhea (Off-Label): Questran is sometimes used off-label to treat bile acid diarrhea. It binds to bile acids in the intestine, reducing their circulation and helping to alleviate diarrhea.
• Relief of Itching in Liver Disease (Off-Label): Cholestyramine may be used off-label to relieve itching associated with liver diseases.

What special precautions should I follow?

Regarding special precautions for Questran, it’s crucial to follow your healthcare provider’s instructions and be aware of the following:

• Allergies: Inform your healthcare provider if you are allergic to cholestyramine or any other ingredients in Questran.
• Digestive Disorders: If you have certain digestive disorders, such as a history of bowel obstruction or a tendency toward constipation, use Questran with caution and under the supervision of a healthcare professional.
• Other Medications: Cholestyramine may interfere with the absorption of other medications. Inform your doctor about all the medications, including over-the-counter drugs and supplements, that you are taking.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. The safety of cholestyramine during pregnancy and breastfeeding is not well-established, and your doctor will weigh the potential benefits and risks.
• Monitoring: Regular monitoring of cholesterol levels and liver function may be necessary during treatment with Questran.
• Gastrointestinal Issues: Questran may cause gastrointestinal side effects such as constipation, bloating, or flatulence. If these symptoms are severe or persistent, consult your healthcare provider.
• Vitamin Deficiency: Cholestyramine can interfere with the absorption of fat-soluble vitamins (A, D, E, K). Your healthcare provider may recommend vitamin supplements.

Always follow your healthcare provider’s instructions and guidance when taking Questran. If you experience any unusual or severe side effects, contact your healthcare professional promptly. It’s essential to have open communication with your doctor to ensure the medication is safe and effective for your specific health condition.

What special dietary instructions should I follow?

• Timing of Questran Administration: Take Questran either 1 hour before or 4-6 hours after other medications to avoid interference with their absorption.
• Dietary Fat Intake: While taking Questran, follow a low-fat diet. High-fat meals may reduce the effectiveness of the medication.

What should I do if I forget a dose?

• Take the Missed Dose As Soon As Possible: If you forget a dose, take it as soon as you remember. However, if it’s almost time for your next dose, skip the missed dose and resume your regular dosing schedule.
• Do Not Double Dose: Do not take a double dose to make up for a missed one. Taking more than the prescribed amount can lead to side effects and complications.
• Consult Your Healthcare Provider: If you’re unsure about what to do or if you have questions about missed doses, consult your healthcare provider or pharmacist.

What side effects can this medication cause?

Cholestyramine, the active ingredient in Questran, can cause side effects. It’s important to note that not everyone will experience these side effects, and some individuals may experience side effects that are not listed. Common side effects may include:

• Gastrointestinal Distress: Questran can cause gastrointestinal side effects, including constipation, bloating, flatulence, and abdominal discomfort.
• Nausea and Vomiting: Some individuals may experience nausea or vomiting, especially when they first start taking Questran.
• Difficulty Swallowing: Cholestyramine is a powder that needs to be mixed with a liquid before ingestion. Some people may find it difficult to swallow the mixture.
• Decreased Absorption of Nutrients: Because Questran binds to bile acids in the intestine, it can interfere with the absorption of fat-soluble vitamins (A, D, E, K) and other nutrients. Your healthcare provider may recommend supplements.
• Potential for Bowel Obstruction: Individuals with a history of bowel obstruction or those prone to constipation should use Questran with caution, as it may exacerbate these conditions.
• Allergic Reactions: While rare, allergic reactions to cholestyramine are possible. Seek medical attention if you experience symptoms such as rash, itching, swelling, severe dizziness, or difficulty breathing.
• Interference with Other Medications: Cholestyramine may interfere with the absorption of other medications. It’s important to take other medications at least 1 hour before or 4 to 6 hours after taking Questran.
• Liver Function: Rarely, there have been reports of liver function abnormalities in individuals taking Questran. Regular monitoring of liver function may be recommended.

It’s crucial to report any side effects to your healthcare provider. If you experience severe or persistent side effects, do not stop taking the medication without consulting your doctor. They can provide guidance on managing side effects or may adjust your treatment plan if necessary.

This list is not exhaustive, and individual responses to medications can vary. Always consult with your healthcare provider for personalized advice and information tailored to your specific health situation.

What should I know about storage and disposal of this medication?

Storage and Disposal of Questran:

• Storage:
  • Store Questran at room temperature, away from moisture and heat.
  • Keep the medication in its original container with the lid tightly closed.
  • Do not store Questran in the bathroom.
• Disposal:
  • Follow any specific disposal instructions provided by your healthcare provider or pharmacist.
  • Dispose of expired or unused medications in accordance with local regulations. Do not flush them down the toilet unless instructed to do so.

In case of emergency/overdose

• Seek Immediate Medical Attention: If you suspect an overdose or experience severe symptoms, seek emergency medical attention or call your local poison control center.
• Symptoms of Overdose: Overdose symptoms may include severe constipation, stomach pain, or severe bloating.

What other information should I know?

• Follow Healthcare Provider’s Instructions: Take Questran exactly as prescribed by your healthcare provider. Do not alter the dosage without consulting your doctor.
• Regular Monitoring: Your healthcare provider may recommend regular monitoring of cholesterol levels and liver function during treatment with Questran.
• Interaction with Other Medications: Inform your healthcare provider about all the medications, including over-the-counter drugs and supplements, that you are taking. Cholestyramine may interact with the absorption of other medications.
• Diet and Lifestyle Changes: Questran is often part of a comprehensive approach to managing cholesterol levels. Follow any dietary or lifestyle recommendations provided by your healthcare provider.
• Adherence to Medication: Take Questran consistently as prescribed. Consistency is important for the medication to be effective.
• Communication with Healthcare Provider: Report any side effects or concerns to your healthcare provider promptly.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using Questran with your healthcare provider.
• Follow-Up Appointments: Attend follow-up appointments with your healthcare provider to monitor your response to treatment and adjust your treatment plan if needed.

Always consult with your healthcare provider or pharmacist for specific guidance tailored to your individual health needs. If you have any questions or concerns about Questran, don’t hesitate to seek clarification from your healthcare professional.