WARNING

Acetaminophen and codeine are commonly combined in prescription medications to treat pain, typically in the form of a combination tablet or liquid. However, it’s important to be aware of the potential risks associated with this combination:

• Addiction and Dependence: Codeine is an opioid analgesic that can be habit-forming and lead to physical and psychological dependence. Prolonged use or misuse may result in addiction.
• Respiratory Depression: Opioids, including codeine, can cause respiratory depression, slowing down breathing. This risk is particularly high at higher doses or in individuals with respiratory conditions.
• Liver Damage: Acetaminophen, when taken in excess, can cause severe liver damage. Combining it with other medications that contain acetaminophen or consuming alcohol while taking it increases the risk of liver injury.
• Allergic Reactions: Some individuals may be allergic to acetaminophen or codeine, leading to potentially serious allergic reactions. Symptoms may include rash, itching, swelling, severe dizziness, or difficulty breathing.
• Gastrointestinal Effects: Opioids can cause constipation, which may become severe with prolonged use. Acetaminophen, in high doses, can also cause stomach upset or gastrointestinal bleeding.
• Central Nervous System Effects: Both acetaminophen and codeine can affect the central nervous system, leading to drowsiness, dizziness, and impaired coordination. This can interfere with the ability to perform tasks that require alertness.
• Overdose: Taking more than the prescribed dose of a medication containing acetaminophen and codeine can lead to overdose, which can be fatal. Symptoms of overdose may include difficulty breathing, extreme drowsiness, confusion, and unconsciousness.
• Interaction with Other Medications: Acetaminophen and codeine may interact with other medications, including certain antidepressants, sedatives, and antihistamines, potentially leading to harmful effects.

It is crucial to take medications containing acetaminophen and codeine only as prescribed by a healthcare professional. Patients should inform their doctors about any existing health conditions, medications, or substances they are currently using to minimize the risk of adverse effects and interactions. Additionally, regular communication with healthcare providers can help in monitoring and adjusting the treatment plan as needed.

Why is this medication prescribed?

Acetaminophen and codeine are often prescribed together to manage pain. Here’s an overview of their uses and general guidelines for their use:

• Pain Relief: Codeine is an opioid analgesic that can provide pain relief. Acetaminophen is a non-opioid pain reliever and fever reducer. When combined, they can offer a more effective pain-relieving effect than either drug alone.
• Moderate to Severe Pain: This combination is often used for the management of moderate to severe pain, such as pain following surgery, dental procedures, or injury.
• Cough Suppression: Codeine also has antitussive (cough-suppressant) properties, and the combination may be used to alleviate cough symptoms.

How should this medicine be used?

Here are general guidelines on how Acetaminophen and codeine should be used:

• Dosage: The dosage will be determined by your healthcare provider based on your individual needs, the severity of your pain, and other factors. It’s crucial to follow the prescribed dosage and not exceed it.
• Administration: Typically, acetaminophen and codeine are taken orally in the form of tablets or liquid. The medication may be taken with or without food, but taking it with food or milk can help reduce the likelihood of stomach upset.
• Frequency: The medication is usually taken every 4 to 6 hours as needed for pain relief. It’s important not to take more than the prescribed dose or take it more frequently than recommended.
• Avoid Alcohol: It’s advisable to avoid alcohol while taking acetaminophen and codeine, as both substances can cause central nervous system depression, and the combination may increase the risk of side effects.
• Short-Term Use: Acetaminophen and codeine are typically prescribed for short-term use due to the potential for dependence and the risks associated with long-term opioid use.
• Regular Monitoring: Your healthcare provider may monitor your response to the medication and adjust the dosage as needed. If your pain is not well controlled or if you experience side effects, it’s important to communicate with your healthcare provider.

It’s crucial to use acetaminophen and codeine only under the supervision and guidance of a healthcare professional. Misuse or overuse of medications containing opioids can lead to serious health consequences, including addiction and overdose. If you have any questions or concerns about your medication, it’s important to discuss them with your healthcare provider.

Other uses for this medicine

• Cough Relief: The codeine component of the medication has antitussive (cough-suppressant) properties, and the combination may be used to alleviate cough symptoms.
• Fever Reduction: Acetaminophen is effective in reducing fever, and the combination may be prescribed for this purpose.

What special precautions should I follow?

Here are some general precautions:

• Liver Function: Acetaminophen is metabolized by the liver, and excessive use or overdose can lead to liver damage. It’s crucial to adhere to the recommended dosage and avoid combining the medication with other products containing acetaminophen.
• Kidney Function: Codeine is excreted by the kidneys, so individuals with impaired kidney function should use this medication with caution. Adjustments to the dosage may be necessary.
• Respiratory Conditions: Codeine is an opioid and can suppress respiratory function, especially at higher doses. Caution is advised in individuals with respiratory conditions such as asthma or chronic obstructive pulmonary disease (COPD).
• Pregnancy and Breastfeeding: Acetaminophen is generally considered safe during pregnancy, but the use of opioids, including codeine, requires careful consideration. High doses of codeine during pregnancy may lead to withdrawal symptoms in the newborn. If you are pregnant or breastfeeding, consult with your healthcare provider before using this medication.
• Interactions with Other Medications: Acetaminophen and codeine may interact with other medications, including certain antidepressants, antihistamines, and sedatives. Inform your healthcare provider about all the medications you are taking.
• Avoid Alcohol and Sedatives: Combining acetaminophen and codeine with alcohol or other central nervous system depressants can increase the risk of respiratory depression and other side effects.
• Dependency and Withdrawal: Codeine is an opioid and has the potential for dependence. Long-term use should be monitored, and withdrawal symptoms may occur if the medication is abruptly discontinued.
• Allergic Reactions: If you have a known allergy to acetaminophen, codeine, or related medications, inform your healthcare provider. Serious allergic reactions are rare but can occur.

Always follow your healthcare provider’s instructions and notify them of any existing medical conditions or medications you are taking. If you experience any adverse effects or have concerns about the medication, contact your healthcare provider promptly. Do not self-adjust the dosage or stop taking the medication without consulting your healthcare professional.

What special dietary instructions should I follow?

Special Dietary Instructions for Acetaminophen and Codeine:

• Food Intake: Acetaminophen and codeine can be taken with or without food. However, if the medication causes stomach upset, taking it with food may help alleviate this side effect.
• Fluid Intake: Stay adequately hydrated while taking acetaminophen and codeine, especially if you experience constipation as a side effect.

What should I do if I forget a dose?

• Take It as Soon as Possible: If you miss a dose, take it as soon as you remember. However, if it is close to the time of your next scheduled dose, skip the missed dose and resume your regular dosing schedule.
• Do Not Double Up: Do not double up on doses to make up for a missed one. Taking more than the prescribed amount can increase the risk of adverse effects.
• Consult Your Healthcare Provider: If you have questions about missed doses or are unsure about what to do, contact your healthcare provider for guidance.

What side effects can this medication cause?

Acetaminophen and codeine are commonly combined in medications to provide pain relief. However, like any medications, they can cause side effects. It’s important to use them under the guidance of a healthcare professional and to follow the prescribed dosage. Here are some potential side effects associated with acetaminophen and codeine:

Common Side Effects:

• Drowsiness: Codeine is a central nervous system depressant and can cause drowsiness.
• Dizziness: Some people may experience dizziness, especially when standing up quickly.
• Nausea and Vomiting: Both acetaminophen and codeine can cause nausea and vomiting.
• Constipation: Codeine is known to cause constipation in some individuals.
• Lightheadedness: Feeling lightheaded or faint is a possible side effect.

Serious Side Effects (Seek Medical Attention):

• Allergic Reactions: Serious allergic reactions, though rare, can occur. Symptoms may include rash, itching, swelling, severe dizziness, or difficulty breathing.
• Liver Problems: Acetaminophen can cause liver damage, especially when taken in high doses or over a prolonged period. Seek medical attention if you experience symptoms like dark urine, persistent nausea or vomiting, or yellowing of the eyes/skin (jaundice).
• Respiratory Depression: Codeine, being an opioid, can suppress breathing, especially in higher doses. This is more common in sensitive individuals or when combined with other respiratory depressants.

Long-Term Risks:

• Dependency and Addiction: Codeine is an opioid and has the potential for abuse and addiction.
• Tolerance: Over time, the body may develop tolerance to the analgesic effects, requiring higher doses for the same pain relief.

It’s crucial to use acetaminophen and codeine exactly as prescribed by a healthcare professional. Combining these medications with alcohol or other drugs that depress the central nervous system can increase the risk of adverse effects, including respiratory depression.

If you experience any unusual or severe side effects, it’s important to contact your healthcare provider promptly. They can help determine the best course of action and whether any adjustments to your treatment plan are necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal:

• Storage: Store acetaminophen and codeine at room temperature, away from moisture and light. Follow specific storage instructions provided by the pharmacist or healthcare provider.
• Keep Away from Children: Keep the medication out of reach of children and pets to prevent accidental ingestion.
• Secure Container: Store the medication in a secure container to avoid misuse or unauthorized access.
• Disposal: Dispose of unused or expired medication properly. Follow local regulations for drug disposal, and check if there are take-back programs or designated drop-off locations in your area.

In case of emergency/overdose

• Seek Immediate Medical Attention: If you suspect an overdose of acetaminophen and codeine, seek emergency medical attention immediately. Overdose symptoms may include difficulty breathing, extreme drowsiness, confusion, nausea, vomiting, or unconsciousness.
• Contact Poison Control: If available, contact your local poison control center (in the United States, you can call 1-800-222-1222) for guidance on what to do in case of an overdose.
• Provide Information: Be prepared to provide information about the amount of medication ingested, the time of ingestion, and any symptoms the person is experiencing.

What other information should I know?

• Follow Prescription Instructions: Take acetaminophen and codeine exactly as prescribed by your healthcare provider. Do not adjust the dosage without consulting them.
• Regular Monitoring: Regularly monitor your response to the medication and report any side effects or concerns to your healthcare provider.
• Avoid Alcohol: Refrain from consuming alcohol while taking acetaminophen and codeine, as it can increase the risk of side effects and liver damage.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care about your use of acetaminophen and codeine, including dentists and emergency room personnel.
• Potential Interactions: Be aware of potential drug interactions. Inform your healthcare provider about all medications, including over-the-counter drugs and supplements, that you are taking.
• Pregnancy and Breastfeeding: If you are pregnant, planning to become pregnant, or breastfeeding, discuss the risks and benefits of using acetaminophen and codeine with your healthcare provider.
• Avoid Driving and Operating Machinery: Exercise caution when driving or operating machinery, especially until you understand how the medication affects you.
• Medical Alert Bracelet: If you have a known allergy to codeine or other opioids, consider wearing a medical alert bracelet to inform healthcare providers in case of an emergency.

Always consult with your healthcare provider or pharmacist if you have specific questions about the storage, disposal, or use of acetaminophen and codeine. Following their guidance will help ensure the safe and effective use of the medication.