WARNING

Promethegan is a brand name for promethazine, which is an antihistamine used to treat various conditions such as allergies, nausea, and motion sickness. Promethegan suppositories are a form of this medication that is inserted into the rectum.

As with any medication, there are potential risks and side effects associated with Promethegan suppositories. It’s important to note that individual responses to medication can vary, and not everyone will experience these side effects. Some potential risks and side effects of Promethegan suppositories include:

• Drowsiness: Promethegan can cause drowsiness, and this effect may be intensified when administered in suppository form.
• Impaired alertness and coordination: The medication can impair mental alertness and physical coordination, making activities such as driving or operating heavy machinery risky.
• Dry mouth: Promethegan may cause dryness of the mouth.
• Constipation: The use of suppositories, in general, can lead to constipation.
• Blurred vision: Promethegan can cause blurred vision or other visual disturbances.
• Urinary retention: Some individuals may experience difficulty emptying their bladder while using Promethegan.
• Low blood pressure: Promethegan can cause a drop in blood pressure, especially when standing up from a sitting or lying position.
• Allergic reactions: While rare, allergic reactions to promethazine can occur. Symptoms may include rash, itching, swelling, severe dizziness, or difficulty breathing.
• Extrapyramidal symptoms: In rare cases, promethazine may cause extrapyramidal symptoms such as muscle spasms, restlessness, and tremors.

It’s important to use Promethegan suppositories under the guidance and prescription of a healthcare professional. Be sure to inform your healthcare provider about any pre-existing medical conditions, allergies, or other medications you may be taking to minimize the risk of adverse reactions. If you experience severe or persistent side effects, seek medical attention promptly. This information is not exhaustive, and it’s crucial to consult with a healthcare professional for personalized advice based on your specific health situation.

Why is this medication prescribed?

Promethegan suppositories contain the active ingredient promethazine, which is an antihistamine with various therapeutic uses. The medication is prescribed for several reasons:

• Nausea and Vomiting: Promethegan is often prescribed to alleviate nausea and vomiting associated with surgery, chemotherapy, or certain medical conditions.
• Motion Sickness: It can be used to prevent and treat motion sickness, including during travel.
• Allergic Reactions: Promethegan may be prescribed to manage allergic reactions, including allergic rhinitis (hay fever) and allergic conjunctivitis.
• Sedation: Due to its sedative effects, Promethegan may be used as a pre-anesthetic to relax patients before surgery.
• Insomnia: In some cases, Promethegan may be used to help induce sleep in individuals with insomnia.

How should this medicine be used?

The use of Promethegan suppositories should be strictly in accordance with the prescribed dosage and under the supervision of a healthcare professional. Here are general guidelines on how Promethegan suppositories are typically used:

• Dosage: The dosage will be determined by the healthcare provider based on the patient’s age, medical condition, and the specific purpose of the medication.
• Administration: The suppository is inserted into the rectum. It’s essential to follow the instructions provided by the healthcare provider or the medication’s packaging.
• Frequency: The frequency of administration will depend on the specific condition being treated. Follow the prescribed schedule provided by your healthcare provider.
• Hydration: It’s important to stay well-hydrated while using Promethegan, especially if the medication causes dry mouth.
• Avoid Alcohol: It is advisable to avoid alcohol while taking Promethegan, as it can enhance the sedative effects of the medication.
• Caution with Driving and Machinery: Due to its sedative properties, Promethegan can impair alertness and coordination. Avoid activities that require mental focus or physical coordination, such as driving or operating machinery, until you know how the medication affects you.

Always consult with your healthcare provider for personalized instructions and to discuss any potential interactions with other medications you may be taking. If you experience any unusual or severe side effects, contact your healthcare provider promptly. This information is a general overview, and specific instructions may vary based on individual circumstances.

Other uses for this medicine

In addition to treating allergic reactions, nausea, and motion sickness, Promethegan may be used for other conditions, including:

• Insomnia: It may be used in certain cases to aid sleep.
• Sedation: Promethegan has sedative effects and may be used in preoperative and postoperative situations.
• Adjunct to analgesics: It can enhance the pain-relieving effects of certain pain medications.

What special precautions should I follow?

As for special precautions when using Promethegan suppositories, consider the following:

• Medical History: Inform your healthcare provider about your complete medical history, including any allergies, respiratory conditions, liver or kidney problems, and a history of seizures.
• Pregnancy and Breastfeeding: Inform your healthcare provider if you are pregnant or breastfeeding, as the use of Promethegan during pregnancy or breastfeeding should be carefully evaluated due to potential risks.
• Children and Older Adults: Special care is needed when using Promethegan in children or older adults, as they may be more sensitive to its effects. Dosage adjustments may be necessary.
• Driving and Operating Machinery: Avoid activities requiring mental alertness and coordination, such as driving or operating machinery, until you are aware of how Promethegan affects you, as it may cause drowsiness.
• Alcohol and Other Sedatives: Avoid consuming alcohol and other medications with sedative effects while using Promethegan, as it can enhance the sedation.
• Avoid Sun Exposure: Promethegan may increase sensitivity to sunlight. Limit sun exposure and use sunscreen or protective clothing to prevent sunburn.
• Constipation: Adequate fluid intake is essential to prevent constipation, which can be a side effect of Promethegan.

Always follow the prescribed dosage and administration instructions provided by your healthcare provider. If you have any concerns or experience adverse effects, contact your healthcare professional promptly. This information is a general guideline, and individual circumstances may require specific precautions.

What special dietary instructions should I follow?

There are no specific dietary restrictions associated with Promethegan suppositories. However, maintaining a well-balanced diet and staying hydrated can contribute to overall health and may help manage potential side effects.

What should I do if I forget a dose?

• Missed Dose: If you forget to use a Promethegan suppository, use it as soon as you remember.
• Close to the Next Dose: If it is almost time for your next dose, skip the missed dose and resume your regular dosing schedule.
• Double Dose: Do not double up on doses to make up for a missed one. Taking extra doses can increase the risk of side effects.

What side effects can this medication cause?

Promethegan suppositories, containing the antihistamine promethazine, can cause various side effects. It’s important to note that not everyone will experience these side effects, and their severity can vary. If you are prescribed Promethegan and notice any unusual or persistent side effects, it’s crucial to contact your healthcare provider. Common side effects of Promethegan suppositories may include:

• Drowsiness: Promethazine has sedative properties and can cause drowsiness, impairing mental alertness and coordination.
• Dry Mouth: Promethegan may lead to dryness of the mouth.
• Blurred Vision: Some individuals may experience blurred vision or other visual disturbances.
• Constipation: The use of suppositories, in general, can lead to constipation.
• Urinary Retention: Difficulty in emptying the bladder may occur in some individuals.
• Low Blood Pressure: Promethegan can cause a drop in blood pressure, especially upon standing up.
• Allergic Reactions: While rare, allergic reactions to promethazine can occur. Symptoms may include rash, itching, swelling, severe dizziness, or difficulty breathing.
• Extrapyramidal Symptoms: In rare cases, promethazine may cause extrapyramidal symptoms such as muscle spasms, restlessness, and tremors.
• Nausea and Vomiting: Paradoxically, some individuals may experience nausea and vomiting as a side effect.
• Increased Sensitivity to Sunlight: Promethegan may increase sensitivity to sunlight, so it’s important to take precautions to avoid sunburn.

It’s important to use Promethegan under the guidance of a healthcare professional and to report any side effects promptly. The above list is not exhaustive, and other side effects may occur. Additionally, individual responses to medication can vary, so what may be a common side effect for one person may not be experienced by another.

If you experience severe or persistent side effects, seek medical attention promptly. Do not discontinue or change the dosage of Promethegan without consulting your healthcare provider. They can provide guidance on managing side effects or adjust the treatment plan if necessary.

What should I know about storage and disposal of this medication?

Storage and Disposal of Promethegan Suppository:

• Storage:
  • Keep Promethegan suppositories at room temperature, away from excessive heat and moisture.
  • Store the medication in its original packaging or container, and keep it out of reach of children.
• Disposal:
  • Dispose of unused or expired medications according to local guidelines and regulations.
  • Do not flush medications down the toilet unless instructed to do so. Instead, use a medication take-back program or follow specific disposal instructions provided by your healthcare provider or pharmacy.

In case of emergency/overdose

• Emergency Assistance: In case of an emergency or suspected overdose, call emergency services (such as 911 in the United States) immediately.
• Overdose Symptoms: Symptoms of a Promethegan overdose may include severe drowsiness, unconsciousness, hallucinations, seizures, and difficulty breathing.
• Seek Medical Attention: If you suspect an overdose or experience severe side effects, seek medical attention promptly.

What other information should I know?

• Medical and Laboratory Tests: Inform healthcare providers about your use of Promethegan before undergoing medical or laboratory tests, as it may interfere with the results.
• Interactions: Notify your healthcare provider of all medications, supplements, and herbal products you are taking to avoid potential drug interactions.
• Avoid Alcohol: Avoid alcohol while taking Promethegan, as it can enhance the sedative effects of the medication.
• Inform Healthcare Providers: Inform all healthcare providers involved in your care (including dentists and pharmacists) about your use of Promethegan.
• Avoid Driving and Machinery: Due to its sedative effects, avoid activities requiring mental alertness and coordination until you know how Promethegan affects you.
• Sun Sensitivity: Promethegan may increase sensitivity to sunlight. Take precautions such as using sunscreen and wearing protective clothing.
• Pregnancy and Breastfeeding: Consult with your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding, as the use of Promethegan during pregnancy and breastfeeding should be carefully evaluated.
• Follow Instructions: Follow your healthcare provider’s instructions regarding dosage, administration, and any additional recommendations.

Always keep the lines of communication open with your healthcare provider and follow their guidance for the safe and effective use of Promethegan. If you have specific questions or concerns, do not hesitate to reach out to your healthcare provider or pharmacist.